Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions

Medical Oncology

Volumn 32, Issue 1, 2015, Pages

  Liu, Maoxi ^a   Du, Kunli ^a   Fu, Zhongxue ^a   Zhang, Shouru ^a   Wu, Xingye ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Colon cancer cells; HIF1 ; Hypoxia; PLD2; Up regulation

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PHOSPHOLIPASE D2; SMALL INTERFERING RNA; HIF1A PROTEIN, HUMAN; PHOSPHOLIPASE D;

ADULT; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CANCER STAGING; CELL NUCLEUS; CLINICAL ARTICLE; COLON CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL HYPOXIA; COLON TUMOR; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; METABOLISM; MIDDLE AGED; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; XENOGRAFT;

ADULT; AGED; ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE, TUMOR; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; PHOSPHOLIPASE D; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 84919935724     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-014-0394-9     Document Type: Article

References (41)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics 2012. CA Cancer J Clin. 2012;62:10–29.
2. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
3. Tsunaki H, Yasunori K. Mammalian phospholipase D: structure regulation and physiological function of phospholipase D and its link to pathology. Adv Biochem Health Dis. 2014;10:343–58.
4. Young-Hoon L, Young-Seuk B. Phospholipase D2 downregulation reduces cellular senescence through a reactive oxygen species P53-P21 pathway. FEBS Lett. 2014;588(17):3251–8.
5. Gomez-Cambronero J. Phospholipase D in cell signaling:from a myriad of cell functions to cancer growth and metastasis. J Biol Chem. 2014;289(33):22557–66.
6. Nakashima S, Nozawa Y. Possible role of phospholipase D in cellular differentiation and apoptosis. Chem Phys Lipids. 1999;98:153–64.
7. Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem. 1995;720:29640–3.
8. Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, Bar-Sagi D, Morris AJ, Froham MA. phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol. 1997;7:191–201.
9. Peng JHF, Feng Y, Rhodes PG. Down-regulation of phospholipase D2 mRNA in neonatal rat brainstem and cerebellum after Hypoxia-Ischemia. Neurochem Res. 2006;31:1191–6.
10. Mozzicato S, Joshi BV, Jacobson KA, Liang BT. Role of direct RhoA-phospholipase D1 interaction in mediating adenosine-induced protection from cardiac ischemia. FASEB J. 2004;18(2):406–8.
11. Yamakawa H, Banno Y, Nakashima S, Sawada M, Yamada J, Yoshimura S, et al. Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role. Neuro Rep. 2000;16:3647–50.
12. Uchida N, Okamura S, Kuwano H. Phospholipase D activity in human gastric carcinoma. Anticancer Res. 1999;19:77–86.
13. Ahn MJ, Park SY, Kim WK, Cho JH, Chang BJ, Kim DJ, et al. A single nucleotide polymorphism in the phospholipase D1 gene is associated with risk of non-small lung cancer. Int J Biomed Sci. 2012;8(2):121–8.
14. Park MH, Min DS. Quercetin-induced downregulation of PLD1 inhibits proliferation and invasion in U87 glioma cells. Biochem Biophys Res Commun. 2011;412(4):710–5.
15. Toschi A, Edelstein J, Rockwell P, Ohh M, Foster DA. HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene. 2008;27(19):2746–53.
16. Noh DY, Ahn SJ, Lee RA, Park IA, Kim JH, Suh PG, Ryu SH, Lee KH, Ham LS. Overexpression of phospholipase D in human breast cancer tissues. Cancer Lett. 2000;161:207–14.
17. Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J. Phospholipase D drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model. Oncogene. 2013;32:5551–62.
18. Son J, Kang DW, Yang KM. Phospholipase D inhibitor enhance radiosensitivity of breast cancer cells. Exp Mol Med. 2013;45:e38. doi:10.1038/emm.2013.75.
19. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF1-α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature. 1998;394:485–90.
20. Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995;92:5510–4.
21. Tanimoto K, Makino Y, Pereira T, et al. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBOJ. 2000;19:4298–309.
22. Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Bio. 2000;2:423–7.
23. Toffoli S, Michiels C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J. 2008;275:2991–3002.
24. Harris AL. Hypoxia—a key regulatory factor in tumor growth. Nat Rev Cancer. 2002;2:38–47.
25. Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol. 2006;59:15–26.
26. Manalo DJ, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 2005;105:659–69.
27. Sansom L, Hutchins GGA, Shires M, Hemmings G, et al. Hypoxia response proteins HIF1-alpha, CAIX and GLUT1 as potential prognostic biomarkers in colorectal cancer. J Pathol. 2012;228(suppl.1):S7.
28. Yoshimura H, Dhar DK, Kohno H, Kubota H, et al. Prognostic impact of hypoxia-inducible factors 1 alpha and 2 alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res. 2004;10(24):8554–60.
29. Kang DW, Park M-K, Oh H-J, et al. Phospholipase D1 Has a pivotal role in interleukin-1 beta-driven chronic autoimmune arthritis through regulation of NF-kappa B, hypoxia-inducible factor 1 alpha, and FoxO3a. Mol Cell Biol. 2013;33(14):2760–72.
30. Wu XY, Fu ZX, Wang XH, Shen W. Identification of differential proteins in colon cancer SW480 cells with HIF1-alpha silence by proteome analysis. Neoplasma. 2010;57(4):299–305.
31. Oshimoto H, Okamura S, Yoshida M, Mori M. Increased activity and expression of Phospholipase D2 in human colorectal cancer. Oncol Res. 2003;14:31–7.
32. Saito M, Iwadate M, Higashimoto M, Ono K, et al. Expression of phospholipase D2 in human colorectal carcinoma. Oncol Rep. 2007;18:1329–34.
33. Yamada Y, Hamajima N, Kato T, Iwata H, et al. Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. J Mol Med. 2003;81:126–31.
34. Kong D, Su G, Zha L, Zhang H, Xiang J, et al. Coexpression of HMGA2 and Oct4 predicts an unfavorable progression in human gastric cancer. Med Oncol. 2014;31(130):3–10.
35. Nishida A, Emoto K, Shimizu M, Uozumi T, Yamawaki S. Brain ischemia decreases phosphatidylcholine-phospholipase D but not phosphatidylinositol-phospholipase C in rats. Stroke. 1994;25:1247–51.
36. Kang DW, Min DS. Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NF-kappa B signaling pathway and enhances invasion of breast cancer cells. Cancer Lett. 2010;294:125–33.
37. Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, et al. P50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Res. 2006;66:11432–40.
38. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/Hej and C58BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085–8.
39. Park MH, Ahn BH, Hong YK, et al. Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kB/Sp1-mediated signaling pathways [J]. Carcinogenesis. 2009;30(2):356–65.
40. Kang DW, Min DS. positive feedback regulation between phospholipase D and wnt signaling promotes wnt-driven anchorage-independent growth of colorectal cancer cells. Plos One. 2010;5(8):2109.
41. Shen Q, Stanton ML, Feng W, Rodriquez ME, Ramondetta L, Chen L, et al. Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTOR pathway in endometrial carcinoma. Int J Clin Exp Pathol. 2010;4(1):13–21.