Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Mihret, Adane ^a,b   Loxton, Andre G ^c   Bekele, Yonas ^a   Kaufmann, Stefan H E ^d   Kidd, Martin ^e   Haks, Mariëlle C ^f   Ottenhoff, Tom H M ^f   Aseffa, Abraham ^a   Howe, Rawleigh ^a   Walzl, Gerhard ^c  

^a ARMAUER HANSEN RESEARCH INSTITUTE   (Ethiopia)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

^c UNIVERSITY OF STELLENBOSCH   (South Africa)

^d MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^e STELLENBOSCH UNIVERSITY   (South Africa)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; INTERLEUKIN 7 RECEPTOR; LACTOFERRIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PROTEIN BCL 2; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BCL2 GENE; BLR1 GENE; BPI GENE; CCL19 GENE; CLINICAL ARTICLE; FCGR1A GENE; FEMALE; FOXP3 GENE; FPR1 GENE; GENE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; HUMAN; IL4D2 GENE; IL7R GENE; LATENT TUBERCULOSIS; LTF GENE; LUNG TUBERCULOSIS; MALE; MARCO GENE; MMP9 GENE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; SPUTUM SMEAR; TGFB1 GENE; BLOOD; CASE CONTROL STUDY; ETHIOPIA; FAMILY SIZE; GENE EXPRESSION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTIPLEX POLYMERASE CHAIN REACTION; MYCOBACTERIUM TUBERCULOSIS; SPUTUM;

ADULT; CASE-CONTROL STUDIES; ETHIOPIA; FAMILY CHARACTERISTICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; MALE; MULTIPLEX POLYMERASE CHAIN REACTION; MYCOBACTERIUM TUBERCULOSIS; SPUTUM; TUBERCULOSIS, PULMONARY;

EID: 84901693358     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-257     Document Type: Article

References (37)

