Tissue-specific GHR knockout mice: Metabolic phenotypes

Frontiers in Endocrinology

Volumn 5, Issue DEC, 2014, Pages

  Sun, Liou Y ^a   Bartke, Andrzej ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RECEPTOR; INTERLEUKIN 1BETA; SOMATOMEDIN C RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; GLUCOSE INTOLERANCE; HUMAN; LIPID HOMEOSTASIS; LIPOLYSIS; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 84920179550     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00243     Document Type: Article

References (24)

1. A. Bartke, L.Y. Sun, and V. Longo, Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiological reviews 93 (2013) 571-98.
2. Y. Zhou, B.C. Xu, H.G. Maheshwari, L. He, M. Reed, M. Lozykowski, S. Okada, L. Cataldo, K. Coschigamo, T.E. Wagner, G. Baumann, and J.J. Kopchick, A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 13215-20.
3. E.O. List, L. Sackmann-Sala, D.E. Berryman, K. Funk, B. Kelder, E.S. Gosney, S. Okada, J. Ding, D. Cruz-Topete, and J.J. Kopchick, Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocrine reviews 32 (2011) 356-86.
4. S. Yakar, J.L. Liu, B. Stannard, A. Butler, D. Accili, B. Sauer, and D. LeRoith, Normal growth and development in the absence of hepatic insulin-like growth factor I. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 7324-9.
5. S. Yakar, J.L. Liu, A.M. Fernandez, Y. Wu, A.V. Schally, J. Frystyk, S.D. Chernausek, W. Mejia, and D. Le Roith, Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity. Diabetes 50 (2001) 1110-8.
6. E.O. List, D.E. Berryman, K. Funk, E.S. Gosney, A. Jara, B. Kelder, X. Wang, L. Kutz, K. Troike, N. Lozier, V. Mikula, E.R. Lubbers, H. Zhang, C. Vesel, R.K. Junnila, S.J. Frank, M.M. Masternak, A. Bartke, and J.J. Kopchick, The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Molecular endocrinology 27 (2013) 524-35.
7. K.Y. Lee, S.J. Russell, S. Ussar, J. Boucher, C. Vernochet, M.A. Mori, G. Smyth, M. Rourk, C. Cederquist, E.D. Rosen, B.B. Kahn, and C.R. Kahn, Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 62 (2013) 864-74.
8. M. Bluher, M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, B.B. Kahn, and C.R. Kahn, Adipose tissue selective insulin receptor knockout protects against obesity and obesityrelated glucose intolerance. Developmental cell 3 (2002) 25-38.
9. J.M. Olefsky, and C.K. Glass, Macrophages, inflammation, and insulin resistance. Annual review of physiology 72 (2010) 219-46.
10. C.P. Liang, S. Han, T. Senokuchi, and A.R. Tall, The macrophage at the crossroads of insulin resistance and atherosclerosis. Circulation research 100 (2007) 1546-55.
11. C. Lu, P.A. Kumar, J. Sun, A. Aggarwal, Y. Fan, M.A. Sperling, C.N. Lumeng, and R.K. Menon, Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. The Journal of biological chemistry 288 (2013) 15725-35.
12. Y. Fan, R.K. Menon, P. Cohen, D. Hwang, T. Clemens, D.J. DiGirolamo, J.J. Kopchick, D. Le Roith, M. Trucco, and M.A. Sperling, Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. The Journal of biological chemistry 284 (2009) 19937-44.
13. E.O. List, D.E. Berryman, K. Funk, A. Jara, B. Kelder, F. Wang, M.B. Stout, X. Zhi, L. Sun, T.A. White, N.K. LeBrasseur, T. Pirtskhalava, T. Tchkonia, E.A. Jensen, W. Zhang, M.M. Masternak, J.L. Kirkland, R.A. Miller, A. Bartke, and J.J. Kopchick, Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology 155 (2014) 1793-805.
14. A.A. Butler, and D. Le Roith, Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annual review of physiology 63 (2001) 141-64.
15. J.R. Florini, D.Z. Ewton, and S.A. Coolican, Growth hormone and the insulin-like growth factor system in myogenesis. Endocrine reviews 17 (1996) 481-517.
16. P. Klover, W. Chen, B.M. Zhu, and L. Hennighausen, Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 23 (2009) 3140-8.
17. A. Sotiropoulos, M. Ohanna, C. Kedzia, R.K. Menon, J.J. Kopchick, P.A. Kelly, and M. Pende, Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation. Proceedings of the National Academy of Sciences of the United States of America 103 (2006) 7315-20.
18. M.D. Mavalli, D.J. DiGirolamo, Y. Fan, R.C. Riddle, K.S. Campbell, T. van Groen, S.J. Frank, M.A. Sperling, K.A. Esser, M.M. Bamman, and T.L. Clemens, Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. The Journal of clinical investigation 120 (2010) 4007-20.
19. A. Vijayakumar, Y. Wu, H. Sun, X. Li, Z. Jeddy, C. Liu, G.J. Schwartz, S. Yakar, and D. LeRoith, Targeted loss of GHR signaling in mouse skeletal muscle protects against highfat diet-induced metabolic deterioration. Diabetes 61 (2012) 94-103.
20. A.S. Rudenski, D.R. Matthews, J.C. Levy, and R.C. Turner, Understanding "insulin resistance": both glucose resistance and insulin resistance are required to model human diabetes. Metabolism: clinical and experimental 40 (1991) 908-17.
21. J.H. Nielsen, E.D. Galsgaard, A. Moldrup, B.N. Friedrichsen, N. Billestrup, J.A. Hansen, Y.C. Lee, and C. Carlsson, Regulation of beta-cell mass by hormones and growth factors. Diabetes 50 Suppl 1 (2001) S25-9.
22. N. Billestrup, and J.H. Nielsen, The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I. Endocrinology 129 (1991) 883-8.
23. J.H. Nielsen, S. Linde, B.S. Welinder, N. Billestrup, and O.D. Madsen, Growth hormone is a growth factor for the differentiated pancreatic beta-cell. Molecular endocrinology 3 (1989) 165-73.
24. Y. Wu, C. Liu, H. Sun, A. Vijayakumar, P.R. Giglou, R. Qiao, J. Oppenheimer, S. Yakar, and D. LeRoith, Growth hormone receptor regulates beta cell hyperplasia and glucosestimulated insulin secretion in obese mice. The Journal of clinical investigation 121 (2011) 2422-6.