Metabolic engineering of Enterobacter cloacae for high-yield production of enantiopure (2R,3R)-2,3-butanediol from lignocellulose-derived sugars

Metabolic Engineering

Volumn 28, Issue , 2015, Pages 19-27

  Li, Lixiang ^a,b   Li, Kun ^a   Wang, Yu ^b   Chen, Chao ^a   Xu, Youqiang ^a   Zhang, Lijie ^a   Han, Binbin ^a   Gao, Chao ^a   Tao, Fei ^b   Ma, Cuiqing ^a   Xu, Ping ^b  

^a SHANDONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University   (China)

Author keywords

(2R,3R) 2,3 Butanediol; 2,3 Butanediol dehydrogenase; Carbon catabolite repression; Enterobacter cloacae; Metabolic engineering

Indexed keywords

BIOFUELS; CARBON; CELLULOSE; ENCODING (SYMBOLS); FERMENTATION; GENE ENCODING; GLUCOSE; LIGNIN; METABOLISM; PRODUCTIVITY; TOXICITY;

(2R,3R)-2,3-BUTANEDIOL; 2 ,3-BUTANEDIOL DEHYDROGENASE; BIOSYNTHETIC GENE CLUSTER; BIOTECHNOLOGICAL PRODUCTION; CARBON CATABOLITE REPRESSION; ENTEROBACTER CLOACAE; FED-BATCH FERMENTATION; LIGNOCELLULOSIC HYDROLYSATES;

METABOLIC ENGINEERING;

2,3 BUTANEDIOL; 2,3 BUTANEDIOL DEHYDROGENASE; GLUCOSE; LACTATE DEHYDROGENASE; LIGNOCELLULOSE; UNCLASSIFIED DRUG; XYLOSE; BACTERIAL PROTEIN; BIOFUEL; BUTANEDIOL; LIGNIN;

ARTICLE; BACTERIAL STRAIN; BIOCATALYST; CARBON SOURCE; CATABOLITE REPRESSION; ENTEROBACTER CLOACAE; FED BATCH FERMENTATION; GENE CLUSTER; GENE OVEREXPRESSION; GLUCOSE INTAKE; GLUCOSE UTILIZATION; METABOLIC ENGINEERING; MICROBIAL BIOMASS; NONHUMAN; PRODUCTIVITY; PROMOTER REGION; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM;

BACTERIA (MICROORGANISMS); ENTEROBACTER CLOACAE;

BACTERIAL PROTEINS; BIOFUELS; BUTYLENE GLYCOLS; ENTEROBACTER CLOACAE; GLUCOSE; LIGNIN; METABOLIC ENGINEERING; XYLOSE;

EID: 84919915096     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.11.010     Document Type: Article

References (44)

