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Volumn 23, Issue 1, 2015, Pages 1-15

The critical role of bisphosphonates to target bone cancer metastasis: An overview

Author keywords

Bisphosphonates; Bone metastasis; Cancer; Targeting

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; ETIDRONIC ACID; IBANDRONIC ACID; LIPOSOME; NANOPARTICLE; PAMIDRONIC ACID; RISEDRONIC ACID; ZOLEDRONIC ACID;

EID: 84919880045     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2014.950668     Document Type: Review
Times cited : (58)

References (119)
  • 1
    • 84864367909 scopus 로고    scopus 로고
    • Global cancer transitions according to the Human Development Index (2008-2030): A population-based study
    • Bray F, Jemal A, Grey N, et al. Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol 2012;13:790-801.
    • (2012) Lancet Oncol , vol.13 , pp. 790-801
    • Bray, F.1    Jemal, A.2    Grey, N.3
  • 2
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. New Engl J Med 2004;350:1655-64.
    • (2004) New Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 3
    • 79551505431 scopus 로고    scopus 로고
    • The use of bisphosphonates in cancer treatment
    • Coleman R. The use of bisphosphonates in cancer treatment. Ann New York Acad Sci 2011;1218:3-14.
    • (2011) Ann New York Acad Sci , vol.1218 , pp. 3-14
    • Coleman, R.1
  • 4
    • 77950690023 scopus 로고    scopus 로고
    • Interleukin-6 in bone metastasis and cancer progression
    • Ara T, De Clerck YA. Interleukin-6 in bone metastasis and cancer progression. Eur J Cancer 2010;46:1223-31.
    • (2010) Eur J Cancer , vol.46 , pp. 1223-1231
    • Ara, T.1    De Clerck, Y.A.2
  • 5
    • 0036148327 scopus 로고    scopus 로고
    • Actions of bisphosphonates in animal models of breast cancer
    • Padalecki SS, Guise TA. Actions of bisphosphonates in animal models of breast cancer. Breast Cancer Res 2002;4:35-41.
    • (2002) Breast Cancer Res , vol.4 , pp. 35-41
    • Padalecki, S.S.1    Guise, T.A.2
  • 6
    • 58149387662 scopus 로고    scopus 로고
    • Normal bone anatomy and physiology
    • Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrology 2008;3:S131-9.
    • (2008) Clin J Am Soc Nephrology , vol.3 , pp. S131-S139
    • Clarke, B.1
  • 7
    • 84866705165 scopus 로고    scopus 로고
    • Changes in cytokines of the bone microenvironment during breast cancer metastasis
    • Sosnoski DM, Krishnan V, Kraemer WJ, et al. Changes in cytokines of the bone microenvironment during breast cancer metastasis. Int J Breast Cancer 2012;2012:1-9.
    • (2012) Int J Breast Cancer , vol.2012 , pp. 1-9
    • Sosnoski, D.M.1    Krishnan, V.2    Kraemer, W.J.3
  • 8
    • 33750733277 scopus 로고    scopus 로고
    • Molecular mechanisms of action of bisphosphonates: Current status
    • Roelofs AJ, Thompson K, Gordon S, Rogers MJ. Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res 2006;12:6222s-30s.
    • (2006) Clin Cancer Res , vol.12 , pp. 6222s-6230s
    • Roelofs, A.J.1    Thompson, K.2    Gordon, S.3    Rogers, M.J.4
  • 9
    • 84875722622 scopus 로고    scopus 로고
    • Molecular aspects of cancer cell resistance to chemotherapy
    • Rebucci M, Michiels C. Molecular aspects of cancer cell resistance to chemotherapy. Biochem Pharmacol 2013;85:1219-26.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1219-1226
    • Rebucci, M.1    Michiels, C.2
  • 10
    • 82955229539 scopus 로고    scopus 로고
    • The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy
    • Wu CP, Hsieh CH, Wu YS. The emergence of drug transporter-mediated multidrug resistance to cancer chemotherapy. Mol Pharm 2011;8:1996-2011.
    • (2011) Mol Pharm , vol.8 , pp. 1996-2011
    • Wu, C.P.1    Hsieh, C.H.2    Wu, Y.S.3
  • 11
    • 84890355236 scopus 로고    scopus 로고
    • Enhanced activity of doxorubicin in drug resistant A549 tumor cells by encapsulation of P glycoprotein inhibitor in PLGA based nanovectors
    • Xu L, Li H, Wang Y, et al. Enhanced activity of doxorubicin in drug resistant A549 tumor cells by encapsulation of P glycoprotein inhibitor in PLGA based nanovectors. Oncol Lett 2013;7:387-92.
    • (2013) Oncol Lett , vol.7 , pp. 387-392
    • Xu, L.1    Li, H.2    Wang, Y.3
  • 12
    • 3042796964 scopus 로고    scopus 로고
    • Bisphosphonates: New therapeutic agents for the treatment of bone tumors
    • Heymann D, Ory B, Gouin F, et al. Bisphosphonates: new therapeutic agents for the treatment of bone tumors. Trend Mol Med 2004;10:337-43.
    • (2004) Trend Mol Med , vol.10 , pp. 337-343
    • Heymann, D.1    Ory, B.2    Gouin, F.3
  • 13
    • 0242503684 scopus 로고    scopus 로고
    • New insights into the molecular mechanisms of action of bisphosphonates
    • Rogers, MJ. New insights into the molecular mechanisms of action of bisphosphonates. Curr Pharm Des 2003;9:2643-58.
    • (2003) Curr Pharm des , vol.9 , pp. 2643-2658
    • Rogers, M.J.1
  • 14
    • 0034748323 scopus 로고    scopus 로고
    • The cellular uptake and metabolism of clodronate in RAW 264 macrophages
    • Monkkonen H, Rogers MJ, Makkonen N, et al. The cellular uptake and metabolism of clodronate in RAW 264 macrophages. Pharm Res 2011;18:1550-5.
    • (2011) Pharm Res , vol.18 , pp. 1550-1555
    • Monkkonen, H.1    Rogers, M.J.2    Makkonen, N.3
  • 15
    • 33644748133 scopus 로고    scopus 로고
    • Thematic review series: Lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
    • Lane KT, Beese LS. Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res 2006;47:681-99.
