Broad adaptive immune responses to M. tuberculosis antigens precede TST conversion in tuberculosis exposed household contacts in a TB-endemic setting

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Buchwald, Ulrike K ^a,c   Adetifa, Ifedayo M O ^a   Bottomley, Christian ^b   Owiafe, Patrick K ^a   Donkor, Simon ^a   Bojang, Adama L ^a   Sutherland, Jayne S ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 3; MYCOBACTERIUM ANTIGEN; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL ANTIGEN;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; CLINICAL ARTICLE; CONTACT EXAMINATION; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HIGH RISK POPULATION; HOUSEHOLD; HUMAN; HUMAN CELL; INFECTION RISK; INNATE IMMUNITY; INTERFERON GAMMA RELEASE ASSAY; LATENT TUBERCULOSIS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; SCREENING; TH1 CELL; TH17 CELL; TH2 CELL; TUBERCULIN SKIN TEST CONVERSION; TUBERCULIN TEST; CELL CULTURE; ENDEMIC DISEASE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; YOUNG ADULT;

MYCOBACTERIUM TUBERCULOSIS;

ADULT; ANTIGENS, BACTERIAL; CELLS, CULTURED; CONTACT TRACING; ENDEMIC DISEASES; FEMALE; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; TUBERCULIN TEST; TUBERCULOSIS; YOUNG ADULT;

EID: 84920146965     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116268     Document Type: Article

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