1. Avci A., Saha B.C., Dien B.S., Kennedy G.J., Cotta M.A. Response surface optimization of corn stover pretreatment using dilute phosphoric acid for enzymatic hydrolysis and ethanol production. Bioresour. Technol. 2013, 130:603-612.
2. Cao N.J., Xia Y.K., Gong C.S., Tsao G.T. Production of 2,3-butanediol from pretreated corncob by Klebsiella oxytoca in the presence of fungal cellulose. Appl. Biochem. Biotechnol. 1997, 63:129-139.
3. Celińska E., Grajek W. Biotechnological production of 2,3-butanediol--current state and prospects. Biotechnol. Adv. 2009, 27:715-725.
4. Cheng K.K., Liu Q., Zhang J.A., Li J.P., Xu J.M., Wang G.H. Improved 2,3-butanediol production from corncob acid hydrolysate by fed-batch fermentation using Klebsiella oxytoca. Process Biochem. 2010, 45:613-616.
5. Clomburg J.M., Gonzalez R. Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology. Appl. Microbiol. Biotechnol. 2010, 86:419-434.
6. De Anda R., Lara A.R., Hernández V., Hernández-Montalvo V., Gosset G., Bolívar F., Ramírez O.T. Replacement of the glucose phosphotransferase transport system by galactose permease reduces acetate accumulation and improves process performance of Escherichia coli for recombinant protein production without impairment of growth rate. Metab. Eng. 2006, 8:281-290.
7. Grover B.P., Garg S.K., Verma J. Production of 2,3-butanediol from wood hydrolysate by Klebsiella pneumonia. World J. Microbiol. Biotechnol. 1990, 6:328-332.
8. Häßler T., Schieder D., Pfaller R., Faulstich M., Sieber V. Enhanced fed-batch fermentation of 2,3-butanediol by Paenibacillus polymyxa DSM 365. Bioresour. Technol. 2012, 124:237-244.
9. Horton R,M., Ho S.N., Pullen J.K., Hunt H.D., Cai Z., Pease L.R. Gene splicing by overlap extension. Methods Enzymol. 1993, 217:270-279.
10. Ji X.J., Huang H., Ouyang P.K. Microbial 2,3-butanediol production: a state-of-the-art review. Biotechnol. Adv. 2011, 29:351-364.
11. Ji X.J., Nie Z.K., Huang H., Ren L.J., Peng C., Ouyang P.K. Elimination of carbon catabolite repression in Klebsiella oxytoca for efficient 2,3-butanediol production from glucose-xylose mixtures. Appl. Microbiol. Biotechnol. 2011, 89:1119-1125.
12. Jiang L.Q., Fang Z., Li X.K., Luo J. Production of 2,3-butanediol from cellulose and Jatropha hulls after ionic liquid pretreatment and dilute-acid hydrolysis. AMB Express 2013, 3:48.
13. Keasling J.D. Synthetic biology and the development of tools for metabolic engineering. Metab. Eng. 2012, 14:189-195.
14. Kim J.H., Block D.E., Mills D.A. Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass. Appl. Microbiol. Biotechnol. 2010, 88:1077-1085.
15. Kim S.J., Seo S.O., Park Y.C., Jin Y.S., Seo J.H. Production of 2,3-butanediol from xylose by engineered Saccharomyces cerevisiae. J. Biotechnol. 2014, 192:376-382. 10.1016/j.jbiotec.2013.12.017.
16. Köpke M., Mihalcea C., Liew F., Tizard J.H., Ali M.S., Conolly J.J., Al-Sinawi B., Simpson S.D. 2,3-Butanediol production by acetogenic bacteria, an alternative route to chemical synthesis, using industrial waste gas. Appl. Environ. Microbiol. 2011, 77:5467-5475.
17. Li L., Wang Y., Zhang L., Ma C., Wang A., Tao F., Xu P. Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineered Escherichia coli. Bioresour. Technol. 2012, 115:111-116.
18. Lian J., Chao R., Zhao H. Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol. Metab. Eng. 2014, 23:92-99.
19. Marwoto B., Nakashimada Y., Kakizono T., Nishio N. Enhancement of (R,R)-2,3-butanediol production from xylose by Paenibacillus polymyxa at elevated temperatures. Biotechnol. Lett. 2002, 24:109-114.
20. Minty J.J., Singer M.E., Scholz S.A., Bae C.H., Ahn J.H., Foster C.E., Liao J.C., Lin X.N. Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass. Proc. Natl. Acad. Sci. USA 2013, 110:14592-14597.
21. Nakashimada Y., Marwoto B., Kashiwamura T., Kakizono T., Nishio N. Enhanced 2,3-butanediol production by addition of acetic acid in Paenibacillus polymyxa. J. Biosci. Bioeng. 2000, 90:661-664.
22. Nicholson W.L. The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase. Appl. Environ. Microbiol. 2008, 74:6832-6838.