    • (2006) J Lipid Res , vol.47 , pp. 681-699
    • Lane, K.T.1    Beese, L.S.2
  • 16
    • 32044435884 scopus 로고    scopus 로고
    • Isoprenylated proteins
    • McTaggart S. Isoprenylated proteins. Cell Mol Life Sci 2006;63:255-67.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 255-267
    • McTaggart, S.1
  • 17
    • 0036359076 scopus 로고    scopus 로고
    • Alendronate disturbs vesicular trafficking in osteoclasts
    • Alakangas A, Selander K, Mulari M, et al. Alendronate disturbs vesicular trafficking in osteoclasts. Calcif Tissue Int 2002;70:40-7.
    • (2002) Calcif Tissue Int , vol.70 , pp. 40-47
    • Alakangas, A.1    Selander, K.2    Mulari, M.3
  • 18
    • 78751507954 scopus 로고    scopus 로고
    • Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase
    • Ohno K, Mori K, Orita M, Takeuchi M. Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. Curr Med Chem 2011;18:220-33.
    • (2011) Curr Med Chem , vol.18 , pp. 220-233
    • Ohno, K.1    Mori, K.2    Orita, M.3    Takeuchi, M.4
  • 19
    • 69249206543 scopus 로고    scopus 로고
    • The critical role of the bone microenvironment in cancer metastases
    • Casimiro S, Guise TA, Chirgwin J. The critical role of the bone microenvironment in cancer metastases. Mol Cell Endocrinol 2009;310:71-81.
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 71-81
    • Casimiro, S.1    Guise, T.A.2    Chirgwin, J.3
  • 20
    • 13444306377 scopus 로고    scopus 로고
    • Crosstalk between cancer cells and bone microenvironment in bone metastasis
    • Yoneda T, Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem Biophys Res Commun 2005;328:679-87.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 679-687
    • Yoneda, T.1    Hiraga, T.2
  • 21
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009;28:151-66.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 22
    • 52449124146 scopus 로고    scopus 로고
    • Cadherin-11 promotes the metastasis of prostate cancer cells to bone
    • Chu K, Cheng CJ, Ye X, et al. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res 2008;6:1259-67.
    • (2008) Mol Cancer Res , vol.6 , pp. 1259-1267
    • Chu, K.1    Cheng, C.J.2    Ye, X.3
  • 23
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer, trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer, trials and tribulations. Science 2002;295:2387-92.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 24
    • 70450218151 scopus 로고    scopus 로고
    • Cell adhesion molecules: Role and clinical significance in cancer
    • Makrilia N, Kollias A, Manolopoulos L, Syrigos K. Cell adhesion molecules: role and clinical significance in cancer. Cancer Invest 2009;27:1023-37.
    • (2009) Cancer Invest , vol.27 , pp. 1023-1037
    • Makrilia, N.1    Kollias, A.2    Manolopoulos, L.3    Syrigos, K.4
  • 25
    • 84859419686 scopus 로고    scopus 로고
    • Could targeting bone delay cancer progression? Potential mechanisms of action of bisphosphonates
    • Aft R, Perez J-R, Raje N, et al. Could targeting bone delay cancer progression? Potential mechanisms of action of bisphosphonates. Crit Rev Oncol Hematol 2012;82:233-48.
    • (2012) Crit Rev Oncol Hematol , vol.82 , pp. 233-248
    • Aft, R.1    Perez, J.-R.2    Raje, N.3
  • 26
    • 77953225810 scopus 로고    scopus 로고
    • Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
    • Eyles J, Puaux A-L, Wang X, et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest 2010;120:2030-9.
    • (2010) J Clin Invest , vol.120 , pp. 2030-2039
    • Eyles, J.1    Puaux, A.-L.2    Wang, X.3
  • 27
    • 72249093615 scopus 로고    scopus 로고
    • Tumor self-seeding by circulating cancer cells
    • Kim M-Y, Oskarsson T, Acharyya S, et al. Tumor self-seeding by circulating cancer cells. Cell 2009;139:1315-26.
    • (2009) Cell , vol.139 , pp. 1315-1326
    • Kim, M.-Y.1    Oskarsson, T.2    Acharyya, S.3
  • 28
    • 77955497101 scopus 로고    scopus 로고
    • Current and emerging concepts in tumour metastasis
    • Coghlin C, Murray GI. Current and emerging concepts in tumour metastasis. J Pathol 2010;222:1-15.
    • (2010) J Pathol , vol.222 , pp. 1-15
    • Coghlin, C.1    Murray, G.I.2
  • 29
    • 33846269625 scopus 로고    scopus 로고
    • Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells
    • Bellahcene A, Bachelier R, Detry C, et al. Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Res Tr 2007;101:135-48.
    • (2007) Breast Cancer Res Tr , vol.101 , pp. 135-148
    • Bellahcene, A.1    Bachelier, R.2    Detry, C.3
  • 30
    • 77956643639 scopus 로고    scopus 로고
    • Osteomimicry: How tumor cells try to deceive the bone
    • Rucci N, Teti A. Osteomimicry: how tumor cells try to deceive the bone. Front Biosci 2010;2:907-15.
    • (2010) Front Biosci , vol.2 , pp. 907-915
    • Rucci, N.1    Teti, A.2
  • 32
    • 54049091219 scopus 로고    scopus 로고
    • RANKL inhibition in the treatment of bone metastases
    • Lipton A, Jun S. RANKL inhibition in the treatment of bone metastases. Curr Opin Support Palliat Care 2008;2:197-203.
    • (2008) Curr Opin Support Palliat Care , vol.2 , pp. 197-203
    • Lipton, A.1    Jun, S.2
  • 33
    • 84872181358 scopus 로고    scopus 로고
    • Optimal management of bone metastases in breast cancer patients
    • Wong M, Pavlakis N. Optimal management of bone metastases in breast cancer patients. Breast Cancer Target Ther 2011;3:35-60.
    • (2011) Breast Cancer Target Ther , vol.3 , pp. 35-60
    • Wong, M.1    Pavlakis, N.2
  • 34
    • 67649280600 scopus 로고    scopus 로고
    • RANKL inhibition: Clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases
    • Terpos E, Efstathiou E, Christoulas D, et al. RANKL inhibition: clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases. Expert Opin Bio Ther 2009;9:465-79.
