Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease

Neuroscience Letters

Volumn 587, Issue , 2015, Pages 126-131

  Kanamaru, Takuya ^a   Kamimura, Naomi ^a   Yokota, Takashi ^a   Iuchi, Katsuya ^a   Nishimaki, Kiyomi ^a   Takami, Shinya ^b   Akashiba, Hiroki ^b   Shitaka, Yoshitsugu ^b   Katsura, Ken ichiro ^a   Kimura, Kazumi ^a   Ohta, Shigeo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; APP transgenic mice; DAL mice; Oxidative stress

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; TAU PROTEIN; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; AMYLOID; MITOCHONDRIAL PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BODY WEIGHT; BRAIN; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; GLIOSIS; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; LEARNING AND MEMORY TEST; LIFESPAN; MAZE TEST; MEMORY DISORDER; MOUSE; MOUSE MODEL; NERVE CELL DEGENERATION; NONHUMAN; OBJECT RECOGNITION TEST; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SPATIAL LEARNING; SPATIAL MEMORY; SURVIVAL RATE; TRANSGENIC MOUSE; ANIMAL; GENETICS; LEARNING; METABOLISM; PHOSPHORYLATION; PSYCHOLOGY;

ALDEHYDE DEHYDROGENASE; ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; GLIOSIS; LEARNING; MEMORY DISORDERS; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PHOSPHORYLATION; TAU PROTEINS;

EID: 84919926227     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.12.033     Document Type: Article

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