Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 257-269

  Wu, Mingyi ^a,b   Wen, Dandan ^a,b,c   Gao, Na ^a   Xiao, Chuang ^a,b   Yang, Lian ^a   Xu, Li ^a   Lian, Wu ^a,b   Peng, Wenlie ^b   Jiang, Jianmin ^b   Zhao, Jinhua ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c CHANGSHA CENTRAL HOSPITAL   (China)

Author keywords

Anticoagulant; Antithrombotic; Factor Xase inhibitor; Fucosylated chondroitin sulfate; Structureeactivity relationship

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9A; CARBOHYDRATE; CARBOXYL GROUP; FUCOSYLATED CHONDROITIN SULFATE; FUCOSYLATED CHONDROITIN SULFATE DERIVATIVE; GLYCOSAMINOGLYCAN; INTRINSIC FACTOR; TRISACCHARIDE; UNCLASSIFIED DRUG; CHONDROITIN SULFATE; CYSTEINE PROTEINASE; ENZYME INHIBITOR; FIBRINOLYTIC AGENT;

ANTICOAGULATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG SULFATION; FUCOSYLATION; IN VITRO STUDY; IN VIVO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; SEA CUCUMBER; THROMBOCYTE ACTIVATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD CLOTTING; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HUMAN; INBRED MOUSE STRAIN; METABOLISM; MOUSE; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THROMBOSIS;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CHONDROITIN SULFATES; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FACTOR XII; FIBRINOLYTIC AGENTS; HUMANS; MICE; MICE, INBRED STRAINS; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOSIS;

EID: 84920160745     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.054     Document Type: Article

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