    • (2009) Expert Opin Bio Ther , vol.9 , pp. 465-479
    • Terpos, E.1    Efstathiou, E.2    Christoulas, D.3
  • 35
    • 52049103847 scopus 로고    scopus 로고
    • The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
    • Meads MB, Hazlehurst LA, Dalton WS. The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance. Clin Cancer Res 2008;14:2519-26.
    • (2008) Clin Cancer Res , vol.14 , pp. 2519-2526
    • Meads, M.B.1    Hazlehurst, L.A.2    Dalton, W.S.3
  • 36
    • 43749115751 scopus 로고    scopus 로고
    • The bone marrow niche: Habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites
    • Shiozawa Y, Havens A, Pienta K, Taichman R. The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia 2008;22:941-50.
    • (2008) Leukemia , vol.22 , pp. 941-950
    • Shiozawa, Y.1    Havens, A.2    Pienta, K.3    Taichman, R.4
  • 37
    • 25144455552 scopus 로고    scopus 로고
    • Zoledronic acid exerts its antitumor effect in multiple myeloma interfering with the bone marrow microenvironment
    • Corso A, Ferretti E, Lazzarino M. Zoledronic acid exerts its antitumor effect in multiple myeloma interfering with the bone marrow microenvironment. Hematology 2005;10:215-24.
    • (2005) Hematology , vol.10 , pp. 215-224
    • Corso, A.1    Ferretti, E.2    Lazzarino, M.3
  • 38
    • 68949155165 scopus 로고    scopus 로고
    • Bone marrow derived cells in tumor angiogenesis and growth: Are they the good, the bad or the evil?
    • Shaked Y, Voest EE. Bone marrow derived cells in tumor angiogenesis and growth: are they the good, the bad or the evil? Biochimica Biophys Acta Rev Cancer 2009;1796:1-4.
    • (2009) Biochimica Biophys Acta Rev Cancer , vol.1796 , pp. 1-4
    • Shaked, Y.1    Voest, E.E.2
  • 39
    • 77952090934 scopus 로고    scopus 로고
    • EPCs and pathological angiogenesis: When good cells go bad
    • Li Calzi S, Neu MB, Shaw LC, et al. EPCs and pathological angiogenesis: when good cells go bad. Microvasc Res 2010;79:207-16.
    • (2010) Microvasc Res , vol.79 , pp. 207-216
    • Li Calzi, S.1    Neu, M.B.2    Shaw, L.C.3
  • 40
    • 33646408780 scopus 로고    scopus 로고
    • Inhibition of bone-derived insulin-like growth factors by a ligand-specific antibody suppresses the growth of human multiple myeloma in the human adult bone explanted in NOD/SCID mouse
    • Araki K, Sangai T, Miyamoto Si, et al. Inhibition of bone-derived insulin-like growth factors by a ligand-specific antibody suppresses the growth of human multiple myeloma in the human adult bone explanted in NOD/SCID mouse. Int J Cancer 2006;118:2602-8.
    • (2006) Int J Cancer , vol.118 , pp. 2602-2608
    • Araki, K.1    Sangai, T.2    Si, M.3
  • 41
    • 74949144325 scopus 로고    scopus 로고
    • Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment
    • Kimura T, Kuwata T, Ashimine S, et al. Targeting of bone-derived insulin-like growth factor-II by a human neutralizing antibody suppresses the growth of prostate cancer cells in a human bone environment. Clin Cancer Res 2010;16:121-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 121-129
    • Kimura, T.1    Kuwata, T.2    Ashimine, S.3
  • 42
    • 84919883860 scopus 로고    scopus 로고
    • Effect of zoledronic acid acts on the interaction between mesenchymal stem cells and breast cancer cells within the bone microenvironment
    • Normanno N, Gallo M, Lamura L, De Luca A. Effect of zoledronic acid acts on the interaction between mesenchymal stem cells and breast cancer cells within the bone microenvironment. J Clin Oncol 2012;82:233-48.
    • (2012) J Clin Oncol , vol.82 , pp. 233-248
    • Normanno, N.1    Gallo, M.2    Lamura, L.3    De Luca, A.4
  • 43
    • 52049093658 scopus 로고    scopus 로고
    • The urokinase receptor (u-PAR) - A link between tumor cell dormancy and minimal residual disease in bone marrow?
    • Allgayer H, Aguirre-Ghiso JA. The urokinase receptor (u-PAR) - a link between tumor cell dormancy and minimal residual disease in bone marrow? APMIS 2008;116:602-14.
    • (2008) APMIS , vol.116 , pp. 602-614
    • Allgayer, H.1    Aguirre-Ghiso, J.A.2
  • 44
    • 33746620430 scopus 로고    scopus 로고
    • Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency
    • Suzuki M, Mose ES, Montel V, Tarin D. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am J Pathol 2006;169:673-81.
    • (2006) Am J Pathol , vol.169 , pp. 673-681
    • Suzuki, M.1    Mose, E.S.2    Montel, V.3    Tarin, D.4
  • 45
    • 79958852461 scopus 로고    scopus 로고
    • Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44(+)CD24(lo) cancer stem cell phenotype
    • Reuben JM, Lee BN, Gao H, et al. Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44(+)CD24(lo) cancer stem cell phenotype. Eur J Cancer 2011;47:1527-36.
    • (2011) Eur J Cancer , vol.47 , pp. 1527-1536
    • Reuben, J.M.1    Lee, B.N.2    Gao, H.3
  • 46
    • 34548856802 scopus 로고    scopus 로고
    • Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients
    • Watson MA, Ylagan LR, Trinkaus KM. Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients. Clin Cancer Res 2007;13:5001-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 5001-5009
    • Watson, M.A.1    Ylagan, L.R.2    Trinkaus, K.M.3
  • 47
    • 49949087770 scopus 로고    scopus 로고
    • An osteoclast-targeting agent for imaging and therapy of bone metastasis
    • Liu W, Hajibeigi A, Lin M, et al. An osteoclast-targeting agent for imaging and therapy of bone metastasis. Bioorg Med Chem Lett 2008;18:4789-93.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 4789-4793
    • Liu, W.1    Hajibeigi, A.2    Lin, M.3
  • 48
    • 18844450688 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
    • Muller V, Stahmann N, Riethdorf S, et al. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res 2005;11:3678-85.
