Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells

Clinical Immunology

Volumn 156, Issue 2, 2015, Pages 85-97

  Rahman, Sayma ^a   Rehn, Anders ^a   Rahman, Jubayer ^a   Andersson, Jan ^a   Svensson, Mattias ^a   Brighenti, Susanna ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antimicrobial peptide; B cell; Human; Lung; T cell; Tuberculosis

Indexed keywords

25 HYDROXYERGOCALCIFEROL; CALCIFEDIOL; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CD20 ANTIGEN; CD3 ANTIGEN; CD68 ANTIGEN; GAMMA INTERFERON; GRANULYSIN; GRANZYME A; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; MESSENGER RNA; PERFORIN; SYNDECAN 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CLINICAL ARTICLE; CYTOKINE RESPONSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY INFILTRATE; LUNG TUBERCULOSIS; MALE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; UPREGULATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; BIOSYNTHESIS; BLOOD; COMPLICATION; CYTOLOGY; GRANULOMA; IMMUNOLOGY; LUNG; METABOLISM; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PATHOLOGY;

25-HYDROXYVITAMIN D 2; ADULT; ANTIGENS, CD20; ANTIMICROBIAL CATIONIC PEPTIDES; B-LYMPHOCYTES; CALCIFEDIOL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRANULOMA; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKINS; LUNG; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES, REGULATORY; TUBERCULOSIS, PULMONARY; VITAMIN D DEFICIENCY;

EID: 84919897426     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2014.12.003     Document Type: Article

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