Ropinirole in the treatment of restless legs syndrome: Results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 75, Issue 1, 2004, Pages 92-97

  Trenkwalder, C ^a   Garcia Borreguero, D ^b   Montagna, P ^c   Lainey, E ^d   De Weerd, A W ^e   Tidswell, P ^f   Saletu Zyhlarz, G ^g   Telstad, W ^h   Ferini Strambi, L ⁱ  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^e MEDICAL CENTER HAAGLANDEN   (Netherlands)

^f Synexus Ltd   (United Kingdom)

^g UNIVERSITY OF VIENNA   (Austria)

^h Sentralsjukehuset i Sogn og Fjordane   (Norway)

ⁱ VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; PLACEBO; ROPINIROLE;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EUROPE; FEMALE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RESTLESS LEGS SYNDROME; SOMNOLENCE; UPPER RESPIRATORY TRACT INFECTION; VOMITING;

EID: 0345863904     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Allen R, Kirsch J, Abetz L, et al. The impact of restless legs syndrome (RLS) on sleep and cognitive functioning [abstract]. Eur J Neurol 2002;9(suppl 2):50.
2. Kirsch J, Abetz L, Allen R, et al. The impact of restless legs syndrome (RLS) on quality of life (QoL) [abstract]. Eur J Neurol 2002;9(suppl 2):201.
3. Phillips B, Young T, Finn L, et al. Epidemiology of restless legs symptoms in adults. Arch Intern Med 2000;160:2137-41.
4. Rothdach AJ, Trenkwalder C, Haberstock J, et al. Prevalence and risk factors of RLS in an elderly population: the MEMO study. Neurology 2000;54:1064-8.
5. Ulfberg J, Nystrom B, Carter N, et al. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 2001;16:1159-63.
6. Brodeur C, Montplaisir J, Godbout R, et al. Treatment of restless legs syndrome and periodic movements during sleep with L-dapa: a double-blind, controlled study. Neurology 1988;38:1845-8.
7. Trenkwalder C, Stiasny K, Pollmächer T, et al. L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial. Sleep 1995;18:681-8.
8. Allen RP, Earley G. Augmentation of the restless legs syndrome with carbidopa/levodopa. Sleep 1996;19:205-13.
9. Earley CJ, Yaffee JB, Allen RP. Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome. Neurology 1998;51:1599-602.
10. Ferini-Strambi L. Restless legs syndrome augmentation and pramipexole treatment. Sleep Med 2002;3:S23-5.
11. Staedt J, Hunerjager H, Ruther E, et al. Pergolide: treatment of choice in restless legs syndrome and nocturnal myoclonus syndrome. Long-term follow-up on pergolide. J Neural Transm 1998;105:265-8.
12. Wetter TC, Stiasny K, Winkelmann J, et al. A randomized controlled study of pergolide in patients with restless legs syndrome. Neurology 1999;52:944-50.
13. Stiasny K, Wetter TC, Winkelmann J, et al. Long-term effects of pergolide in the treatment of restless legs syndrome. Neurology 2001;56:1399-402.
14. Danoff SK, Grasso ME, Terry PB, et al. Pleuropulmonary disease due to pergolide use for restless legs syndrome. Chest 2001;120:313-16.
15. Freeman A, Rye DB, Bliwise D, et al. Ropinirole for restless legs syndrome (RLS): an open-label and double-blind placebo-controlled study [abstract]. Neurology 2001;56(suppl 3):A5.
16. Montplaisir J, Denesle R, Petit D. Pramipexole in the treatment of restless legs syndrome: a follow-up study. Eur J Neurol 2000;7(suppl 1):27-31.
17. Ondo W. Ropinirole for restless legs syndrome. Mov Disord 1999;14:138-40.
18. Saletu M, Anderer P, Saletu B, et al. Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole. 2. Findings on periodic leg movements, arousals and respiratory variables. Neuropsychobiology 2000;41:190-9.
19. Walters AS, The International Restless Legs Syndrome Study Group. Toward a better definition of the restless legs syndrome. Mov Disord 1995;10:634-42.
20. The International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-32.
21. Saletu B, Gruber G, Saletu M, et al. Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole. 1. Findings on objective and subjective sleep and awakening quality. Neuropsychobiology 2000;41:181-9.
22. Allen R, Hening W, Montplaisir J, et al. Restless legs syndrome (RLS) is a common disorder rarely diagnosed in Europe or USA: the REST (RLS epidemiology, symptoms and treatment) study in primary care. Mov Disord 2002;17(suppl 5):S240-1.