Immunosuppression after sepsis: Systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Markwart, Robby ^a   Condotta, Stephanie A ^b   Requardt, Robert P ^a   Borken, Farina ^a   Schubert, Katja ^a   Weigel, Cynthia ^a   Bauer, Michael ^a   Griffith, Thomas S ^c,d   Förster, Martin ^a   Brunkhorst, Frank M ^a   Badovinac, Vladimir P ^b   Rubio, Ignacio ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY OF IOWA   (United States)

^c Minneapolis Veterans Affairs Health Care System University   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; T LYMPHOCYTE RECEPTOR; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL LOSS; CELLULAR IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOKINE RESPONSE; EX VIVO STUDY; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PERITONITIS; SEPSIS; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE; UPREGULATION; ADAPTIVE IMMUNITY; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; COMPLICATION; CYTOLOGY; DISEASE MODEL; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; METABOLISM; TRANSGENIC MOUSE;

ADAPTIVE IMMUNITY; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOSUPPRESSION; INFLAMMATION; LYMPHOPENIA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SEPSIS; T-LYMPHOCYTES;

EID: 84919922592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115094     Document Type: Article

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