Chemokines and chemokine receptors in the brain

Chemokine Receptors and NeuroAIDS: Beyond Co-Receptor Function and Links to Other Neuropathologies

Volumn , Issue , 2010, Pages 173-189

  Parsadaniantz, Stéphane Mélik ^a   Banisadr, Ghazal ^a   Sarret, Philippe ^a   Rostène, William ^a  

^a INSERM   (France)

Author keywords

CCL2 CCR2; CCL4 CCR5; Central nervous system; Chemokine; Chemokine receptor; CXCL12 CXCR4; Neuromodulation; Neuronal activity

Indexed keywords

EID: 84920052678     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0793-6_8     Document Type: Chapter

References (94)

1. Abbadie C (2005) Chemokines, chemokine receptors and pain. Trends Immunol 26:529-534.
2. Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ (2003) Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci U S A 100:7947-7952.
3. Ahn DK, Lee KR, Lee HJ, Kim SK, Choi HS, Lim EJ, Park JS (2005) Intracisternal administration of chemokines facilitated formalin-induced behavioral responses in the orofacial area of freely moving rats. Brain Res Bull 66:50-58.
4. Bajetto A, Bonavia R, Barbero S, Piccioli P, Costa A, Florio T, Schettini G (1999) Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cellderived factor 1. J Neurochem 73:2348-2357.
5. Banisadr G, Fontanges P, Haour F, Kitabgi P, Rostene W, Melik Parsadaniantz S (2002a) Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Eur J NeuroSci 16:1661-1671.
6. Banisadr G, Gosselin RD, Mechighel P, Rostene W, Kitabgi P, Melik Parsadaniantz S (2005) Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. J Comp Neurol 492:178-192.
7. Banisadr G, Queraud-Lesaux F, Boutterin MC, Pelaprat D, Zalc B, Rostene W, Haour F, Parsadaniantz SM (2002b) Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. J Neurochem 81:257-269.
8. Banisadr G, Skrzydelski D, Kitabgi P, Rostene W, Parsadaniantz SM (2003) Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. Eur J NeuroSci 18:1593-1606.
9. Benamar K, Geller EB, Adler MW (2008) First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain. J Pharmacol Exp Ther 325:641-645.
10. Bezzi P, Domercq M, Brambilla L et al (2001) CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702-710.
11. Bhangoo SK, Ren D, Miller RJ, Chan DM, Ripsch MS, Weiss C, McGinnis C, White FA (2007) CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav Immun 21:581-591.
12. Biber K, Sauter A, Brouwer N, Copray SC, Boddeke HW (2001) Ischemia-induced neuronal expression of the microglia attracting chemokine Secondary Lymphoid-tissue Chemokine (SLC). Glia 34:121-133.
13. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA (1996) The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
14. Boddeke EW, Meigel I, Frentzel S, Biber K, Renn LQ, Gebicke-Harter P (1999) Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. Eur J Pharmacol 374:309-313.
15. Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ (2000) Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci 20:RC87.
16. Che X, Ye W, Panga L, Wu DC, Yang GY (2001) Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res 902:171-177.
17. Chen X, Geller EB, Rogers TJ, Adler MW (2007) The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats. Brain Res 1153:52-57.
18. Coughlan CM, McManus CM, Sharron M et al (2000) Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience 97:591-600.
19. Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH (1991) Interleukin-8 as a mediator of sympathetic pain. Br J Pharmacol 104:765-767.
20. Cunha JM, Cunha FQ, Poole S, Ferreira SH (2000) Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br J Pharmacol 130:1418-1424.
21. Dansereau MA, Gosselin RD, Pohl M et al (2008) Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. J Neurochem 106:757-769.
22. Flugel A, Hager G, Horvat A, Spitzer C, Singer GM, Graeber MB, Kreutzberg GW, Schwaiger FW (2001) Neuronal MCP-1 expression in response to remote nerve injury. J Cereb Blood Flow Metab 21:69-76.
23. Gillard SE, Lu M, Mastracci RM, Miller RJ (2002) Expression of functional chemokine receptors by rat cerebellar neurons. J Neuroimmunol 124:16-28.
24. Giovannelli A, Limatola C, Ragozzino D, Mileo AM, Ruggieri A, Ciotti MT, Mercanti D, Santoni A, Eusebi F (1998) CXC chemokines interleukin-8 (IL-8) and growth-related gene product alpha (GROalpha) modulate Purkinje neuron activity in mouse cerebellum. J Neuroimmunol 92:122-132.
25. Gosselin RD, Valera C, Banisadr G, Mechighel P, Rostene W, Kitabgi P, Melik Parsadaniantz S (2005) Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurons. J Neurochem 95:1023-1035.
26. Guyon A, Rovere C, Cervantes A, Allaeys I, Nahon JL (2005) Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells. J Neurochem 93:963-973.
27. Guyon A, Skrzydelski D, Rovere C, Rostene W, Parsadaniantz SM, Nahon JL (2006) Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: Presynaptic mechanisms. J Neurochem 96:1540-1550.
28. Harrison JK, Jiang Y, Chen S et al (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A 95:10896-10901.
29. Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU (2002) Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 69:418-426.
30. Herzberg U, Sagen J (2001) Peripheral nerve exposure to HIV viral envelope protein gp120 induces neuropathic pain and spinal gliosis. J Neuroimmunol 116:29-39.
31. Hesselgesser J, Halks-Miller M, DelVecchio V, Peiper SC, Hoxie J, Kolson DL, Taub D, Horuk R (1997) CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 7:112-121.
32. Holmes FE, Arnott N, Vanderplank P et al (2008) Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour. J Neurochem 106(2):640-649.
33. Horuk R, Martin AW, Wang Z et al (1997) Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol 158:2882-2890.
34. Joseph EK, Chen X, Khasar SG, Levine JD (2004) Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain 107:147-158.
35. Jung H, Toth PT, White FA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104:254-263.
36. Kaiser E, Forster R, Wolf I, Ebensperger C, Kuehl WM, Lipp M (1993) The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues. Eur J Immunol 23:2532-2539.
37. Keswani SC, Polley M, Pardo CA, Griffin JW, McArthur JC, Hoke A (2003) Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons. Ann Neurol 54:287-296.
38. Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD (1999) Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: Implications for the neuropathogenesis of AIDS. J Immunol 163:1636-1646.
39. Langford D, Sanders VJ, Mallory M, Kaul M, Masliah E (2002) Expression of stromal cellderived factor 1alpha protein in HIV encephalitis. J Neuroimmunol 127:115-126.
40. Lavi E, Strizki JM, Ulrich AM, Zhang W, Fu L, Wang Q, O'Connor M, Hoxie JA, Gonzalez- Scarano F (1997) CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol 151:1035-1042.
41. Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M (2000) Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes. Eur J NeuroSci 12:117-125.
42. Limatola C, Giovannelli A, Maggi L et al (2000) SDF-1alpha-mediated modulation of synaptic transmission in rat cerebellum. Eur J NeuroSci 12:2497-2504.
43. Lindia JA, McGowan E, Jochnowitz N, Abbadie C (2005) Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. J Pain 6:434-438.
44. Melli G, Keswani SC, Fischer A, Chen W, Hoke A (2006) Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy. Brain 129:1330-1338.
45. Menetski J, Mistry S, Lu M, Mudgett JS, Ransohoff RM, Demartino JA, MacIntyre DE, Abbadie C (2007) Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses. Neuroscience 149:706-714.
46. Meng SZ, Oka A, Takashima S (1999) Developmental expression of monocyte chemoattractant protein-1 in the human cerebellum and brainstem. Brain Dev 21:30-35.
47. Meucci O, Fatatis A, Simen AA, Bushell TJ, Gray PW, Miller RJ (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc Natl Acad Sci U S A 95:14500-14505.
48. Meucci O, Fatatis A, Simen AA, Miller RJ (2000) Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 97:8075-8080.
49. Milligan E, Zapata V, Schoeniger D, Chacur M, Green P, Poole S, Martin D, Maier SF, Watkins LR (2005) An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine. Eur J NeuroSci 22:2775-2782.
50. Milligan ED, Zapata V, Chacur M et al (2004) Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur J NeuroSci 20:2294-2302.
51. Mizuno T, Kawanokuchi J, Numata K, Suzumura A (2003) Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res 979:65-70.
52. Nishiyori A, Minami M, Ohtani Y, Takami S, Yamamoto J, Kawaguchi N, Kume T, Akaike A, Satoh M (1998) Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 429:167-172.
53. Oberlin E, Amara A, Bachelerie F et al (1996) The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833-835.
54. Oh SB, Endoh T, Simen AA, Ren D, Miller RJ (2002) Regulation of calcium currents by chemokines and their receptors. J Neuroimmunol 123:66-75.
55. Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ (2001) Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci 21:5027-5035.
56. Ohtani Y, Minami M, Kawaguchi N, Nishiyori A, Yamamoto J, Takami S, Satoh M (1998) Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells. Neurosci Lett 249:163-166.
57. Patterson CE, Daley JK, Echols LA, Lane TE, Rall GF (2003) Measles virus infection induces chemokine synthesis by neurons. J Immunol 171:3102-3109.
58. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic, San Diago, CA.
59. Pello OM, Martinez-Munoz L, Parrillas V et al (2008) Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol 38(2):537-549.
60. Pujol F, Kitabgi P, Boudin H (2005) The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons. J Cell Sci 118:1071-1080.
61. Puma C, Danik M, Quirion R, Ramon F, Williams S (2001) The chemokine interleukin-8 acutely reduces Ca(2+) currents in identified cholinergic septal neurons expressing CXCR1 and CXCR2 receptor mRNAs. J Neurochem 78:960-971.
62. Qin X, Wan Y, Wang X (2005) CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. J Neurosci Res 82:51-62.