    • (2005) Clin Cancer Res , vol.11 , pp. 3678-3685
    • Muller, V.1    Stahmann, N.2    Riethdorf, S.3
  • 49
    • 23944466427 scopus 로고    scopus 로고
    • A pooled analysis of bone marrow micrometastasis in breast cancer
    • Braun S, Vogl FD, Naume B. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 2005;353:793-802.
    • (2005) N Engl J Med , vol.353 , pp. 793-802
    • Braun, S.1    Vogl, F.D.2    Naume, B.3
  • 50
    • 34547743433 scopus 로고    scopus 로고
    • Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 65 primary breast carcinomas
    • Schindlbeck C, Kampik T, Janni W. Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 65 primary breast carcinomas. Breast Cancer Res 2005;7:1174-85.
    • (2005) Breast Cancer Res , vol.7 , pp. 1174-1185
    • Schindlbeck, C.1    Kampik, T.2    Janni, W.3
  • 51
    • 33947098505 scopus 로고    scopus 로고
    • Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy
    • Berg A, Berner A, Lilleby W, et al. Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy. Int J Cancer 2007;120:1603-9.
    • (2007) Int J Cancer , vol.120 , pp. 1603-1609
    • Berg, A.1    Berner, A.2    Lilleby, W.3
  • 52
    • 71049146656 scopus 로고    scopus 로고
    • Disseminated tumor cells and the risk of locoregional recurrence in nonmetastatic breast cancer
    • Bidard F-C, Kirova Y, Vincent-Salomon A, et al. Disseminated tumor cells and the risk of locoregional recurrence in nonmetastatic breast cancer. Ann Oncol 2009;20:1836-41.
    • (2009) Ann Oncol , vol.20 , pp. 1836-1841
    • Bidard, F.-C.1    Kirova, Y.2    Vincent-Salomon, A.3
  • 53
    • 50349096764 scopus 로고    scopus 로고
    • Disseminated tumor cells of breast cancer patients: A strong prognostic factor for distant and local relapse
    • Bidard FC, Vincent-Salomon A, Gomme S, et al. Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse. Clin Cancer Res 2008;14:3306-11.
    • (2008) Clin Cancer Res , vol.14 , pp. 3306-3311
    • Bidard, F.C.1    Vincent-Salomon, A.2    Gomme, S.3
  • 54
    • 47649129262 scopus 로고    scopus 로고
    • Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients
    • Brunsvig PF, Flatmark K, Aamdal S, et al. Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients. Lung Cancer 2008;61:170-6.
    • (2008) Lung Cancer , vol.61 , pp. 170-176
    • Brunsvig, P.F.1    Flatmark, K.2    Aamdal, S.3
  • 55
    • 20144385756 scopus 로고    scopus 로고
    • Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer
    • Cristofanilli M, Hayes DF, Budd GT, et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 2005;23:1420-30.
    • (2005) J Clin Oncol , vol.23 , pp. 1420-1430
    • Cristofanilli, M.1    Hayes, D.F.2    Budd, G.T.3
  • 56
    • 33846938350 scopus 로고    scopus 로고
    • Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancer
    • Garcia JA, Rosenberg JE, Weinberg V, et al. Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancer. BJU Int 2007;99:519-24.
    • (2007) BJU Int , vol.99 , pp. 519-524
    • Garcia, J.A.1    Rosenberg, J.E.2    Weinberg, V.3
  • 57
    • 54449101194 scopus 로고    scopus 로고
    • Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment
    • Kollermann J, Weikert S, Schostak M, et al. Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment. J Clin Oncol 2008;26:4928-33.
    • (2008) J Clin Oncol , vol.26 , pp. 4928-4933
    • Kollermann, J.1    Weikert, S.2    Schostak, M.3
  • 58
    • 59449087476 scopus 로고    scopus 로고
    • Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence
    • Morgan TM, Lange PH, Porter MP, et al. Disseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence. Clin Cancer Res 2009;15:677-83.
    • (2009) Clin Cancer Res , vol.15 , pp. 677-683
    • Morgan, T.M.1    Lange, P.H.2    Porter, M.P.3
  • 59
    • 0037301981 scopus 로고    scopus 로고
    • Mechanisms of osteolytic bone metastases inbreast carcinoma
    • Kakonen SM, Mundy GR. Mechanisms of osteolytic bone metastases inbreast carcinoma. Cancer 2003;97:834-9.
    • (2003) Cancer , vol.97 , pp. 834-839
    • Kakonen, S.M.1    Mundy, G.R.2
  • 60
    • 77951224754 scopus 로고    scopus 로고
    • Mechanisms of breast cancer bone metastasis
    • Zhang Y, Ma B, Fan Q. Mechanisms of breast cancer bone metastasis. Cancer Lett 2010;292:1-7.
    • (2010) Cancer Lett , vol.292 , pp. 1-7
    • Zhang, Y.1    Ma, B.2    Fan, Q.3
  • 61
    • 34548454049 scopus 로고    scopus 로고
    • Biology of RANK, RANKL, and osteoprotegerin
    • Boyce BF, Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthrit Res Ther 2007;9:S1.
    • (2007) Arthrit Res Ther , vol.9 , pp. S1
    • Boyce, B.F.1    Xing, L.2
  • 62
    • 70349685313 scopus 로고    scopus 로고
    • Bisphosphonate use in patients with lung cancer and bone metastases: Recommendations of a European expert panel
    • De Marinis F, Eberhardt W, Harper PG, et al. Bisphosphonate use in patients with lung cancer and bone metastases: recommendations of a European expert panel. J Thorac Oncol 2009;4:1280-8.
    • (2009) J Thorac Oncol , vol.4 , pp. 1280-1288
    • De Marinis, F.1    Eberhardt, W.2    Harper, P.G.3
  • 63
    • 79958695940 scopus 로고    scopus 로고
    • Bisphosphonates: The first 40 years
    • Russell RGG. Bisphosphonates: The first 40 years. Bone 2011;49:2-19.
    • (2011) Bone , vol.49 , pp. 2-19
    • Russell, R.G.G.1
  • 64
    • 78649962502 scopus 로고    scopus 로고
    • Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases
    • Aapro M, Saad F, Costa L. Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases. The Oncologist 2010;15:1147-58.
