Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease

European Journal of Immunology

Volumn 39, Issue 3, 2009, Pages 723-729

  Sutherland, Jayne S ^a   Adetifa, Ifedayo M ^a   Hill, Philip C ^a,b   Adegbola, Richard A ^a   Ota, Martin O C ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cytokines; Mycobacterium tuberculosis infection; T cells; Tuberculosis disease

Indexed keywords

BACTERIAL ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; TH1 CELL; TUBERCULOSIS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY;

HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-2; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 64049095274     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838693     Document Type: Article

References (28)

1. Global Tuberculosis Control: Surveillance, Planning, Financing, WHO report 2007, Geneva, World Health Organization (WHO/HTM/TB/2007.376).
2. Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A. and Bloom, B. R., An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 1993. 178: 2249-2254.
3. Newport, M. J., Huxley, C. M., Huston, S., Hawrylowicz, C. M., Oostra, B. A., Williamson, R. and Levin, M., A mutation in the interferon-gamma-receptor gene and susceptibility tomycobacterial infection. N. Engl. J. Med. 1996. 335: 1941-1949.
4. Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schreiber, R. et al, Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995. 2: 561-572.
5. Leal, I. S., Smedegard, B., Andersen, P. and Appelberg, R., Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation. Immunology 2001. 104: 157-161.
6. Goldsack, L. and Kirman, J. R., Half-truths and selective memory: interferon gamma, CD4+T cells and protective memory against tuberculosis. Tuberculosis 2007. 87: 465-473.
7. Dockrell, H., Gamma interferon - key, but not sufficient for protection against TB? Microbiology Today 2007; November: 172-175.
8. Yamada, G., Shijubo, N., Shigehara, K., Okamura, H., Kurimoto, M. and Abe, S., Increased levels of circulating interleukin-18 in patients with advanced tuberculosis. Am. J. Respir. Crit. Care Med. 2000. 161: 1786-1789.
9. Khader, S. A., Partida-Sanchez, S., Bell, G., Jelley-Gibbs, D. M., Swain, S., Pearl, J. E., Ghilardi, N. et al., Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J. Exp. Med. 2006. 203: 1805-1815.
10. Wu, B., Huang, C., Kato-Maeda, M., Hopewell, P. C., Daley, C. L., Krensky, A. M. and Clayberger, C., Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease. J. Immunol. 2007. 178: 3688-3694.
11. Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel-Moreno, J., Cilley, G. E., Shen, F. et al., IL-23 and IL-17 in the establishment of protective pulmonary CD4+T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat. Immunol. 2007. 8: 369-377.
12. Scriba, T. J., Kalsdorf, B., Abrahams, D. A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y. et al., Distinct, specific IL- 17- and IL-22-producing CD4+T cell subsets contribute to the human anti-mycobacterial immune response. J. Immunol. 2008. 180: 1962-1970.
13. Beveridge, N. E., Price, D. A., Casazza, J. P., Pathan, A. A., Sander, C. R., Asher, T. E., Ambrozak, D. R. et al., Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD41memory T lymphocyte populations. Eur. J. Immunol. 2007. 37: 3089-3100.
14. Soares, A. P., Scriba, T. J., Joseph, S., Harbacheuski, R., Murray, R. A., Gelderbloem, S. J., Hawkridge, A. et al., Bacillus Calmette-Guerin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J. Immunol. 2008. 180: 3569-3577.
15. Hawkridge, T., Scriba, T. J., Gelderbloem, S., Smit, E., Tameris, M., Moyo, S., Lang, T. et al., Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. J. Infect. Dis. 2008. 198: 544-552.
16. Mueller, H., Detjen, A. K., Schuck, S. D., Gutschmidt, A., Wahn, U., Magdorf, K., Kaufmann, S. H. E. and Jacobsen, M., Mycobacterium tuberculosis-specific CD4+, IFNg+, and TNFa+ multifunctional memory T cells coexpress GM-CSF. Cytokine 2008. 43: 143-148.
17. Smith, S. M., Klein, M. R., Malin, A. S., Sillah, J., Huygen, K., Andersen, P., McAdam, K. P. and Dockrell, H. M., Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia. Infect. Immun. 2000. 68: 7144-7148.
18. Harari, A., Petitpierre, S., Vallelian, F. and Pantaleo, G., Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: Changes after antiretroviral therapy. Blood 2004. 103: 966-972.
19. Betts, M. R., Nason, M. C., West, S. M., De Rosa, S. C., Migueles, S. A., Abraham, J. and Lederman, M. M., HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+T cells. Blood 2006. 107: 4781-4789.
20. Younes, S. A., Yassine-Diab, B., Dumont, A. R., Boulassel, M. R., Grossman, Z., Routy, J. P. and Sekaly, R. P., HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J. Exp. Med. 2003. 198: 1909-1922.
21. Duvall, M. G., Precopio, M. L., Ambrozak, D. A., Jaye, A., McMichael, A. J., Whittle, H. C., Roederer, M. et al., Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur. J. Immunol. 2008. 38: 350-363.
22. Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W., Davey, D. F., Flynn, B. J., Hoff, S. T. et al., Multifunctional Th1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nature Med. 2007. 13: 843-850.
23. Dooms, H., Kahn, E., Knoechel, B. and Abbas, A. K., IL-2 induces a competitive survival advantage in T Lymphocytes. J. Immunol. 2004. 172: 5973-5979.
24. Day, C. L., Mkhwanazi, N., Reddy, S., Mncube, Z., Van der Stok, M., Klenerman, P. and Walker, B. D., Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1 infected persons. J. Infect. Dis. 2008. 197: 990-999.
25. Pfeffer, K., Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev. 2003. 14: 185-191.
26. Chakravarty, S. D., Zhu, G., Tsai, M. C., Mohan, V. P., Marino, S., Kirschner, D. E., Huang, L. et al., Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. Infect Immun. 2008. 76: 916-926.
27. Balcewicz-Sablinska, M. K., Keane, J., Kornfeld, H. and Remold, H. G., Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-α. J. Immunol. 1998. 61: 2636-2641.
28. Jamil, B., Shahid, F., Hasan, Z., Nasir, N., Razzaki, T., Dawood, G. and Hussain, R., Interferong/IL10 ratio defines the disease severity in pulmonary and extra pulmonary tuberculosis. Tuberculosis 2007. 87: 279-287.