Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome

Neurology

Volumn 62, Issue 9, 2004, Pages 1563-1567

  Connor, James R ^a   Wang, X S ^a   Patton, S M ^a   Menzies, S L ^a   Troncoso, J C ^b   Earley, C J ^b   Allen, R P ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; NEUROMELANIN; TRANSFERRIN RECEPTOR;

ADULT; AGED; ARTICLE; AUTOPSY; BINDING ASSAY; CASE REPORT; CELL FREE SYSTEM; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IRON TRANSPORT; LASER CAPTURE MICRODISSECTION; MOTOR DYSFUNCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTLESS LEGS SYNDROME; SUBSTANTIA NIGRA; TRANSCRIPTION REGULATION;

EID: 2342554293     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000123251.60485.AC     Document Type: Article

References (36)

1. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Prevalance and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology 2000;54:1064-1068.
2. Ulfberg J, Nystrom B, Carter N, Edling C. Prevalence of restless legs syndrome among men aged 18 to 64 years: an association with somatic disease and neuropsychiatric symptoms. Mov Disord 2001;16:1159-1163.
3. Ulfberg J, Nystrom B, Carter N, Edling C. Restless legs syndrome among working-aged women. Eur Neurol 2001;46:17-19.
4. Earley CJ. Clinical practice. Restless legs syndrome. N Engl J Med 2003;348:2103-2109.
5. Nordlander NB. Therapy in restless legs. Acta Med Scand 1953;145:453-457.
6. Ekbom KA. Restless legs syndrome. Neurology 1960;10:868-873.
7. O'Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994;23:200-203.
8. Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep 1998;21:371-377.
9. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen RP. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome. Neurology 2000;54:1698-1700.
10. Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 2001; 56:263-265.
11. Connor JR, Boyer PJ, Menzies SL, et al. Neuropathological examination suggests impaired brain iron acquisition in restless legs syndrome. Neurology 2003;61:304-309.
12. Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003;4:101-119.
13. Allen RP, Earley CJ. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset. Sleep Med 2000;1:11-19.
14. Zecca L, Gallorini M, Schunemann V, et al. Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J Neurochem 2001;76:1766-1773.
15. Bartzokis G, Beckson M, Hance DB, Marx P, Foster JA, Marder SR. MR evaluation of age-related increase of brain iron in young adult and older normal males. Magn Reson Imaging 1997;15:29-35.
16. Hu J, Connor JR. Demonstration and characterization of the iron regulatory protein in human brain. J Neurochem 1996;67:838-844.
17. Han J, Day JR, Thomson K, Connor JR, Beard JL. Iron deficiency alters H- and L-ferritin expression in rat brain. Cell Mol Biol (Noisy-legrand) 2000;46:517-528.
18. Earley CJ, Heckler D, Allen RP. IV iron treatment for the restless legs syndrome (RLS). Sleep 2001;24:A359.
19. Erikson KM, Jones BC, Hess EJ, Zhang Q, Beard JL. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacol Biochem Behav 2001;69:409-418.
20. Beard JL, Erikson KM, Jones BC. Neurobehavioral analysis of developmental iron deficiency in rats. Behav Brain Res 2002;134:517-524.
21. Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol 2001;18:128-147.
22. Burdo JR, Menzies SL, Simpson IA, et al. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 2001;66:1198-1207.
23. Han J, Day JR, Connor JR, Beard JL. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci 2003;6:1-10.
24. Youdim MB, Ben-Shachar D, Riederer P. The possible role of iron in the etiopathology of Parkinson's disease. Mov Disord 1993;8:1-12.
25. Jellinger KA. The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease. Drugs Aging 1999;14:115-140.
26. Tong X, Kawabata H, Koeffier HP. Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level. Br J Haematol 2002;116:458-464.
27. Barisani D, Conte D. Transferrin receptor 1 (TfR1) and putative stimulator of Fe transport (SFT) expression in iron deficiency and overload: an overview. Blood Cells Mol Dis 2002;29:498-505.
28. Rouault TA. Post-transcriptional regulation of human iron metabolism by iron regulatory proteins. Blood Cells Mol Dis 2002;29:309-314.
29. Chan RY, Seiser C, Schulman HM, Kuhn LC, Ponka P. Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells. Eur J Biochem 1994;220:683-692.
30. Koeller DM, Casey JL, Hentze MW, et al. A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA. Proc Natl Acad Sci USA 1989;86:3574-3578.
31. Mullner EW, Neupert B, Kuhn LC. A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell 1989;58:373-382.
32. Oshiro S, Nozawa K, Hori M, et al. Modulation of iron regulatory protein-1 by various metals. Biochem Biophys Res Commun 2002;290:213-218.
33. Toth I, Bridges KR. Ascorbic acid enhances ferritin mRNA translation by an IRP/aconitase switch. J Biol Chem 1995;270:19540-19544.
34. Samaniego F, Chin J, Iwai K, Rouault TA, Klausner RD. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. J Biol Chem 1994;269:30904-30910.
35. Guo B, Phillips JD, Yu Y, Leibold EA. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem 1995;270:21645-21651.
36. Earley CJ, Allen RP, Beard JL, Connor JR. Insight into the pathophysiology of restless legs syndrome. J Neurosci Res 2000;62:623-628.