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Volumn 287, Issue 34, 2012, Pages 28206-28214

Chemically programmed bispecific antibodies that recruit and activate T cells

Author keywords

[No Author keywords available]

Indexed keywords

C (PROGRAMMING LANGUAGE); CELL CULTURE; CYTOTOXICITY; T-CELLS; TUMORS;

EID: 84865235085     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.384594     Document Type: Article
Times cited : (22)

References (33)
  • 1
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter, P. (2001) Improving the efficacy of antibody-based cancer therapies. Nat. Rev. Cancer 1, 118-129
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 2
    • 77956381860 scopus 로고    scopus 로고
    • Research and development of next generation of antibody-based therapeutics
    • Li, J., and Zhu, Z. (2010) Research and development of next generation of antibody-based therapeutics. Acta Pharmacol. Sin. 31, 1198-1207
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 1198-1207
    • Li, J.1    Zhu, Z.2
  • 4
    • 80155150449 scopus 로고    scopus 로고
    • Buy buy bispecific antibodies
    • Holmes, D. (2011) Buy buy bispecific antibodies. Nat. Rev. Drug Discov. 10, 798-800
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 798-800
    • Holmes, D.1
  • 5
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy. The light at the end of the tunnel?
    • Chames, P., and Baty, D. (2009) Bispecific antibodies for cancer therapy. The light at the end of the tunnel? mAbs 1, 539-547
    • (2009) mAbs , vol.1 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 6
    • 0026493687 scopus 로고
    • G19.4(alpha CD3) x B43(α CD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells
    • Anderson, P. M., Crist, W., Hasz, D., Carroll, A. J., Myers, D. E., and Uckun, F. M. (1992) G19.4(alpha CD3) x B43(α CD19) monoclonal antibody heteroconjugate triggers CD19 antigen-specific lysis of t(4;11) acute lymphoblastic leukemia cells by activated CD3 antigen-positive cytotoxic T cells. Blood 80, 2826-2834
    • (1992) Blood , vol.80 , pp. 2826-2834
    • Anderson, P.M.1    Crist, W.2    Hasz, D.3    Carroll, A.J.4    Myers, D.E.5    Uckun, F.M.6
  • 7
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific T-cell engaging antibodies for cancer therapy
    • Baeuerle, P. A., and Reinhardt, C. (2009) Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res. 69, 4941-4944
    • (2009) Cancer Res. , vol.69 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 9
    • 79955979077 scopus 로고    scopus 로고
    • DARTs take aim at BiTEs
    • Rader, C. (2011) DARTs take aim at BiTEs. Blood 117, 4403-4404
    • (2011) Blood , vol.117 , pp. 4403-4404
    • Rader, C.1
  • 13
    • 78649876890 scopus 로고    scopus 로고
    • Synthetic receptors with antibody-like binding affinities
    • Kodadek, T. (2010) Synthetic receptors with antibody-like binding affinities. Curr. Opin. Chem. Biol. 14, 713-720
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 713-720
    • Kodadek, T.1
  • 14
    • 80555156091 scopus 로고    scopus 로고
    • In silico design of small molecules
    • Bernardo, P. H., and Tong, J. C. (2012) In silico design of small molecules. Methods Mol. Biol. 800, 25-31
    • (2012) Methods Mol. Biol. , vol.800 , pp. 25-31
    • Bernardo, P.H.1    Tong, J.C.2
  • 16
    • 50449091735 scopus 로고    scopus 로고
    • An engineered selenocysteine defines a unique class of antibody derivatives
    • Hofer, T., Thomas, J. D., Burke, T. R., Jr., and Rader, C. (2008) An engineered selenocysteine defines a unique class of antibody derivatives. Proc. Natl. Acad. Sci. U.S.A. 105, 12451-12456
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 12451-12456
    • Hofer, T.1    Thomas, J.D.2    Burke Jr., T.R.3    Rader, C.4
  • 20
    • 72449121780 scopus 로고    scopus 로고
    • Molecularly defined antibody conjugation through a selenocysteine interface
    • Hofer, T., Skeffington, L. R., Chapman, C. M., and Rader, C. (2009) Molecularly defined antibody conjugation through a selenocysteine interface. Biochemistry 48, 12047-12057
    • (2009) Biochemistry , vol.48 , pp. 12047-12057
    • Hofer, T.1    Skeffington, L.R.2    Chapman, C.M.3    Rader, C.4
  • 21
    • 77954535224 scopus 로고    scopus 로고
    • Essential roles of VLA-4 in the hematopoietic system
    • Imai, Y., Shimaoka, M., and Kurokawa, M. (2010) Essential roles of VLA-4 in the hematopoietic system. Int. J. Hematol. 91, 569-575
    • (2010) Int. J. Hematol. , vol.91 , pp. 569-575
    • Imai, Y.1    Shimaoka, M.2    Kurokawa, M.3
  • 22
    • 66549113998 scopus 로고    scopus 로고
    • Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d). Importance for interactions with the stromal microenvironment and specific targeting
    • Kurtova, A. V., Tamayo, A. T., Ford, R. J., and Burger, J. A. (2009) Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d). Importance for interactions with the stromal microenvironment and specific targeting. Blood 113, 4604-4613
    • (2009) Blood , vol.113 , pp. 4604-4613
    • Kurtova, A.V.1    Tamayo, A.T.2    Ford, R.J.3    Burger, J.A.4