    • (2010) The Oncologist , vol.15 , pp. 1147-1158
    • Aapro, M.1    Saad, F.2    Costa, L.3
  • 65
    • 73949150107 scopus 로고    scopus 로고
    • Effect of bisphosphonates on pain and quality of life in patients with bone metastases
    • Costa L, Major PP. Effect of bisphosphonates on pain and quality of life in patients with bone metastases. Nature Clin Pract Oncol 2009;6:163-74.
    • (2009) Nature Clin Pract Oncol , vol.6 , pp. 163-174
    • Costa, L.1    Major, P.P.2
  • 66
    • 74749097970 scopus 로고    scopus 로고
    • Differences between bisphosphonates in binding affinities for hydroxyapatite
    • Lawson M, Xia Z, Barnett B, et al. Differences between bisphosphonates in binding affinities for hydroxyapatite. J Biomed Mat Res 2010;92:149-55.
    • (2010) J Biomed Mat Res , vol.92 , pp. 149-155
    • Lawson, M.1    Xia, Z.2    Barnett, B.3
  • 67
    • 79955468598 scopus 로고    scopus 로고
    • The angiogenic process as a therapeutic target in cancer
    • Bridges EM, Harris AL. The angiogenic process as a therapeutic target in cancer. Biochem Pharmacol 2011;81:1183-91.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1183-1191
    • Bridges, E.M.1    Harris, A.L.2
  • 68
    • 79958756501 scopus 로고    scopus 로고
    • Bisphosphonates in preclinical bone oncology
    • Clézardin P, Benzaïd I, Croucher PI. Bisphosphonates in preclinical bone oncology. Bone 2011;49:66-70.
    • (2011) Bone , vol.49 , pp. 66-70
    • Clézardin, P.1    Benzaïd, I.2    Croucher, P.I.3
  • 69
    • 77449157439 scopus 로고    scopus 로고
    • Bone metastases from advanced cancers
    • Fitch M, Maxwell C, Ryan C, et al. Bone metastases from advanced cancers. Clin J Oncol Nur 2009;13:701-10.
    • (2009) Clin J Oncol Nur , vol.13 , pp. 701-710
    • Fitch, M.1    Maxwell, C.2    Ryan, C.3
  • 70
    • 74649086008 scopus 로고    scopus 로고
    • Progress in osteoporosis and fracture prevention: Focus on postmenopausal women
    • Saag KG, Geusens P. Progress in osteoporosis and fracture prevention: focus on postmenopausal women. Arthritis Res Ther 2009;11:420-425.
    • (2009) Arthritis Res Ther , vol.11 , pp. 420-425
    • Saag, K.G.1    Geusens, P.2
  • 71
    • 33746926292 scopus 로고    scopus 로고
    • Clodronate-liposome-mediated depletion of tumourassociated macrophages: A new and highly effective antiangiogenic therapy approach
    • Zeisberger SM, Odermatt B, Marty C, et al. Clodronate-liposome-mediated depletion of tumourassociated macrophages: a new and highly effective antiangiogenic therapy approach. Br J Cancer 2006;95:272-81.
    • (2006) Br J Cancer , vol.95 , pp. 272-281
    • Zeisberger, S.M.1    Odermatt, B.2    Marty, C.3
  • 72
    • 73349097532 scopus 로고    scopus 로고
    • Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs
    • Hafeman S, London C, Elmslie R, Dow S. Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs. Cancer Immun Immunother 2010;59:441-52.
    • (2010) Cancer Immun Immunother , vol.59 , pp. 441-452
    • Hafeman, S.1    London, C.2    Elmslie, R.3    Dow, S.4
  • 73
    • 35548960086 scopus 로고    scopus 로고
    • Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity
    • Lipton A, Cook RJ, Major P, et al. Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. Oncologist 2007;12:1035-43.
    • (2007) Oncologist , vol.12 , pp. 1035-1043
    • Lipton, A.1    Cook, R.J.2    Major, P.3
  • 74
    • 66949136282 scopus 로고    scopus 로고
    • Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: A meta-analysis of randomized clinical trials
    • Machado M, Cruz LS, Tannus G, Fonseca M. Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: a meta-analysis of randomized clinical trials. Clin Ther 2009;31:962-79.
    • (2009) Clin Ther , vol.31 , pp. 962-979
    • Machado, M.1    Cruz, L.S.2    Tannus, G.3    Fonseca, M.4
  • 75
    • 79961079796 scopus 로고    scopus 로고
    • Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel- alendronate conjugate on breast cancer bone metastasis mouse model
    • Miller K, Eldar-Boock A, Polyak D, et al. Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel- alendronate conjugate on breast cancer bone metastasis mouse model. Mol Pharm 2011;8:1052-62.
    • (2011) Mol Pharm , vol.8 , pp. 1052-1062
    • Miller, K.1    Eldar-Boock, A.2    Polyak, D.3
  • 76
    • 84864296921 scopus 로고    scopus 로고
    • Alendronate coated poly-lactic-co-glycolic acid (PLGA) nanoparticles for active targeting of metastatic breast cancer
    • Thamake SI, Raut SL, Gryczynski Z, et al. Alendronate coated poly-lactic-co-glycolic acid (PLGA) nanoparticles for active targeting of metastatic breast cancer. Biomaterials 2012;33:7164-73.
    • (2012) Biomaterials , vol.33 , pp. 7164-7173
    • Thamake, S.I.1    Raut, S.L.2    Gryczynski, Z.3
  • 77
    • 77957669507 scopus 로고    scopus 로고
    • Absorption and safety of alendronate, a nitrogen-containing bisphosphonate, after intrapulmonary administration in rats
    • Katsumi H, Nakatani M, Sano J-I, et al. Absorption and safety of alendronate, a nitrogen-containing bisphosphonate, after intrapulmonary administration in rats. Int J Pharm 2010;400:124-30.
    • (2010) Int J Pharm , vol.400 , pp. 124-130
    • Katsumi, H.1    Nakatani, M.2    Sano, J.-I.3
  • 78
    • 61749103586 scopus 로고    scopus 로고
    • Alendronate-induced esophagitis: Possible pathogenic role of hypersensitivity to alendronate
    • Naniwa T, Maeda T, Mizoshita T, et al. Alendronate-induced esophagitis: possible pathogenic role of hypersensitivity to alendronate. Int Med (Tokyo, Japan) 2008;47:2083-5.