63. Ragozzino D (2002) CXC chemokine receptors in the central nervous system: role in cerebellar neuromodulation and development. J Neurovirol 8:559-572.
64. Ragozzino D, Di Angelantonio S, Trettel F, Bertollini C, Maggi L, Gross C, Charo IF, Limatola C, Eusebi F (2006) Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. J Neurosci 26:10488-10498.
65. Ragozzino D, Giovannelli A, Mileo AM, Limatola C, Santoni A, Eusebi F (1998) Modulation of the neurotransmitter release in rat cerebellar neurons by GRO beta. Neuroreport 9:3601-3606.
66. Ragozzino D, Renzi M, Giovannelli A, Eusebi F (2002) Stimulation of chemokine CXC receptor 4 induces synaptic depression of evoked parallel fibers inputs onto Purkinje neurons in mouse cerebellum. J Neuroimmunol 127:30-36.
67. Robinson S, Tani M, Strieter RM, Ransohoff RM, Miller RH (1998) The chemokine growthregulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation. J Neurosci 18:10457-10463.
68. Rostene W, Kitabgi P, Parsadaniantz SM (2007) Chemokines: A new class of neuromodulator? Nat Rev Neurosci 8:895-903.
69. Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL (1998) Chemokines and receptors in HIV encephalitis. AIDS 12:1021-1026.
70. Schwaeble WJ, Stover CM, Schall TJ et al (1998) Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Lett 439:203-207.
71. Skrzydelski D, Guyon A, Dauge V, Rovere C, Apartis E, Kitabgi P, Nahon JL, Rostene W, Parsadaniantz SM (2007) The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system. J Neurochem 102:1175-1183.
72. Stumm RK, Rummel J, Junker V, Culmsee C, Pfeiffer M, Krieglstein J, Hollt V, Schulz S (2002) A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: Isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. J Neurosci 22:5865-5878.
73. Sui Y, Potula R, Dhillon N et al (2004) Neuronal apoptosis is mediated by CXCL10 overexpression in simian human immunodeficiency virus encephalitis. Am J Pathol 164:1557-1566.
74. Sun JH, Yang B, Donnelly DF, Ma C, LaMotte RH (2006) MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J Neurophysiol 96:2189-2199.
75. Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, Rogers TJ (2002) Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci U S A 99:10276-10281.
76. Tanaka T, Minami M, Nakagawa T, Satoh M (2004) Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain. Neurosci Res 48:463-469.
77. Thibeault I, Laflamme N, Rivest S (2001) Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J Comp Neurol 434:461-477.
78. Tong N, Perry SW, Zhang Q et al (2000) Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J Immunol 164:1333-1339.
79. Tsuda M, Inoue K, Salter MW (2005) Neuropathic pain and spinal microglia: A big problem from molecules in "small" glia. Trends Neurosci 28:101-107.
80. Vallat AV, De Girolami U, He J et al (1998) Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol 152:167-178.
81. Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC (2004) Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J NeuroSci 20:1150-1160.
82. Vit JP, Ohara PT, Tien DA, Fike JR, Eikmeier L, Beitz A, Wilcox GL, Jasmin L (2006) The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. Pain 120:188-201.
83. Wallace VC, Blackbeard J, Pheby T, Segerdahl AR, Davies M, Hasnie F, Hall S, McMahon SB, Rice AS (2007) Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy. Pain 133(1-3):47-63.
84. Wang X, Ellison JA, Siren AL, Lysko PG, Yue TL, Barone FC, Shatzman A, Feuerstein GZ (1998) Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat. J Neurochem 71:1194-1204.
85. Westmoreland SV, Alvarez X, deBakker C, Aye P, Wilson ML, Williams KC, Lackner AA (2002) Developmental expression patterns of CCR5 and CXCR4 in the rhesus macaque brain. J Neuroimmunol 122:146-158.
86. Westmoreland SV, Rottman JB, Williams KC, Lackner AA, Sasseville VG (1998) Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis. Am J Pathol 152:659-665.
87. White FA, Jung H, Miller RJ (2007) Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci U S A 104:20151-20158.
88. Xia M, Qin S, McNamara M, Mackay C, Hyman BT (1997) Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. Am J Pathol 150:1267-1274.
89. Xia MQ, Bacskai BJ, Knowles RB, Qin SX, Hyman BT (2000) Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: In vitro ERK1/2 activation and role in Alzheimer's disease. J Neuroimmunol 108:227-235.
90. Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT (1998) Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 153:31-37.
91. Zhang J, De Koninck Y (2006) Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem 97:772-783.
92. Zhang JM, An J (2007) Cytokines, inflammation, and pain. Int Anesthesiol Clin 45:27-37.
93. Zhang RX, Liu B, Wang L, Ren K, Qiao JT, Berman BM, Lao L (2005) Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 118:125-136.
94. Zheng J, Thylin MR, Ghorpade A et al (1999) Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. J Neuroimmunol 98:185-200.