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Volumn 16, Issue 11, 2014, Pages 1-17

Restless Legs Syndrome: Pathophysiology and Treatment

Author keywords

Dopamine; Gabapentin; Gabapentin enacarbil; Iron; Methadone; Oxycodone; Periodic limb movement; Pramipexole; Pregabalin; Restless legs syndrome; Ropinirole; Rotigotine

Indexed keywords

DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; OPIATE RECEPTOR; PREGABALIN;

EID: 84920115074     PISSN: 10928480     EISSN: 15343138     Source Type: Journal    
DOI: 10.1007/s11940-014-0317-2     Document Type: Review
Times cited : (38)

References (149)
  • 1
    • 0037738587 scopus 로고    scopus 로고
    • Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health. Sleep Med. 2003;4(2):101–19. Most accepted definition of RLS
    • Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health. Sleep Med. 2003;4(2):101–19. Most accepted definition of RLS.
  • 2
    • 0031027378 scopus 로고    scopus 로고
    • Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria
    • PID: 8990055, COI: 1:STN:280:DyaK2s7ksVahuw%3D%3D
    • Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lesperance P. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12(1):61–5.
    • (1997) Mov Disord , vol.12 , Issue.1 , pp. 61-65
    • Montplaisir, J.1    Boucher, S.2    Poirier, G.3    Lavigne, G.4    Lapierre, O.5    Lesperance, P.6
  • 3
    • 84874104144 scopus 로고    scopus 로고
    • Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome
    • PID: 23372468
    • Giannaki CD, Zigoulis P, Karatzaferi C, Hadjigeorgiou GM, George KP, Gourgoulianis K, et al. Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. J Clin Sleep Med. 2013;9(2):147–53.
    • (2013) J Clin Sleep Med , vol.9 , Issue.2 , pp. 147-153
    • Giannaki, C.D.1    Zigoulis, P.2    Karatzaferi, C.3    Hadjigeorgiou, G.M.4    George, K.P.5    Gourgoulianis, K.6
  • 4
    • 84867024439 scopus 로고    scopus 로고
    • Prospective study of restless legs syndrome and coronary heart disease among women
    • Li Y, Walters AS, Chiuve SE, Rimm EB, Winkelman JW, Gao X. Prospective study of restless legs syndrome and coronary heart disease among women. Circulation. 2012;126(14):1689–94.
    • (2012) Circulation , vol.126 , Issue.14 , pp. 1689-1694
    • Li, Y.1    Walters, A.S.2    Chiuve, S.E.3    Rimm, E.B.4    Winkelman, J.W.5    Gao, X.6
  • 5
    • 85056035173 scopus 로고    scopus 로고
    • Prevalence of stroke in restless legs syndrome: Initial results point to the need for more sophisticated studies
    • PID: 20721325
    • Walters AS, Moussouttas M, Siddiqui F, Silveira DC, Fuentes K, Wang L, et al. Prevalence of stroke in restless legs syndrome: initial results point to the need for more sophisticated studies. Open Neurol J. 2010;4:73–7.
    • (2010) Open Neurol J , vol.4 , pp. 73-77
    • Walters, A.S.1    Moussouttas, M.2    Siddiqui, F.3    Silveira, D.C.4    Fuentes, K.5    Wang, L.6
  • 6
    • 37849034199 scopus 로고    scopus 로고
    • Association of restless legs syndrome and cardiovascular disease in the sleep heart health study
    • PID: 18166705
    • Winkelman JW, Shahar E, Sharief I, Gottlieb DJ. Association of restless legs syndrome and cardiovascular disease in the sleep heart health study. Neurology. 2008;70(1):35–42.
    • (2008) Neurology , vol.70 , Issue.1 , pp. 35-42
    • Winkelman, J.W.1    Shahar, E.2    Sharief, I.3    Gottlieb, D.J.4
  • 7
    • 84873615661 scopus 로고    scopus 로고
    • Vascular risk factors, cardiovascular disease, and restless legs syndrome in women
    • PID: 23410562, 227 e221-222
    • Winter AC, Schurks M, Glynn RJ, Buring JE, Gaziano JM, Berger K, et al. Vascular risk factors, cardiovascular disease, and restless legs syndrome in women. Am J Med. 2013;126(3):220–7. 227 e221-222.
    • (2013) Am J Med , vol.126 , Issue.3 , pp. 220-227
    • Winter, A.C.1    Schurks, M.2    Glynn, R.J.3    Buring, J.E.4    Gaziano, J.M.5    Berger, K.6
  • 8
    • 84880508435 scopus 로고    scopus 로고
    • A time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population
    • PID: 23374090
    • Szentkiralyi A, Volzke H, Hoffmann W, Happe S, Berger K. A time sequence analysis of the relationship between cardiovascular risk factors, vascular diseases and restless legs syndrome in the general population. J Sleep Res. 2013;22(4):434–42.
    • (2013) J Sleep Res , vol.22 , Issue.4 , pp. 434-442
    • Szentkiralyi, A.1    Volzke, H.2    Hoffmann, W.3    Happe, S.4    Berger, K.5
  • 9
    • 78650301949 scopus 로고    scopus 로고
    • Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep
    • PID: 20851046
    • Manconi M, Ferri R, Zucconi M, Clemens S, Rundo F, Oldani A, et al. Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep. Sleep Med. 2011;12(1):47–55.
    • (2011) Sleep Med , vol.12 , Issue.1 , pp. 47-55
    • Manconi, M.1    Ferri, R.2    Zucconi, M.3    Clemens, S.4    Rundo, F.5    Oldani, A.6
  • 10
    • 84862742618 scopus 로고    scopus 로고
    • Dissociation of periodic leg movements from arousals in restless legs syndrome
    • PID: 22718547
    • Manconi M, Ferri R, Zucconi M, Bassetti CL, Fulda S, Arico D, et al. Dissociation of periodic leg movements from arousals in restless legs syndrome. Ann Neurol. 2012;71(6):834–44.
    • (2012) Ann Neurol , vol.71 , Issue.6 , pp. 834-844
    • Manconi, M.1    Ferri, R.2    Zucconi, M.3    Bassetti, C.L.4    Fulda, S.5    Arico, D.6
  • 11
    • 0016651432 scopus 로고
    • Growing pains and restless legs
    • PID: 1130184, COI: 1:STN:280:DyaE2M7mtFKrsA%3D%3D
    • Ekbom KA. Growing pains and restless legs. Acta Paediatr Scand. 1975;64(2):264–6.
    • (1975) Acta Paediatr Scand , vol.64 , Issue.2 , pp. 264-266
    • Ekbom, K.A.1
  • 12
    • 3042531662 scopus 로고    scopus 로고
    • Some children with growing pains may actually have restless legs syndrome
    • PID: 15283013
    • Rajaram SS, Walters AS, England SJ, Mehta D, Nizam F. Some children with growing pains may actually have restless legs syndrome. Sleep. 2004;27(4):767–73.
    • (2004) Sleep , vol.27 , Issue.4 , pp. 767-773
    • Rajaram, S.S.1    Walters, A.S.2    England, S.J.3    Mehta, D.4    Nizam, F.5
  • 13
    • 84888135299 scopus 로고    scopus 로고
    • Pediatric restless legs syndrome diagnostic criteria: An update by the international restless legs syndrome study group
    • PID: 24184054
    • Picchietti DL, Bruni O, de Weerd A, Durmer JS, Kotagal S, Owens JA, et al. Pediatric restless legs syndrome diagnostic criteria: an update by the international restless legs syndrome study group. Sleep Med. 2013;14(12):1253–9.
    • (2013) Sleep Med , vol.14 , Issue.12 , pp. 1253-1259
    • Picchietti, D.L.1    Bruni, O.2    de Weerd, A.3    Durmer, J.S.4    Kotagal, S.5    Owens, J.A.6
  • 14
    • 84875181382 scopus 로고    scopus 로고
    • Restless legs syndrome: A comprehensive overview on its epidemiology, risk factors, and treatment
    • PID: 22038683
    • Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. 2012;16(4):987–1007.
    • (2012) Sleep Breath , vol.16 , Issue.4 , pp. 987-1007
    • Yeh, P.1    Walters, A.S.2    Tsuang, J.W.3
  • 15
    • 0942298195 scopus 로고    scopus 로고
    • Sex and the risk of restless legs syndrome in the general population
    • PID: 14744844
    • Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164(2):196–202.
    • (2004) Arch Intern Med , vol.164 , Issue.2 , pp. 196-202
    • Berger, K.1    Luedemann, J.2    Trenkwalder, C.3    John, U.4    Kessler, C.5
  • 16
    • 76949098056 scopus 로고    scopus 로고
    • Pregnancy accounts for most of the gender difference in prevalence of familial RLS
    • PID: 19592302
    • Pantaleo NP, Hening WA, Allen RP, Earley CJ. Pregnancy accounts for most of the gender difference in prevalence of familial RLS. Sleep Med. 2010;11(3):310–3.
    • (2010) Sleep Med , vol.11 , Issue.3 , pp. 310-313
    • Pantaleo, N.P.1    Hening, W.A.2    Allen, R.P.3    Earley, C.J.4
  • 17
    • 0034102395 scopus 로고    scopus 로고
    • Abnormalities in csf concentrations of ferritin and transferrin in restless legs syndrome
    • PID: 10762522, COI: 1:CAS:528:DC%2BD3cXjtF2ltLs%3D
    • Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. Abnormalities in csf concentrations of ferritin and transferrin in restless legs syndrome. Neurology. 2000;54(8):1698–700.
    • (2000) Neurology , vol.54 , Issue.8 , pp. 1698-1700
    • Earley, C.J.1    Connor, J.R.2    Beard, J.L.3    Malecki, E.A.4    Epstein, D.K.5    Allen, R.P.6
  • 18
    • 0035936633 scopus 로고    scopus 로고
    • Mri measurement of brain iron in patients with restless legs syndrome
    • PID: 11160969, COI: 1:STN:280:DC%2BD3M7pt1ygsw%3D%3D
    • Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. Mri measurement of brain iron in patients with restless legs syndrome. Neurology. 2001;56(2):263–5.
    • (2001) Neurology , vol.56 , Issue.2 , pp. 263-265
    • Allen, R.P.1    Barker, P.B.2    Wehrl, F.3    Song, H.K.4    Earley, C.J.5
  • 19
    • 54049083091 scopus 로고    scopus 로고
    • T2 relaxometry and fmri of the brain in late-onset restless legs syndrome
    • PID: 18794493, COI: 1:STN:280:DC%2BD1cngs1amtA%3D%3D
    • Astrakas LG, Konitsiotis S, Margariti P, Tsouli S, Tzarouhi L, Argyropoulou MI. T2 relaxometry and fmri of the brain in late-onset restless legs syndrome. Neurology. 2008;71(12):911–6.