23. Qureshi N., Singh V., Liu S., Ezeji T.C., Saha B.C., Cotta M.A. Process integration for simultaneous saccharification, fermentation, and recovery (SSFR): production of butanol from corn stover using Clostridium beijerinckii P260. Bioresour. Technol. 2014, 154:222-228.
24. Ragauskas A.J., Williams C.K., Davison B.H., Britovsek G., Cairney J., Eckert C.A., Frederick W.J., Hallett J.P., Leak D.J., Liotta C.L., Mielenz J.R., Murphy R., Templer R., Tschaplinski T. The path forward for biofuels and biomaterials. Science 2006, 311:484-489.
25. Rogers P., Chen JS., Zidwick M.J. Organic acid and solvent production. Part III: butanol, acetone and isopropanol; 1,3- and 1,2-propanediol production; and 2,3-butanediol production. Prokaryotes 2006, 1:672-755.
26. Sadhu K.M., Matteson D.S., Hurst G.D., Kurosky J.M. (R,R)-2,3-Butanediol as chiral directing group in the synthesis of (αS)-α-chloroboronic esters. Organometallics 1984, 3:804-806.
27. Sambrook J., Russell D.W. Molecular Cloning: A Laboratory Manual 2001, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. 3rd ed.
28. Sheehan J., Himmel M. Enzymes, energy, and the environment: a strategic perspective on the U.S. department of energy[U+05F3]s research and development activities for bioethanol. Biotechnol. Prog. 1999, 15:817-827.
29. Shen X., Lin Y., Jain R., Yuan Q., Yan Y. Inhibition of acetate accumulation leads to enhanced production of (R,R)-2,3-butanediol from glycerol in Escherichia coli. J. Ind. Microbiol. Biotechnol. 2012, 39:1725-1729.
30. Siemerink M.A., Kuit W., López Contreras A.M., Eggink G., van der Oost J., Kengen S.W. D-2,3-butanediol production due to heterologous expression of an acetoin reductase in Clostridium acetobutylicum. Appl. Environ. Microbiol. 2011, 77:2582-2588.
31. Syu M.J. Biological production of 2,3-butanediol. Appl. Microbiol. Biotechnol. 2001, 55:10-18.
32. Vinuselvi P., Kim M.K., Lee S.K., Ghim C.M. Rewiring carbon catabolite repression for microbial cell factory. BMB Rep. 2012, 45:59-70.
33. Wang A., Wang Y., Jiang T., Li L., Ma C., Xu P. Production of 2,3-butanediol from corncob molasses, a waste by-product in xylitol production. Appl. Microbiol. Biotechnol. 2010, 87:965-970.
34. Wang A., Xu Y., Ma C., Gao C., Li L., Wang Y., Tao F., Xu P. Efficient 2,3-butanediol production from cassava powder by a crop-biomass-utilizer, Enterobacter cloacae subsp. dissolvens SDM. PLoS One 2012, 7:e40442.
35. Wang Y., Tao F., Xu P. Glycerol dehydrogenase plays a dual role in glycerol metabolism and 2,3-butanediol formation in Klebsiella pneumoniae. J. Biol. Chem. 2014, 289:6080-6090.
36. Xu Y., Tao F., Ma C., Xu P. New constitutive vectors: useful genetic engineering tools for biocatalysis. Appl. Environ. Microbiol. 2013, 79:2836-2840.
37. Xu Y., Wang A., Tao F., Su F., Tang H., Ma C., Xu P. Genome sequence of Enterobacter cloacae subsp. dissolvens SDM, an efficient biomass-utilizing producer of platform chemical 2,3-butanediol. J. Bacteriol. 2012, 194:897-898.
38. Xu Y., Chu H., Gao C., Tao F., Zhou Z., Li K., Li L., Ma C., Xu P. Systematic metabolic engineering of Escherichia coli for high-yield production of fuel bio-chemical 2,3-butanediol. Metab. Eng. 2014, 23:22-33.
39. Xue Z., Wang L., Ju J., Yu B., Xu P., Ma Y. Efficient production of polymer-grade l-lactic acid from corn stover hydrolysate by thermophilic Bacillus sp. strain XZL4. SpringerPlus 2012, 1:43.
40. Yan Y., Lee C.C., Liao J.C. Enantioselective synthesis of pure (R,R)-2,3-butanediol in Escherichia coli with stereospecific secondary alcohol dehydrogenases. Org. Biomol. Chem. 2009, 7:3914-3917.
41. Yu B., Sun J., Bommareddy R.R., Song L., Zeng A.P. Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12321. Appl. Environ. Microbiol. 2011, 77:4230-4233.
42. Zeng A.P., Sabra W. Microbial production of diols as platform chemicals: recent progresses. Curr. Opin. Biotechnol. 2011, 22:749-757.
43. Zhang L., Sun J., Hao Y., Zhu J., Chu J., Wei D., Shen Y. Microbial production of 2,3-butanediol by a surfactant (serrawettin)-deficient mutant of Serratia marcescens H30. J. Ind. Microbiol. Biotechnol. 2010, 37:857-862.
44. Zhang L., Xu Q., Zhan S., Li Y., Lin H., Sun S., Sha L., Hu K., Guan X., Shen Y. A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30. Appl. Microbiol. Biotechnol. 2014, 98:1175-1184.