Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells

Experimental and Molecular Medicine

Volumn 45, Issue 8, 2013, Pages

  Son, Ju Cheol ^a,b   Kang, Dong Woo ^a   Yang, Kwang Mo ^b   Choi, Kang Yell ^c   Son, Tae Gen ^b   Min, Do Sik ^a,c  

^a Pusan National University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Breast cancer; Phospholipase D; Phospholipase D inhibitor; Radiosensitivity

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; PHOSPHOLIPASE INHIBITOR; RADIOSENSITIZING AGENT; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VU 0155069; VU 0285655 1;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MOLECULARLY TARGETED THERAPY; MONOTHERAPY; RADIATION DOSE; RADIATION EXPOSURE; RADIOSENSITIVITY; TREATMENT OUTCOME;

EID: 84882988351     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.75     Document Type: Article

References (24)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T et al. Cancer statistics. CA Cancer J Clin 2008;58:71-96.
2. Candelaria M, Garcia-Arias A, Cetina L, Duenas-Gonzalez A. Radiosensitizers in cervical cancer: cisplatin and beyond. Radiat Oncol 2006;1:15-31.
3. Selvy PE, Lavieri RR, Lindsley CW, Brown HA. Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev 2011;111:6064-6119.
4. Huang P, Frohman MA. The potential for phospholipase D as a new therapeutic target. Expert Opin Ther Targets 2007;11:707-716.
5. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 2009;5:108-117.
6. Lee SJ, Yang ES, Kim SY, Shin SW, Park JW. Regulation of heat shockinduced apoptosis by sensitive to apoptosis gene protein. Free Radic Bio Med 2008;45:167-176.
7. Haykal J, Geara F, Haddadin MJ, Smith A, Gail-Muhtasib H. The radiosensitizer 2-benzoyl-3-phenyl-6, 7-dichloro-quinoxaline 1, 4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells. Radiat Oncol 2009;4:25-34.
8. Supiot S, Gouard S, Charrier J, Apostolidis C, Charal JF, Barber J et al. Mechanisms of cell sensitization to alpha radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines. Clin Cancer Res 2005;11:7047s-7052s.
9. Hu Q, Hill RP. Radiosensitivity, apoptosis and repair of DNA double-strand breaks in radiation-sensitive Chinese hamster ovary cell mutants treated at different dose rates. Radiat Res 1996;146:636-645.
10. Ivashkevich A, Redon CE, Nakamura AJ, Martin RF, Martin OA. Use of the H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett 2012;327:123-133.
11. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA doublestranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273:5858-5868.
12. Su W, Chen Q, Frohman MA. Targeting phospholipase D with smallmolecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncol 2009;9:1477-1486.
13. Gozgit JM, Pentecost BT, Marconi SA, Ricketts-Loriaux RS, Otis CN, Arcaro KF. PLD1 is overexpressed in an ER-negative MCF-7 cell line variant and a subset of phosphor-Akt-negative breast carcinomas. Br J Cancer 2007;97:809-817.
14. Yamada Y, Banno Y, Yoshida H, Kikuchi R, Akao Y, Murate T et al. Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation. Arch Med Res 2006;37:696-699.
15. Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-1113.
16. Kang DW, Lee SH, Yoon JW, Park WS, Choi KY, Min DS. Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/β-catenin/TCF signaling axis. Cancer Res 2010;70:4233-4242.
17. Avila MA, Otero G, Cansado J, Dritschilo A, Velasco JA, Notario V. Activation of phospholipase D participates in signal transduction pathways responsive to gamma-radiation. Cancer Res 1993;1:4474-4476.
18. Haber JE. Partners and pathways repairing a double-strand break. Trends Genet 2000;16:259-264.
19. Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001;27:247-254.
20. Olive PL. The DNA single and double strand breaks in cell killing by ionizing radiation. Radiat Res 1998;150:S42-S51.
21. Rothkamm K, Lobrich M. Evidence for a lack of DNA double strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci USA 2003;100:5057-5062.
22. Nazarov IB, Smirnova AN, Krutilina RI, Svetlova MP, Solovjeva LV, Nikiforov AA et al. Dephosphorylation of histone γ-H2AX during repair of DNA double strand break repair during the mammalian cells and its inhibition by calyculin A. Radiat Res 2003;160:309-317.
23. Olive PL, Banath JP. Phosphorylation of histone H2AX as a measure of radiosensitivity. Int J Radiat Oncol Biol Phys 2004;58:331-335.
24. Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ et al. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 2004;279:2273-2280.