Synthesis and biological evaluation of pentacyclic strychnos alkaloids as selective modulators of the ABCC10 (MRP7) efflux pump

Journal of Medicinal Chemistry

Volumn 57, Issue 24, 2014, Pages 10383-10390

  Teijaro, Christiana N ^a   Munagala, Surendrachary ^a   Zhao, Senzhi ^a   Sirasani, Gopal ^a   Kokkonda, Praveen ^a   Malofeeva, Ekaterina V ^b   Hopper Borge, Elizabeth ^b   Andrade, Rodrigo B ^a  

^a Temple University   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

19 ACETOXYALSTOLUCINE B; 19 HYDROXYALSTOLUCINE B; 19,20 DIHYDROXYAKUAMMICINE; ADENOSINE TRIPHOSPHATASE; ALSTOLUCINE A; ALSTOLUCINE B; ALSTOLUCINE F; ANTINEOPLASTIC ALKALOID; ECHITAMIDINE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 7; MULTIDRUG RESISTANCE PROTEIN; N DEMETHYLALSOGUCINE; PACLITAXEL; UNCLASSIFIED DRUG; ABCC10 PROTEIN, HUMAN; ALKALOID; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLE ALKALOID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER RESISTANCE; CELL TRANSFER; DRUG SENSITIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; PROTEIN FUNCTION; STRYCHNOS; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; HEK293 CELL LINE; HUMAN; MULTIDRUG RESISTANCE; SYNTHESIS;

ADENOSINE TRIPHOSPHATASES; ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INDOLE ALKALOIDS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PACLITAXEL; STRYCHNOS;

EID: 84920150403     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501189p     Document Type: Article

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