-
1
-
-
34548018304
-
The insulin-like growth factor 1 receptor in cancer: Old focus, new future
-
DOI 10.1016/j.ejca.2007.05.021, PII S0959804907004340
-
Hartog H, Wesseling J, Boezen HM, van der Graaf WT (2007) The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer 43:1895-1904 (Pubitemid 47284866)
-
(2007)
European Journal of Cancer
, vol.43
, Issue.13
, pp. 1895-1904
-
-
Hartog, H.1
Wesseling, J.2
Boezen, H.M.3
Van Der Graaf, W.T.A.4
-
2
-
-
33846874575
-
The role of the IGF system in cancer growth and metastasis: Overview and recent insights
-
DOI 10.1210/er.2006-0001
-
Samani AA, Yakar S, LeRoith D, Brodt P (2007) The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28:20-47 (Pubitemid 46220849)
-
(2007)
Endocrine Reviews
, vol.28
, Issue.1
, pp. 20-47
-
-
Samani, A.A.1
Yakar, S.2
LeRoith, D.3
Brodt, P.4
-
3
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI, Persaud Y, Janakiraman M et al (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480:387-390
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
-
4
-
-
0028233617
-
The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients
-
DOI 10.1016/0959-8049(94)90247-X
-
Railo MJ, von Smitten K, Pekonen F (1994) The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur J Cancer 30A:307-311 (Pubitemid 24152469)
-
(1994)
European Journal of Cancer Part A: General Topics
, vol.30
, Issue.3
, pp. 307-311
-
-
Railo, M.J.1
Smitten, K.V.2
Pekonen, F.3
-
5
-
-
84857920393
-
Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
-
Yerushalmi R, Gelmon KA, Leung S et al (2011) Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes. Breast Cancer Res Treat 132:131-142
-
(2011)
Breast Cancer Res Treat
, vol.132
, pp. 131-142
-
-
Yerushalmi, R.1
Gelmon, K.A.2
Leung, S.3
-
6
-
-
0033305004
-
Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
-
Lee AV, Jackson JG, Gooch JL et al (1999) Enhancement of insulinlike growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. MolEndocrinol 13:787-796 (Pubitemid 30645331)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.5
, pp. 787-796
-
-
Lee, A.V.1
Jackson, J.G.2
Gooch, J.L.3
Hilsenbeck, S.G.4
Coronado-Heinsohn, E.5
Osborne, C.K.6
Yee, D.7
-
7
-
-
33846846385
-
Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: Involvement of transcription factor Sp1
-
DOI 10.1677/joe.1.07016
-
Maor S, Mayer D, Yarden RI et al (2006) Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. JEndocrinol 191:605-612 (Pubitemid 46210286)
-
(2006)
Journal of Endocrinology
, vol.191
, Issue.3
, pp. 605-612
-
-
Maor, S.1
Mayer, D.2
Yarden, R.I.3
Lee, A.V.4
Sarfstein, R.5
Werner, H.6
Papa, M.Z.7
-
8
-
-
63649117164
-
Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells
-
Santen RJ, Fan P, Zhang Z et al (2009) Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids 74:586-594
-
(2009)
Steroids
, vol.74
, pp. 586-594
-
-
Santen, R.J.1
Fan, P.2
Zhang, Z.3
-
9
-
-
57149137029
-
Crosstalk between IGF1R and estrogen receptor signaling in breast cancer
-
Fagan DH, Yee D (2008) Crosstalk between IGF1R and estrogen receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia 13:423-429
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 423-429
-
-
Fagan, D.H.1
Yee, D.2
-
10
-
-
54249157471
-
Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
-
Cao L, Yu Y, Darko I et al (2008) Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res 68:8039-8048
-
(2008)
Cancer Res
, vol.68
, pp. 8039-8048
-
-
Cao, L.1
Yu, Y.2
Darko, I.3
-
11
-
-
68849128275
-
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
-
Zha J, O'Brien C, Savage H et al (2009) Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol Cancer Ther 8:2110-2121
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2110-2121
-
-
Zha, J.1
O'Brien, C.2
Savage, H.3
-
12
-
-
4944266313
-
High interstitial fluid pressure - An obstacle in cancer therapy
-
DOI 10.1038/nrc1456
-
Heldin CH, Rubin K, Pietras K, Ostman A (2004) High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 4:806-813 (Pubitemid 39331152)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.10
, pp. 806-813
-
-
Heldin, C.-H.1
Rubin, K.2
Pietras, K.3
