-
1
-
-
0026010027
-
Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
-
O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R, III, Le Beau MM, Earp HS, Liu ET. 1991. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 11:5016-5031.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5016-5031
-
-
O'Bryan, J.P.1
Frye, R.A.2
Cogswell, P.C.3
Neubauer, A.4
Kitch, B.5
Prokop, C.6
Espinosa III, R.7
Le Beau, M.M.8
Earp, H.S.9
Liu, E.T.10
-
2
-
-
46449103344
-
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
-
Linger RM, Keating AK, Earp HS, Graham DK. 2008. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res 100:35-83. http://dx.doi.org/10.1016/S0065-230X(08)00002-X.
-
(2008)
Adv Cancer Res
, vol.100
, pp. 35-83
-
-
Linger, R.M.1
Keating, A.K.2
Earp, H.S.3
Graham, D.K.4
-
3
-
-
0028913076
-
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
-
Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, Masiakowski P, Ryan TE, Tobkes NJ, Chen DH, DiStefano PS, Long GL, Basilico C, Goldfarb MP, Lemke G, Glass DJ, Yancopoulos GD. 1995. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80:661-670. http://dx.doi.org/10.1016/0092-8674(95)90520-0.
-
(1995)
Cell
, vol.80
, pp. 661-670
-
-
Stitt, T.N.1
Conn, G.2
Gore, M.3
Lai, C.4
Bruno, J.5
Radziejewski, C.6
Mattsson, K.7
Fisher, J.8
Gies, D.R.9
Jones, P.F.10
Masiakowski, P.11
Ryan, T.E.12
Tobkes, N.J.13
Chen, D.H.14
DiStefano, P.S.15
Long, G.L.16
Basilico, C.17
Goldfarb, M.P.18
Lemke, G.19
Glass, D.J.20
Yancopoulos, G.D.21
more..
-
4
-
-
78649714537
-
Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis
-
Caberoy NB, Zhou Y, Li W. 2010. Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J 29:3898-3910. http://dx.doi.org/10.1038/emboj.2010.265.
-
(2010)
EMBO J
, vol.29
, pp. 3898-3910
-
-
Caberoy, N.B.1
Zhou, Y.2
Li, W.3
-
5
-
-
0029910706
-
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases
-
Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K. 1996. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem 271:30022-30027. http://dx.doi.org/10.1074/jbc.271.47.30022.
-
(1996)
J Biol Chem
, vol.271
, pp. 30022-30027
-
-
Nagata, K.1
Ohashi, K.2
Nakano, T.3
Arita, H.4
Zong, C.5
Hanafusa, H.6
Mizuno, K.7
-
6
-
-
0028938732
-
The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage
-
O'Bryan JP, Fridell YW, Koski R, Varnum B, Liu ET. 1995. The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage. J Biol Chem 270:551-557. http://dx.doi.org/10.1074/jbc.270.2.551.
-
(1995)
J Biol Chem
, vol.270
, pp. 551-557
-
-
O'Bryan, J.P.1
Fridell, Y.W.2
Koski, R.3
Varnum, B.4
Liu, E.T.5
-
7
-
-
27444442173
-
Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells
-
Hall MO, Obin MS, Heeb MJ, Burgess BL, Abrams TA. 2005. Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells. Exp Eye Res 81:581-591. http://dx.doi.org/10.1016/j.exer.2005.03.017.
-
(2005)
Exp Eye Res
, vol.81
, pp. 581-591
-
-
Hall, M.O.1
Obin, M.S.2
Heeb, M.J.3
Burgess, B.L.4
Abrams, T.A.5
-
8
-
-
14644411712
-
A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells
-
Wu Y, Singh S, Georgescu MM, Birge RB. 2005. A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells. J Cell Sci 118:539-553. http://dx.doi.org/10.1242/jcs.01632.
-
(2005)
J Cell Sci
, vol.118
, pp. 539-553
-
-
Wu, Y.1
Singh, S.2
Georgescu, M.M.3
Birge, R.B.4
-
9
-
-
70450252025
-
Identification of tubby and tubby-like protein 1 as eat-me signals by phage display
-
Caberoy NB, Maiguel D, Kim Y, Li W. 2010. Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp Cell Res 316:245-257. http://dx.doi.org/10.1016/j.yexcr.2009.10.008.
