Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs

Cancer Immunology, Immunotherapy

Volumn 59, Issue 3, 2010, Pages 441-452

  Hafeman, Scott ^a   London, Cheryl ^b   Elmslie, Robyn ^c   Dow, Steven ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Veterinary Referral Center of Colorado   (United States)

Author keywords

Bisphosphonate; Cancer; Dendritic cell; Immune; Macrophage

Indexed keywords

CARBOPLATIN; CLODRONIC ACID; LIPOSOME; LOMUSTINE; PREDNISONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL KILLING; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; EXPERIMENTAL DOG; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MALIGNANT HISTIOCYTOSIS; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR REGRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CLODRONIC ACID; DOG DISEASES; DOGS; HISTIOCYTIC SARCOMA; LIPOSOMES; MACROPHAGES; MONOCYTES;

EID: 73349097532     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-009-0763-y     Document Type: Article

References (43)

1. VK Affolter PF Moore 2000 Canine cutaneous and systemic histiocytosis: reactive histiocytosis of dermal dendritic cells Am J Dermatopathol 22 40 48 10.1097/00000372-200002000-00009 1:STN:280:DC%2BD3c7mt1SnsA%3D%3D 10698216 (Pubitemid 30109083)
2. VK Affolter PF Moore 2002 Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs Vet Pathol 39 74 83 10.1354/vp.39-1-74 1:STN:280:DC%2BD38zlvVOkuw%3D%3D 12102221
3. F Alves-Rosa C Stanganelli J Cabrera N van Rooijen MS Palermo MA Isturiz 2000 Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model Blood 96 2834 2840 1:CAS:528:DC%2BD3cXnt12gtrY%3D 11023519
4. RC Bird P Deinnocentes S Lenz EE Thacker DT Curiel BF Smith 2008 An allogeneic hybrid-cell fusion vaccine against canine mammary cancer Vet Immunol Immunopathol 123 289 304 10.1016/j.vetimm.2008.02.013 1:CAS:528: DC%2BD1cXlvF2qtrs%3D 18423623
5. P Bucsky RM Egeler 1998 Malignant histiocytic disorders in children. Clinical and therapeutic approaches with a nosologic discussion Hematol Oncol Clin North Am 12 465 471 10.1016/S0889-8588(05)70523-2 1:STN:280: DyaK1c3it1OhtA%3D%3D 9561913 (Pubitemid 28175893)
6. MG Cecchini R Felix H Fleisch PH Cooper 1987 Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages J Bone Miner Res 2 135 142 1:CAS:528:DyaL2sXkvV2rtrc%3D 3455162
7. P Clezardin P Fournier S Boissier O Peyruchaud 2003 In vitro and in vivo antitumor effects of bisphosphonates Curr Med Chem 10 173 180 1:CAS:528:DC%2BD3sXlt1CrtA%3D%3D 12570716
8. SW Dow RE Elmslie AP Willson L Roche C Gorman TA Potter 1998 In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma J Clin Invest 101 2406 2414 10.1172/JCI510 1:CAS:528:DyaK1cXjvVWrurY%3D 9616212
9. JC Frith J Monkkonen S Auriola H Monkkonen MJ Rogers 2001 The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis Arthritis Rheum 44 2201 2210 10.1002/1529-0131(200109)44:9<2201::AID-ART374>3.0.CO;2-E 1:CAS:528:DC%2BD3MXpt12lt7g%3D 11592386 (Pubitemid 33644066)
10. JC Frith J Monkkonen GM Blackburn RG Russell MJ Rogers 1997 Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro J Bone Miner Res 12 1358 1367 10.1359/jbmr.1997.12.9.1358 1:CAS:528:DyaK2sXmt1Wks7s%3D 9286751 (Pubitemid 27375378)