Ostman, A.4
-
13
-
-
0033302303
-
Transport of molecules, particles, and cells in solid tumors
-
Jain RK (1999) Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1:241-263
-
(1999)
Annu Rev Biomed Eng
, vol.1
, pp. 241-263
-
-
Jain, R.K.1
-
14
-
-
79851482773
-
ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model
-
Heskamp S, van Laarhoven HW, Molkenboer-Kuenen JD et al (2010) ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model. J Nucl Med 51:1565-1572
-
(2010)
J Nucl Med
, vol.51
, pp. 1565-1572
-
-
Heskamp, S.1
Van Laarhoven, H.W.2
Molkenboer-Kuenen, J.D.3
-
15
-
-
84875912401
-
Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer
-
Brom M, Joosten L, Oyen WJ et al (2012) Improved labelling of DTPA- and DOTA-conjugated peptides and antibodies with 111In in HEPES and MES buffer. EJNMMI Res 2:4
-
(2012)
EJNMMI Res
, vol.2
, pp. 4
-
-
Brom, M.1
Joosten, L.2
Oyen, W.J.3
-
16
-
-
63849284181
-
U-SPECTII: An ultra-high-resolution device for molecular small-animal imaging
-
van der Have F, Vastenhouw B, Ramakers RM et al (2009) U-SPECTII: an ultra-high-resolution device for molecular small-animal imaging. J Nucl Med 50:599-605
-
(2009)
J Nucl Med
, vol.50
, pp. 599-605
-
-
Van Der Have, F.1
Vastenhouw, B.2
Ramakers, R.M.3
-
17
-
-
80052157331
-
Abstract S1-4: A randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC)
-
Kaufman PA, Ferrero JM, Bourgeois H et al (2010) Abstract S1-4: a randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC). Cancer Res 70:S1-S4
-
(2010)
Cancer Res
, vol.70
-
-
Kaufman, P.A.1
Ferrero, J.M.2
Bourgeois, H.3
-
18
-
-
84863584930
-
Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: Implications for breast cancer treatment
-
Fagan DH, Uselman RR, Sachdev D, Yee D (2012) Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment. Cancer Res 72:3372-3380
-
(2012)
Cancer Res
, vol.72
, pp. 3372-3380
-
-
Fagan, D.H.1
Uselman, R.R.2
Sachdev, D.3
Yee, D.4
-
19
-
-
80054921787
-
Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment
-
Drury SC, Detre S, Leary A et al (2011) Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment. Endocrine-related Cancer 18:565-577
-
(2011)
Endocrine-related Cancer
, vol.18
, pp. 565-577
-
-
Drury, S.C.1
Detre, S.2
Leary, A.3
-
20
-
-
84055176504
-
Predicting IGF-1R therapy response in bone sarcomas: Immuno-SPECT imaging with radiolabeled R1507
-
Fleuren ED, Versleijen-Jonkers YM, van de Luijtgaarden AC et al (2011) Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507. Clin Cancer Res 17:7693-7703
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7693-7703
-
-
Fleuren, E.D.1
Versleijen-Jonkers, Y.M.2
Van De Luijtgaarden, A.C.3
-
21
-
-
84867574623
-
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: A predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas
-
Asmane I, Watkin E, Alberti L et al (2012) Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. Eur J Cancer 48:3027-3035
-
(2012)
Eur J Cancer
, vol.48
, pp. 3027-3035
-
-
Asmane, I.1
Watkin, E.2
Alberti, L.3
-
22
-
-
58249101005
-
The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/ HER2 inhibitors
-
Huang F, Greer A, Hurlburt W et al (2009) The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/ HER2 inhibitors. Cancer Res 69:161-170
-
(2009)
Cancer Res
, vol.69
, pp. 161-170
-
-
Huang, F.1
Greer, A.2
Hurlburt, W.3
-
23
-
-
0023481357
-
Transport of molecules across tumor vasculature
-
Jain RK (1987) Transport of molecules across tumor vasculature. Cancer Metastasis Rev 6:559-593
-
(1987)
Cancer Metastasis Rev
, vol.6
, pp. 559-593
-
-
Jain, R.K.1
-
24
-
-
84855931910
-
Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: Implications for scheduling of anti-angiogenic drugs
-
Van der Veldt AA, Lubberink M, Bahce I et al (2012) Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs. Cancer Cell 21:82-91
-
(2012)
Cancer Cell
, vol.21
, pp. 82-91
-
-
Van Der Veldt, A.A.1
Lubberink, M.2
Bahce, I.3
-
25
-
-
84877799305
-
Bevacizumab reduces tumor targeting of anti-epidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies
-
