Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 1, 2015, Pages 79-86

  Herías, Veronica ^a   Biessen, Erik A L ^a   Beckers, Cora ^a   Delsing, Dianne ^b   Liao, Mengyang ^c   Daemen, Mat J ^d   Pham, Christine C T N ^e   Heeneman, Sylvia ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e WASHINGTON UNIVERSITY   (United States)

Author keywords

Atherosclerosis; human; inflammation; mice; protease

Indexed keywords

DIPEPTIDYL PEPTIDASE I; CTSC PROTEIN, HUMAN; CTSC PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ARCH; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC PLAQUE; BONE MARROW TRANSPLANTATION; CAROTID ARTERY; CELL DIFFERENTIATION; CHIMERA; CONTROLLED STUDY; DESCENDING AORTA; DISEASE COURSE; DOWN REGULATION; FOAM CELL; HELPER CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; AORTA; AORTIC DISEASES; ATHEROSCLEROSIS; C57BL MOUSE; CAROTID ARTERY DISEASES; CELL CULTURE; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LEUKOCYTE; METABOLISM; PATHOLOGY; TIME FACTOR;

ADAPTIVE IMMUNITY; ANIMALS; AORTA; AORTIC DISEASES; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CATHEPSIN C; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; FOAM CELLS; HUMANS; IMMUNITY, INNATE; LEUKOCYTES; MACROPHAGE ACTIVATION; MICE, INBRED C57BL; MICE, KNOCKOUT; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, LDL; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS;

EID: 84920269389     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304292     Document Type: Article

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