-
(2010)
Exp Cell Res
, vol.316
, pp. 245-257
-
-
Caberoy, N.B.1
Maiguel, D.2
Kim, Y.3
Li, W.4
-
10
-
-
0030664820
-
Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6
-
Nakano T, Ishimoto Y, Kishino J, Umeda M, Inoue K, Nagata K, Ohashi K, Mizuno K, Arita H. 1997. Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6. J Biol Chem 272:29411-29414. http://dx.doi.org/10.1074/jbc.272.47.29411.
-
(1997)
J Biol Chem
, vol.272
, pp. 29411-29414
-
-
Nakano, T.1
Ishimoto, Y.2
Kishino, J.3
Umeda, M.4
Inoue, K.5
Nagata, K.6
Ohashi, K.7
Mizuno, K.8
Arita, H.9
-
11
-
-
0028878702
-
The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding
-
Bellosta P, Costa M, Lin DA, Basilico C. 1995. The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding. Mol Cell Biol 15:614-625.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 614-625
-
-
Bellosta, P.1
Costa, M.2
Lin, D.A.3
Basilico, C.4
-
12
-
-
0032543712
-
Determinants for transformation induced by the Axl receptor tyrosine kinase
-
Burchert A, Attar EC, McCloskey P, Fridell YW, Liu ET. 1998. Determinants for transformation induced by the Axl receptor tyrosine kinase. Oncogene 16:3177-3187. http://dx.doi.org/10.1038/sj.onc.1201865.
-
(1998)
Oncogene
, vol.16
, pp. 3177-3187
-
-
Burchert, A.1
Attar, E.C.2
McCloskey, P.3
Fridell, Y.W.4
Liu, E.T.5
-
13
-
-
70149109569
-
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL
-
Liu L, Greger J, Shi H, Liu Y, Greshock J, Annan R, Halsey W, Sathe GM, Martin AM, Gilmer TM. 2009. Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res 69:6871-6878. http://dx.doi.org/10.1158/0008-5472.CAN-08-4490.
-
(2009)
Cancer Res
, vol.69
, pp. 6871-6878
-
-
Liu, L.1
Greger, J.2
Shi, H.3
Liu, Y.4
Greshock, J.5
Annan, R.6
Halsey, W.7
Sathe, G.M.8
Martin, A.M.9
Gilmer, T.M.10
-
14
-
-
0029655520
-
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase
-
Fridell YW, Jin Y, Quilliam LA, Burchert A, McCloskey P, Spizz G, Varnum B, Der C, Liu ET. 1996. Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Mol Cell Biol 16:135-145.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 135-145
-
-
Fridell, Y.W.1
Jin, Y.2
Quilliam, L.A.3
Burchert, A.4
McCloskey, P.5
Spizz, G.6
Varnum, B.7
Der, C.8
Liu, E.T.9
-
15
-
-
0037290890
-
Macrophage regulation by Tyro 3 family receptors
-
Lemke G, Lu Q. 2003. Macrophage regulation by Tyro 3 family receptors. Curr Opin Immunol 15:31-36. http://dx.doi.org/10.1016/S0952-7915(02)00016-X.
-
(2003)
Curr Opin Immunol
, vol.15
, pp. 31-36
-
-
Lemke, G.1
Lu, Q.2
-
16
-
-
0035854442
-
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
-
Lu Q, Lemke G. 2001. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293:306-311. http://dx.doi.org/10.1126/science.1061663.
-
(2001)
Science
, vol.293
, pp. 306-311
-
-
Lu, Q.1
Lemke, G.2
-
17
-
-
0033594411
-
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
-
Lu Q, Gore M, Zhang Q, Camenisch T, Boast S, Casagranda F, Lai C, Skinner MK, Klein R, Matsushima GK, Earp HS, GoffSP, Lemke G. 1999. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398:723-728. http://dx.doi.org/10.1038/19554.