11. S Gazzaniga AI Bravo A Guglielmotti N van Rooijen F Maschi A Vecchi A Mantovani J Mordoh R Wainstok 2007 Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft J Invest Dermatol 127 2031 2041 10.1038/sj.jid.5700827 1:CAS:528:DC%2BD2sXns1yls78%3D 17460736 (Pubitemid 47075380)
12. JR Green 2003 Antitumor effects of bisphosphonates Cancer 97 840 847 10.1002/cncr.11128 12548584
13. DM Howarth GS Gilchrist BP Mullan GA Wiseman JH Edmonson PJ Schomberg 1999 Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome Cancer 85 2278 2290 10.1002/(SICI)1097-0142(19990515)85:10<2278::AID- CNCR25>3.0.CO;2-U 1:STN:280:DyaK1M3ls1Knsw%3D%3D 10326709 (Pubitemid 29215570)
14. DE Hughes KR Wright HL Uy A Sasaki T Yoneda GD Roodman GR Mundy BF Boyce 1995 Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo J Bone Miner Res 10 1478 1487 1:CAS:528:DyaK2MXpsFGmsbo%3D 8686503
15. MB Jordan N van Rooijen S Izui J Kappler P Marrack 2003 Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model Blood 101 594 601 10.1182/blood-2001-11-0061 1:CAS:528: DC%2BD3sXkvVWruw%3D%3D 12393630 (Pubitemid 36077582)
16. L Lauren T Osterman T Karhi 1991 Pharmacokinetics of clodronate after single intravenous, intramuscular and subcutaneous injections in rats Pharmacol Toxicol 69 365 368 10.1111/j.1600-0773.1991.tb01312.x 1:CAS:528: DyaK38XhsFeitw%3D%3D 1839447
17. PP Lehenkari M Kellinsalmi JP Napankangas KV Ylitalo J Monkkonen MJ Rogers A Azhayev HK Vaananen IE Hassinen 2002 Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite Mol Pharmacol 61 1255 1262 10.1124/mol.61.5.1255 1:CAS:528:DC%2BD38XjtlGksr8%3D 11961144 (Pubitemid 34441791)
18. JH Lin 1996 Bisphosphonates: a review of their pharmacokinetic properties Bone 18 75 85 10.1016/8756-3282(95)00445-9 1:CAS:528:DyaK28XisVGjs7g%3D 8833200 (Pubitemid 26092586)
19. JD Loike SC Silverstein 1983 A fluorescence quenching technique using trypan blue to differentiate between attached and ingested glutaraldehyde-fixed red blood cells in phagocytosing murine macrophages J Immunol Methods 57 373 379 10.1016/0022-1759(83)90097-2 1:STN:280:DyaL3s7jslWksw%3D%3D 6402550
20. MacEwen EG, Withrow SJ (1996) Small animal clinical oncology. Saunders Co, Philadelphia, PA
21. M Mathes M Jordan S Dow 2006 Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs Exp Hematol 34 1393 1402 10.1016/j.exphem.2006.05.014 1:CAS:528:DC%2BD28Xps1Omu7c%3D 16982332 (Pubitemid 44374833)
22. J Monkkonen TD Heath 1993 The effects of liposome-encapsulated and free clodronate on the growth of macrophage-like cells in vitro: the role of calcium and iron Calcif Tissue Int 53 139 146 10.1007/BF01321893 1:CAS:528: DyaK2cXht1Crtr0%3D 8402323
23. J Monkkonen M Taskinen SO Auriola A Urtti 1994 Growth inhibition of macrophage-like and other cell types by liposome-encapsulated, calcium-bound, and free bisphosphonates in vitro J Drug Target 2 299 308 10.3109/ 10611869409015910 1:CAS:528:DyaK2MXitVKrtrc%3D 7858955
24. KJ Moore G Matlashewski 1994 Intracellular infection by Leishmania donovani inhibits macrophage apoptosis J Immunol 152 2930 2937 1:CAS:528:DyaK2cXisVagt7Y%3D 8144893