    • (2008) Neurology , vol.71 , Issue.12 , pp. 911-916
    • Astrakas, L.G.1    Konitsiotis, S.2    Margariti, P.3    Tsouli, S.4    Tzarouhi, L.5    Argyropoulou, M.I.6
  • 20
    • 27144525483 scopus 로고    scopus 로고
    • Brain parenchyma sonography differentiates rls patients from normal controls and patients with parkinson's disease
    • Schmidauer C, Sojer M, Stocckner H, Hogel B, Wenning W, Poewe W. Brain parenchyma sonography differentiates rls patients from normal controls and patients with parkinson's disease. Mov Disord. 2005;20(supple10):S43.
    • (2005) Mov Disord , vol.20 , pp. S43
    • Schmidauer, C.1    Sojer, M.2    Stocckner, H.3    Hogel, B.4    Wenning, W.5    Poewe, W.6
  • 21
    • 52649174218 scopus 로고    scopus 로고
    • Multiregional brain iron deficiency in restless legs syndrome
    • PID: 18442125
    • Godau J, Klose U, Di Santo A, Schweitzer K, Berg D. Multiregional brain iron deficiency in restless legs syndrome. Mov Disord. 2008;23(8):1184–7.
    • (2008) Mov Disord , vol.23 , Issue.8 , pp. 1184-1187
    • Godau, J.1    Klose, U.2    Di Santo, A.3    Schweitzer, K.4    Berg, D.5
  • 22
    • 2342554293 scopus 로고    scopus 로고
    • Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome
    • PID: 15136682, COI: 1:CAS:528:DC%2BD2cXjt1yltbY%3D
    • Connor JR, Wang XS, Patton SM, Menzies SL, Troncoso JC, Earley CJ, et al. Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome. Neurology. 2004;62(9):1563–7.
    • (2004) Neurology , vol.62 , Issue.9 , pp. 1563-1567
    • Connor, J.R.1    Wang, X.S.2    Patton, S.M.3    Menzies, S.L.4    Troncoso, J.C.5    Earley, C.J.6
  • 23
    • 70449413420 scopus 로고    scopus 로고
    • Mitochondrial ferritin in the substantia nigra in restless legs syndrome
    • PID: 19816198, COI: 1:CAS:528:DC%2BD1MXhtlens7bO
    • Snyder AM, Wang X, Patton SM, Arosio P, Levi S, Earley CJ, et al. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol. 2009;68(11):1193–9.
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.11 , pp. 1193-1199
    • Snyder, A.M.1    Wang, X.2    Patton, S.M.3    Arosio, P.4    Levi, S.5    Earley, C.J.6
  • 24
    • 3042622113 scopus 로고    scopus 로고
    • Circadian variation in neuroendocrine response to l-dopa in patients with restless legs syndrome
    • PID: 15283001
    • Garcia-Borreguero D, Larrosa O, Granizo JJ, de la Llave Y, Hening WA. Circadian variation in neuroendocrine response to l-dopa in patients with restless legs syndrome. Sleep. 2004;27(4):669–73.
    • (2004) Sleep , vol.27 , Issue.4 , pp. 669-673
    • Garcia-Borreguero, D.1    Larrosa, O.2    Granizo, J.J.3    de la Llave, Y.4    Hening, W.A.5
  • 25
    • 33645931007 scopus 로고    scopus 로고
    • Circadian changes in csf dopaminergic measures in restless legs syndrome
    • PID: 16564215
    • Earley CJ, Hyland K, Allen RP. Circadian changes in csf dopaminergic measures in restless legs syndrome. Sleep Med. 2006;7(3):263–8.
    • (2006) Sleep Med , vol.7 , Issue.3 , pp. 263-268
    • Earley, C.J.1    Hyland, K.2    Allen, R.P.3
  • 26
    • 60949097459 scopus 로고    scopus 로고
    • Does the endogenous opiate system play a role in the restless legs syndrome? A pilot post-mortem study
    • PID: 19167016, COI: 1:CAS:528:DC%2BD1MXisFGqsb4%3D
    • Walters AS, Ondo WG, Zhu W, Le W. Does the endogenous opiate system play a role in the restless legs syndrome? A pilot post-mortem study. J Neurol Sci. 2009;279(1–2):62–5.
    • (2009) J Neurol Sci , vol.279 , Issue.1-2 , pp. 62-65
    • Walters, A.S.1    Ondo, W.G.2    Zhu, W.3    Le, W.4
  • 27
    • 0042626103 scopus 로고    scopus 로고
    • Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome
    • PID: 12913188, COI: 1:STN:280:DC%2BD3sznslOktA%3D%3D
    • Connor JR, Boyer PJ, Menzies SL, Dellinger B, Allen RP, Ondo WG, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology. 2003;61(3):304–9.
    • (2003) Neurology , vol.61 , Issue.3 , pp. 304-309
    • Connor, J.R.1    Boyer, P.J.2    Menzies, S.L.3    Dellinger, B.4    Allen, R.P.5    Ondo, W.G.6
  • 28
    • 4444247566 scopus 로고    scopus 로고
    • Neuropathology of primary restless leg syndrome: Absence of specific tau- and alpha-synuclein pathology
    • PID: 15197711
    • Pittock SJ, Parrett T, Adler CH, Parisi JE, Dickson DW, Ahlskog JE. Neuropathology of primary restless leg syndrome: absence of specific tau- and alpha-synuclein pathology. Mov Disord. 2004;19(6):695–9.
    • (2004) Mov Disord , vol.19 , Issue.6 , pp. 695-699
    • Pittock, S.J.1    Parrett, T.2    Adler, C.H.3    Parisi, J.E.4    Dickson, D.W.5    Ahlskog, J.E.6
  • 29
    • 71549117331 scopus 로고    scopus 로고
    • Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
    • PID: 19467991
    • Connor JR, Wang XS, Allen RP, Beard JL, Wiesinger JA, Felt BT, et al. Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain. 2009;132(Pt 9):2403–12.
    • (2009) Brain , vol.132 , pp. 2403-2412
    • Connor, J.R.1    Wang, X.S.2    Allen, R.P.3    Beard, J.L.4    Wiesinger, J.A.5    Felt, B.T.6
  • 30
    • 0028905465 scopus 로고
    • Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine d2-receptor alteration
    • PID: 7786913, COI: 1:STN:280:DyaK2Mzgs1Gjuw%3D%3D
    • Staedt J, Stoppe G, Kogler A, Riemann H, Hajak G, Munz DL, et al. Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine d2-receptor alteration. Eur Arch Psychiatry Clin Neurosci. 1995;245(1):8–10.
    • (1995) Eur Arch Psychiatry Clin Neurosci , vol.245 , Issue.1 , pp. 8-10
    • Staedt, J.1    Stoppe, G.2    Kogler, A.3    Riemann, H.4    Hajak, G.5    Munz, D.L.6
  • 31
    • 0032935438 scopus 로고    scopus 로고
    • Positron emission tomographic studies in restless legs syndrome
    • PID: 9918358, COI: 1:STN:280:DyaK1M7hsV2itQ%3D%3D
    • Trenkwalder C, Walters AS, Hening WA, Chokroverty S, Antonini A, Dhawan V, et al. Positron emission tomographic studies in restless legs syndrome. Mov Disord. 1999;14(1):141–5.
    • (1999) Mov Disord , vol.14 , Issue.1 , pp. 141-145
    • Trenkwalder, C.1    Walters, A.S.2    Hening, W.A.3    Chokroverty, S.4    Antonini, A.5    Dhawan, V.6
  • 32
    • 0033596829 scopus 로고    scopus 로고
    • Striatal dopaminergic function in restless legs syndrome: 18f-dopa and 11c-raclopride pet studies
    • PID: 10102408, COI: 1:STN:280:DyaK1M3gtVGgsw%3D%3D
    • Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in restless legs syndrome: 18f-dopa and 11c-raclopride pet studies. Neurology. 1999;52(5):932–7.
    • (1999) Neurology , vol.52 , Issue.5 , pp. 932-937
    • Turjanski, N.1    Lees, A.J.2    Brooks, D.J.3
  • 33
    • 0842312542 scopus 로고    scopus 로고
    • Normal striatal d2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep
    • PID: 15061265, COI: 1:CAS:528:DC%2BD2cXnt1emurg%3D
    • Tribl GG, Asenbaum S, Happe S, Bonelli RM, Zeitlhofer J, Auff E. Normal striatal d2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep. Nucl Med Commun. 2004;25(1):55–60.
    • (2004) Nucl Med Commun , vol.25 , Issue.1 , pp. 55-60
    • Tribl, G.G.1    Asenbaum, S.2    Happe, S.3    Bonelli, R.M.4    Zeitlhofer, J.5    Auff, E.6
  • 34
    • 84871909837 scopus 로고    scopus 로고
    • Increased synaptic dopamine in the putamen in restless legs syndrome
    • PID: 23288971
    • Earley CJ, Kuwabara H, Wong DF, Gamaldo C, Salas RE, Brasic JR, et al. Increased synaptic dopamine in the putamen in restless legs syndrome. Sleep. 2013;36(1):51–7.
    • (2013) Sleep , vol.36 , Issue.1 , pp. 51-57
    • Earley, C.J.1    Kuwabara, H.2    Wong, D.F.3    Gamaldo, C.4    Salas, R.E.5    Brasic, J.R.6
  • 35
    • 58149520934 scopus 로고    scopus 로고
    • Abnormally increased csf 3-ortho-methyldopa (3-omd) in untreated restless legs syndrome (rls) patients indicates more severe disease and possibly abnormally increased dopamine synthesis
    • PID: 18226951
    • Allen RP, Connor JR, Hyland K, Earley CJ. Abnormally increased csf 3-ortho-methyldopa (3-omd) in untreated restless legs syndrome (rls) patients indicates more severe disease and possibly abnormally increased dopamine synthesis. Sleep Med. 2009;10(1):123–8.
    • (2009) Sleep Med , vol.10 , Issue.1 , pp. 123-128
    • Allen, R.P.1    Connor, J.R.2    Hyland, K.3    Earley, C.J.4
  • 36
    • 61449104982 scopus 로고    scopus 로고
    • Poststroke restless legs syndrome and lesion location: Anatomical considerations
    • PID: 18816657
    • Lee SJ, Kim JS, Song IU, An JY, Kim YI, Lee KS. Poststroke restless legs syndrome and lesion location: anatomical considerations. Mov Disord. 2009;24(1):77–84.