-
(1999)
Nature
, vol.398
, pp. 723-728
-
-
Lu, Q.1
Gore, M.2
Zhang, Q.3
Camenisch, T.4
Boast, S.5
Casagranda, F.6
Lai, C.7
Skinner, M.K.8
Klein, R.9
Matsushima, G.K.10
Earp, H.S.11
Goff, S.P.12
Lemke, G.13
-
18
-
-
0034163837
-
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
-
D'Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, Vollrath D. 2000. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9:645-651. http://dx.doi.org/10.1093/hmg/9.4.645.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 645-651
-
-
D'Cruz, P.M.1
Yasumura, D.2
Weir, J.3
Matthes, M.T.4
Abderrahim, H.5
LaVail, M.M.6
Vollrath, D.7
-
19
-
-
33644876133
-
Expression of axl in lung adenocarcinoma and correlation with tumor progression
-
Shieh YS, Lai CY, Kao YR, Shiah SG, Chu YW, Lee HS, Wu CW. 2005. Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia 7:1058-1064. http://dx.doi.org/10.1593/neo.05640.
-
(2005)
Neoplasia
, vol.7
, pp. 1058-1064
-
-
Shieh, Y.S.1
Lai, C.Y.2
Kao, Y.R.3
Shiah, S.G.4
Chu, Y.W.5
Lee, H.S.6
Wu, C.W.7
-
20
-
-
75749115996
-
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
-
Gjerdrum C, Tiron C, Hoiby T, Stefansson I, Haugen H, Sandal T, Collett K, Li S, McCormack E, Gjertsen BT, Micklem DR, Akslen LA, Glackin C, Lorens JB. 2010. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A 107:1124-1129. http://dx.doi.org/10.1073/pnas.0909333107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1124-1129
-
-
Gjerdrum, C.1
Tiron, C.2
Hoiby, T.3
Stefansson, I.4
Haugen, H.5
Sandal, T.6
Collett, K.7
Li, S.8
McCormack, E.9
Gjertsen, B.T.10
Micklem, D.R.11
Akslen, L.A.12
Glackin, C.13
Lorens, J.B.14
-
21
-
-
27144492628
-
Multiple roles for the receptor tyrosine kinase axl in tumor formation
-
Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE, McLaughlin J, Swift SE, Pali ES, Yam G, Wong S, Lasaga J, Shen MR, Yu S, Xu W, Hitoshi Y, Bogenberger J, Nor JE, Payan DG, Lorens JB. 2005. Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res 65:9294-9303. http://dx.doi.org/10.1158/0008-5472.CAN-05-0993.
-
(2005)
Cancer Res
, vol.65
, pp. 9294-9303
-
-
Holland, S.J.1
Powell, M.J.2
Franci, C.3
Chan, E.W.4
Friera, A.M.5
Atchison, R.E.6
McLaughlin, J.7
Swift, S.E.8
Pali, E.S.9
Yam, G.10
Wong, S.11
Lasaga, J.12
Shen, M.R.13
Yu, S.14
Xu, W.15
Hitoshi, Y.16
Bogenberger, J.17
Nor, J.E.18
Payan, D.G.19
Lorens, J.B.20
more..
-
22
-
-
76749123429
-
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
-
Holland SJ, Pan A, Franci C, Hu YM, Chang B, Li WQ, Duan M, Torneros A, Yu JX, Heckrodt TJ, Zhang J, Ding PY, Apatira A, Chua J, Brandt R, Pine P, GoffD, Singh R, Payan DG, Hitoshi Y. 2010. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res 70:1544-1554. http://dx.doi.org/10.1158/0008-5472.CAN-09-2997.
-
(2010)
Cancer Res
, vol.70
, pp. 1544-1554
-
-
Holland, S.J.1
Pan, A.2
Franci, C.3
Hu, Y.M.4
Chang, B.5
Li, W.Q.6
Duan, M.7
Torneros, A.8
Yu, J.X.9
Heckrodt, T.J.10
Zhang, J.11
Ding, P.Y.12
Apatira, A.13
Chua, J.14
Brandt, R.15
Pine, P.16
Goff, D.17
Singh, R.18
Payan, D.G.19
Hitoshi, Y.20
more..