Heskamp S, Boerman OC, Molkenboer-Kuenen JD, et al. (2013) Bevacizumab reduces tumor targeting of anti-epidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies. Int J Cancer 133:307-314
-
(2013)
Int J Cancer
, vol.133
, pp. 307-314
-
-
Heskamp, S.1
Boerman, O.C.2
Molkenboer-Kuenen, J.D.3
-
26
-
-
0036531804
-
Hormonal regulation of VEGF in orthotopic MCF7 human breast cancer
-
Bogin L, Degani H (2002) Hormonal regulation of VEGF in orthotopic MCF7 human breast cancer. Cancer Res 62:1948-1951 (Pubitemid 34408435)
-
(2002)
Cancer Research
, vol.62
, Issue.7
, pp. 1948-1951
-
-
Bogin, L.1
Degani, H.2
-
27
-
-
0033602501
-
Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells
-
DOI 10.1016/S0303-7207(99)00003-9, PII S0303720799000039
-
Ruohola JK, Valve EM, Karkkainen MJ et al (1999) Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol Cell Endocrinol 149:29-40 (Pubitemid 29236221)
-
(1999)
Molecular and Cellular Endocrinology
, vol.149
, Issue.1-2
, pp. 29-40
-
-
Ruohola, J.K.1
Valve, E.M.2
Karkkainen, M.J.3
Joukov, V.4
Alitalo, K.5
Harkonen, P.L.6
-
28
-
-
0346059598
-
Tamoxifen Inhibits Secretion of Vascular Endothelial Growth Factor in Breast Cancer in Vivo
-
Garvin S, Dabrosin C (2003) Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Res 63:8742-8748 (Pubitemid 38064052)
-
(2003)
Cancer Research
, vol.63
, Issue.24
, pp. 8742-8748
-
-
Garvin, S.1
Dabrosin, C.2
-
29
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto A, Pollak M (2009) Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 28:3009-3021
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
30
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A et al (2009) Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 27:5800-5807
-
(2009)
J Clin Oncol
, vol.27
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
-
31
-
-
83255163333
-
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: Results of a phase II Sarcoma Alliance for Research through Collaboration study
-
Pappo AS, Patel SR, Crowley J et al (2011) R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J Clin Oncol 29:4541-4547
-
(2011)
J Clin Oncol
, vol.29
, pp. 4541-4547
-
-
Pappo, A.S.1
Patel, S.R.2
Crowley, J.3
-
32
-
-
83355174075
-
Randomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer
-
Ramalingam SS, Spigel DR, Chen D et al (2011) Randomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer. J Clin Oncol 29:4574-4580
-
(2011)
J Clin Oncol
, vol.29
, pp. 4574-4580
-
-
Ramalingam, S.S.1
Spigel, D.R.2
Chen, D.3
-
33
-
-
84904431313
-
A randomized phase II/III study of the anti-IGF-1R antibody MK-0646 (dalotuzumab) in chemorefractory metastatic colorectal cancer (mCRC) with wilde-type (wit) KRAS status
-
Watkins DJ, Tabernero J, Schmoll H, et al. (2011) A randomized phase II/III study of the anti-IGF-1R antibody MK-0646 (dalotuzumab) in chemorefractory metastatic colorectal cancer (mCRC) with wilde-type (wit) KRAS status. J Clin Oncol 29:S3515
-
(2011)
J Clin Oncol
, vol.29
-
-
Watkins, D.J.1
Tabernero, J.2
Schmoll, H.3
-
34
-
-
84864683719
-
Optimization of IGF-1R SPECT/CT imaging using (111)In-labeled F(ab')2 and Fab fragments of the monoclonal antibody R1507
-
Heskamp S, van Laarhoven HW, Molkenboer-Kuenen JD, et al. (2012) Optimization of IGF-1R SPECT/CT imaging using (111)In-labeled F(ab')2 and Fab fragments of the monoclonal antibody R1507. Mol Pharm 9:2314-2321
-
(2012)
Mol Pharm
, vol.9
, pp. 2314-2321
-
-
Heskamp, S.1
Van Laarhoven, H.W.2
Molkenboer-Kuenen, J.D.3
-
35
-
-
48249128676
-
The level of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin)
-
Cornelissen B, McLarty K, Kersemans V, Reilly RM (2008) The level of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin). Nucl Med Biol 35:645-653
-
(2008)
Nucl Med Biol
, vol.35
, pp. 645-653
-
-
Cornelissen, B.1
McLarty, K.2
Kersemans, V.3
Reilly, R.M.4
-
36
-
-
84855410318
-
Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the Affibody molecule 111In-DOTA-ZIGF1R:4551
-
Tolmachev V,Malmberg J, Hofstrom C et al (2012) Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the Affibody molecule 111In-DOTA-ZIGF1R:4551. J Nucl Med 53:90-97
-
(2012)
J Nucl Med
, vol.53
, pp. 90-97
-
-
Tolmachev, V.1
Malmberg, J.2
Hofstrom, C.3
|