    • (2009) Mov Disord , vol.24 , Issue.1 , pp. 77-84
    • Lee, S.J.1    Kim, J.S.2    Song, I.U.3    An, J.Y.4    Kim, Y.I.5    Lee, K.S.6
  • 37
    • 0033965173 scopus 로고    scopus 로고
    • Clinical correlates of 6-hydroxydopamine injections into a11 dopaminergic neurons in rats: A possible model for restless legs syndrome
    • PID: 10634257, COI: 1:STN:280:DC%2BD3c%2FpslOhsQ%3D%3D
    • Ondo WG, He Y, Rajasekaran S, Le WD. Clinical correlates of 6-hydroxydopamine injections into a11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord. 2000;15(1):154–8.
    • (2000) Mov Disord , vol.15 , Issue.1 , pp. 154-158
    • Ondo, W.G.1    He, Y.2    Rajasekaran, S.3    Le, W.D.4
  • 38
    • 34247882793 scopus 로고    scopus 로고
    • Locomotion is increased in a11-lesioned mice with iron deprivation: A possible animal model for restless legs syndrome
    • PID: 17483695, COI: 1:CAS:528:DC%2BD2sXmtVyqsbc%3D
    • Qu S, Le W, Zhang X, Xie W, Zhang A, Ondo WG. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol. 2007;66(5):383–8.
    • (2007) J Neuropathol Exp Neurol , vol.66 , Issue.5 , pp. 383-388
    • Qu, S.1    Le, W.2    Zhang, X.3    Xie, W.4    Zhang, A.5    Ondo, W.G.6
  • 39
    • 70350770999 scopus 로고    scopus 로고
    • The dopaminergic neurons of the a11 system in rls autopsy brains appear normal
    • PID: 19307154
    • Earley CJ, Allen RP, Connor JR, Ferrucci L, Troncoso J. The dopaminergic neurons of the a11 system in rls autopsy brains appear normal. Sleep Med. 2009;10(10):1155–7.
    • (2009) Sleep Med , vol.10 , Issue.10 , pp. 1155-1157
    • Earley, C.J.1    Allen, R.P.2    Connor, J.R.3    Ferrucci, L.4    Troncoso, J.5
  • 40
    • 0022197604 scopus 로고
    • Effect of iron chelators on dopamine d2 receptors
    • PID: 2993525, COI: 1:CAS:528:DyaL2MXlsFCksL8%3D
    • Ben-Shachar D, Finberg JP, Youdim MB. Effect of iron chelators on dopamine d2 receptors. J Neurochem. 1985;45(4):999–1005.
    • (1985) J Neurochem , vol.45 , Issue.4 , pp. 999-1005
    • Ben-Shachar, D.1    Finberg, J.P.2    Youdim, M.B.3
  • 41
    • 34147212105 scopus 로고    scopus 로고
    • Spinal cord dopamine receptor expression and function in mice with 6-ohda lesion of the a11 nucleus and dietary iron deprivation
    • PID: 17342757, COI: 1:CAS:528:DC%2BD2sXks1Ohtrg%3D
    • Zhao H, Zhu W, Pan T, Xie W, Zhang A, Ondo WG, et al. Spinal cord dopamine receptor expression and function in mice with 6-ohda lesion of the a11 nucleus and dietary iron deprivation. J Neurosci Res. 2007;85(5):1065–76.
    • (2007) J Neurosci Res , vol.85 , Issue.5 , pp. 1065-1076
    • Zhao, H.1    Zhu, W.2    Pan, T.3    Xie, W.4    Zhang, A.5    Ondo, W.G.6
  • 42
    • 0034655576 scopus 로고    scopus 로고
    • Identification of iron responsive genes by screening cdna libraries from suppression subtractive hybridization with antisense probes from three iron conditions
    • PID: 10734200, COI: 1:CAS:528:DC%2BD3cXjtlKgs7s%3D
    • Ye Z, Connor JR. Identification of iron responsive genes by screening cdna libraries from suppression subtractive hybridization with antisense probes from three iron conditions. Nucleic Acids Res. 2000;28(8):1802–7.
    • (2000) Nucleic Acids Res , vol.28 , Issue.8 , pp. 1802-1807
    • Ye, Z.1    Connor, J.R.2
  • 43
    • 2442553766 scopus 로고    scopus 로고
    • Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome
    • PID: 15140607, COI: 1:CAS:528:DC%2BD2cXktVOlsb0%3D
    • Wang X, Wiesinger J, Beard J, Felt B, Menzies S, Earley C, et al. Thy1 expression in the brain is affected by iron and is decreased in restless legs syndrome. J Neurol Sci. 2004;220(1–2):59–66.
    • (2004) J Neurol Sci , vol.220 , Issue.1-2 , pp. 59-66
    • Wang, X.1    Wiesinger, J.2    Beard, J.3    Felt, B.4    Menzies, S.5    Earley, C.6
  • 44
    • 0032498624 scopus 로고    scopus 로고
    • Thy-1 is a component common to multiple populations of synaptic vesicles
    • PID: 9456327, COI: 1:CAS:528:DyaK1cXhtVams7g%3D
    • Jeng CJ, McCarroll SA, Martin TF, Floor E, Adams J, Krantz D, et al. Thy-1 is a component common to multiple populations of synaptic vesicles. J Cell Biol. 1998;140(3):685–98.
    • (1998) J Cell Biol , vol.140 , Issue.3 , pp. 685-698
    • Jeng, C.J.1    McCarroll, S.A.2    Martin, T.F.3    Floor, E.4    Adams, J.5    Krantz, D.6
  • 45
    • 0027265673 scopus 로고
    • Thy-1 immunoreactivity distinguishes patches/striosomes from matrix in the early postnatal striatum of the rat
    • PID: 7900932, COI: 1:CAS:528:DyaK2cXlsFSm
    • Shults CW, Kimber TA. Thy-1 immunoreactivity distinguishes patches/striosomes from matrix in the early postnatal striatum of the rat. Brain Res Dev Brain Res. 1993;75(1):136–40.
    • (1993) Brain Res Dev Brain Res , vol.75 , Issue.1 , pp. 136-140
    • Shults, C.W.1    Kimber, T.A.2
  • 46
    • 20144388860 scopus 로고    scopus 로고
    • The role of opioids in restless legs syndrome: An [11c] diprenorphine pet study
    • von Spiczak S, Whone AL, Hammers A, Asselin MC, Turkheimer F, Tings T, et al. The role of opioids in restless legs syndrome: an [11c] diprenorphine pet study. Brain. 2005;128(Pt 4):906–17.
    • (2005) Brain , vol.128 , pp. 906-917
    • von Spiczak, S.1    Whone, A.L.2    Hammers, A.3    Asselin, M.C.4    Turkheimer, F.5    Tings, T.6
  • 47
    • 1842785359 scopus 로고    scopus 로고
    • Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome
    • PID: 14985260, COI: 1:STN:280:DC%2BD2c7ltFSmsA%3D%3D
    • Stiasny-Kolster K, Magerl W, Oertel WH, Moller JC, Treede RD. Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome. Brain. 2004;127(Pt 4):773–82.
    • (2004) Brain , vol.127 , pp. 773-782
    • Stiasny-Kolster, K.1    Magerl, W.2    Oertel, W.H.3    Moller, J.C.4    Treede, R.D.5
  • 48
    • 84879783040 scopus 로고    scopus 로고
    • Hyperalgesia and functional sensory loss in restless legs syndrome
    • PID: 23707286
    • Stiasny-Kolster K, Pfau DB, Oertel WH, Treede RD, Magerl W. Hyperalgesia and functional sensory loss in restless legs syndrome. Pain. 2013;154(8):1457–63.
    • (2013) Pain , vol.154 , Issue.8 , pp. 1457-1463
    • Stiasny-Kolster, K.1    Pfau, D.B.2    Oertel, W.H.3    Treede, R.D.4    Magerl, W.5
  • 49
    • 84879489508 scopus 로고    scopus 로고
    • Thalamic glutamate/glutamine in restless legs syndrome: Increased and related to disturbed sleep
    • PID: 23624560, COI: 1:CAS:528:DC%2BC3sXosFKhtbk%3D
    • Allen RP, Barker PB, Horska A, Earley CJ. Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology. 2013;80(22):2028–34.
    • (2013) Neurology , vol.80 , Issue.22 , pp. 2028-2034
    • Allen, R.P.1    Barker, P.B.2    Horska, A.3    Earley, C.J.4
  • 50
    • 84922633233 scopus 로고    scopus 로고
    • Restless legs syndrome and central nervous system gamma-aminobutyric acid: Preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity
    • Winkelman JW, Schoerning L, Platt S, Jensen J. Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity. Sleep Med (2014).
    • (2014) Sleep Med
    • Winkelman, J.W.1    Schoerning, L.2    Platt, S.3    Jensen, J.4
  • 51
    • 84878647787 scopus 로고    scopus 로고
    • Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/willis-ekbom disease
    • PID: 23758918, COI: 1:CAS:528:DC%2BC3sXhtVams7rI
    • Patton SM, Cho YW, Clardy TW, Allen RP, Earley CJ, Connor JR. Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/willis-ekbom disease. Fluids Barriers CNS. 2013;10(1):20.
    • (2013) Fluids Barriers CNS , vol.10 , Issue.1 , pp. 20
    • Patton, S.M.1    Cho, Y.W.2    Clardy, T.W.3    Allen, R.P.4    Earley, C.J.5    Connor, J.R.6
  • 52
    • 0030996046 scopus 로고    scopus 로고
    • Cerebral generators involved in the pathogenesis of the restless legs syndrome
    • PID: 9153526, COI: 1:STN:280:DyaK2s3pslyqtg%3D%3D
    • Bucher SF, Seelos KC, Oertel WH, Reiser M, Trenkwalder C. Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol. 1997;41(5):639–45.
    • (1997) Ann Neurol , vol.41 , Issue.5 , pp. 639-645
    • Bucher, S.F.1    Seelos, K.C.2    Oertel, W.H.3    Reiser, M.4    Trenkwalder, C.5
  • 53
    • 12844259629 scopus 로고    scopus 로고
    • Bilateral thalamic gray matter changes in patients with restless legs syndrome
    • PID: 15670702
    • Etgen T, Draganski B, Ilg C, Schroder M, Geisler P, Hajak G, et al. Bilateral thalamic gray matter changes in patients with restless legs syndrome. Neuroimage. 2005;24(4):1242–7.
    • (2005) Neuroimage , vol.24 , Issue.4 , pp. 1242-1247
    • Etgen, T.1    Draganski, B.2    Ilg, C.3    Schroder, M.4    Geisler, P.5    Hajak, G.6
  • 54
    • 0029730801 scopus 로고    scopus 로고
    • Restless legs syndrome: Clinicoetiologic correlates
    • PID: 8960723, COI: 1:STN:280:DyaK2s7itVSmsA%3D%3D
    • Ondo W, Jankovic J. Restless legs syndrome: clinicoetiologic correlates. Neurology. 1996;47(6):1435–41.
