TGF-Β1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells

Oncogene

Volumn 30, Issue 19, 2011, Pages 2230-2241

  Pakala, S B ^a   Singh, K ^a,c   Reddy, S D N ^a   Ohshiro, K ^a   Li, D Q ^a   Mishra, L ^b   Kumar, R ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

epithelial to mesenchymal transition; FosB; MTA1; target gene transcription; TGF 1 signaling

Indexed keywords

HISTONE DEACETYLASE 2; METASTASIS ASSOCIATED PROTEIN 1; PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE DEACETYLASES; HUMANS; MICE; MICROSCOPY, CONFOCAL; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79955862101     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.608     Document Type: Article

References (30)

1. Balasenthil S, Gururaj AE, Talukder AH, Bagheri-Yarmand R, Arrington T, Haas BJ et al. (2007). Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res 67: 7132-7138. (Pubitemid 47206540)
2. Bui-Nguyen TM, Pakala SB, Sirigiri RD, Xia W, Hung MC, Sarin SK et al. (2010). NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx. Oncogene 29: 1179-1189.
3. Condeelis J, Segall JE. (2003). Intravital imaging of cell movement in tumours. Nat Rev Cancer 3: 921-930. (Pubitemid 37500177)
4. Dannenmann C, Shabani N, Friese K, Jeschke U, Mylonas I, Bruning A. (2008). The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO. Cancer Biol Ther 7: 1460-1467.
5. Deckers M, van Dinther M, Buijs J, Que I, Lowik C, van der Pluijm G et al. (2006). The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66: 2202-2209.
6. Eferl R, Wagner EF. (2003). AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868. (Pubitemid 37383716)
7. Gery S, Tanosaki S, Bose S, Bose N, Vadgama J, Koeffler HP. (2005). Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer. Clin Cancer Res 11: 3184-3190. (Pubitemid 40627863)
8. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H et al. (2006). MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci USA 103: 6670-6675.
9. Hofer MD, Menke A, Genze F, Gierschik P, Giehl K. (2004). Expression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells. Br J Cancer 90: 455-462. (Pubitemid 38250645)
10. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED et al. (2007). Epithelial-mesenchymal and mesenchymal- epithelial transitions in carcinoma progression. J Cell Physiol 213: 374-383. (Pubitemid 47509716)
11. Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang Z et al. (2002). A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 418: 654-657.
12. Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, Ten Dijke P et al. (2003). Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol 23: 4494-4510. (Pubitemid 36734741)
13. Lee TC, Zhang Y, Schwartz RJ. (1994). Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis. Oncogene 9: 1047-1052. (Pubitemid 24095012)
14. MacLellan WR, Lee TC, Schwartz RJ, Schneider MD. (1994). Transforming growth factor-beta response elements of the skeletal alpha-actin gene. combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1. J Biol Chem 269: 16754-16760.
15. Mahoney MG, Simpson A, Jost M, Noe M, Kari C, Pepe D et al. (2002). Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. Oncogene 21: 2161-2170. (Pubitemid 34311370)
16. Manavathi B, Kumar R. (2007). Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem 282: 1529-1533. (Pubitemid 47076673)
17. Massague J, Seoane J, Wotton D. (2005). Smad transcription factors. Genes Dev 19: 2783-2810. (Pubitemid 41739965)
18. Mazumdar A, Wang RA, Mishra SK, Adam L, Bagheri-Yarmand R, Mandal M et al. (2001). Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol 3: 30-37. (Pubitemid 32114829)
19. Michl P, Downward J. (2006). CUTL1: a key mediator of TGFbeta-induced tumor invasion. Cell Cycle 5: 132-134. (Pubitemid 43131144)
20. Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R et al. (2005). CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7: 521-532. (Pubitemid 40799246)
21. Molli PR, Singh RR, Lee SW, Kumar R. (2008). MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene. Oncogene 27: 1971-1980. (Pubitemid 351442737)
22. Ohnishi YN, Sakumi K, Yamazaki K, Ohnishi YH, Miura T, Tominaga Y et al. (2008). Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cel 19: 4717-4729.
23. Pakala SB, Bui-Nguyen TM, Reddy SD, Li DQ, Peng S, Rayala SK et al. (2010). Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. J Biol Chem 285: 23590-23597.
24. Peinado H, Quintanilla M, Cano A. (2003). Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278: 21113-21123. (Pubitemid 36806424)
25. Radisky DC. (2005). Epithelial-mesenchymal transition. J Cell Sci 118: 4325-4326.
26. Thiery JP. (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
27. Tong D, Heinze G, Schremmer M, Schuster E, Czerwenka K, Leodolter S et al. (2007). Expression of the human MTA1 gene in breast cell lines and in breast cancer tissues. Oncol Res 16: 465-470.
28. Von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M et al. (2009). E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology 137: 361-371.
29. Zavadil J, Bottinger EP. (2005). TGF-beta and epithelial-to-mesench-ymal transitions. Oncogene 24: 5764-5774.
30. Zhang H, Stephens LC, Kumar R. (2006). Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res 12: 1479-1486.