-
23
-
-
77957109253
-
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
-
Ye X, Li Y, Stawicki S, Couto S, Eastham-Anderson J, Kallop D, Weimer R, WuY, Pei L. 2010. An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29:5254-5264. http://dx.doi.org/10.1038/onc.2010.268.
-
(2010)
Oncogene
, vol.29
, pp. 5254-5264
-
-
Ye, X.1
Li, Y.2
Stawicki, S.3
Couto, S.4
Eastham-Anderson, J.5
Kallop, D.6
Weimer, R.7
Wu, Y.8
Pei, L.9
-
24
-
-
70349705633
-
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis
-
Li Y, Ye X, Tan C, Hongo JA, Zha J, Liu J, Kallop D, Ludlam MJ, Pei L. 2009. Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene 28:3442-3455. http://dx.doi.org/10.1038/onc.2009.212.
-
(2009)
Oncogene
, vol.28
, pp. 3442-3455
-
-
Li, Y.1
Ye, X.2
Tan, C.3
Hongo, J.A.4
Zha, J.5
Liu, J.6
Kallop, D.7
Ludlam, M.J.8
Pei, L.9
-
25
-
-
84895922043
-
AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells
-
Asiedu MK, Beauchamp-Perez FD, Ingle JN, Behrens MD, Radisky DC, Knutson KL. 2014. AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells. Oncogene 33:1316-1324. http://dx.doi.org/10.1038/onc.2013.57.
-
(2014)
Oncogene
, vol.33
, pp. 1316-1324
-
-
Asiedu, M.K.1
Beauchamp-Perez, F.D.2
Ingle, J.N.3
Behrens, M.D.4
Radisky, D.C.5
Knutson, K.L.6
-
26
-
-
0037115488
-
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity
-
Cote JF, Vuori K. 2002. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J Cell Sci 115:4901-4913. http://dx.doi.org/10.1242/jcs.00219.
-
(2002)
J Cell Sci
, vol.115
, pp. 4901-4913
-
-
Cote, J.F.1
Vuori, K.2
-
27
-
-
0036045768
-
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
-
Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS. 2002. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 4:574-582. http://dx.doi.org/10.1038/ncb824.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 574-582
-
-
Brugnera, E.1
Haney, L.2
Grimsley, C.3
Lu, M.4
Walk, S.F.5
Tosello-Trampont, A.C.6
Macara, I.G.7
Madhani, H.8
Fink, G.R.9
Ravichandran, K.S.10
-
28
-
-
0036713381
-
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins
-
Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA. 2002. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat Cell Biol 4:639-647. http://dx.doi.org/10.1038/ncb835.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 639-647
-
-
Meller, N.1
Irani-Tehrani, M.2
Kiosses, W.B.3
Del Pozo, M.A.4
Schwartz, M.A.5
-
29
-
-
10744223552
-
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
-
Grimsley CM, Kinchen JM, Tosello-Trampont AC, Brugnera E, Haney LB, Lu M, Chen Q, Klingele D, Hengartner MO, Ravichandran KS. 2004. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem 279:6087-6097. http://dx.doi.org/10.1074/jbc. M307087200.
-
(2004)
J Biol Chem
, vol.279
, pp. 6087-6097
-
-
Grimsley, C.M.1
Kinchen, J.M.2
Tosello-Trampont, A.C.3
Brugnera, E.4
Haney, L.B.5
Lu, M.6
Chen, Q.7
Klingele, D.8
Hengartner, M.O.9
Ravichandran, K.S.10
-
30
-
-
34447565145
-
Dock4 is regulated by RhoG and promotes Rac-dependent cell migration
-
Hiramoto K, Negishi M, Katoh H. 2006. Dock4 is regulated by RhoG and promotes Rac-dependent cell migration. Exp Cell Res 312:4205-4216. http://dx.doi.org/10.1016/j.yexcr.2006.09.006.