    • (1996) Neurology , vol.47 , Issue.6 , pp. 1435-1441
    • Ondo, W.1    Jankovic, J.2
  • 55
    • 0034649387 scopus 로고    scopus 로고
    • Restless legs syndrome in monozygotic twins: Clinical correlates
    • PID: 11087794, COI: 1:STN:280:DC%2BD3M%2FlvFymtg%3D%3D
    • Ondo WG, Vuong KD, Wang Q. Restless legs syndrome in monozygotic twins: clinical correlates. Neurology. 2000;55(9):1404–6.
    • (2000) Neurology , vol.55 , Issue.9 , pp. 1404-1406
    • Ondo, W.G.1    Vuong, K.D.2    Wang, Q.3
  • 56
    • 34248161525 scopus 로고    scopus 로고
    • Canadian restless legs syndrome twin study
    • PID: 17485653, COI: 1:STN:280:DC%2BD2s3nsFyhug%3D%3D
    • Xiong L, Jang K, Montplaisir J, Levchenko A, Thibodeau P, Gaspar C, et al. Canadian restless legs syndrome twin study. Neurology. 2007;68(19):1631–3.
    • (2007) Neurology , vol.68 , Issue.19 , pp. 1631-1633
    • Xiong, L.1    Jang, K.2    Montplaisir, J.3    Levchenko, A.4    Thibodeau, P.5    Gaspar, C.6
  • 57
    • 0036714378 scopus 로고    scopus 로고
    • Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families
    • PID: 12205641
    • Winkelmann J, Muller-Myhsok B, Wittchen HU, Hock B, Prager M, Pfister H, et al. Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families. Ann Neurol. 2002;52(3):297–302.
    • (2002) Ann Neurol , vol.52 , Issue.3 , pp. 297-302
    • Winkelmann, J.1    Muller-Myhsok, B.2    Wittchen, H.U.3    Hock, B.4    Prager, M.5    Pfister, H.6
  • 58
  • 59
    • 34547497308 scopus 로고    scopus 로고
    • Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    • PID: 17637780, COI: 1:CAS:528:DC%2BD2sXot1Cmsb0%3D
    • Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet. 2007;39(8):1000–6.
    • (2007) Nat Genet , vol.39 , Issue.8 , pp. 1000-1006
    • Winkelmann, J.1    Schormair, B.2    Lichtner, P.3    Ripke, S.4    Xiong, L.5    Jalilzadeh, S.6
  • 60
    • 48349142470 scopus 로고    scopus 로고
    • Ptprd (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
    • PID: 18660810, COI: 1:CAS:528:DC%2BD1cXptVKrsro%3D
    • Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, et al. Ptprd (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nat Genet. 2008;40(8):946–8.
    • (2008) Nat Genet , vol.40 , Issue.8 , pp. 946-948
    • Schormair, B.1    Kemlink, D.2    Roeske, D.3    Eckstein, G.4    Xiong, L.5    Lichtner, P.6
  • 61
    • 0037162352 scopus 로고    scopus 로고
    • Evidence for a genetic association between monoamine oxidase a and restless legs syndrome
    • PID: 12136060, COI: 1:CAS:528:DC%2BD38Xmt1Sisbg%3D
    • Desautels A, Turecki G, Montplaisir J, Brisebois K, Sequeira A, Adam B, et al. Evidence for a genetic association between monoamine oxidase a and restless legs syndrome. Neurology. 2002;59(2):215–9.
    • (2002) Neurology , vol.59 , Issue.2 , pp. 215-219
    • Desautels, A.1    Turecki, G.2    Montplaisir, J.3    Brisebois, K.4    Sequeira, A.5    Adam, B.6
  • 62
    • 43049183671 scopus 로고    scopus 로고
    • Variants in the neuronal nitric oxide synthase (nnos, nos1) gene are associated with restless legs syndrome
    • PID: 18058820
    • Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, et al. Variants in the neuronal nitric oxide synthase (nnos, nos1) gene are associated with restless legs syndrome. Mov Disord. 2008;23(3):350–8.
    • (2008) Mov Disord , vol.23 , Issue.3 , pp. 350-358
    • Winkelmann, J.1    Lichtner, P.2    Schormair, B.3    Uhr, M.4    Hauk, S.5    Stiasny-Kolster, K.6
  • 63
    • 20144387708 scopus 로고    scopus 로고
    • Restless legs syndrome: Confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity
    • PID: 15824258
    • Desautels A, Turecki G, Montplaisir J, Xiong L, Walters AS, Ehrenberg BL, et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol. 2005;62(4):591–6.
    • (2005) Arch Neurol , vol.62 , Issue.4 , pp. 591-596
    • Desautels, A.1    Turecki, G.2    Montplaisir, J.3    Xiong, L.4    Walters, A.S.5    Ehrenberg, B.L.6
  • 65
    • 2342527865 scopus 로고    scopus 로고
    • Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p
    • PID: 15077200, COI: 1:CAS:528:DC%2BD2cXjvVeis7Y%3D
    • Chen S, Ondo WG, Rao S, Li L, Chen Q, Wang Q. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet. 2004;74(5):876–85.
    • (2004) Am J Hum Genet , vol.74 , Issue.5 , pp. 876-885
    • Chen, S.1    Ondo, W.G.2    Rao, S.3    Li, L.4    Chen, Q.5    Wang, Q.6
  • 66
    • 84880588922 scopus 로고    scopus 로고
    • Fine-mapping of restless legs locus 4 (rls4) identifies a haplotype over the spats2l and kctd18 genes
    • PID: 23054586
    • Pichler I, Schwienbacher C, Zanon A, Fuchsberger C, Serafin A, Facheris MF, et al. Fine-mapping of restless legs locus 4 (rls4) identifies a haplotype over the spats2l and kctd18 genes. J Mol Neurosci. 2012;49(3):600–5.
    • (2012) J Mol Neurosci , vol.49 , Issue.3 , pp. 600-605
    • Pichler, I.1    Schwienbacher, C.2    Zanon, A.3    Fuchsberger, C.4    Serafin, A.5    Facheris, M.F.6
  • 67
    • 33748696387 scopus 로고    scopus 로고
    • A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13
    • PID: 16966564, COI: 1:STN:280:DC%2BD28rktF2ktw%3D%3D
    • Levchenko A, Provost S, Montplaisir JY, Xiong L, St-Onge J, Thibodeau P, et al. A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13. Neurology. 2006;67(5):900–1.
    • (2006) Neurology , vol.67 , Issue.5 , pp. 900-901
    • Levchenko, A.1    Provost, S.2    Montplaisir, J.Y.3    Xiong, L.4    St-Onge, J.5    Thibodeau, P.6
  • 68
    • 77955789208 scopus 로고    scopus 로고
    • Autosomal dominant restless legs syndrome maps to chromosome 20p13 (rls-5) in a dutch kindred
    • PID: 20645405
    • Sas AM, Di Fonzo A, Bakker SL, Simons EJ, Oostra BA, Maat-Kievit AJ, et al. Autosomal dominant restless legs syndrome maps to chromosome 20p13 (rls-5) in a dutch kindred. Mov Disord. 2010;25(11):1715–22.
    • (2010) Mov Disord , vol.25 , Issue.11 , pp. 1715-1722
    • Sas, A.M.1    Di Fonzo, A.2    Bakker, S.L.3    Simons, E.J.4    Oostra, B.A.5    Maat-Kievit, A.J.6
  • 69
    • 40349112722 scopus 로고    scopus 로고
    • Evidence for linkage of restless legs syndrome to chromosome 9p: Are there two distinct loci?[see comment]
    • PID: 18032746, COI: 1:CAS:528:DC%2BD1cXivVehur4%3D
    • Lohmann-Hedrich K, Neumann A, Kleensang A, Lohnau T, Muhle H, Djarmati A, et al. Evidence for linkage of restless legs syndrome to chromosome 9p: are there two distinct loci?[see comment]. Neurology. 2008;70(9):686–94.
    • (2008) Neurology , vol.70 , Issue.9 , pp. 686-694
    • Lohmann-Hedrich, K.1    Neumann, A.2    Kleensang, A.3    Lohnau, T.4    Muhle, H.5    Djarmati, A.6
  • 70
    • 61449215329 scopus 로고    scopus 로고
    • Autosomal-dominant locus for restless legs syndrome in french-canadians on chromosome 16p12.1
    • PID: 18946881
    • Levchenko A, Montplaisir JY, Asselin G, Provost S, Girard SL, Xiong L, et al. Autosomal-dominant locus for restless legs syndrome in french-canadians on chromosome 16p12.1. Mov Disord. 2009;24(1):40–50.
    • (2009) Mov Disord , vol.24 , Issue.1 , pp. 40-50
    • Levchenko, A.1    Montplaisir, J.Y.2    Asselin, G.3    Provost, S.4    Girard, S.L.5    Xiong, L.6
  • 71
    • 84862692068 scopus 로고    scopus 로고
    • A novel locus for restless legs syndrome maps to chromosome 19p in an irish pedigree
    • PID: 22411506, COI: 1:CAS:528:DC%2BC38XmtFens78%3D
    • Skehan EB, Abdulrahim MM, Parfrey NA, Hand CK. A novel locus for restless legs syndrome maps to chromosome 19p in an irish pedigree. Neurogenetics. 2012;13(2):125–32.
    • (2012) Neurogenetics , vol.13 , Issue.2 , pp. 125-132
    • Skehan, E.B.1    Abdulrahim, M.M.2    Parfrey, N.A.3    Hand, C.K.4
  • 72
    • 84863731594 scopus 로고    scopus 로고
    • A novel locus for restless legs syndrome on chromosome 13q
    • PID: 22797413, COI: 1:CAS:528:DC%2BC38Xht1CntrfL
    • Balaban H, Bayrakli F, Kartal U, Pinarbasi E, Topaktas S, Kars HZ. A novel locus for restless legs syndrome on chromosome 13q. Eur Neurol. 2012;68(2):111–6.
    • (2012) Eur Neurol , vol.68 , Issue.2 , pp. 111-116
    • Balaban, H.1    Bayrakli, F.2    Kartal, U.3    Pinarbasi, E.4    Topaktas, S.5    Kars, H.Z.6
  • 73
    • 84870336681 scopus 로고    scopus 로고
    • Exome sequencing in a family with restless legs syndrome
    • PID: 23192925, COI: 1:CAS:528:DC%2BC3sXjs1KntQ%3D%3D
    • Weissbach A, Siegesmund K, Bruggemann N, Schmidt A, Kasten M, Pichler I, et al. Exome sequencing in a family with restless legs syndrome. Mov Disord. 2012;27(13):1686–9.
