Effects of acute dopamine-agonist treatment in restless legs syndrome on heart rate variability during sleep

Sleep Medicine

Volumn 12, Issue 1, 2011, Pages 47-55

  Manconi, Mauro ^a   Ferri, Raffaele ^b   Zucconi, Marco ^a   Clemens, Stefan ^c   Rundo, Francesco ^b   Oldani, Alessandro ^a   Ferini Strambi, Luigi ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Dopamine; Heart rate variability; Periodic leg movements; Polysomnography; Restless legs syndrome; Sleep

Indexed keywords

PLACEBO; PRAMIPEXOLE;

ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART RATE VARIABILITY; HUMAN; MALE; NONREM SLEEP; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTLESS LEGS SYNDROME; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SLEEP; SYMPATHETIC NERVE CELL; VAGUS TONE;

BENZOTHIAZOLES; DOPAMINE AGONISTS; ELECTROMYOGRAPHY; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MOVEMENT; POLYSOMNOGRAPHY; PROSPECTIVE STUDIES; RESTLESS LEGS SYNDROME; SINGLE-BLIND METHOD; SLEEP;

EID: 78650301949     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2010.03.019     Document Type: Article

References (52)

1. Berger K., Luedemann J., Trenkwalder C., John U., Kessler C. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 2004, 164:196-202.
2. Allen R.P., Picchietti D., Hening W.A., Trenkwalder C., Walters A.S., Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health. Sleep Med 2003, 4:101-119.
3. Manconi M., Ferri R., Zucconi M., Oldani A., Fantini M.L., Castronovo V., et al. First night efficacy of pramipexole in restless legs syndrome and periodic leg movements. Sleep Med 2007, 8:491-497.
4. Saletu M., Anderer P., Saletu B., Hauer C., Mandl M., Semler B., et al. Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole. Hum Psychopharmacol 2001, 16:177-187.
5. Iber C, Ancoli-Israel S, Chesson A Jr., Quan SF. The AASM manual for the scoring of sleep and associated events. Rules, terminology and technical specifications. IL: Westchester; 2007.
6. Hening W. The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clin Neurophysiol 2004, 115:1965-1974.
7. Sforza E., Pichot V., Barthelemy J.C., Haba-Rubio J., Roche F. Cardiovascular variability during periodic leg movements: a spectral analysis approach. Clin Neurophysiol 2005, 116:1096-1104.
8. Rajendra A.U., Paul J.K., Kannathal N., Lim C.M., Suri J.S. Heart rate variability: a review. Med Biol Eng Comput 2006, 44:1031-1051.
9. Carrier J., Frenette S., Montplaisir J., Paquet J., Drapeau C., Morettini J. Effects of periodic leg movements during sleep in middle-aged subjects without sleep complaints. Mov Disord 2005, 20:1127-1132.
10. Ferrillo F., Beelke M., Canovaro P., Watanabe T., Arico D., Rizzo P., et al. Changes in cerebral and autonomic activity heralding periodic limb movements in sleep. Sleep Med 2004, 5:407-412.
11. Ferri R., Zucconi M., Rundo F., Spruyt K., Manconi M., Ferini-Strambi L. Heart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleep. Clin Neurophysiol 2007, 118:438-448.
12. Gosselin N., Lanfranchi P., Michaud M., Fantini L., Carrier J., Lavigne G., et al. Age and gender effects on heart rate activation associated with periodic leg movements in patients with restless legs syndrome. Clin Neurophysiol 2003, 114:2188-2195.
13. Sforza E., Nicolas A., Lavigne G., Gosselin A., Petit D., Montplaisir J. EEG and cardiac activation during periodic leg movements in sleep: support for a hierarchy of arousal responses. Neurology 1999, 52:786-791.
14. Ferri R., Parrino L., Smerieri A., Terzano M.G., Elia M., Musumeci S.A., et al. Cyclic alternating pattern and spectral analysis of heart rate variability during normal sleep. J Sleep Res 2000, 9:13-18.
15. Yang C.K., Jordan A.S., White D.P., Winkelman J.W. Heart rate response to respiratory events with or without leg movements. Sleep 2006, 29:553-556.
16. Walters A.S., Rye D.B. Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep 2009, 32:589-597.
17. Rechtschaffen A., Kales A. A manual of standardized terminology, techniques and scoring system of sleep stages of human subjects 1968, US Government Printing Office, Washington.
18. Ferri R., Zucconi M., Manconi M., Bruni O., Miano S., Plazzi G., et al. Computer-assisted detection of nocturnal leg motor activity in patients with restless legs syndrome and periodic leg movements during sleep. Sleep 2005, 28:998-1004.
19. Zucconi M., Ferri R., Allen R., Baier P.C., Bruni O., Chokroverty S., et al. The official world association of sleep medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the international restless legs syndrome study group (IRLSSG). Sleep Med 2006, 7:175-183.
20. Ferri R., Zucconi M. Heart rate and spectral EEG changes accompanying periodic and isolated leg movements during sleep. Sleep 2008, 31:16-17.
21. Siegel, S. Nonparametric statistics: for the behavioural sciences. New York: McGraw Hill; 1956.
