Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15725-15735

  Lu, Chunxia ^a   Kumar, P Anil ^a   Sun, Jinhong ^a   Aggarwal, Anjali ^a   Fan, Yong ^c   Sperling, Mark A ^c   Lumeng, Carey N ^a,b   Menon, Ram K ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; CHRONIC INFLAMMATION; DELETERIOUS EFFECTS; DIET-INDUCED OBESITY; GLUCOSE HOMEOSTASIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; PRO-INFLAMMATORY CYTOKINES;

GLUCOSE; INSULIN; MACROPHAGES; MAMMALS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TISSUE;

NUTRITION;

GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; OSTEOPONTIN; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE HOMEOSTASIS; HORMONE ACTION; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INSULIN SENSITIVITY; LIPID DIET; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ADIPOSE TISSUE; GROWTH HORMONE; INFLAMMATION; MACROPHAGES; OBESITY;

ADIPOSE TISSUE; ANIMALS; CARRIER PROTEINS; DIET; GLUCOSE; GROWTH HORMONE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; NF-KAPPA B; OBESITY; OSTEOPONTIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RESPONSE ELEMENTS;

MUS;

EID: 84878402558     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.460212     Document Type: Article

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