    • (2012) Mov Disord , vol.27 , Issue.13 , pp. 1686-1689
    • Weissbach, A.1    Siegesmund, K.2    Bruggemann, N.3    Schmidt, A.4    Kasten, M.5    Pichler, I.6
  • 74
    • 48449103550 scopus 로고    scopus 로고
    • Susceptibility genes for restless legs syndrome are not associated with parkinson disease
    • PID: 18625969, COI: 1:STN:280:DC%2BD1cvltVWrtA%3D%3D
    • Vilarino-Guell C, Soto AI, Young JE, Lin SC, Uitti RJ, Wszolek ZK, et al. Susceptibility genes for restless legs syndrome are not associated with parkinson disease. Neurology. 2008;71(3):222–3.
    • (2008) Neurology , vol.71 , Issue.3 , pp. 222-223
    • Vilarino-Guell, C.1    Soto, A.I.2    Young, J.E.3    Lin, S.C.4    Uitti, R.J.5    Wszolek, Z.K.6
  • 75
    • 84893861016 scopus 로고    scopus 로고
    • Association of candidate genetic variants with restless legs syndrome in end stage renal disease: A multicenter case-control study in taiwan
    • PID: 24433515, COI: 1:STN:280:DC%2BC2czmtFarsQ%3D%3D
    • Lin CH, Chen ML, Wu VC, Li WY, Sy HN, Wu SL, et al. Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in taiwan. Eur J Neurol. 2014;21(3):492–8.
    • (2014) Eur J Neurol , vol.21 , Issue.3 , pp. 492-498
    • Lin, C.H.1    Chen, M.L.2    Wu, V.C.3    Li, W.Y.4    Sy, H.N.5    Wu, S.L.6
  • 76
    • 35549013932 scopus 로고    scopus 로고
    • Restless legs syndrome (rls) in uremic patients is related to the frequency of hemodialysis sessions
    • PID: 11124621, COI: 1:STN:280:DC%2BD3M7htVyitw%3D%3D
    • Huiqi Q, Shan L, Mingcai Q. Restless legs syndrome (rls) in uremic patients is related to the frequency of hemodialysis sessions. Nephron. 2000;86(4):540.
    • (2000) Nephron , vol.86 , Issue.4 , pp. 540
    • Huiqi, Q.1    Shan, L.2    Mingcai, Q.3
  • 77
    • 0038493372 scopus 로고
    • Restless legs syndrome treated successfully by kidney transplantation--a case report
    • Yasuda T, Nishimura A, Katsuki Y, Tsuji Y. Restless legs syndrome treated successfully by kidney transplantation--a case report. Clin Transpl (1986) 138.
    • (1986) Clin Transpl , pp. 138
    • Yasuda, T.1    Nishimura, A.2    Katsuki, Y.3    Tsuji, Y.4
  • 78
    • 0036765159 scopus 로고    scopus 로고
    • Long-term course of restless legs syndrome in dialysis patients after kidney transplantation
    • PID: 12360562
    • Winkelmann J, Stautner A, Samtleben W, Trenkwalder C. Long-term course of restless legs syndrome in dialysis patients after kidney transplantation. Mov Disord. 2002;17(5):1072–6.
    • (2002) Mov Disord , vol.17 , Issue.5 , pp. 1072-1076
    • Winkelmann, J.1    Stautner, A.2    Samtleben, W.3    Trenkwalder, C.4
  • 79
    • 34248567842 scopus 로고    scopus 로고
    • Evaluation of effect of renal transplantation in treatment of restless legs syndrome
    • PID: 17524912, COI: 1:STN:280:DC%2BD2szhtlSntw%3D%3D
    • Azar SA, Hatefi R, Talebi M. Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplant Proc. 2007;39(4):1132–3.
    • (2007) Transplant Proc , vol.39 , Issue.4 , pp. 1132-1133
    • Azar, S.A.1    Hatefi, R.2    Talebi, M.3
  • 80
    • 4644227573 scopus 로고    scopus 로고
    • Restless legs syndrome and pregnancy
    • PID: 15452299, COI: 1:STN:280:DC%2BD2cvotlylug%3D%3D, Largest study of RLS during pregnancy
    • Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63(6):1065–9. Largest study of RLS during pregnancy.
    • (2004) Neurology , vol.63 , Issue.6 , pp. 1065-1069
    • Manconi, M.1    Govoni, V.2    De Vito, A.3    Economou, N.T.4    Cesnik, E.5    Casetta, I.6
  • 81
    • 34249059592 scopus 로고    scopus 로고
    • Predisposing factors of restless legs syndrome in pregnancy
    • PID: 17285614
    • Tunc T, Karadag YS, Dogulu F, Inan LE. Predisposing factors of restless legs syndrome in pregnancy. Mov Disord. 2007;22(5):627–31.
    • (2007) Mov Disord , vol.22 , Issue.5 , pp. 627-631
    • Tunc, T.1    Karadag, Y.S.2    Dogulu, F.3    Inan, L.E.4
  • 82
    • 0036186469 scopus 로고    scopus 로고
    • Exploring the relationship between parkinson disease and restless legs syndrome
    • PID: 11890847
    • Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between parkinson disease and restless legs syndrome. Arch Neurol. 2002;59(3):421–4.
    • (2002) Arch Neurol , vol.59 , Issue.3 , pp. 421-424
    • Ondo, W.G.1    Vuong, K.D.2    Jankovic, J.3
  • 83
    • 85076502445 scopus 로고    scopus 로고
    • Does idiopathic restless legs syndrome delay onset and reduce severity of parkinson’s disease
    • Ondo W, Chen S, Dragan E. Does idiopathic restless legs syndrome delay onset and reduce severity of parkinson’s disease. Mov Disord. 2014;29(Supple1):S303.
    • (2014) Mov Disord , vol.29 , pp. S303
    • Ondo, W.1    Chen, S.2    Dragan, E.3
  • 84
    • 84755160681 scopus 로고    scopus 로고
    • Effect of tetrabenazine use on restless legs syndrome
    • PID: 20817597
    • Ondo WG, Jia JJ. Effect of tetrabenazine use on restless legs syndrome. Sleep Med. 2010;11(9):958–9.
    • (2010) Sleep Med , vol.11 , Issue.9 , pp. 958-959
    • Ondo, W.G.1    Jia, J.J.2
  • 85
    • 84857049270 scopus 로고    scopus 로고
    • Prevalence of neuroleptic-induced restless legs syndrome in patients taking neuroleptic drugs
    • PID: 22099638
    • Jagota P, Asawavichienjinda T, Bhidayasiri R. Prevalence of neuroleptic-induced restless legs syndrome in patients taking neuroleptic drugs. J Neurol Sci. 2012;314(1–2):158–60.
    • (2012) J Neurol Sci , vol.314 , Issue.1-2 , pp. 158-160
    • Jagota, P.1    Asawavichienjinda, T.2    Bhidayasiri, R.3
  • 86
    • 84867738028 scopus 로고    scopus 로고
    • European guidelines on management of restless legs syndrome: Report of a joint task force by the European federation of neurological societies, the European neurological society and the European sleep research society
    • PID: 22937989
    • Garcia-Borreguero D, Ferini-Strambi L, Kohnen R, O'Keeffe S, Trenkwalder C, Hogl B, et al. European guidelines on management of restless legs syndrome: report of a joint task force by the European federation of neurological societies, the European neurological society and the European sleep research society. Eur J Neurol. 2012;19(11):1385–96.
    • (2012) Eur J Neurol , vol.19 , Issue.11 , pp. 1385-1396
    • Garcia-Borreguero, D.1    Ferini-Strambi, L.2    Kohnen, R.3    O'Keeffe, S.4    Trenkwalder, C.5    Hogl, B.6
  • 87
    • 84880101555 scopus 로고    scopus 로고
    • The long-term treatment of restless legs syndrome/willis-ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: a report from the international restless legs syndrome study group
    • PID: 23859128, Only review of long-term management of disease
    • Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Hogl B, et al. The long-term treatment of restless legs syndrome/willis-ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the international restless legs syndrome study group. Sleep Med. 2013;14(7):675–84. Only review of long-term management of disease.
    • (2013) Sleep Med , vol.14 , Issue.7 , pp. 675-684
    • Garcia-Borreguero, D.1    Kohnen, R.2    Silber, M.H.3    Winkelman, J.W.4    Earley, C.J.5    Hogl, B.6
  • 88
    • 84884617766 scopus 로고    scopus 로고
    • Willis-ekbom disease foundation revised consensus statement on the management of restless legs syndrome
    • PID: 24001490, Recent review of treatment options
    • Silber MH, Becker PM, Earley C, Garcia-Borreguero D, Ondo WG. Willis-ekbom disease foundation revised consensus statement on the management of restless legs syndrome. Mayo Clin Proc. 2013;88(9):977–86. Recent review of treatment options.
    • (2013) Mayo Clin Proc , vol.88 , Issue.9 , pp. 977-986
    • Silber, M.H.1    Becker, P.M.2    Earley, C.3    Garcia-Borreguero, D.4    Ondo, W.G.5
  • 89
    • 84894932546 scopus 로고    scopus 로고
    • What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications
    • PID: 23746768
    • Hornyak M, Scholz H, Kohnen R, Bengel J, Kassubek J, Trenkwalder C. What treatment works best for restless legs syndrome? Meta-analyses of dopaminergic and non-dopaminergic medications. Sleep Med Rev. 2014;18(2):153–64.
    • (2014) Sleep Med Rev , vol.18 , Issue.2 , pp. 153-164
    • Hornyak, M.1    Scholz, H.2    Kohnen, R.3    Bengel, J.4    Kassubek, J.5    Trenkwalder, C.6
  • 90
    • 84881291975 scopus 로고    scopus 로고
    • Predictors of placebo response in restless legs syndrome studies
    • PID: 23749799
    • Ondo WG, Hossain MM, Gordon MF, Reess J. Predictors of placebo response in restless legs syndrome studies. Neurology. 2013;81(2):193–4.
