Comparison of the efficacies of oral iron and pramipexole for the treatment of restless legs syndrome patients with low serum ferritin

European Journal of Neurology

Volumn 21, Issue 2, 2014, Pages 260-266

  Lee, C S ^a   Lee, S D ^b   Kang, S H ^c   Park, H Y ^a   Yoon, I Y ^a  

^a Seoul National University Bundang Hospital   (South Korea)

^b Korean Armed Forces Capital Hospital   (South Korea)

^c Veterans Health Service Medical Center   (South Korea)

Author keywords

Dopamine agonist; Ferritin; Iron; Pramipexole; Restless legs syndrome

Indexed keywords

FERRITIN; FERROUS SULFATE; HEMOGLOBIN; PRAMIPEXOLE;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BEDTIME DOSAGE; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG WITHDRAWAL; EPWORTH SLEEPINESS SCALE; FEMALE; FERRITIN BLOOD LEVEL; HEART PALPITATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSOMNIA; IRON BINDING CAPACITY; IRON THERAPY; MALE; NAUSEA; PITTSBURGH SLEEP QUALITY INDEX; PRIORITY JOURNAL; RATING SCALE; RESTLESS LEGS SYNDROME; TREATMENT DURATION; TREATMENT RESPONSE;

DOPAMINE AGONIST; FERRITIN; IRON; PRAMIPEXOLE; RESTLESS LEGS SYNDROME;

ADULT; AGED; AGED, 80 AND OVER; BENZOTHIAZOLES; DOPAMINE AGONISTS; FEMALE; FERRITINS; HUMANS; IRON; MALE; MIDDLE AGED; RESTLESS LEGS SYNDROME; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84892479822     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12286     Document Type: Article

References (29)

1. Allen RP, Walters AS, Montplaisir J, et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 2005; 165: 1286-1292.
2. Kushida C, Martin M, Nikam P, et al. Burden of restless legs syndrome on health-related quality of life. Qual Life Res 2007; 16: 617-624.
3. Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol 2001; 18: 128-147.
4. Aurora RN, Kristo DA, Bista SR, et al. The treatment of restless legs syndrome and periodic limb movement disorder in adults - an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep 2012; 35: 1039-1062.
5. Allen R. Dopamine and iron in the pathophysiology of restless legs syndrome (RLS). Sleep Med 2004; 5: 385-391.
6. Silber MH, Ehrenberg BL, Allen RP, et al. An algorithm for the management of restless legs syndrome. Mayo Clin Proc 2004; 79: 916-922.
7. Thorpy MJ. New paradigms in the treatment of restless legs syndrome. Neurology 2005; 64: S28-S33.
8. National Heart, Lung, and Blood Institute Working Group on Restless Legs Syndrome. Restless legs syndrome: detection and management in primary care. Am Fam Physician 2000; 62: 108-114.
9. O'Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994; 23: 200-203.
10. Wang J, O'Reilly B, Venkataraman R, Mysliwiec V, Mysliwiec A. Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebo-controlled study. Sleep Med 2009; 10: 973-975.
11. Grote L, Leissner L, Hedner J, Ulfberg J. A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome. Mov Disord 2009; 24: 1445-1452.
12. Morgan JC, Ames M, Sethi KD. Response to ropinirole in restless legs syndrome is independent of baseline serum ferritin. J Neurol Neurosurg Psychiatry 2008; 79: 964-965.
13. Silber MH, Richardson JW. Multiple blood donations associated with iron deficiency in patients with restless legs syndrome. Mayo Clin Proc 2003; 78: 52-54.
14. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the Restless Legs Syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health. Sleep Med 2003; 4: 101-119.
15. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003; 4: 121-132.
16. Inoue Y, Kuroda K, Hirata K, Uchimura N, Kagimura T, Shimizu T. Efficacy, safety and dose-response of pramipexole in Japanese patients with primary restless legs syndrome: randomized trial. Neuropsychobiology 2011; 63: 35-42.
17. Winkelman JW, Sethi KD, Kushida CA, et al. Efficacy and safety of pramipexole in restless legs syndrome. Neurology 2006; 67: 1034-1039.
18. Oertel WH, Stiasny-Kolster K, Bergtholdt B, et al. Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-RLS study). Mov Disord 2007; 22: 213-219.
19. Davis BJ, Rajput A, Rajput ML, Aul EA, Eichhorn GR. A randomized, double-blind placebo-controlled trial of iron in restless legs syndrome. Eur Neurol 2000; 43: 70-75.
20. Earley CJ, Horska A, Mohamed MA, Barker PB, Beard JL, Allen RP. A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome. Sleep Med 2009; 10: 206-211.
21. Earley CJ, Allen RP, Beard JL, Connor JR. Insight into the pathophysiology of restless legs syndrome. J Neurosci Res 2000; 62: 623-628.
22. Kim KW, Yoon IY, Chung S, et al. Prevalence, comorbidities and risk factors of restless legs syndrome in the Korean elderly population - results from the Korean Longitudinal Study on Health and Aging. J Sleep Res 2010; 19: 87-92.
23. Miranda M, Kagi M, Fabres L, et al. Pramipexole for the treatment of uremic restless legs in patients undergoing hemodialysis. Neurology 2004; 62: 831-832.
24. Pellecchia MT, Vitale C, Sabatini M, et al. Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release. Clin Neuropharmacol 2004; 27: 178-181.
25. Adamson JW. Iron Deficiency and Other Hypoproliferative Anemias. In: Fauci AS, Braumwald E, Kasper DL, et al., eds. Harrison's Principles of Internal Medicine. 17 edn. New York: McGraw-Hill Companies Inc., 2008: 628-632.
26. Trenkwalder C, Hogl B, Benes H, Kohnen R. Augmentation in restless legs syndrome is associated with low ferritin. Sleep Med 2008; 9: 572-574.
27. Van Nueten JM, Schuurkes JA. Studies on the role of dopamine and dopamine blockers in gastroduodenal motility. Scand J Gastroenterol Suppl 1984; 96: 89-99.
28. Goddard AF, James MW, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. Gut 2011; 60: 1309-1316.
29. Winkelman JW, Johnston L. Augmentation and tolerance with long-term pramipexole treatment of restless legs syndrome (RLS). Sleep Med 2004; 5: 9-14.