-
(2006)
Exp Cell Res
, vol.312
, pp. 4205-4216
-
-
Hiramoto, K.1
Negishi, M.2
Katoh, H.3
-
31
-
-
78649329795
-
An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling
-
Patel M, Margaron Y, Fradet N, Yang Q, Wilkes B, Bouvier M, Hofmann K, Cote JF. 2010. An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling. Curr Biol 20:2021-2027. http://dx.doi.org/10.1016/j.cub.2010.10.028.
-
(2010)
Curr Biol
, vol.20
, pp. 2021-2027
-
-
Patel, M.1
Margaron, Y.2
Fradet, N.3
Yang, Q.4
Wilkes, B.5
Bouvier, M.6
Hofmann, K.7
Cote, J.F.8
-
32
-
-
58149292257
-
An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling
-
Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, Cote JF. 2008. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell 19:4837-4851. http://dx.doi.org/10.1091/mbc. E08-04-0345.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4837-4851
-
-
Komander, D.1
Patel, M.2
Laurin, M.3
Fradet, N.4
Pelletier, A.5
Barford, D.6
Cote, J.F.7
-
33
-
-
84896363604
-
Insights into the biological functions of Dock family guanine nucleotide exchange factors
-
Laurin M, Cote JF. 2014. Insights into the biological functions of Dock family guanine nucleotide exchange factors. Genes Dev 28:533-547. http://dx.doi.org/10.1101/gad.236349.113.
-
(2014)
Genes Dev
, vol.28
, pp. 533-547
-
-
Laurin, M.1
Cote, J.F.2
-
34
-
-
84876890072
-
Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis
-
Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe- Kains B, Muller WJ, Cote JF. 2013. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc Natl Acad Sci U S A 110:7434-7439. http://dx.doi.org/10.1073/pnas.1213050110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 7434-7439
-
-
Laurin, M.1
Huber, J.2
Pelletier, A.3
Houalla, T.4
Park, M.5
Fukui, Y.6
Haibe-Kains, B.7
Muller, W.J.8
Cote, J.F.9
-
35
-
-
84900390547
-
EGFRvIII stimulates glioma growth and invasion through PKAdependent serine phosphorylation of Dock180
-
Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY. 2013. EGFRvIII stimulates glioma growth and invasion through PKAdependent serine phosphorylation of Dock180. Oncogene 33:2504-2512. http://dx.doi.org/10.1038/onc.2013.198.
-
(2013)
Oncogene
, vol.33
, pp. 2504-2512
-
-
Feng, H.1
Hu, B.2
Vuori, K.3
Sarkaria, J.N.4
Furnari, F.B.5
Cavenee, W.K.6
Cheng, S.Y.7
-
36
-
-
84863147746
-
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
-
Feng H, Hu B, Jarzynka MJ, Li Y, Keezer S, Johns TG, Tang CK, Hamilton RL, Vuori K, Nishikawa R, Sarkaria JN, Fenton T, Cheng T, Furnari FB, Cavenee WK, Cheng SY. 2012. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. Proc Natl Acad Sci U S A 109:3018-3023. http://dx.doi.org/10.1073/pnas.1121457109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 3018-3023
-
-
Feng, H.1
Hu, B.2
Jarzynka, M.J.3
Li, Y.4
Keezer, S.5
Johns, T.G.6
Tang, C.K.7
Hamilton, R.L.8
Vuori, K.9
Nishikawa, R.10
Sarkaria, J.N.11
Fenton, T.12
Cheng, T.13
Furnari, F.B.14
Cavenee, W.K.15
Cheng, S.Y.16
-
37
-
-
84055191095
-
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha- stimulated glioma tumorigenesis in mice and humans
-
Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY. 2011. Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRalpha- stimulated glioma tumorigenesis in mice and humans. J Clin Invest 121:4670-4684. http://dx.doi.org/10.1172/JCI58559.