    • (2013) Neurology , vol.81 , Issue.2 , pp. 193-194
    • Ondo, W.G.1    Hossain, M.M.2    Gordon, M.F.3    Reess, J.4
  • 91
    • 0345863904 scopus 로고    scopus 로고
    • Ropinirole in the treatment of restless legs syndrome: Results from the treat rls 1 study, a 12 week, randomised, placebo controlled study in 10 European countries
    • PID: 14707315, COI: 1:STN:280:DC%2BD2c%2FjvVSguw%3D%3D
    • Trenkwalder C, Garcia-Borreguero D, Montagna P, Lainey E, de Weerd AW, Tidswell P, et al. Ropinirole in the treatment of restless legs syndrome: results from the treat rls 1 study, a 12 week, randomised, placebo controlled study in 10 European countries. J Neurol Neurosurg Psychiatry. 2004;75(1):92–7.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , Issue.1 , pp. 92-97
    • Trenkwalder, C.1    Garcia-Borreguero, D.2    Montagna, P.3    Lainey, E.4    de Weerd, A.W.5    Tidswell, P.6
  • 92
    • 19944426849 scopus 로고    scopus 로고
    • Ropinirole is effective in the treatment of restless legs syndrome. Treat rls 2: A 12-week, double-blind, randomized, parallel-group, placebo-controlled study
    • PID: 15390050
    • Walters AS, Ondo WG, Dreykluft T, Grunstein R, Lee D, Sethi K. Ropinirole is effective in the treatment of restless legs syndrome. Treat rls 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled study. Mov Disord. 2004;19(12):1414–23.
    • (2004) Mov Disord , vol.19 , Issue.12 , pp. 1414-1423
    • Walters, A.S.1    Ondo, W.G.2    Dreykluft, T.3    Grunstein, R.4    Lee, D.5    Sethi, K.6
  • 93
    • 23844543985 scopus 로고    scopus 로고
    • Ropinirole is effective, well tolerated treatment for moderate-to-severe rls: Results of a u.S. Study
    • Bogan R, Connolly G, Rederich G. Ropinirole is effective, well tolerated treatment for moderate-to-severe rls: results of a u.S. Study. Mov Disord. 2005;20(supple10):S61.
    • (2005) Mov Disord , vol.20 , pp. S61
    • Bogan, R.1    Connolly, G.2    Rederich, G.3
  • 94
    • 33847767130 scopus 로고    scopus 로고
    • Efficacy of pramipexole in restless legs syndrome: A six-week, multicenter, randomized, double-blind study (effect-rls study)
    • PID: 17133582
    • Oertel WH, Stiasny-Kolster K, Bergtholdt B, Hallstrom Y, Albo J, Leissner L, et al. Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-rls study). Mov Disord. 2007;22(2):213–9.
    • (2007) Mov Disord , vol.22 , Issue.2 , pp. 213-219
    • Oertel, W.H.1    Stiasny-Kolster, K.2    Bergtholdt, B.3    Hallstrom, Y.4    Albo, J.5    Leissner, L.6
  • 95
    • 33750353526 scopus 로고    scopus 로고
    • Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome
    • PID: 16755554
    • Trenkwalder C, Stiasny-Kolster K, Kupsch A, Oertel WH, Koester J, Reess J. Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome. Mov Disord. 2006;21(9):1404–10.
    • (2006) Mov Disord , vol.21 , Issue.9 , pp. 1404-1410
    • Trenkwalder, C.1    Stiasny-Kolster, K.2    Kupsch, A.3    Oertel, W.H.4    Koester, J.5    Reess, J.6
  • 96
    • 33746534956 scopus 로고    scopus 로고
    • Efficacy and safety of pramipexole in idiopathic restless legs syndrome: A polysomnographic dose-finding study-the prelude study
    • PID: 16815748
    • Partinen M, Hirvonen K, Jama L, Alakuijala A, Hublin C, Tamminen I, et al. Efficacy and safety of pramipexole in idiopathic restless legs syndrome: a polysomnographic dose-finding study-the prelude study. Sleep Med. 2006;7(5):407–17.
    • (2006) Sleep Med , vol.7 , Issue.5 , pp. 407-417
    • Partinen, M.1    Hirvonen, K.2    Jama, L.3    Alakuijala, A.4    Hublin, C.5    Tamminen, I.6
  • 97
    • 49849083845 scopus 로고    scopus 로고
    • Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: A randomised, double-blind, placebo-controlled trial
    • PID: 18515185, COI: 1:CAS:528:DC%2BD1cXptVWju7Y%3D
    • Trenkwalder C, Benes H, Poewe W, Oertel WH, Garcia-Borreguero D, de Weerd AW, et al. Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2008;7(7):595–604.
    • (2008) Lancet Neurol , vol.7 , Issue.7 , pp. 595-604
    • Trenkwalder, C.1    Benes, H.2    Poewe, W.3    Oertel, W.H.4    Garcia-Borreguero, D.5    de Weerd, A.W.6
  • 98
    • 40849113591 scopus 로고    scopus 로고
    • Efficacy of rotigotine transdermal system in severe restless legs syndrome: A randomized, double-blind, placebo-controlled, six-week dose-finding trial in europe
    • PID: 17553743
    • Oertel WH, Benes H, Garcia-Borreguero D, Geisler P, Hogl B, Saletu B, et al. Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in europe. Sleep Med. 2008;9(3):228–39.
    • (2008) Sleep Med , vol.9 , Issue.3 , pp. 228-239
    • Oertel, W.H.1    Benes, H.2    Garcia-Borreguero, D.3    Geisler, P.4    Hogl, B.5    Saletu, B.6
  • 99
    • 0031677642 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome
    • PID: 9855508, COI: 1:CAS:528:DyaK1MXhsVOnug%3D%3D
    • Earley CJ, Yaffee JB, Allen RP. Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome. Neurology. 1998;51(6):1599–602.
    • (1998) Neurology , vol.51 , Issue.6 , pp. 1599-1602
    • Earley, C.J.1    Yaffee, J.B.2    Allen, R.P.3
  • 100
    • 0030865047 scopus 로고    scopus 로고
    • Pergolide: Treatment of choice in restless legs syndrome (rls) and nocturnal myoclonus syndrome (nms). A double-blind randomized crossover trial of pergolide versus l-dopa
    • COI: 1:CAS:528:DyaK2sXmt1Srsrk%3D
    • Staedt J, Wassmuth F, Ziemann U, Hajak G, Ruther E, Stoppe G. Pergolide: Treatment of choice in restless legs syndrome (rls) and nocturnal myoclonus syndrome (nms). A double-blind randomized crossover trial of pergolide versus l-dopa. J Neural Transm (Budapest). 1997;104(4-5):461–8.
    • (1997) J Neural Transm (Budapest) , vol.104 , Issue.4-5 , pp. 461-468
    • Staedt, J.1    Wassmuth, F.2    Ziemann, U.3    Hajak, G.4    Ruther, E.5    Stoppe, G.6
  • 101
    • 0001846221 scopus 로고    scopus 로고
    • A randomized long-term placebo controlled multicenter trial of pergolide in the treatment of restless legs syndrome with central evaluation of polysomnographic data
    • Trenkwalder C, Brandenburg U, Hundemer H, Lledo A, Quail D. A randomized long-term placebo controlled multicenter trial of pergolide in the treatment of restless legs syndrome with central evaluation of polysomnographic data. Neurology. 2001;56(Supple 3):A5.
    • (2001) Neurology , vol.56 , pp. A5
    • Trenkwalder, C.1    Brandenburg, U.2    Hundemer, H.3    Lledo, A.4    Quail, D.5
  • 102
    • 0033596810 scopus 로고    scopus 로고
    • A randomized controlled study of pergolide in patients with restless legs syndrome
    • PID: 10102410, COI: 1:CAS:528:DyaK1MXit1Wnt7o%3D
    • Wetter TC, Stiasny K, Winkelmann J, Buhlinger A, Brandenburg U, Penzel T, et al. A randomized controlled study of pergolide in patients with restless legs syndrome. Neurology. 1999;52(5):944–50.
    • (1999) Neurology , vol.52 , Issue.5 , pp. 944-950
    • Wetter, T.C.1    Stiasny, K.2    Winkelmann, J.3    Buhlinger, A.4    Brandenburg, U.5    Penzel, T.6
  • 103
    • 0023683723 scopus 로고
    • A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome
    • PID: 3067654, COI: 1:STN:280:DyaL1M7kvFShsA%3D%3D
    • Walters AS, Hening WA, Kavey N, Chokroverty S, Gidro-Frank S. A double-blind randomized crossover trial of bromocriptine and placebo in restless legs syndrome. Ann Neurol. 1988;24(3):455–8.
    • (1988) Ann Neurol , vol.24 , Issue.3 , pp. 455-458
    • Walters, A.S.1    Hening, W.A.2    Kavey, N.3    Chokroverty, S.4    Gidro-Frank, S.5
  • 104
    • 0032810939 scopus 로고    scopus 로고
    • Nocturnal subcutaneous apomorphine infusion in parkinson's disease and restless legs syndrome
    • PID: 10478579, COI: 1:CAS:528:DyaK1MXlvVKgtbg%3D
    • Reuter I, Ellis CM, Ray Chaudhuri K. Nocturnal subcutaneous apomorphine infusion in parkinson's disease and restless legs syndrome. Acta Neurol Scand. 1999;100(3):163–7.
    • (1999) Acta Neurol Scand , vol.100 , Issue.3 , pp. 163-167
    • Reuter, I.1    Ellis, C.M.2    Ray Chaudhuri, K.3
  • 105
    • 1042267992 scopus 로고    scopus 로고
    • Role of dopamine receptor agonists in the treatment of restless legs syndrome
    • PID: 14731057, COI: 1:CAS:528:DC%2BD2cXhvVWhs7Y%3D
    • Happe S, Trenkwalder C. Role of dopamine receptor agonists in the treatment of restless legs syndrome. CNS Drugs. 2004;18(1):27–36.
    • (2004) CNS Drugs , vol.18 , Issue.1 , pp. 27-36
    • Happe, S.1    Trenkwalder, C.2
  • 106
    • 29844452491 scopus 로고    scopus 로고
    • Transdermal lisuride: Short-term efficacy and tolerability study in patients with severe restless legs syndrome
    • PID: 16194624
    • Benes H. Transdermal lisuride: short-term efficacy and tolerability study in patients with severe restless legs syndrome. Sleep Med. 2006;7(1):31–5.
    • (2006) Sleep Med , vol.7 , Issue.1 , pp. 31-35
    • Benes, H.1
  • 107
    • 0033573403 scopus 로고    scopus 로고
    • Rapid onset of action of levodopa in restless legs syndrome: A double-blind, randomized, multicenter, crossover trial
    • PID: 10617168, COI: 1:STN:280:DC%2BD3c%2FotlCmug%3D%3D
    • Benes H, Kurella B, Kummer J, Kazenwadel J, Selzer R, Kohnen R. Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial. Sleep. 1999;22(8):1073–81.