    • (2008) Int Med (Tokyo, Japan) , vol.47 , pp. 2083-2085
    • Naniwa, T.1    Maeda, T.2    Mizoshita, T.3
  • 79
    • 82255175215 scopus 로고    scopus 로고
    • Nanotechnologies to use bisphosphonates as potent anticancer agents: The effects of zoledronic acid encapsulated into liposomes
    • Marra M, Salzano G, Leonetti C, et al. Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes. Nanomedicine 2011;7:955-64.
    • (2011) Nanomedicine , vol.7 , pp. 955-964
    • Marra, M.1    Salzano, G.2    Leonetti, C.3
  • 80
    • 4344679079 scopus 로고    scopus 로고
    • Bone cancer pain: The effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis
    • Sevcik MA, Luger NM, Mach DB, et al. Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis. Pain 2004;111:169-80.
    • (2004) Pain , vol.111 , pp. 169-180
    • Sevcik, M.A.1    Luger, N.M.2    Mach, D.B.3
  • 81
    • 84856213743 scopus 로고    scopus 로고
    • Bisphosphonate-decorated lipid nanoparticles designed as drug carriers for bone diseases
    • Wang G, Mostafa NZ, Incani V, et al. Bisphosphonate-decorated lipid nanoparticles designed as drug carriers for bone diseases. J Biomed Mat Res 2012;100:684-93.
    • (2012) J Biomed Mat Res , vol.100 , pp. 684-693
    • Wang, G.1    Mostafa, N.Z.2    Incani, V.3
  • 82
    • 16344365082 scopus 로고    scopus 로고
    • Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems
    • Baliga MS, Meleth S, Katiyar SK. Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems. Clin Cancer Res 2005;11:1918-27.
    • (2005) Clin Cancer Res , vol.11 , pp. 1918-1927
    • Baliga, M.S.1    Meleth, S.2    Katiyar, S.K.3
  • 83
    • 1942501727 scopus 로고    scopus 로고
    • Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: Results from two randomised, placebo-controlled phase III studies
    • Body J-J, Diel I, Lichinitzer M, et al. Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies. Brit J Cancer 2004;90:1133-7.
    • (2004) Brit J Cancer , vol.90 , pp. 1133-1137
    • Body, J.-J.1    Diel, I.2    Lichinitzer, M.3
  • 84
    • 84875245132 scopus 로고    scopus 로고
    • Randomized, double-blinded, placebo-controlled, trial of risedronate for the prevention of bone mineral density loss in nonmetastatic prostate cancer patients receiving radiation therapy plus androgen deprivation therapy
    • Choo R, Lukka H, Cheung P, et al. Randomized, double-blinded, placebo-controlled, trial of risedronate for the prevention of bone mineral density loss in nonmetastatic prostate cancer patients receiving radiation therapy plus androgen deprivation therapy. Int J Radiat Oncol Biol Phys 2013;85:1239-45.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , pp. 1239-1245
    • Choo, R.1    Lukka, H.2    Cheung, P.3
  • 85
    • 33646089442 scopus 로고    scopus 로고
    • Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite
    • Nancollas G, Tang R, Phipps R, et al. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone 2006;38:617-27.
    • (2006) Bone , vol.38 , pp. 617-627
    • Nancollas, G.1    Tang, R.2    Phipps, R.3
  • 86
    • 84885988024 scopus 로고    scopus 로고
    • Adjuvant zoledronic acid therapy for patients with early stage breast cancer: An updated systematic review and meta-analysis
    • He M, Fan W, Zhang X. Adjuvant zoledronic acid therapy for patients with early stage breast cancer: an updated systematic review and meta-analysis. J Hematol Oncol 2013;6:1-8.
    • (2013) J Hematol Oncol , vol.6 , pp. 1-8
    • He, M.1    Fan, W.2    Zhang, X.3
  • 87
    • 63749110469 scopus 로고    scopus 로고
    • The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
    • Hirbe AC, Roelofs AJ, Floyd DH, et al. The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 2009;44:908-16.
    • (2009) Bone , vol.44 , pp. 908-916
    • Hirbe, A.C.1    Roelofs, A.J.2    Floyd, D.H.3
  • 88
    • 17544363336 scopus 로고    scopus 로고
    • Bisphosphonates and bone metastases: Current status and future directions
    • Krempien R, Niethammer A, Harms W, Debus J. Bisphosphonates and bone metastases: current status and future directions. Expert Rev 2005;5:295-305.
    • (2005) Expert Rev , vol.5 , pp. 295-305
    • Krempien, R.1    Niethammer, A.2    Harms, W.3    Debus, J.4
  • 89
    • 10744233992 scopus 로고    scopus 로고
    • Zoledronic acid is superior to pamidronate for the treatment of bone metastasis in breast carcinoma patients with at least one osteolytic lesion
    • Rosen LS, Gordon D, Dugan W. Zoledronic acid is superior to pamidronate for the treatment of bone metastasis in breast carcinoma patients with at least one osteolytic lesion. Cancer 2004;100:36-43.
    • (2004) Cancer , vol.100 , pp. 36-43
    • Rosen, L.S.1    Gordon, D.2    Dugan, W.3
  • 90
    • 79951817613 scopus 로고    scopus 로고
    • The backbone of progress-preclinical studies and innovations with zoledronic acid
    • Green JR, Guenther A. The backbone of progress-preclinical studies and innovations with zoledronic acid. Crit Rev Oncol Hemat 2011;77:S3-12.
    • (2011) Crit Rev Oncol Hemat , vol.77 , pp. S3-S12
    • Green, J.R.1    Guenther, A.2
  • 91
    • 68349160814 scopus 로고    scopus 로고
    • Imaging transforming growth factorbeta signaling dynamics and therapeutic response in breast cancer bone metastasis
    • Korpal M, Yan J, Lu X, et al. Imaging transforming growth factorbeta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nature Med 2009;15:960-6.
