Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine

European Journal of Pharmacology

Volumn 703, Issue 1-3, 2013, Pages 53-61

  Nagakura, Akira ^a   Shitaka, Yoshitsugu ^a   Yarimizu, Junko ^a   Matsuoka, Nobuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Donepezil; Memantine; Morris water maze; PS1 APP transgenic mice; Y maze

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DONEPEZIL; MEMANTINE; PRESENILIN 1;

AGE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TISSUE LEVEL; FEMALE; MAZE TEST; MORRIS WATER MAZE TASK; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SPATIAL MEMORY; TASK PERFORMANCE; TRANSGENIC MOUSE; WORKING MEMORY; Y MAZE TASK;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; FEMALE; INDANS; MAZE LEARNING; MEMANTINE; MEMORY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NOOTROPIC AGENTS; PIPERIDINES; RECEPTORS, AMPA;

EID: 84874943504     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.12.023     Document Type: Article

References (43)

1. G.W. Arendash, D.L. King, M.N. Gordon, D. Morgan, J.M. Hatcher, C.E. Hope, and D.M. Diamond Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes Brain Res. 891 2001 42 53
2. K.R. Bales, E.T. Tzavara, S. Wu, M.R. Wade, F.P. Bymaster, S.M. Paul, and G.G. Nomikos Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody J. Clin. Invest. 116 2006 825 832
3. C.A. Barnes, W. Danysz, and C.G. Parsons Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats Eur. J. Neurosci 8 1996 565 571
4. J. Birks, and R.J. Harvey Donepezil for dementia due to Alzheimer's disease Cochrane Database Syst. Rev. 25 2006
5. K. Blennow, M.J. De Leon, and H. Zetterberg Alzheimer's disease Lancet 368 2006 387 403
6. W.P. Chang, X. Huang, D. Downs, J.R. Cirrito, G. Koelsch, D.M. Holtzman, A.K. Ghosh, and J. Tang β-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice FASEB J. 25 2011 775 784
7. T.A. Comery, R.L. Martone, S. Aschmies, K.P. Atchison, G. Diamantidis, X. Gong, H. Zhou, A.F. Kreft, M.N. Pangalos, J. Sonnenberg-Reines, J.S. Jacobsen, and K.L. Marquis Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease J. Neurosci. 25 2005 8898 8902
8. J.T. Coyle, D.L. Price, and M.R. DeLong Alzheimer's disease: a disorder of cortical cholinergic innervation Science 219 1983 1184 1190
9. P. Davies, and A.J. Maloney Selective loss of central cholinergic neurons in Alzheimer's disease Lancet 2 1976 1403
10. I. Dewachter, R.K. Filipkowski, C. Priller, L. Ris, J. Neyton, S. Croes, D. Terwel, M. Gysemans, H. Devijver, P. Borghgraef, E. Godaux, L. Kaczmarek, J. Herms, and F. Van Leuven Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice Neurobiol. Aging 30 2009 241 256
11. K.T. Dineley, X. Xia, D. Bui, J.D. Sweatt, and H. Zheng Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins J. Biol. Chem. 277 2002 22768 22780
12. H. Dong, C.A. Csernansky, M.V. Martin, A. Bertchume, D. Vallera, and J.G. Csernansky Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease Psychopharmacology 181 2005 145 152
13. H. Dong, C.M. Yuede, C. Coughlan, B. Lewis, and J.G. Csernansky Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease Neuropsychopharmacology 33 2008 3226 3236
14. D. Games, D. Adams, R. Alessandrini, R. Barbour, P. Berthelette, C. Blackwell, T. Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-Wood, K. Khan, M. Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L. Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert, B. Snyder, F. Soriano, H. Tan, J. Vitale, S. Wadsworth, B. Wolozin, and J. Zhao Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein Nature 373 1995 523 527
15. M.J. Ginski, and J.M. Witkin Sensitive and rapid behavioral differentiation of N-methyl-d-aspartate receptor antagonists Psychopharmacology 114 1994 573 582
16. J. Hartmann, C. Kiewert, and J. Klein Neurotransmitters and energy metabolites in amyloid-bearing APP(SWE)xPSEN1dE9 Mouse Brain J. Pharmacol. Exp. Ther. 332 2010 364 370
17. M.B. Hesselink, B.G. De Boer, D.D. Breimer, and W. Danysz Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study Pharm. Res. 16 1999 637 642
18. L. Holcomb, M.N. Gordon, E. McGowan, X. Yu, S. Benkovic, P. Jantzen, K. Wright, I. Saad, R. Mueller, D. Morgan, S. Sanders, C. Zehr, K. O'Campo, J. Hardy, C.M. Prada, C. Eckman, S. Younkin, K. Hsiao, and K. Duff Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes Nat. Med. 4 1998 97 100
19. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
