Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families

Annals of Neurology

Volumn 52, Issue 3, 2002, Pages 297-302

  Winkelmann, Juliane ^a   Muller Myhsok, Bertram ^b   Wittchen, Hans Ulrich ^a   Hock, Bettina ^a   Prager, Muriel ^a   Pfister, Hildegard ^a   Strohle, Andreas ^a   Eisensehr, Ilonka ^c   Dichgans, Martin ^a   Gasser, Thomas ^a   Trenkwalder, Claudia ^a,d  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; FAMILIAL DISEASE; FEMALE; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIFACTORIAL GENETIC DISORDER; ONSET AGE; PENETRANCE; PRIORITY JOURNAL; RELATIVE; RESTLESS LEGS SYNDROME; SEGREGATION ANALYSIS;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CHILD; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENES, DOMINANT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; RESTLESS LEGS SYNDROME;

EID: 0036714378     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10282     Document Type: Article

References (28)

1. Periodic limb movements and restless legs syndrome
2. Toward a better definition of the restless legs syndrome
3. Restless legs syndrome: A disease in search of identity
4. Prevalence and risk factors of RLS in an elderly population: The MEMO study
5. Epidemiology of restless legs symptoms in adults
6. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria
7. Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
8. Restless legs syndrome: Clinicoetiologic correlates
9. Familial restless legs with periodic movements in sleep: Electrophysiologic, biochemical, and pharmacologic study
10. Clinical symptoms and possible anticipation in a large kindred of familial restless legs syndrome
11. Variable expressivity in familial restless legs syndrome
12. Studies of penetrance and anticipation in five autosomal-dominant restless legs syndrome pedigrees
13. A questionnaire study of 138 patients with restless legs syndrome: The "Night-Walkers" survey
14. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset
15. Identification of a major susceptibility locus for restless legs syndrome on chromosome 12 q
16. Estimation of parameters for a mixture of normal distributions
17. A variance components/major locus likelihood approximation for quantitative, polychotomos, and multivariate data
18. Sampling schemes and ascertainment
19. A new look at the statistical model identification
20. Genetic epidemiology of breast cancer: Segregation analysis of 200 Danish pedigrees
21. Population and familial relative risks of disease associated with environmental factors in the presence of gene-environment interaction
22. Restless legs syndrome in monocygotic twins: Clinical correlates
23. Inheritance of human breast cancer: Evidence for autosomal dominant transmission in high-risk families
24. Multiple etiologies for Alzheimer disease are revealed by segregation analysis
25. Genetic complexity and Parkinson's disease