    • (2009) Nature Med , vol.15 , pp. 960-966
    • Korpal, M.1    Yan, J.2    Lu, X.3
  • 92
    • 33846523379 scopus 로고    scopus 로고
    • Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma
    • Horie N, Murata H, Kimura S, et al. Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma. Br J Cancer 2007;96:255-61.
    • (2007) Br J Cancer , vol.96 , pp. 255-261
    • Horie, N.1    Murata, H.2    Kimura, S.3
  • 93
    • 28844439011 scopus 로고    scopus 로고
    • Anti-tumour activity of zoledronic acid
    • Philippe Cleźardin P. Anti-tumour activity of zoledronic acid. Cancer Treat Rev 2005;31:S1-8.
    • (2005) Cancer Treat Rev , vol.31 , pp. S1-S8
    • Philippe Cleźardin, P.1
  • 94
    • 84862830241 scopus 로고    scopus 로고
    • Bone metastasis targeting: A novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel
    • Chaudhari KR, Kumar A, Khandelwal MVK, et al. Bone metastasis targeting: a novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel. J Control Release 2012;158:470-8.
    • (2012) J Control Release , vol.158 , pp. 470-478
    • Chaudhari, K.R.1    Kumar, A.2    Khandelwal, M.V.K.3
  • 95
    • 33846834057 scopus 로고    scopus 로고
    • Bone targeting potential of bisphosphonate-targeted liposomes: Preparation, characterization and hydroxyapatite binding in vitro
    • Hengst V, Oussoren C, Kissel T, Storm G. Bone targeting potential of bisphosphonate-targeted liposomes: preparation, characterization and hydroxyapatite binding in vitro. Int J Pharm 2007;331:224-7.
    • (2007) Int J Pharm , vol.331 , pp. 224-227
    • Hengst, V.1    Oussoren, C.2    Kissel, T.3    Storm, G.4
  • 96
    • 67649947124 scopus 로고    scopus 로고
    • Synthesis of calcium phosphate-binding liposome for drug delivery
    • Anada T, Takeda Y, Honda Y, et al. Synthesis of calcium phosphate-binding liposome for drug delivery. Bioorg Med Chem Lett 2009;19:4148-50.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4148-4150
    • Anada, T.1    Takeda, Y.2    Honda, Y.3
  • 97
    • 33646080124 scopus 로고    scopus 로고
    • Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
    • Leu C-T, Luegmayr E, Freedman LP, et al. Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy. Bone 2006;38:628-36.
    • (2006) Bone , vol.38 , pp. 628-636
    • Leu, C.-T.1    Luegmayr, E.2    Freedman, L.P.3
  • 98
    • 34548033267 scopus 로고    scopus 로고
    • Design of surface-modified poly (D, L -lactide-co-glycolide) nanoparticles for targeted drug delivery to bone
    • Choi S-W, Kim J-H. Design of surface-modified poly (D, L -lactide-co-glycolide) nanoparticles for targeted drug delivery to bone. J Control Release 2007;122:24-30.
    • (2007) J Control Release , vol.122 , pp. 24-30
    • Choi, S.-W.1    Kim, J.-H.2
  • 99
    • 67649911249 scopus 로고    scopus 로고
    • A novel biomaterial for osteotropic drug nanocarriers: Synthesis and biocompatibility evaluation of a PLGA-ALE conjugate
    • Pignatello R, Cenni E, Micieli D, et al. A novel biomaterial for osteotropic drug nanocarriers: synthesis and biocompatibility evaluation of a PLGA-ALE conjugate. Nanomedicine 2009;4:161-75.
    • (2009) Nanomedicine , vol.4 , pp. 161-175
    • Pignatello, R.1    Cenni, E.2    Micieli, D.3
  • 100
    • 0027406163 scopus 로고
    • High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse
    • Bain SD, Bailey MC, Celino DL, et al. High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse. J Bone Miner Res 1993;8:435-42.
    • (1993) J Bone Miner Res , vol.8 , pp. 435-442
    • Bain, S.D.1    Bailey, M.C.2    Celino, D.L.3
  • 101
    • 0029056755 scopus 로고
    • The use of estrogens and progestins and the risk of breast cancer in postmenopausal women
    • Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. New Engl J Med 1995;332:1589-93.
    • (1995) New Engl J Med , vol.332 , pp. 1589-1593
    • Colditz, G.A.1    Hankinson, S.E.2    Hunter, D.J.3
  • 102
    • 0031945527 scopus 로고    scopus 로고
    • Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug-IV - Effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats
    • Fujisaki J, Tokunaga Y, Takahashi T, et al. Osteotropic drug delivery system (ODDS) based on bisphosphonic prodrug-IV - effects of osteotropic estradiol on bone mineral density and uterine weight in ovariectomized rats. J Drug Target 1998;5:129-38.
    • (1998) J Drug Target , vol.5 , pp. 129-138
    • Fujisaki, J.1    Tokunaga, Y.2    Takahashi, T.3
  • 103
    • 0029666168 scopus 로고    scopus 로고
    • Effect of 17β-estradiolbisphosphonate conjugates, potential bone-seeking estrogen prodrugs, on 17β-estradiol serum kinetics and bone mass in rats
    • Bauss F, Esswein A, Reiff K, et al. Effect of 17β-estradiolbisphosphonate conjugates, potential bone-seeking estrogen prodrugs, on 17β-estradiol serum kinetics and bone mass in rats. Calcif Tissue Int 1996;59:168-73.
    • (1996) Calcif Tissue Int , vol.59 , pp. 168-173
    • Bauss, F.1    Esswein, A.2    Reiff, K.3
  • 104
    • 75149155164 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens
    • Morioka M, Kamizono A, Takikawa H, et al. Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens. Bioorg Med Chem 2010;18:1143-8.
    • (2010) Bioorg Med Chem , vol.18 , pp. 1143-1148
    • Morioka, M.1    Kamizono, A.2    Takikawa, H.3
  • 105
    • 84857924218 scopus 로고    scopus 로고
    • Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis
    • Arns S, Gibe R, Moreau A, et al. Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis. Bioorg Med Chem Lett 2012;20:2131-40.
    • (2012) Bioorg Med Chem Lett , vol.20 , pp. 2131-2140
    • Arns, S.1    Gibe, R.2    Moreau, A.3
  • 106
    • 79961076051 scopus 로고    scopus 로고
    • Dendritic poly (ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms
    • Clementi C, Miller K, Mero A, et al. Dendritic poly (ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms. Mol Pharm 2011;8:1063-72.
