IL-1 acts on T cells to enhance the magnitude of in vivo immune responses

Cytokine

Volumn 56, Issue 1, 2011, Pages 122-125

  Ben Sasson, S Z ^a   Caucheteux, Stephane ^a   Crank, Michelle ^a   Hu Li, Jane ^a   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

CD4; CD8; IL 1 receptor; IL 1RA; Lipopolysaccharide

Indexed keywords

CYTOKINE; GRANZYME B; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ANTIGEN SPECIFICITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNIZATION; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TH17 CELL;

ANIMALS; CROSS-PRIMING; HUMANS; IMMUNITY; INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-1; T-LYMPHOCYTES; VACCINES;

EID: 80052776071     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.07.006     Document Type: Review

References (11)

1. Gery I., Gershon R.K., Waksman B.H. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. J Exp Med 1972, 136:128-142.
2. Arden L., et al. Revised nomenclature for antigen-nonspecific T cell proliferation and helper factors. J Immunol 1979, 123:2928-2929.
3. Khoruts A., Osness R.E., Jenkins M.K. IL-2 acts on antigen presenting cells to enhance the in vivo proliferation of antigen-stimulated naïve CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands. Eur J Immunol 2004, 34:10085-10090.
4. Ben-Sasson S.Z., Hu-Li J., Quiel J., Cauchetaux S., Ratner M., Shapira I., et al. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci USA 2009, 106:7119-7124.
5. Vallabhapurapu S., Karin M. Regulation and function of NF-κB transcription factors in the immune system. Ann Rev Immuol 2009, 27:693-733.
6. Guo L., Wei G., Zhu J., Liao W., Leonard W.J., Zhao K., et al. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci USA 2009, 106:13463-13468.
7. Rochman I., Paul W.E., Ben-Sasson S.Z. IL-6 increases primed cell expansion and survival. J Immunol 2005, 174:4761-4767.
8. Helle M., Boeije L., Aarden L.A. IL-6 is an intermediate in IL-1-induced thymocyte proliferation. J Immunol 1989, 142:43335-43338.
9. Chung Y., Chang S.H., Martinez G.J., Yang X.O., Nurieva R., Kang H.S., et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 2009, 30:576-587.
10. Gulen M.F., Kang Z., Bulek K., Youzhong W., Kim T.W., Chen Y., et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010, 32:54-66.
11. Lee W.W., Kang S.W., Choi J., Lee S.H., Shah K., Evnon E.E., et al. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2010, 115:530-540.