Synthesis and evaluation of Strychnos alkaloids as MDR reversal agents for cancer cell eradication

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1148-1155

  Munagala, Surendrachary ^a   Sirasani, Gopal ^a   Kokkonda, Praveen ^a   Phadke, Manali ^b   Krynetskaia, Natalia ^b   Lu, Peihua ^c   Sharom, Frances J ^c   Chaudhury, Sidhartha ^d   Abdulhameed, Mohamed Diwan M ^d   Tawa, Gregory ^d   Wallqvist, Anders ^d   Martinez, Rogelio ^b   Childers, Wayne ^b   Abou Gharbia, Magid ^b   Krynetskiy, Evgeny ^b   Andrade, Rodrigo B ^a  

^a Temple University   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^c UNIVERSITY OF GUELPH   (Canada)

^d U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

Author keywords

ABCB1; Docking; Multidrug resistance; P glycoprotein; Resensitization; Strychnos alkaloids; Total synthesis

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALKALOID; MULTIDRUG RESISTANCE PROTEIN; STRYCHNOS ALKALOID; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE REVERSAL; PHARMACODYNAMICS; PHOTOCHEMICAL QUENCHING; PROTEIN BINDING; PROTEIN INTERACTION; STRYCHNOS;

STRYCHNOS;

ABCB1; DOCKING; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; RESENSITIZATION; STRYCHNOS ALKALOIDS; TOTAL SYNTHESIS;

ADENOSINE TRIPHOSPHATASES; ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDOLE ALKALOIDS; INDOLES; MOLECULAR DOCKING SIMULATION; P-GLYCOPROTEIN; PROTEIN CONFORMATION; STRYCHNOS; TUBOCURARINE; VERAPAMIL;

EID: 84892813894     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.022     Document Type: Article

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