Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs

International Journal of Molecular Sciences

Volumn 16, Issue 1, 2015, Pages 660-676

  Wu, Wenting ^a   Ichihara, Gaku ^b   Hashimoto, Naozumi ^a   Hasegawa, Yoshinori ^a   Hayashi, Yasuhiko ^c   Tada Oikawa, Saeko ^d   Suzuki, Yuka ^d   Chang, Jie ^a   Kato, Masashi ^a   D’Alessandro Gabazza, Corina N ^e   Gabazza, Esteban C ^e   Ichihara, Sahoko ^d  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d MIE UNIVERSITY   (Japan)

^e MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Animal model; Bleomycin; Metal fume fever; Pulmonary fibrosis; Zinc oxide nanoparticles

Indexed keywords

BLEOMYCIN; CALVASCULIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTOXIN; GELATINASE A; HYDROXYPROLINE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR; ZINC OXIDE NANOPARTICLE; CCL2 PROTEIN, MOUSE; CYTOKINE; METAL NANOPARTICLE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; ZINC OXIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPIRATION; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPOSURE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; LIGHT SCATTERING; LUNG LAVAGE; LUNG WEIGHT; LYMPHOCYTE COUNT; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRASOUND; UPREGULATION; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG POTENTIATION; LUNG; LUNG FIBROSIS; METABOLISM; PATHOLOGY;

ANIMALIA; MURINAE; MUS;

ANIMALS; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL2; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FEMALE; INTERLEUKIN-1BETA; LUNG; METAL NANOPARTICLES; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; TRANSFORMING GROWTH FACTOR BETA; ZINC OXIDE;

EID: 84920262339     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16010660     Document Type: Article

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