22. Greiser K.H., Kluttig A., Schumann B., Swenne C.A., Kors J.A., Kuss O., et al. Cardiovascular diseases, risk factors and short-term heart rate variability in an elderly general population: the CARLA study 2002-2006. Eur J Epidemiol 2009, 24:123-142.
23. Penzel T., Kantelhardt J.W., Lo C.C., Voigt K., Vogelmeier C. Dynamics of heart rate and sleep stages in normals and patients with sleep apnea. Neuropsychopharmacology 2003, 28(Suppl. 1):S48-S53.
24. Senard J.M., Verwaerde P., Rascol O., Montastruc J.L. Effects of acute levodopa administration on blood pressure and heart variability in never treated parkinsonians. Hypertens Res 1995, 18(Suppl. 1):S175-S177.
25. Guggisberg A.G., Hess C.W., Mathis J. The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. Sleep 2007, 30:755-766.
26. Pennestri M.H., Montplaisir J., Colombo R., Lavigne G., Lanfranchi P.A. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 2007, 68:1213-1218.
27. Morgan B.J., Dempsey J.A., Pegelow D.F., Jacques A., Finn L., Palta M., et al. Blood pressure perturbations caused by subclinical sleep-disordered breathing. Sleep 1998, 21:737-746.
28. Parati G., Lombardi C., Narkiewicz K. Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk. Am J Physiol Regul Integr Comp Physiol 2007, 293:R1671-R1683.
29. Bonomini F., Tengattini S., Fabiano A., Bianchi R., Rezzani R. Atherosclerosis and oxidative stress. Histol Histopathol 2008, 23:381-390.
30. Winkelman J.W., Finn L., Young T. Prevalence and correlates of restless legs syndrome symptoms in the Wisconsin sleep cohort. Sleep Med 2006, 7:545-552.
31. Ulfberg J., Nystrom B., Carter N., Edling C. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 2001, 16:1159-1163.
32. Ohayon M.M., Roth T. Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res 2002, 53:547-554.
33. Phillips B., Hening W., Britz P., Mannino D. Prevalence and correlates of restless legs syndrome: results from the 2005 national sleep foundation poll. Chest 2006, 129:76-80.
34. Ondo W.G., He Y., Rajasekaran S., Le W.D. Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord 2000, 15:154-158.
35. Clemens S., Rye D., Hochman S. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology 2006, 67:125-130.
36. Rottach K.G., Schaner B.M., Kirch M.H., Zivotofsky A.Z., Teufel L.M., Gallwitz T., et al. Restless legs syndrome as side effect of second generation antidepressants. J Psychiatr Res 2008, 43:70-75.
37. Jose P.A., Eisner G.M., Felder R.A. Renal dopamine receptors in health and hypertension. Pharmacol Ther 1998, 80:149-182.
38. Felder R.A., Seikaly M.G., Cody P., Eisner G.M., Jose P.A. Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. Hypertension 1990, 15:560-569.
39. Kunimi M., Seki G., Hara C., Taniguchi S., Uwatoko S., Goto A., et al. Dopamine inhibits renal Na+. Kidney Int 2000, 57:534-543.
40. Clemens S., Hochman S. Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 2004, 24:11337-11345.
41. Asico L.D., Ladines C., Fuchs S., Accili D., Carey R.M., Semeraro C., et al. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest 1998, 102:493-498.
42. Kujawa K., Leurgans S., Raman R., Blasucci L., Goetz C.G. Acute orthostatic hypotension when starting dopamine agonists in Parkinson's disease. Arch Neurol 2000, 57:1461-1463.
43. Robertson D. The pathophysiology and diagnosis of orthostatic hypotension. Clin Auton Res 2008, 18(Suppl. 1):2-7.
44. Lang A.E. Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: the role of domperidone therapy. Arch Neurol 2001, 58:835.
45. Lopes DF Sr., Zanella MT, Andriolo A, Ribeiro AB, Chacra AR. Peripheral dopaminergic blockade for the treatment of diabetic orthostatic hypotension. Clin Pharmacol Ther 1988;44:670-4.
46. Gentric A., Fouilhoux A., Caroff M., Mottier D., Jouquan J. Dopamine B hydroxylase deficiency responsible for severe dysautonomic orthostatic hypotension in an elderly patient. J Am Geriatr Soc 1993, 41:550-551.
47. Amsden G.W., Georgian F. Orthostatic hypotension induced by sertraline withdrawal. Pharmacotherapy 1996, 16:684-686.
48. Winkelman J.W., Shahar E., Sharief I., Gottlieb D.J. Association of restless legs syndrome and cardiovascular disease in the sleep heart health study. Neurology 2008, 70:35-42.
49. Hogl B., Kiechl S., Willeit J., Saletu M., Frauscher B., Seppi K., et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology 2005, 64:1920-1924.
50. Sforza E., Jouny C., Ibanez V. Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response. Clin Neurophysiol 2000, 111:1611-1619.
51. Terzano M.G., Parrino L., Sherieri A., Chervin R., Chokroverty S., Guilleminault C., et al. Atlas, rules, and recording techniques for the scoring of cyclic alternating pattern (CAP) in human sleep. Sleep Med 2001, 2:537-553.
52. Ferri R., Manconi M., Aricò D., Sagrada C., Zucconi M., Bruni O., et al. Acute dopamine-agonist treatment in Restless Legs Syndrome. Effects on sleep architecture and NREM sleep instability. Sleep 2010, 33:793-800.