20. P.N. Lacor, M.C. Buniel, P.W. Furlow, A.S. Clemente, P.T. Velasco, M. Wood, K.L. Viola, and W.L. Klein A beta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease J. Neurosci. 27 2007 796 807
21. S. Lesné, M.T. Koh, L. Kotilinek, R. Kayed, C.G. Glabe, A. Yang, M. Gallagher, and K.H. Ashe A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 2006 352 357
22. Q. Liu, Y. Huang, F. Xue, A. Simard, J. DeChon, G. Li, J. Zhang, L. Lucero, M. Wang, M. Sierks, G. Hu, Y. Chang, R.J. Lukas, and J. Wu A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides J. Neurosci. 29 2009 918 929
23. H. Martinez-Coria, K.N. Green, L.M. Billings, M. Kitazawa, M. Albrecht, G. Rammes, C.G. Parsons, S. Gupta, P. Banerjee, and F.M. LaFerla Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice Am. J. Pathol. 176 2010 870 880
24. T. Maurice, and A. Privat SA4503, a novel cognitive enhancer with σ1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice Eur. J. Pharmacol. 328 1997 9 18
25. R. Minkeviciene, P. Banerjee, and H. Tanila Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease J. Pharmacol. Exp. Ther. 311 2004 677 682
26. K. Noda-Saita, A. Yoneyama, Y. Shitaka, Y. Hirai, K. Terai, J. Wu, T. Takeda, K. Hyodo, N. Osakabe, T. Yamaguchi, and M. Okada Quantitative analysis of amyloid plaques in a mouse model of Alzheimer's disease by phase-contrast X-ray computed tomography Neuroscience 138 2006 1205 1213
27. H. Ogura, T. Kosasa, Y. Kuriya, and Y. Yamanishi Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats Methods Find Exp. Clin. Pharmacol. 22 2000 89 95
28. C.G. Parsons, W. Danysz, and G. Quack Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist-a review of preclinical data Neuropharmacology 38 1999 735 767
29. Parsons, C.G., Danysz, W., Quack, G., 2000. Memantineandtheamino-alkyl- cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists-in vitrocharacterisation.AminoAcids19,157-166.
30. S. Pugazhenthi, M. Wang, S. Pham, C.I. Sze, and C.B. Eckman Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons Mol. Neurodegener. 19 2011 6 16
31. B. Reisberg, R. Doody, A. Stöffler, F. Schmitt, S. Ferris, and H.J. Möbius Memantine study group. Memantine in moderate-to-severe Alzheimer's disease N. Engl. J. Med. 348 2003 1333 1341
32. S.L. Rogers, R.S. Doody, R.C. Mohs, and L.T. Friedhoff Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil study group Arch. Intern. Med. 158 1998 1021 1031
33. M. Sadowski, and T. Wisniewski Disease modifying approaches for Alzheimer's pathology Curr. Pharm. Des. 13 2007 1943 1954
34. H. Scholtzova, Y.Z. Wadghiri, M. Douadi, E.M. Sigurdsson, Y.S. Li, D. Quartermain, P. Banerjee, and T. Wisniewski Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging J. Neurosci. Res. 86 2008 2784 2791
35. G.M. Shankar, B.L. Bloodgood, M. Townsend, D.M. Walsh, D.J. Selkoe, and B.L. Sabatini Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway J. Neurosci. 27 2007 2866 2875
36. H. Sugimoto, H. Ogura, Y. Arai, Y. Limura, and Y. Yamanishi Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor Jpn. J. Pharmacol. 89 2002 7 20
37. A. Takeuchi, M.C. Irizarry, K. Duff, T.C. Saido, K. Hsiao Ashe, M. Hasegawa, D.M. Mann, B.T. Hyman, and T. Iwatsubo Age-related amyloid β deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid β precursor protein swedish mutant is not associated with global neuronal loss Am. J. Pathol. 157 2000 331 339
38. F. Trinchese, S. Liu, F. Battalia, S. Walter, P.M. Mathews, and O. Arancio Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice Ann. Neurol. 55 2004 801 814
39. D. Van Dam, and P.P. De Deyn Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model Eur. Neuropsychopharmacol. 16 2006 59 69
40. D. Van Dam, K. Coen, and P.P. De Deyn Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease Psychopharmacology 197 2008 37 43
41. K. Wakabayashi, M. Narisawa-Saito, Y. Iwakura, T. Arai, K. Ikeda, H. Takahashi, and H. Nawa Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease Neurobiol. Aging 20 1999 287 295
42. T. Watanabe, N. Yamagata, K. Takasaki, K. Sano, K. Hayakawa, S. Katsurabayashi, N. Egashira, K. Mishima, K. Iwasaki, and M. Fujiwara Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer's disease Brain Res. 1249 2009 222 228
43. K. Welsh, N. Butters, J. Hughes, R. Mohs, and A. Heyman Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures Arch. Neurol. 48 1991 278 281