Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model

Clinical Infectious Diseases

Volumn 40, Issue 2, 2005, Pages 273-278

  Hill, Philip C ^a   Fox, Annette ^a   Jeffries, David J ^a   Jackson Sillah, Dolly ^a   Lugos, Moses D ^a   Owiafe, Patrick K ^a   Donkor, Simon A ^a   Hammond, Abdulrahman S ^a   Corrah, Tumani ^a   Adegbola, Richard A ^a   McAdam, Keith P W J ^a   Brookes, Roger H ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; EARLY ANTIGEN; GAMMA INTERFERON; PROTEIN CFP 10; TUBERCULIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BACTERIUM CULTURE; BACTERIUM DETECTION; CONTROLLED STUDY; DISEASE COURSE; ENDEMIC DISEASE; ENZYME LINKED IMMUNOSPOT ASSAY; EXPOSURE; FEMALE; HUMAN; MALE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SKIN TEST; SPUTUM SMEAR; T LYMPHOCYTE; TUBERCULOSIS;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CONTACT TRACING; FEMALE; GAMBIA; HUMANS; INFANT; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES; TUBERCULIN TEST; TUBERCULOSIS;

EID: 19944428840     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/427030     Document Type: Article

References (20)

1. Floyd S, Ponnighaus JM, Blis L, et al. Kinetics of delayed-type hypersensitivity to tuberculin induced by bacille Calmette-Guérin vaccination in Northern Malawi. J Infect Dis 2002; 186:807-14.
2. Hoft DF, Brown RM, Belshe RB. Mucosal Calmette-Guérin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-γ responses. Clin Infect Dis 2000; 30:S217-22.
3. Fine PEM, Bruce J, Ponnighaus JM, et al. Tuberculin sensitivity: conversions and reversions in a rural African population. Int J Tuberc Lung Dis 1999; 3:962-75.
4. Ewer K, Deeks J, Alvarez L, et al. Comparison of T cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet 2003; 361:1168-73.
5. Demissie A, Ravn P, Olobo J, et al. T cell recognition of Mycobacterium tuberculosis culture filtrate fractions in tuberculosis patients, and their household contacts. Infect Immun 1999; 67:5967-71.
6. Lalvani A, Nagvenkar P, Udwadia Z, et al. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J Infect Dis 2001; 183:469-77.
7. Hill P.C, Brookes RH, Fox A, et al. Large scale evaluation of ELISPOT assay and skin test for the diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in The Gambia. Clin Infect Dis 2004; 38:966-73.
8. Doherty TM, Demissie A, Olobo J, et al. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts to tuberculosis patients. J Clin Microbiol 2002; 40:704-6.
9. National Leprosy and Tuberculosis Programme. Annual Report. The Gambia: KNCV, 2003.
10. Heifets LB, Good RB. Current laboratory methods for the diagnosis of tuberculosis. In: Bloom BR, ed. Tuberculosis: protection, pathogenesis, and control. Washington, DC: American Society for Microbiology, 1994:85-110.
11. + memory T cells. J Exp Med 1997; 186:859-65.
12. Lienhardt C, Bennett S, Del Prete G, et al. Investigation of environmental and host-related risk factors for tuberculosis in Afirca: methodological aspects of a combined design. Am J Epidemiol 2002; 155:1066-73.
13. Jeffries DJ, Donkor SD, Brookes RH, Fox A, Hill PC. Design and implementation of relational databases relevant to the diverse needs of a tuberculosis case contact study in The Gambia. Int J Tub Lung Dis 2004; 8:1095-9.
14. Schim van der Loeff MF, Sarge-Njie R, Ceesay S, et al. Regional differences in HIV trends in The Gambia: results from sentinel surveillance among pregnant women. AIDS 2003; 17:1841-6.
15. Glover JA. Observations of the meningococcus carrier rate and their application to the prevention of cerebrospinal fever. Medical Research Council of the Privvy Council, Special Report Series, No. 50. London: H.M. Stationary Offices, 1920:133-65.
16. Lienhardt C, Fielding K, Sillah J, et al. Risk factors for tuberculosis infection in sub-Saharan Africa: a contact study in The Gambia. Am J Respir Crit Care Med 2003; 168:448-55.
17. Beggs CB, Noakes CJ, Sleigh PA, Fletcher LA, Siddiq K. The transmission of tuberculosis in confined spaces: an analytical review of alternative epidemiological models. Int J Tuberc Lung Dis 2003; 7:1015-26.
18. Godkin AJ, Thomas HC, Openshaw PJ. Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus. J Immunol 2000; 169:2210-4.
19. Carrara S, Vinceti D, Petrosillo N, et al. Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy. Clin Infect Dis 2004; 38:754-6.
20. López B, Aguilar D, Orozco H, et al. A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes. Clin Exp Immunol 2003; 133:30-7.