Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions

Journal of Lipid Research

Volumn 55, Issue 12, 2014, Pages 2665-2675

  Obinata, Hideru ^a   Gutkind, Sarah ^a   Stitham, Jeremiah ^b   Okuno, Toshiaki ^c   Yokomizo, Takehiko ^c   Hwa, John ^b   Hla, Timothy ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell signaling; Drug therapy; Endocytosis; Genetics; Single nucleotide polymorphism; Sphingosine 1 phosphate receptor; Sphingosine phosphate

Indexed keywords

CALCIUM; FINGOLIMOD; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; HYBRID PROTEIN; IMMUNOSUPPRESSIVE AGENT; LYSOPHOSPHOLIPID; MUTANT PROTEIN; PROPANEDIOL DERIVATIVE; S1PR1 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

AGED; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENDOCYTOSIS; ENZYME ACTIVATION; FEMALE; GENE SEQUENCE; GENETIC RISK; GENETIC VARIABILITY; HEART PROTECTION; HUMAN; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SPHINGOSINE 1 PHOSPHATE RECEPTOR GENE; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL CULTURE; CELL LINE; CORONARY ARTERY DISEASE; CRICETULUS; DRUG EFFECTS; DRUG RESISTANCE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; SIGNAL TRANSDUCTION;

AGED; ANIMALS; CASE-CONTROL STUDIES; CELL LINE; CELLS, CULTURED; CORONARY ARTERY DISEASE; CRICETULUS; DRUG RESISTANCE; ENDOCYTOSIS; FEMALE; FINGOLIMOD HYDROCHLORIDE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYSOPHOSPHOLIPIDS; MALE; MIDDLE AGED; MUTANT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84919952264     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.P054163     Document Type: Article

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