    • (1999) Sleep , vol.22 , Issue.8 , pp. 1073-1081
    • Benes, H.1    Kurella, B.2    Kummer, J.3    Kazenwadel, J.4    Selzer, R.5    Kohnen, R.6
  • 108
    • 0037507223 scopus 로고    scopus 로고
    • Acute double-blind, placebo-controlled sleep laboratory and clinical follow-up studies with a combination treatment of rr-l-dopa and sr-l-dopa in restless legs syndrome
    • PID: 12768357, COI: 1:CAS:528:DC%2BD3sXntlKhs7w%3D
    • Saletu M, Anderer P, Hogl B, Saletu-Zyhlarz G, Kunz A, Poewe W, et al. Acute double-blind, placebo-controlled sleep laboratory and clinical follow-up studies with a combination treatment of rr-l-dopa and sr-l-dopa in restless legs syndrome. J Neural Transm. 2003;110(6):611–26.
    • (2003) J Neural Transm , vol.110 , Issue.6 , pp. 611-626
    • Saletu, M.1    Anderer, P.2    Hogl, B.3    Saletu-Zyhlarz, G.4    Kunz, A.5    Poewe, W.6
  • 109
    • 34249022251 scopus 로고    scopus 로고
    • Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: Results from a multi-center, randomized, active controlled trial
    • PID: 17274039
    • Trenkwalder C, Benes H, Grote L, Happe S, Hogl B, Mathis J, et al. Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial. Mov Disord. 2007;22(5):696–703.
    • (2007) Mov Disord , vol.22 , Issue.5 , pp. 696-703
    • Trenkwalder, C.1    Benes, H.2    Grote, L.3    Happe, S.4    Hogl, B.5    Mathis, J.6
  • 110
    • 4344561150 scopus 로고    scopus 로고
    • Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: An open randomized crossover trial versus levodopa sustained release
    • PID: 15319704, COI: 1:CAS:528:DC%2BD2cXmvVars70%3D
    • Pellecchia MT, Vitale C, Sabatini M, Longo K, Amboni M, Bonavita V, et al. Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release. Clin Neuropharmacol. 2004;27(4):178–81.
    • (2004) Clin Neuropharmacol , vol.27 , Issue.4 , pp. 178-181
    • Pellecchia, M.T.1    Vitale, C.2    Sabatini, M.3    Longo, K.4    Amboni, M.5    Bonavita, V.6
  • 111
    • 34250855640 scopus 로고    scopus 로고
    • Validation of the augmentation severity rating scale (asrs): A multicentric, prospective study with levodopa on restless legs syndrome
    • PID: 17543579
    • Garcia-Borreguero D, Kohnen R, Hogl B, Ferini-Strambi L, Hadjigeorgiou GM, Hornyak M, et al. Validation of the augmentation severity rating scale (asrs): a multicentric, prospective study with levodopa on restless legs syndrome. Sleep Med. 2007;8(5):455–63.
    • (2007) Sleep Med , vol.8 , Issue.5 , pp. 455-463
    • Garcia-Borreguero, D.1    Kohnen, R.2    Hogl, B.3    Ferini-Strambi, L.4    Hadjigeorgiou, G.M.5    Hornyak, M.6
  • 112
    • 77749340689 scopus 로고    scopus 로고
    • Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: Results of a prospective multi-center study
    • PID: 19756826
    • Hogl B, Garcia-Borreguero D, Kohnen R, Ferini-Strambi L, Hadjigeorgiou G, Hornyak M, et al. Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study. J Neurol. 2010;257(2):230–7.
    • (2010) J Neurol , vol.257 , Issue.2 , pp. 230-237
    • Hogl, B.1    Garcia-Borreguero, D.2    Kohnen, R.3    Ferini-Strambi, L.4    Hadjigeorgiou, G.5    Hornyak, M.6
  • 113
    • 84893779614 scopus 로고    scopus 로고
    • Comparison of pregabalin with pramipexole for restless legs syndrome
    • PID: 24521108, COI: 1:CAS:528:DC%2BC2cXis1eqt74%3D
    • Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014;370(7):621–31.
    • (2014) N Engl J Med , vol.370 , Issue.7 , pp. 621-631
    • Allen, R.P.1    Chen, C.2    Garcia-Borreguero, D.3    Polo, O.4    DuBrava, S.5    Miceli, J.6
  • 114
    • 84856960608 scopus 로고    scopus 로고
    • Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (willis-ekbom disease): Results from a prospective, multicenter study over 66 weeks
    • PID: 22328464, COI: 1:CAS:528:DC%2BC38Xhs1Glur7E
    • Garcia-Borreguero D, Hogl B, Ferini-Strambi L, Winkelman J, Hill-Zabala C, Asgharian A, et al. Systematic evaluation of augmentation during treatment with ropinirole in restless legs syndrome (willis-ekbom disease): results from a prospective, multicenter study over 66 weeks. Mov Disord. 2012;27(2):277–83.
    • (2012) Mov Disord , vol.27 , Issue.2 , pp. 277-283
    • Garcia-Borreguero, D.1    Hogl, B.2    Ferini-Strambi, L.3    Winkelman, J.4    Hill-Zabala, C.5    Asgharian, A.6
  • 117
    • 4444354362 scopus 로고    scopus 로고
    • Long-term treatment of restless legs syndrome with dopamine agonists
    • PID: 15364685
    • Ondo W, Romanyshyn J, Vuong KD, Lai D. Long-term treatment of restless legs syndrome with dopamine agonists. Arch Neurol. 2004;61(9):1393–7.
    • (2004) Arch Neurol , vol.61 , Issue.9 , pp. 1393-1397
    • Ondo, W.1    Romanyshyn, J.2    Vuong, K.D.3    Lai, D.4
  • 118
    • 2142762707 scopus 로고    scopus 로고
    • Pramipexole in the management of restless legs syndrome: An extended study
    • PID: 14655914
    • Silber MH, Girish M, Izurieta R. Pramipexole in the management of restless legs syndrome: an extended study. Sleep. 2003;26(7):819–21.
    • (2003) Sleep , vol.26 , Issue.7 , pp. 819-821
    • Silber, M.H.1    Girish, M.2    Izurieta, R.3
  • 119
    • 77957343163 scopus 로고    scopus 로고
    • The use of gabapentin enacarbil in the treatment of restless legs syndrome
    • PID: 21179617, COI: 1:CAS:528:DC%2BC3cXhsFyqu7fE
    • Yaltho TC, Ondo WG. The use of gabapentin enacarbil in the treatment of restless legs syndrome. Ther Adv Neurol Disord. 2010;3(5):269–75.
    • (2010) Ther Adv Neurol Disord , vol.3 , Issue.5 , pp. 269-275
    • Yaltho, T.C.1    Ondo, W.G.2
  • 120
    • 58449136583 scopus 로고    scopus 로고
    • Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome
    • PID: 19127491, COI: 1:CAS:528:DC%2BC3cXnt1Kgtb4%3D
    • Merlino G, Serafini A, Young JJ, Robiony F, Gigli GL, Valente M. Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndrome. Curr Opin Investig Drugs. 2009;10(1):91–102.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.1 , pp. 91-102
    • Merlino, G.1    Serafini, A.2    Young, J.J.3    Robiony, F.4    Gigli, G.L.5    Valente, M.6
  • 121
    • 77953361837 scopus 로고    scopus 로고
    • A randomized, double-blind, 6-week, dose-ranging study of pregabalin in patients with restless legs syndrome
    • PID: 20466589
    • Allen R, Chen C, Soaita A, Wohlberg C, Knapp L, Peterson BT, et al. A randomized, double-blind, 6-week, dose-ranging study of pregabalin in patients with restless legs syndrome. Sleep Med. 2010;11(6):512–9.
    • (2010) Sleep Med , vol.11 , Issue.6 , pp. 512-519
    • Allen, R.1    Chen, C.2    Soaita, A.3    Wohlberg, C.4    Knapp, L.5    Peterson, B.T.6
  • 122
    • 77953347801 scopus 로고    scopus 로고
    • Treatment of restless legs syndrome with pregabalin: A double-blind, placebo-controlled study
    • PID: 20427750, COI: 1:CAS:528:DC%2BC3cXntF2gtbo%3D
    • Garcia-Borreguero D, Larrosa O, Williams AM, Albares J, Pascual M, Palacios JC, et al. Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study. Neurology. 2010;74(23):1897–904.
    • (2010) Neurology , vol.74 , Issue.23 , pp. 1897-1904
    • Garcia-Borreguero, D.1    Larrosa, O.2    Williams, A.M.3    Albares, J.4    Pascual, M.5    Palacios, J.C.6
  • 123
    • 79959302556 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome
    • PID: 21677899
    • Lee DO, Ziman RB, Perkins AT, Poceta JS, Walters AS, Barrett RW. A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. J Clin Sleep Med. 2011;7(3):282–92.
    • (2011) J Clin Sleep Med , vol.7 , Issue.3 , pp. 282-292
    • Lee, D.O.1    Ziman, R.B.2    Perkins, A.T.3    Poceta, J.S.4    Walters, A.S.5    Barrett, R.W.6
  • 124
    • 84865209161 scopus 로고    scopus 로고
    • Dose response of gabapentin enacarbil versus placebo in subjects with moderate-to-severe primary restless legs syndrome: An integrated analysis of three 12-week studies
    • PID: 22849331, COI: 1:CAS:528:DC%2BC38XhsFSjtbrM
    • VanMeter SA, Kavanagh ST, Warren S, Barrett RW. Dose response of gabapentin enacarbil versus placebo in subjects with moderate-to-severe primary restless legs syndrome: an integrated analysis of three 12-week studies. CNS Drugs. 2012;26(9):773–80.
    • (2012) CNS Drugs , vol.26 , Issue.9 , pp. 773-780
    • VanMeter, S.A.1    Kavanagh, S.T.2    Warren, S.3    Barrett, R.W.4
  • 125
    • 84871389240 scopus 로고    scopus 로고
    • Gabapentin enacarbil in japanese patients with restless legs syndrome: A 12-week, randomized, double-blind, placebo-controlled, parallel-group study
    • PID: 23121149, COI: 1:CAS:528:DC%2BC38XhvVynsLvO
    • Inoue Y, Hirata K, Uchimura N, Kuroda K, Hattori N, Takeuchi M. Gabapentin enacarbil in japanese patients with restless legs syndrome: a 12-week, randomized, double-blind, placebo-controlled, parallel-group study. Curr Med Res Opin. 2013;29(1):13–21.
    • (2013) Curr Med Res Opin , vol.29 , Issue.1 , pp. 13-21
    • Inoue, Y.1    Hirata, K.2    Uchimura, N.3    Kuroda, K.4    Hattori, N.5    Takeuchi, M.6
  • 126
    • 0037180403 scopus 로고    scopus 로고
    • Treatment of restless legs syndrome with gabapentin: A double-blind, cross-over study
    • PID: 12451200, COI: 1:STN:280:DC%2BD38nptVejsw%3D%3D
    • Garcia-Borreguero D, Larrosa O, de la Llave Y, Verger K, Masramon X, Hernandez G. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology. 2002;59(10):1573–9.
