Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage

Carbohydrate Polymers

Volumn 98, Issue 2, 2013, Pages 1514-1523

  Zhao, Longyan ^a,b   Lai, Sensen ^a,c,d   Huang, Rong ^e   Wu, Mingyi ^a   Gao, Na ^a   Xu, Li ^a,b   Qin, Hongbo ^a   Peng, Wenlie ^c   Zhao, Jinhua ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d Ganzhou Provincial Institute for Food and Drug Control   (China)

^e YUNNAN UNIVERSITY   (China)

Author keywords

Anticoagulant activity; Deacetylation; Deaminative cleavage; Glycosaminoglycan; Sea cucumber

Indexed keywords

ANTICOAGULANT ACTIVITIES; DEACETYLATION; DEAMINATIVE CLEAVAGE; GLYCOSAMINOGLYCANS; SEA CUCUMBER;

BIOACTIVITY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ACETYLATION;

HOLOTHUROIDEA;

ANTICOAGULANT AGENT; CANCER PROCOAGULANT; CYSTEINE PROTEINASE; FUCOSE; GALACTOSAMINE; GLUCURONIC ACID; GLYCOSAMINOGLYCAN; HEPARIN; HEPARIN COFACTOR II; HYDRAZINE; HYDRAZINE DERIVATIVE; L TALO GAMMA LACTONE; L-TALO-GAMMA-LACTONE; LACTONE; NITROUS ACID; THROMBIN; TUMOR PROTEIN;

2,4-O-DISULFATED FUCOSE; 3-O-SULFATED FUCOSE; 4,6-O-DISULFATED N-ACETYLGALACTOSAMINE; 4-O-SULFATED FUCOSE; ANHYDRO-D-TALOSE; ANIMAL; ANTAL; ANTICOAGULATION; APTT; ARTICLE; BLOOD CLOTTING; CHEMISTRY; DD; DEACETYLATION; DEACETYLATION DEGREE; DEAMINATIVE CLEAVAGE; DEPOLYMERIZED FUCOSYLATED GLYCOSAMINOGLYCAN; DFG; DRUG ANTAGONISM; DRUG EFFECT; EC(50); ENZYME ASSAY; FG; FUC2S4S; FUC3S; FUC4S; FUCOSYLATED GLYCOSAMINOGLYCAN; GAG; GALN; GALNAC4S6S; GLCUA; HALF MAXIMAL EFFECTIVE CONCENTRATION; HCII; HUMAN; ISOLATION AND PURIFICATION; LMWH; LOW-MOLECULAR-WEIGHT HEPARIN; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTIAL THROMBOPLASTIN TIME; SEA CUCUMBER; STRUCTURE ACTIVITY RELATION; UFH;

2,4-O-DISULFATED FUCOSE; 3-O-SULFATED FUCOSE; 4,6-O-DISULFATED N-ACETYLGALACTOSAMINE; 4-O-SULFATED FUCOSE; ACTIVATED PARTIAL THROMBOPLASTIN TIME; ANHYDRO-D-TALOSE; ANTAL; ANTICOAGULANT ACTIVITY; APTT; DD; DEACETYLATION; DEACETYLATION DEGREE; DEAMINATIVE CLEAVAGE; DEPOLYMERIZED FUCOSYLATED GLYCOSAMINOGLYCAN; DFG; EC(50); FG; FUC2S4S; FUC3S; FUC4S; FUCOSYLATED GLYCOSAMINOGLYCAN; GAG; GALACTOSAMINE; GALN; GALNAC4S6S; GLCUA; GLUCURONIC ACID; GLYCOSAMINOGLYCAN; HALF MAXIMAL EFFECTIVE CONCENTRATION; HCII; HEPARIN COFACTOR II; LMWH; LOW-MOLECULAR-WEIGHT HEPARIN; SEA CUCUMBER; UFH; UNFRACTIONATED HEPARIN;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CYSTEINE ENDOPEPTIDASES; ENZYME ASSAYS; FUCOSE; GLYCOSAMINOGLYCANS; HEPARIN COFACTOR II; HUMANS; HYDRAZINES; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; NEOPLASM PROTEINS; NITROUS ACID; SEA CUCUMBERS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 84882765904     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2013.07.063     Document Type: Article

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