  • 23
    • 33745295845 scopus 로고    scopus 로고
    • 1 integrin for in vivo tumor imaging
    • DOI 10.1038/nchembio798, PII N798
    • Peng, L., Liu, R., Marik, J., Wang, X., Takada, Y., and Lam, K. S. (2006) Combinatorial chemistry identifies high-affinity peptidomimetics against α4β1 integrin for in vivo tumor imaging. Nat. Chem. Biol. 2, 381-389 (Pubitemid 43936939)
    • (2006) Nature Chemical Biology , vol.2 , Issue.7 , pp. 381-389
    • Peng, L.1    Liu, R.2    Marik, J.3    Wang, X.4    Takada, Y.5    Lam, K.S.6
  • 24
    • 63849329082 scopus 로고    scopus 로고
    • 111In-LLP2A-DOTA polyethylene glycol-targeting α4β1 integrin. Comparative pharmacokinetics for imaging and therapy of lymphoid malignancies
    • Denardo, S. J., Liu, R., Albrecht, H., Natarajan, A., Sutcliffe, J. L., Anderson, C., Peng, L., Ferdani, R., Cherry, S. R., and Lam, K. S. (2009) 111In-LLP2A-DOTA polyethylene glycol-targeting α4β1 integrin. Comparative pharmacokinetics for imaging and therapy of lymphoid malignancies. J. Nucl. Med. 50, 625-634
    • (2009) J. Nucl. Med. , vol.50 , pp. 625-634
    • Denardo, S.J.1    Liu, R.2    Albrecht, H.3    Natarajan, A.4    Sutcliffe, J.L.5    Anderson, C.6    Peng, L.7    Ferdani, R.8    Cherry, S.R.9    Lam, K.S.10
  • 25
    • 53949113568 scopus 로고    scopus 로고
    • Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates
    • Thomas, J. D., Hofer, T., Rader, C., and Burke, T. R., Jr. (2008) Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates. Bioorg. Med. Chem. Lett. 18, 5785-5788
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5785-5788
    • Thomas, J.D.1    Hofer, T.2    Rader, C.3    Burke Jr., T.R.4
  • 27
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • Low, P. S., and Kularatne, S. A. (2009) Folate-targeted therapeutic and imaging agents for cancer. Curr. Opin. Chem. Biol. 13, 256-262
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 28
    • 1342268311 scopus 로고    scopus 로고
    • Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions
    • DOI 10.1172/JCI200411548
    • Antony, A., Tang, Y. S., Khan, R. A., Biju, M. P., Xiao, X., Li, Q. J., Sun, X. L., Jayaram, H. N., and Stabler, S. P. (2004) Translational up-regulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. J. Clin. Invest. 113, 285-301 (Pubitemid 38544213)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.2 , pp. 285-301
    • Antony, A.C.1    Tang, Y.-S.2    Khan, R.A.3    Biju, M.P.4    Xiao, X.5    Li, Q.-J.6    Sun, X.-L.7    Jayaram, H.N.8    Stabler, S.P.9
  • 29
    • 0026604793 scopus 로고
    • Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene
    • Shalaby, M. R., Shepard, H. M., Presta, L., Rodrigues, M. L., Beverley, P. C., Feldmann, M., and Carter, P. (1992) Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene. J. Exp. Med. 175, 217-225
    • (1992) J. Exp. Med. , vol.175 , pp. 217-225
    • Shalaby, M.R.1    Shepard, H.M.2    Presta, L.3    Rodrigues, M.L.4    Beverley, P.C.5    Feldmann, M.6    Carter, P.7
  • 30
    • 0029083736 scopus 로고
    • Identification of heavy chain residues in a humanized anti-CD3 antibody important for efficient antigen binding and T cell activation
    • Zhu, Z., and Carter, P. (1995) Identification of heavy chain residues in a humanized anti-CD3 antibody important for efficient antigen binding and T cell activation. J. Immunol. 155, 1903-1910
    • (1995) J. Immunol. , vol.155 , pp. 1903-1910
    • Zhu, Z.1    Carter, P.2
  • 31
    • 0023834107 scopus 로고
    • Hormone conjugated with antibody to CD3 mediates cytotoxic T cell lysis of human melanoma cells
    • Liu, M. A., Nussbaum, S. R., and Eisen, H. N. (1988) Hormone conjugated with antibody to CD3 mediates cytotoxic T cell lysis of human melanoma cells. Science 239, 395-398 (Pubitemid 18062671)
    • (1988) Science , vol.239 , Issue.4838 , pp. 395-398
    • Liu, M.A.1    Nussbaum, S.R.2    Eisen, H.N.3
  • 32
    • 0029073423 scopus 로고
    • Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate receptor-positive tumor cells for lysis
    • Kranz, D. M., Patrick, T. A., Brigle, K. E., Spinella, M. J., and Roy, E. J. (1995) Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate receptor-positive tumor cells for lysis. Proc. Natl. Acad. Sci. U.S.A. 92, 9057-9061
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 9057-9061
    • Kranz, D.M.1    Patrick, T.A.2    Brigle, K.E.3    Spinella, M.J.4    Roy, E.J.5
  • 33
    • 0032845322 scopus 로고    scopus 로고
    • Bispecific agents target endogenous murine T cells against human tumor xenografts
    • DOI 10.1002/(SICI)1097-0215(19990924)83:1<141::AID-IJC24>3.0.CO;2-0
    • Rund, L. A., Cho, B. K., Manning, T. C., Holler, P. D., Roy, E. J., and Kranz, D. M. (1999) Bispecific agents target endogenous murine T cells against human tumor xenografts. Int. J. Cancer 83, 141-149 (Pubitemid 29409490)
    • (1999) International Journal of Cancer , vol.83 , Issue.1 , pp. 141-149
    • Rund, L.A.1    Cho, B.K.2    Manning, T.C.3    Holler, P.D.4    Roy, E.J.5    Kranz, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.