    • (2011) Mol Pharm , vol.8 , pp. 1063-1072
    • Clementi, C.1    Miller, K.2    Mero, A.3
  • 107
    • 52449095881 scopus 로고    scopus 로고
    • EANM procedure guideline for treatment of refractory metastatic bone pain
    • Bodei L, Lam M, Chiesa C, et al. EANM procedure guideline for treatment of refractory metastatic bone pain. Eur J Nucl Med Mol Imaging 2008;35:1934-40.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 1934-1940
    • Bodei, L.1    Lam, M.2    Chiesa, C.3
  • 108
    • 74949105909 scopus 로고    scopus 로고
    • Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain
    • Paes FM, Serafini AN. Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain. Semin Nucl Med 2010;40:89-104.
    • (2010) Semin Nucl Med , vol.40 , pp. 89-104
    • Paes, F.M.1    Serafini, A.N.2
  • 109
    • 0026704553 scopus 로고
    • Pharmacokinetics of rhenium-186 after administration of rhenium-186-HEDP to patients with bone metastases
    • De Klerk J, Van Dijk A, Zonnenberg B, Rijk P. Pharmacokinetics of rhenium-186 after administration of rhenium-186-HEDP to patients with bone metastases. J Nucl Med 1992;33:646-51.
    • (1992) J Nucl Med , vol.33 , pp. 646-651
    • De Klerk, J.1    Van Dijk, A.2    Zonnenberg, B.3    Rijk, P.4
  • 110
    • 33847334389 scopus 로고    scopus 로고
    • 186Re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model
    • 186Re-complex-conjugated bisphosphonate for the palliation of metastatic bone pain in an animal model. J Nucl Med 2007;48:122-7.
    • (2007) J Nucl Med , vol.48 , pp. 122-127
    • Ogawa, K.1    Mukai, T.2    Asano, D.3
  • 111
    • 77952576745 scopus 로고    scopus 로고
    • 188Re (CO) 3-dipicolylamine-alendronate: A new bisphosphonate conjugate for the radiotherapy of bone metastases
    • 188Re (CO) 3-dipicolylamine-alendronate: a new bisphosphonate conjugate for the radiotherapy of bone metastases. Bioconjugate Chem 2010;21:811-15.
    • (2010) Bioconjugate Chem , vol.21 , pp. 811-815
    • Torres Martin De Rosales, R.1    Finucane, C.2    Foster, J.3
  • 112
    • 77954757272 scopus 로고    scopus 로고
    • A promising approach for treatment of tumor-induced bone diseases: Utilizing bisphosphonate derivatives of nucleoside antimetabolites
    • Reinholz MM, Zinnen SP, Dueck AC, et al. A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. Bone 2010;47:12-22.
    • (2010) Bone , vol.47 , pp. 12-22
    • Reinholz, M.M.1    Zinnen, S.P.2    Dueck, A.C.3
  • 113
    • 84855783521 scopus 로고    scopus 로고
    • Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials
    • McPherson III JC, Runner R, Buxton TB, et al. Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials. Eur J Med Chem 2012;47:615-18.
    • (2012) Eur J Med Chem , vol.47 , pp. 615-618
    • McPherson, J.C.1    Runner, R.2    Buxton, T.B.3
  • 114
    • 84857912381 scopus 로고    scopus 로고
    • Synthesis, characterization and evaluation of bone targeting salmon calcitonin analogs in normal and osteoporotic rats
    • Bhandari KH, Newa M, Chapman J, Doschak MR. Synthesis, characterization and evaluation of bone targeting salmon calcitonin analogs in normal and osteoporotic rats. J Control Release 2012;158:44-52.
    • (2012) J Control Release , vol.158 , pp. 44-52
    • Bhandari, K.H.1    Newa, M.2    Chapman, J.3    Doschak, M.R.4
  • 115
    • 26944464230 scopus 로고    scopus 로고
    • A comparison of mineral affinity of bisphosphonate-protein conjugates constructed with disulfide and thioether linkages
    • Wright JE, Gittens SA, Bansal G, et al. A comparison of mineral affinity of bisphosphonate-protein conjugates constructed with disulfide and thioether linkages. Biomaterials 2006;27:769-84.
    • (2006) Biomaterials , vol.27 , pp. 769-784
    • Wright, J.E.1    Gittens, S.A.2    Bansal, G.3
  • 116
    • 38949211069 scopus 로고    scopus 로고
    • Ligand-modified aminobisphosphonate for linking proteins to hydroxyapatite and bone surface
    • Ehrick RS, Capaccio M, Puleo DA, Bachas LG. Ligand-modified aminobisphosphonate for linking proteins to hydroxyapatite and bone surface. Bioconjugate Chem 2007;19:315-21.
    • (2007) Bioconjugate Chem , vol.19 , pp. 315-321
    • Ehrick, R.S.1    Capaccio, M.2    Puleo, D.A.3    Bachas, L.G.4
  • 117
    • 34547095490 scopus 로고    scopus 로고
    • Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties
    • Murphy MB, Hartgerink JD, Goepferich A, Mikos AG. Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties. Biomacromolecules 2007;8:2237-43.
    • (2007) Biomacromolecules , vol.8 , pp. 2237-2243
    • Murphy, M.B.1    Hartgerink, J.D.2    Goepferich, A.3    Mikos, A.G.4
  • 118
    • 84858002781 scopus 로고    scopus 로고
    • Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
    • Guan M, Yao W, Liu R, et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med 2012;18:456-62.
    • (2012) Nat Med , vol.18 , pp. 456-462
    • Guan, M.1    Yao, W.2    Liu, R.3
  • 119
    • 79955130099 scopus 로고    scopus 로고
    • Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymeralendronate-TNP-470 conjugate in the treatment of bone malignances
    • Segal E, Pan H, Benayoun L, et al. Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymeralendronate-TNP-470 conjugate in the treatment of bone malignances. Biomaterials 2011;32:4450-63.
    • (2011) Biomaterials , vol.32 , pp. 4450-4463
    • Segal, E.1    Pan, H.2    Benayoun, L.3


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