Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance

Biochemical Pharmacology

Volumn 77, Issue 6, 2009, Pages 993-1001

  Zhou, Ying ^a   Hopper Borge, Elizabeth ^b   Shen, Tong ^a   Huang, Xiao Cong ^a   Shi, Zhi ^a   Kuang, Ye Hong ^a,c   Furukawa, Tatsuhiko ^d   Akiyama, Shin ichi ^d   Peng, Xing Xiang ^a   Ashby Jr , Charles R ^a   Chen, Xiang ^c   Kruh, Gary D ^e   Chen, Zhe Sheng ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d KAGOSHIMA UNIVERSITY   (Japan)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cepharanthine; E217 G transport; MDR; MRP7; Paclitaxel

Indexed keywords

CEPHARANTHINE; DACTINOMYCIN; DAUNORUBICIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 7; PACLITAXEL; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; STEPHANIA; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZYLISOQUINOLINES; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PACLITAXEL;

EID: 60649096849     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.12.005     Document Type: Article

References (40)

1. Choudhuri S., and Klaassen C.D. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 25 4 (2006) 231-259
2. Dean M., and Allikmets R. Complete characterization of the human ABC gene family. J Bioenerg Biomembr 33 6 (2001) 475-479
3. Kruh G.D., and Belinsky M.G. The MRP family of drug efflux pumps. Oncogene 22 47 (2003) 7537-7552
4. Cole S.P., Sparks K.E., Fraser K., Loe D.W., Grant C.E., Wilson G.M., et al. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54 22 (1994) 5902-5910
5. Chen Z.S., Furukawa T., Sumizawa T., Ono K., Ueda K., Seto K., et al. ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol 55 5 (1999) 921-928
6. Koike K., Kawabe T., Tanaka T., Toh S., Uchiumi T., Wada M., et al. A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 57 24 (1997) 5475-5479
7. Cui Y., Konig J., Buchholz J.K., Spring H., Leier I., and Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55 5 (1999) 929-937
8. Kawabe T., Chen Z.S., Wada M., Uchiumi T., Ono M., Akiyama S., et al. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett 456 2 (1999) 327-331
9. Kool M., van der Linden M., de Haas M., Scheffer G.L., de Vree J.M., Smith A.J., et al. MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci U S A 96 12 (1999) 6914-6919
10. Zeng H., Bain L.J., Belinsky M.G., and Kruh G.D. Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents. Cancer Res 59 23 (1999) 5964-5967
11. Zelcer N., Saeki T., Reid G., Beijnen J.H., and Borst P. Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem 276 49 (2001) 46400-46407
12. Belinsky M.G., Chen Z.S., Shchaveleva I., Zeng H., and Kruh G.D. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res 62 21 (2002) 6172-6177
13. Schuetz J.D., Connelly M.C., Sun D., Paibir S.G., Flynn P.M., Srinivas R.V., et al. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med 5 9 (1999) 1048-1051
14. Wielinga P.R., Reid G., Challa E.E., van der Heijden I., van Deemter L., de Haas M., et al. Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 62 6 (2002) 1321-1331
15. Chen Z.S., Lee K., and Kruh G.D. Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem 276 36 (2001) 33747-33754
16. Guo Y., Kotova E., Chen Z.S., Lee K., Hopper-Borge E., Belinsky M.G., et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′, 3′-dideoxycytidine and 9′-(2′-phosphonylmethoxyethyl)adenine. J Biol Chem 278 32 (2003) 29509-29514
17. Ono N., Van der Heijden I., Scheffer G.L., Van de Wetering K., Van Deemter E., De Haas M., et al. Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm. Biochem J 406 1 (2007) 31-40
18. Hopper E., Belinsky M.G., Zeng H., Tosolini A., Testa J.R., and Kruh G.D. Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily. Cancer Lett 162 2 (2001) 181-191
19. Chen Z.S., Hopper-Borge E., Belinsky M.G., Shchaveleva I., Kotova E., and Kruh G.D. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol 63 2 (2003) 351-358
20. Hopper-Borge E., Chen Z.S., Shchaveleva I., Belinsky M.G., and Kruh G.D. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Cancer Res 64 14 (2004) 4927-4930
21. Naramoto H., Uematsu T., Uchihashi T., Doto R., Matsuura T., Usui Y., et al. Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines. Int J Oncol 30 2 (2007) 393-401
22. Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K., et al. MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer. Mol Cancer Ther 7 5 (2008) 1150-1155
23. Tsuruo T., Iida H., Tsukagoshi S., and Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41 5 (1981) 1967-1972
24. Thomas H., and Coley H.M. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10 2 (2003) 159-165
25. Baer M.R., George S.L., Dodge R.K., O'Loughlin K.L., Minderman H., Caligiuri M.A., et al. Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 100 4 (2002) 1224-1232
26. Avendano C., and Menendez J.C. Inhibitors of multidrug resistance to antitumor agents (MDR). Curr Med Chem 9 2 (2002) 159-193
27. Utsumi K., Miyahara M., and Sugiyama K. Effect of biscoclaurine alkaloid on the cell membrane related to membrane fluidity. Acta Histochem Cytochem 9 (1976) 59-68
28. Shiraishi N., Akiyama S., Nakagawa M., Kobayashi M., and Kuwano M. Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells. Cancer Res 47 9 (1987) 2413-2416
29. Mukai M., Che X.F., Furukawa T., Sumizawa T., Aoki S., Ren X.Q., et al. Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells. Cancer Sci 94 6 (2003) 557-563
30. Hirai M., Tanaka K., Shimizu T., Tanigawara Y., Yasuhara M., Hori R., et al. Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein. J Pharmacol Exp Ther 275 1 (1995) 73-78
31. Akiyama S., Fojo A., Hanover J.A., Pastan I., and Gottesman M.M. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet 11 2 (1985) 117-126
32. Cornwell M.M., Gottesman M.M., and Pastan I.H. Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells. J Biol Chem 261 17 (1986) 7921-7928
33. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
34. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., and Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47 4 (1987) 936-942
35. Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. 2009; 69(1):178-84.
36. Gekeler V., Ise W., Sanders K.H., Ulrich W.R., and Beck J. The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance. Biochem Biophys Res Commun 208 1 (1995) 345-352
37. Jedlitschky G., Burchell B., and Keppler D. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem 275 39 (2000) 30069-30074
38. Wu J., Suzuki H., Zhou Y.W., Liu W., Yoshihara M., Kato M., et al. Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines. J Cell Biochem 82 2 (2001) 200-214
39. Ikeda R., Che X.F., Yamaguchi T., Ushiyama M., Zheng C.L., Okumura H., et al. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci 96 6 (2005) 372-376
40. Abe T., Koike K., Ohga T., Kubo T., Wada M., Kohno K., et al. Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1. Br J Cancer 72 2 (1995) 418-423