1. van Crevel R, Ottenhoff TH, van der Meer JW. Innate immunity to Mycobacterium tuberculosis. Clin Microbiol Rev 2002, 15:294-309. 10.1128/CMR.15.2.294-309.2002, 118070, 11932234.
2. Moller M, de Wit E, Hoal EG. Past, present and future directions in human genetic susceptibility to tuberculosis. FEMS Immunol Med Microbiol 2010, 58:3-26. 10.1111/j.1574-695X.2009.00600.x, 19780822.
3. Ottenhoff TH, Verreck FA, Lichtenauer-Kaligis EG, Hoeve MA, Sanal O, van Dissel JT. Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae. Nat Genet 2002, 32:97-105. 10.1038/ng0902-97, 12205477.
4. Lalor MK, Floyd S, Gorak-Stolinska P, Ben-Smith A, Weir RE, Smith SG, Newport MJ, Blitz R, Mvula H, Branson K, McGrath N, Crampin AC, Fine PE, Dockrell HM. BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi. J Infect Dis 2011, 204:1075-1085. 10.1093/infdis/jir515, 3164434, 21881123.
5. Sakai T, Matsuoka M, Aoki M, Nosaka K, Mitsuya H. Missense mutation of the interleukin-12 receptor beta1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection. Blood 2001, 97:2688-2694. 10.1182/blood.V97.9.2688, 11313259.
6. Awomoyi AA, Marchant A, Howson JM, McAdam KP, Blackwell JM, Newport MJ. Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J Infect Dis 2002, 186:1808-1814. 10.1086/345920, 12447767.
7. Kim JH, Lee SY, Lee SH, Sin C, Shim JJ, In KH, Yoo SH, Kang KH. NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy. Int J Tuberc Lung Dis 2003, 7:370-375.
8. Lopez-Maderuelo D, Arnalich F, Serantes R, Gonzalez A, Codoceo R, Madero R, Vazquez JJ, Montiel C. Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. Am J Respir Crit Care Med 2003, 167:970-975. 10.1164/rccm.200205-438BC, 12531774.
9. Cooke GS, Campbell SJ, Sillah J, Gustafson P, Bah B, Sirugo G, Bennett S, McAdam KP, Sow O, Lienhardt C, Hill AV. Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. Am J Respir Crit Care Med 2006, 174:339-343. 10.1164/rccm.200601-088OC, 16690980.
10. Ates O, Musellim B, Ongen G, Topal-Sarikaya A. Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J Clin Immunol 2008, 28:232-236. 10.1007/s10875-007-9155-2, 18071881.
11. Mistry R, Cliff JM, Clayton CL, Beyers N, Mohamed YS, Wilson PA, Dockrell HM, Wallace DM, van Helden PD, Duncan K, Lukey PT. Gene-expression patterns in whole blood identify subjects at risk for recurrent tuberculosis. J Infect Dis 2007, 195:357-365. 10.1086/510397, 17205474.
12. Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, Mollenkopf HJ, Ziegler A, Kaufmann SH. Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med (Berl) 2007, 85:613-621. 10.1007/s00109-007-0157-6, 17318616.
13. Lu C, Wu J, Wang H, Wang S, Diao N, Wang F, Gao Y, Chen J, Shao L, Weng X, Zhang Y, Zhang W. Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells. PLoS One 2011, 6:e24290. 10.1371/journal.pone.0024290, 3164189, 21904626.
14. Maertzdorf J, Repsilber D, Parida SK, Stanley K, Roberts T, Black G, Walzl G, Kaufmann SH. Human gene expression profiles of susceptibility and resistance in tuberculosis. Genes Immun 2011, 12:15-22. 10.1038/gene.2010.51, 20861863.
15. Joosten SA, Goeman JJ, Sutherland JS, Opmeer L, de Boer KG, Jacobsen M, Kaufmann SH, Finos L, Magis-Escurra C, Ota MO, Ottenhoff TH, Haks MC. Identification of biomarkers for tuberculosis disease using a novel dual-color RT-MLPA assay. Genes Immun 2012, 13:71-82. 10.1038/gene.2011.64, 21956656.
16. QuantiFERON-TB Gold In-Tube: technical information. http://www.cellestis.com.
17. PAXgene blood RNA procedure. http://www.preanalytix.com.
18. Chegou NN, Black GF, Kidd M, van Helden PD, Walzl G. Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulm Med 2009, 9:21. 10.1186/1471-2466-9-21, 2696407, 19445695.
19. Kaforou M, Wright VJ, Oni T, French N, Anderson ST, Bangani N, Banwell CM, Brent AJ, Crampin AC, Dockrell HM, Eley B, Heyderman RS, Hibberd ML, Kern F, Langford PR, Ling L, Mendelson M, Ottenhoff TH, Zgambo F, Wilkinson RJ, Coin LJ, Levin M. Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Med 2013, 10:e1001538. 10.1371/journal.pmed.1001538, 3805485, 24167453.
20. Sutherland JS, Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, Walzl G, Kaufmann SH, Ottenhoff TH. Differential gene expression of activating Fcgamma receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity. Clin Microbiol Infect 2014, 20:O230-O238. 10.1111/1469-0691.12383, 24205913.
21. Ting LM, Kim AC, Cattamanchi A, Ernst JD. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol 1999, 163:3898-3906.
22. Hwang SA, Welsh KJ, Kruzel ML, Actor JK. Lactoferrin augmentation of the BCG vaccine leads to increased pulmonary integrity. Tuberc Res Treat 2011, 2011:835410. 3335707, 22567270.
23. Schaible UE, Collins HL, Priem F, Kaufmann SH. Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. J Exp Med 2002, 196:1507-1513. 10.1084/jem.20020897, 2194267, 12461085.
24. Abebe F, Bjune G. The protective role of antibody responses during Mycobacterium tuberculosis infection. Clin Exp Immunol 2009, 157:235-243. 10.1111/j.1365-2249.2009.03967.x, 2730849, 19604263.
25. Zhang M, Wang Z, Graner MW, Yang L, Liao M, Yang Q, Gou J, Zhu Y, Wu C, Liu H, Zhou B, Chen X. B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis. Cell Immunol 2011, 270:217-223. 10.1016/j.cellimm.2011.05.009, 21741035.
26. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001, 2:123-128. 10.1038/84219, 11175804.
27. Moller AS, Ovstebo R, Westvik AB, Joo GB, Haug KB, Kierulf P. Effects of bacterial cell wall components (PAMPs) on the expression of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and the chemokine receptor CCR2 by purified human blood monocytes. J Endotoxin Res 2003, 9:349-360.
28. Saukkonen JJ, Bazydlo B, Thomas M, Strieter RM, Keane J, Kornfeld H. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect Immun 2002, 70:1684-1693. 10.1128/IAI.70.4.1684-1693.2002, 127823, 11895930.
29. Izzo AA, Izzo LS, Kasimos J, Majka S. A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection. Tuberculosis (Edinb) 2004, 84:387-396. 10.1016/j.tube.2004.07.001, 15525562.
30. Taylor JL, Hattle JM, Dreitz SA, Troudt JM, Izzo LS, Basaraba RJ, Orme IM, Matrisian LM, Izzo AA. Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infect Immun 2006, 74:6135-6144. 10.1128/IAI.02048-05, 1695484, 16982845.
31. Ito S, Naito M, Kobayashi Y, Takatsuka H, Jiang S, Usuda H, Umezu H, Hasegawa G, Arakawa M, Shultz LD, Elomaa O, Tryggvason K. Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. Arch Histol Cytol 1999, 62:83-95. 10.1679/aohc.62.83, 10223745.
32. Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukhopadhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog 2009, 5:e1000474. 10.1371/journal.ppat.1000474, 2688075, 19521507.
33. Abebe M, Doherty TM, Wassie L, Aseffa A, Bobosha K, Demissie A, Zewdie M, Engers H, Andersen P, Kim L, Huggett J, Rook G, Yamuah LK, Zumla A. Expression of apoptosis-related genes in an Ethiopian cohort study correlates with tuberculosis clinical status. Eur J Immunol 2010, 40:291-301.
34. Abebe M, Kim L, Rook G, Aseffa A, Wassie L, Zewdie M, Zumla A, Engers H, Andersen P, Doherty TM. Modulation of cell death by M. tuberculosis as a strategy for pathogen survival. Clin Dev Immunol 2011, 2011:678570. 3022200, 21253484.
35. Wassie L, Demissie A, Aseffa A, Abebe M, Yamuah L, Tilahun H, Petros B, Rook G, Zumla A, Andersen P, Doherty TM. Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time. PLoS One 2008, 3:e1522. 10.1371/journal.pone.0001522, 2211401, 18231607.
36. Ribeiro-Rodrigues R, Resende Co T, Rojas R, Toossi Z, Dietze R, Boom WH, Maciel E, Hirsch CS. A role for CD4 + CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol 2006, 144:25-34. 10.1111/j.1365-2249.2006.03027.x, 1809641, 16542361.
37. Chen CY, Huang D, Yao S, Halliday L, Zeng G, Wang RC, Chen ZW. IL-2 simultaneously expands Foxp3+ T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector cooperation in immunity to TB. J Immunol 2012, 188:4278-4288. 10.4049/jimmunol.1101291, 3412415, 22474020.