-
(2011)
J Clin Invest
, vol.121
, pp. 4670-4684
-
-
Feng, H.1
Hu, B.2
Liu, K.W.3
Li, Y.4
Lu, X.5
Cheng, T.6
Yiin, J.J.7
Lu, S.8
Keezer, S.9
Fenton, T.10
Furnari, F.B.11
Hamilton, R.L.12
Vuori, K.13
Sarkaria, J.N.14
Nagane, M.15
Nishikawa, R.16
Cavenee, W.K.17
Cheng, S.Y.18
-
38
-
-
50249145697
-
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180
-
Smith HW, Marra P, Marshall CJ. 2008. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol 182:777-790. http://dx.doi.org/10.1083/jcb.200712050.
-
(2008)
J Cell Biol
, vol.182
, pp. 777-790
-
-
Smith, H.W.1
Marra, P.2
Marshall, C.J.3
-
39
-
-
84877734357
-
Association between Galphai2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis
-
Li H, Yang L, Fu H, Yan J, Wang Y, Guo H, Hao X, Xu X, Jin T, Zhang N. 2013. Association between Galphai2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nat Commun 4:1706. http://dx.doi.org/10.1038/ncomms2680.
-
(2013)
Nat Commun
, vol.4
, pp. 1706
-
-
Li, H.1
Yang, L.2
Fu, H.3
Yan, J.4
Wang, Y.5
Guo, H.6
Hao, X.7
Xu, X.8
Jin, T.9
Zhang, N.10
-
40
-
-
48249109104
-
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2
-
Jansson D, Ng AC, Fu A, Depatie C, Al Azzabi M, Screaton RA. 2008. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc Natl Acad Sci U S A 105:10161-10166. http://dx.doi.org/10.1073/pnas.0800796105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10161-10166
-
-
Jansson, D.1
Ng, A.C.2
Fu, A.3
Depatie, C.4
Al Azzabi, M.5
Screaton, R.A.6
-
41
-
-
80655125028
-
The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
-
Patel M, Chiang TC, Tran V, Lee FJ, Cote JF. 2011. The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. J Biol Chem 286:38969-38979. http://dx.doi.org/10.1074/jbc. M111.274191.
-
(2011)
J Biol Chem
, vol.286
, pp. 38969-38979
-
-
Patel, M.1
Chiang, T.C.2
Tran, V.3
Lee, F.J.4
Cote, J.F.5
-
42
-
-
23144450821
-
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
-
Cote JF, Motoyama AB, Bush JA, Vuori K. 2005. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol 7:797-807. http://dx.doi.org/10.1038/ncb1280.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 797-807
-
-
Cote, J.F.1
Motoyama, A.B.2
Bush, J.A.3
Vuori, K.4
-
43
-
-
80054098174
-
Opening up on ELMO regulation: new insights into the control of Rac signaling by the DOCK180/ELMO complex
-
Patel M, Pelletier A, Cote JF. 2011. Opening up on ELMO regulation: new insights into the control of Rac signaling by the DOCK180/ELMO complex. Small GTPases 2:268-275. http://dx.doi.org/10.4161/sgtp.2.5.17716.
-
(2011)
Small GTPases
, vol.2
, pp. 268-275
-
-
Patel, M.1
Pelletier, A.2
Cote, J.F.3
-
44
-
-
20544462391
-
Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck
-
Yokoyama N, deBakker CD, Zappacosta F, Huddleston MJ, Annan RS, Ravichandran KS, Miller WT. 2005. Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. Biochemistry 44:8841-8849. http://dx.doi.org/10.1021/bi0500832.
-
(2005)
Biochemistry
, vol.44
, pp. 8841-8849
-
-
Yokoyama, N.1
deBakker, C.D.2
Zappacosta, F.3
Huddleston, M.J.4
Annan, R.S.5
Ravichandran, K.S.6
Miller, W.T.7
-
45
-
-
80053944035
-
Targeting Axl and Mer kinases in cancer
-
Verma A, Warner SL, Vankayalapati H, Bearss DJ, Sharma S. 2011. Targeting Axl and Mer kinases in cancer. Mol Cancer Ther 10:1763-1773. http://dx.doi.org/10.1158/1535-7163.MCT-11-0116.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1763-1773
-
-
Verma, A.1
Warner, S.L.2
Vankayalapati, H.3
Bearss, D.J.4
Sharma, S.5
-
46
-
-
0030740540
-
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate dockingsite
-
Braunger J, SchleithoffL, Schulz AS, Kessler H, Lammers R, Ullrich A, Bartram CR, Janssen JW. 1997. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate dockingsite. Oncogene 14:2619-2631. http://dx.doi.org/10.1038/sj.onc.1201123.
