Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 1, 2015, Pages 289-298

  O'Dwyer, Karen ^a   Spivak, Aaron T ^a   Ingraham, Karen ^a   Min, Sharon ^a   Holmes, David J ^a   Jakielaszek, Charles ^a   Rittenhouse, Stephen ^a   Kwan, Alan L ^a   Livi, George P ^a   Sathe, Ganesh ^a   Thomas, Elizabeth ^a   Van Horn, Stephanie ^a   Miller, Linda A ^a   Twynholm, Monique ^b   Tomayko, John ^a   Dalessandro, Marybeth ^a,c   Caltabiano, Madelyn ^a,d   Scangarella Oman, Nicole E ^a   Brown, James R ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Stiefel Laboratories Inc   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOMETHYL 1,3 DIHYDRO 1 HYDROXY 7 (3 HYDROXYPROPYL) 2,1 BENZOXABOROLE; GENOMIC DNA; MEROPENEM; 3-(AMINOMETHYL)-7-(3-HYDROXYPROPOXY)-1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROLE; ANTIINFECTIVE AGENT; BORON DERIVATIVE; ENZYME INHIBITOR; LEUCINE TRANSFER RNA LIGASE; URINARY TRACT ANTIINFECTIVE AGENT;

ABDOMINAL INFECTION; ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; DNA SEQUENCE; DRUG EFFICACY; DRUG SCREENING; ESCHERICHIA COLI; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; PHASE 2 CLINICAL TRIAL; PHYLOGENY; URINARY TRACT INFECTION; YOUNG ADULT; ANTAGONISTS AND INHIBITORS; BACTERIAL GENOME; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECTS; ESCHERICHIA COLI INFECTIONS; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTICENTER STUDY; MUTATION; PATHOGENICITY; RANDOMIZED CONTROLLED TRIAL; URINARY TRACT INFECTIONS;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, URINARY; BORON COMPOUNDS; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GENOME, BACTERIAL; HUMANS; LEUCINE-TRNA LIGASE; MUTATION; PHYLOGENY; URINARY TRACT INFECTIONS;

EID: 84920171570     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03774-14     Document Type: Article

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