Chemically synthesized molecules with the targeting and effector functions of antibodies

Journal of the American Chemical Society

Volumn 136, Issue 52, 2014, Pages 18034-18043

  McEnaney, Patrick J ^a,d   Fitzgerald, Kelly J ^b   Zhang, Andrew X ^a,e   Douglass, Eugene F ^a,f   Shan, Weifang ^c   Balog, Aaron ^c   Kolesnikova, Mariya D ^a,g   Spiegel, David A ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e ASTRAZENECA   (United Kingdom)

^f NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^g Axela Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; DISEASE CONTROL; DISEASES; MOLECULES; SYNTHESIS (CHEMICAL); UROLOGY;

ANTIBODY MIMICS; CANCER CELLS; PROSTATE CANCERS; PROSTATE-SPECIFIC MEMBRANE ANTIGENS; SMALL MOLECULES; SYNTHESIZED MOLECULES;

ANTIBODIES;

ANTIBODY; BIOMIMETIC MATERIAL; FC RECEPTOR; GLUTAMATE CARBOXYPEPTIDASE II; GLUTAMATE CARBOXYPEPTIDASE II, HUMAN; MEMBRANE ANTIGEN;

ACYLATION; ANTIGEN BINDING; ARTICLE; BINDING ASSAY; CANCER CELL LINE; CELL ADHESION; CELL PHAGOCYTOSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; CYTOTOXICITY ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIGAND BINDING; MICROSCOPY; MOLECULE; SYNTHESIS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; METABOLISM; MOLECULAR DOCKING; MOLECULAR WEIGHT; PHAGOCYTOSIS; PROTEIN CONFORMATION; TUMOR CELL LINE;

ANTIBODIES; ANTIGENS, SURFACE; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR WEIGHT; PHAGOCYTOSIS; PROTEIN CONFORMATION; RECEPTORS, IGG;

EID: 84920134348     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja509513c     Document Type: Article

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