-
(1997)
Oncogene
, vol.14
, pp. 2619-2631
-
-
Braunger, J.1
Schleithoff, L.2
Schulz, A.S.3
Kessler, H.4
Lammers, R.5
Ullrich, A.6
Bartram, C.R.7
Janssen, J.W.8
-
47
-
-
45249119017
-
In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation
-
Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B. 2008. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. J Neurochem 106:134-146. http://dx.doi.org/10.1111/j.1471-4159.2008.05343.x.
-
(2008)
J Neurochem
, vol.106
, pp. 134-146
-
-
Weinger, J.G.1
Gohari, P.2
Yan, Y.3
Backer, J.M.4
Varnum, B.5
Shafit-Zagardo, B.6
-
48
-
-
84872305189
-
ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions
-
Margaron Y, Fradet N, Cote JF. 2013. ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions. J Biol Chem 288:1184-1199. http://dx.doi.org/10.1074/jbc. M112.431825.
-
(2013)
J Biol Chem
, vol.288
, pp. 1184-1199
-
-
Margaron, Y.1
Fradet, N.2
Cote, J.F.3
-
49
-
-
34250801103
-
Adhesion- related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin- releasing hormone neuronal cells
-
Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME. 2007. Adhesion- related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin- releasing hormone neuronal cells. Endocrinology 148:2806-2814. http://dx.doi.org/10.1210/en.2007-0039.
-
(2007)
Endocrinology
, vol.148
, pp. 2806-2814
-
-
Nielsen-Preiss, S.M.1
Allen, M.P.2
Xu, M.3
Linseman, D.A.4
Pawlowski, J.E.5
Bouchard, R.J.6
Varnum, B.C.7
Heidenreich, K.A.8
Wierman, M.E.9
-
50
-
-
84860110971
-
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2
-
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y. 2012. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol 19:488-497. http://dx.doi.org/10.1016/j.chembiol.2012.03.008.
-
(2012)
Chem Biol
, vol.19
, pp. 488-497
-
-
Nishikimi, A.1
Uruno, T.2
Duan, X.3
Cao, Q.4
Okamura, Y.5
Saitoh, T.6
Saito, N.7
Sakaoka, S.8
Du, Y.9
Suenaga, A.10
Kukimoto-Niino, M.11
Miyano, K.12
Gotoh, K.13
Okabe, T.14
Sanematsu, F.15
Tanaka, Y.16
Sumimoto, H.17
Honma, T.18
Yokoyama, S.19
Nagano, T.20
Kohda, D.21
Kanai, M.22
Fukui, Y.23
more..
-
51
-
-
84862777514
-
RAC1 activation mediates Twist1-induced cancer cell migration
-
Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. 2012. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol 14:366-374. http://dx.doi.org/10.1038/ncb2455.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 366-374
-
-
Yang, W.H.1
Lan, H.Y.2
Huang, C.H.3
Tai, S.K.4
Tzeng, C.H.5
Kao, S.Y.6
Wu, K.J.7
Hung, M.C.8
Yang, M.H.9
-
52
-
-
84859297087
-
Twists and turns of invasion
-
Childs G, Segall JE. 2012. Twists and turns of invasion. Nat Cell Biol 14:337-339. http://dx.doi.org/10.1038/ncb2477.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 337-339
-
-
Childs, G.1
Segall, J.E.2
-
53
-
-
40949156351
-
AXL is a potential target for therapeutic intervention in breast cancer progression
-
Zhang YX, Knyazev PG, Cheburkin YV, Sharma K, Knyazev YP, OrfiL, Szabadkai I, Daub H, Keri G, Ullrich A. 2008. AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer Res 68:1905-1915. http://dx.doi.org/10.1158/0008-5472.CAN-07-2661.