    • (2002) Neurology , vol.59 , Issue.10 , pp. 1573-1579
    • Garcia-Borreguero, D.1    Larrosa, O.2    de la Llave, Y.3    Verger, K.4    Masramon, X.5    Hernandez, G.6
  • 127
    • 0035526254 scopus 로고    scopus 로고
    • Long-term follow-up on restless legs syndrome patients treated with opioids
    • PID: 11748742, COI: 1:STN:280:DC%2BD3MnpvFChsw%3D%3D
    • Walters AS, Winkelmann J, Trenkwalder C, Fry JM, Kataria V, Wagner M, et al. Long-term follow-up on restless legs syndrome patients treated with opioids. Mov Disord. 2001;16(6):1105–9.
    • (2001) Mov Disord , vol.16 , Issue.6 , pp. 1105-1109
    • Walters, A.S.1    Winkelmann, J.2    Trenkwalder, C.3    Fry, J.M.4    Kataria, V.5    Wagner, M.6
  • 128
    • 0027173995 scopus 로고
    • Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo
    • PID: 8341893, COI: 1:STN:280:DyaK3szkt1aqsQ%3D%3D
    • Walters AS, Wagner ML, Hening WA, Grasing K, Mills R, Chokroverty S, et al. Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo. Sleep. 1993;16(4):327–32.
    • (1993) Sleep , vol.16 , Issue.4 , pp. 327-332
    • Walters, A.S.1    Wagner, M.L.2    Hening, W.A.3    Grasing, K.4    Mills, R.5    Chokroverty, S.6
  • 129
    • 0027772627 scopus 로고
    • A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene
    • PID: 8165385, COI: 1:STN:280:DyaK2c3hvVKhsg%3D%3D
    • Kaplan PW, Allen RP, Buchholz DW, Walters JK. A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. Sleep. 1993;16(8):717–23.
    • (1993) Sleep , vol.16 , Issue.8 , pp. 717-723
    • Kaplan, P.W.1    Allen, R.P.2    Buchholz, D.W.3    Walters, J.K.4
  • 130
    • 84887616610 scopus 로고    scopus 로고
    • Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: A double-blind, randomised, placebo-controlled trial with an open-label extension
    • PID: 24140442, COI: 1:CAS:528:DC%2BC3sXhslWlsbjI
    • Trenkwalder C, Benes H, Grote L, Garcia-Borreguero D, Hogl B, Hopp M, et al. Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurol. 2013;12(12):1141–50.
    • (2013) Lancet Neurol , vol.12 , Issue.12 , pp. 1141-1150
    • Trenkwalder, C.1    Benes, H.2    Grote, L.3    Garcia-Borreguero, D.4    Hogl, B.5    Hopp, M.6
  • 131
    • 84875056891 scopus 로고    scopus 로고
    • Overall self-perceived health in restless legs treated with intrathecal morphine
    • PID: 22881705
    • Lindvall P, Hariz GM, Blomstedt P. Overall self-perceived health in restless legs treated with intrathecal morphine. Acta Neurol Scand. 2012;127(4):268–73.
    • (2012) Acta Neurol Scand , vol.127 , Issue.4 , pp. 268-273
    • Lindvall, P.1    Hariz, G.M.2    Blomstedt, P.3
  • 132
    • 18144374107 scopus 로고    scopus 로고
    • Methadone for refractory restless legs syndrome
    • PID: 15580610
    • Ondo WG. Methadone for refractory restless legs syndrome. Mov Disord. 2005;20(3):345–8.
    • (2005) Mov Disord , vol.20 , Issue.3 , pp. 345-348
    • Ondo, W.G.1
  • 133
    • 79955114643 scopus 로고    scopus 로고
    • A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome
    • PID: 21239226
    • Silver N, Allen RP, Senerth J, Earley CJ. A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome. Sleep Med. 2011;12(5):440–4.
    • (2011) Sleep Med , vol.12 , Issue.5 , pp. 440-444
    • Silver, N.1    Allen, R.P.2    Senerth, J.3    Earley, C.J.4
  • 134
    • 0036045235 scopus 로고    scopus 로고
    • Review of receptor agonist and antagonist studies relevant to the opiate system in restless legs syndrome
    • PID: 14592191
    • Walters AS. Review of receptor agonist and antagonist studies relevant to the opiate system in restless legs syndrome. Sleep Med. 2002;3(4):301–4.
    • (2002) Sleep Med , vol.3 , Issue.4 , pp. 301-304
    • Walters, A.S.1
  • 135
    • 0023836656 scopus 로고
    • Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats
    • PID: 2855239
    • Di Chiara G, Imperato A. Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther. 1988;244(3):1067–80.
    • (1988) J Pharmacol Exp Ther , vol.244 , Issue.3 , pp. 1067-1080
    • Di Chiara, G.1    Imperato, A.2
  • 137
    • 84892479822 scopus 로고    scopus 로고
    • Comparison of the efficacies of oral iron and pramipexole for the treatment of restless legs syndrome patients with low serum ferritin
    • PID: 24267148
    • Lee CS, Lee SD, Kang SH, Park HY, Yoon IY. Comparison of the efficacies of oral iron and pramipexole for the treatment of restless legs syndrome patients with low serum ferritin. Eur J Neurol. 2013;21(2):260–6.
    • (2013) Eur J Neurol , vol.21 , Issue.2 , pp. 260-266
    • Lee, C.S.1    Lee, S.D.2    Kang, S.H.3    Park, H.Y.4    Yoon, I.Y.5
  • 138
    • 84874246999 scopus 로고    scopus 로고
    • Lower molecular weight intravenous iron dextran for restless legs syndrome
    • PID: 23333678
    • Cho YW, Allen RP, Earley CJ. Lower molecular weight intravenous iron dextran for restless legs syndrome. Sleep Med. 2013;14(3):274–7.
    • (2013) Sleep Med , vol.14 , Issue.3 , pp. 274-277
    • Cho, Y.W.1    Allen, R.P.2    Earley, C.J.3
  • 139
    • 60849115293 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome
    • PID: 18280205
    • Earley CJ, Horska A, Mohamed MA, Barker PB, Beard JL, Allen RP. A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome. Sleep Med. 2009;10(2):206–11.
    • (2009) Sleep Med , vol.10 , Issue.2 , pp. 206-211
    • Earley, C.J.1    Horska, A.2    Mohamed, M.A.3    Barker, P.B.4    Beard, J.L.5    Allen, R.P.6
  • 140
    • 58249124361 scopus 로고    scopus 로고
    • Pneumatic compression devices are an effective therapy for restless legs syndrome: A prospective, randomized, double-blinded, sham-controlled trial
    • PID: 19017878
    • Lettieri CJ, Eliasson AH. Pneumatic compression devices are an effective therapy for restless legs syndrome: a prospective, randomized, double-blinded, sham-controlled trial. Chest. 2009;135(1):74–80.
    • (2009) Chest , vol.135 , Issue.1 , pp. 74-80
    • Lettieri, C.J.1    Eliasson, A.H.2
  • 141
    • 54049141752 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, pilot trial of botulinum toxin a in restless legs syndrome
    • PID: 18794499
    • Nahab FB, Peckham EL, Hallett M. Double-blind, placebo-controlled, pilot trial of botulinum toxin a in restless legs syndrome. Neurology. 2008;71(12):950–1.
    • (2008) Neurology , vol.71 , Issue.12 , pp. 950-951
    • Nahab, F.B.1    Peckham, E.L.2    Hallett, M.3
  • 142
    • 32544433150 scopus 로고    scopus 로고
    • Vim deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor
    • PID: 16446110
    • Ondo W. Vim deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor. Parkinsonism Relat Disord. 2006;12(2):113–4.
    • (2006) Parkinsonism Relat Disord , vol.12 , Issue.2 , pp. 113-114
    • Ondo, W.1
  • 143
    • 84867470198 scopus 로고    scopus 로고
    • Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome
    • PID: 22995627
    • Ondo WG, Jankovic J, Simpson R, Jimenez-Shahed J. Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome. Sleep Med. 2012;13(9):1202–4.
    • (2012) Sleep Med , vol.13 , Issue.9 , pp. 1202-1204
    • Ondo, W.G.1    Jankovic, J.2    Simpson, R.3    Jimenez-Shahed, J.4
  • 144
    • 84876129630 scopus 로고    scopus 로고
    • Early childhood-onset restless legs syndrome: Symptoms and effect of oral iron treatment
    • PID: 23360128
    • Tilma J, Tilma K, Norregaard O, Ostergaard JR. Early childhood-onset restless legs syndrome: symptoms and effect of oral iron treatment. Acta Paediatr. 2013;102(5):e221–6.
    • (2013) Acta Paediatr , vol.102 , Issue.5 , pp. e221-e226
    • Tilma, J.1    Tilma, K.2    Norregaard, O.3    Ostergaard, J.R.4
  • 145
    • 84886782220 scopus 로고    scopus 로고
    • Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose
    • PID: 23993871
    • Grim K, Lee B, Sung AY, Kotagal S. Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. Sleep Med. 2013;14(11):1100–4.
    • (2013) Sleep Med , vol.14 , Issue.11 , pp. 1100-1104
    • Grim, K.1    Lee, B.2    Sung, A.Y.3    Kotagal, S.4
  • 148
    • 79955082048 scopus 로고    scopus 로고
    • L-dopa improves restless legs syndrome and periodic limb movements in sleep but not attention-deficit-hyperactivity disorder in a double-blind trial in children
    • PID: 21463967
    • England SJ, Picchietti DL, Couvadelli BV, Fisher BC, Siddiqui F, Wagner ML, et al. L-dopa improves restless legs syndrome and periodic limb movements in sleep but not attention-deficit-hyperactivity disorder in a double-blind trial in children. Sleep Med. 2011;12(5):471–7.
    • (2011) Sleep Med , vol.12 , Issue.5 , pp. 471-477
    • England, S.J.1    Picchietti, D.L.2    Couvadelli, B.V.3    Fisher, B.C.4    Siddiqui, F.5    Wagner, M.L.6
  • 149
    • 77954975750 scopus 로고    scopus 로고
    • The pharmacological treatment for uremic restless legs syndrome: Evidence-based review
    • PID: 20544816
    • de Oliveira MM, Conti CF, Valbuza JS, de Carvalho LB, do Prado GF. The pharmacological treatment for uremic restless legs syndrome: Evidence-based review. Mov Disord. 2010;25(10):1335–42.
    • (2010) Mov Disord , vol.25 , Issue.10 , pp. 1335-1342
    • de Oliveira, M.M.1    Conti, C.F.2    Valbuza, J.S.3    de Carvalho, L.B.4    do Prado, G.F.5


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