-
(2008)
Cancer Res
, vol.68
, pp. 1905-1915
-
-
Zhang, Y.X.1
Knyazev, P.G.2
Cheburkin, Y.V.3
Sharma, K.4
Knyazev, Y.P.5
Orfi, L.6
Szabadkai, I.7
Daub, H.8
Keri, G.9
Ullrich, A.10
-
54
-
-
84896265825
-
G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates
-
Hamoud N, Tran V, Croteau LP, Kania A, Cote JF. 2014. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc Natl Acad Sci U S A 111:3745-3750. http://dx.doi.org/10.1073/pnas.1313886111.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 3745-3750
-
-
Hamoud, N.1
Tran, V.2
Croteau, L.P.3
Kania, A.4
Cote, J.F.5
-
55
-
-
0035812719
-
Guidance of cell migration by the Drosophila PDGF/VEGF receptor
-
Duchek P, Somogyi K, Jekely G, Beccari S, Rorth P. 2001. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell 107:17-26. http://dx.doi.org/10.1016/S0092-8674(01)00502-5.
-
(2001)
Cell
, vol.107
, pp. 17-26
-
-
Duchek, P.1
Somogyi, K.2
Jekely, G.3
Beccari, S.4
Rorth, P.5
-
56
-
-
84888114833
-
Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments
-
Liu ZC, Odell N, Geisbrecht ER. 2013. Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments. J Cell Sci 126:5210-5223. http://dx.doi.org/10.1242/jcs.132241.
-
(2013)
J Cell Sci
, vol.126
, pp. 5210-5223
-
-
Liu, Z.C.1
Odell, N.2
Geisbrecht, E.R.3
-
57
-
-
84894047355
-
Dock4 forms a complex with SH3YL1 and regulates cancer cell migration
-
Kobayashi M, Harada K, Negishi M, Katoh H. 2014. Dock4 forms a complex with SH3YL1 and regulates cancer cell migration. Cell Signal 26:1082-1088. http://dx.doi.org/10.1016/j.cellsig.2014.01.027.
-
(2014)
Cell Signal
, vol.26
, pp. 1082-1088
-
-
Kobayashi, M.1
Harada, K.2
Negishi, M.3
Katoh, H.4
-
58
-
-
0142211201
-
An SH2 domain-dependent, phosphotyrosine- independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action
-
Mahajan NP, Earp HS. 2003. An SH2 domain-dependent, phosphotyrosine- independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. J Biol Chem 278:42596-42603. http://dx.doi.org/10.1074/jbc. M305817200.
-
(2003)
J Biol Chem
, vol.278
, pp. 42596-42603
-
-
Mahajan, N.P.1
Earp, H.S.2
-
59
-
-
40849096161
-
Growth arrest-specific gene 6 expression in human breast cancer
-
Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E, Gallagher E, Goldrick AM, Dervan PA, Mc Cann A, Kerin MJ. 2008. Growth arrest-specific gene 6 expression in human breast cancer. Br J Cancer 98:1141-1146. http://dx.doi.org/10.1038/sj.bjc.6604260.
-
(2008)
Br J Cancer
, vol.98
, pp. 1141-1146
-
-
Mc Cormack, O.1
Chung, W.Y.2
Fitzpatrick, P.3
Cooke, F.4
Flynn, B.5
Harrison, M.6
Fox, E.7
Gallagher, E.8
Goldrick, A.M.9
Dervan, P.A.10
Mc Cann, A.11
Kerin, M.J.12
-
60
-
-
78349310110
-
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4
-
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y. 2010. DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res 107:1102-1105. http://dx.doi.org/10.1161/CIRCRESAHA.110.223388.
-
(2010)
Circ Res
, vol.107
, pp. 1102-1105
-
-
Sanematsu, F.1
Hirashima, M.2
Laurin, M.3
Takii, R.4
Nishikimi, A.5
Kitajima, K.6
Ding, G.7
Noda, M.8
Murata, Y.9
Tanaka, Y.10
Masuko, S.11
Suda, T.12
Meno, C.13
Cote, J.F.14
Nagasawa, T.15
Fukui, Y.16
|