25. PF Moore VK Affolter W Vernau 2006 Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages Vet Pathol 43 632 645 10.1354/vp.43-5-632 1:STN:280:DC%2BD28rkt1enug%3D%3D 16966440 (Pubitemid 44379939)
26. AJ Roelofs K Thompson S Gordon MJ Rogers 2006 Molecular mechanisms of action of bisphosphonates: current status Clin Cancer Res 12 6222s 6230s 10.1158/1078-0432.CCR-06-0843 1:CAS:528:DC%2BD28XhtFWhsbfI 17062705 (Pubitemid 44703794)
27. MJ Rogers S Gordon HL Benford FP Coxon SP Luckman J Monkkonen JC Frith 2000 Cellular and molecular mechanisms of action of bisphosphonates Cancer 88 2961 2978 10.1002/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L 1:CAS:528:DC%2BD3cXksVCmsLw%3D 10898340
28. K Selander P Lehenkari HK Vaananen 1994 The effects of bisphosphonates on the resorption cycle of isolated osteoclasts Calcif Tissue Int 55 368 375 10.1007/BF00299317 1:CAS:528:DyaK2MXhvFWhtLw%3D 7532540 (Pubitemid 24332745)
29. KS Selander J Monkkonen EK Karhukorpi P Harkonen R Hannuniemi HK Vaananen 1996 Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages Mol Pharmacol 50 1127 1138 1:CAS:528:DyaK28XntFCqsrk%3D 8913344
30. P Serafini I Borrello V Bronte 2006 Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression Semin Cancer Biol 16 53 65 10.1016/j.semcancer.2005.07.005 1:CAS:528: DC%2BD28XotVCmuw%3D%3D 16168663 (Pubitemid 43139709)
31. KA Skorupski CA Clifford MC Paoloni A Lara-Garcia L Barber MS Kent AK LeBlanc A Sabhlok EA Mauldin FS Shofer CG Couto KU Sorenmo 2007 CCNU for the treatment of dogs with histiocytic sarcoma J Vet Int Med 21 121 126 10.1892/0891-6640(2007)21[121:CFTTOD]2.0.CO;2 (Pubitemid 46266156)
32. PR Twentyman M Luscombe 1987 A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity Br J Cancer 56 279 285 1:STN:280:DyaL1c%2FisVOisQ%3D%3D 3663476
33. M van Engeland LJ Nieland FC Ramaekers B Schutte CP Reutelingsperger 1998 Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure Cytometry 31 1 9 10.1002/(SICI)1097-0320(19980101) 31:1<1::AID-CYTO1>3.0.CO;2-R 9450519 (Pubitemid 28050057)
34. N van Rooijen N Kors 1989 Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen Calcif Tissue Int 45 153 156 10.1007/BF02556058 2505906
35. N van Rooijen N Kors H ter Hart E Claassen 1988 In vitro and in vivo elimination of macrophage tumor cells using liposome-encapsulated dichloromethylene diphosphonate Virchows Arch B Cell Pathol Incl Mol Pathol 54 241 245 10.1007/BF02899217 2895535
36. N Van Rooijen A Sanders 1994 Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications J Immunol Methods 174 83 93 10.1016/0022-1759(94)90012-4 8083541 (Pubitemid 124013923)
37. N van Rooijen A Sanders TK van den Berg 1996 Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine J Immunol Methods 193 93 99 10.1016/0022-1759(96)00056-7 8690935 (Pubitemid 26184748)
38. I Vermes C Haanen H Steffens-Nakken C Reutelingsperger 1995 A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V J Immunol Methods 184 39 51 10.1016/0022-1759(95)00072-I 1:CAS:528:DyaK2MXnt1Ojsbo%3D 7622868
39. K Villikka K Perttunen J Rosnell H Ikavalko H Vaho L Pylkkanen 2002 The absolute bioavailability of clodronate from two different oral doses Bone 31 418 421 10.1016/S8756-3282(02)00841-4 1:CAS:528:DC%2BD38XmvVCktbY%3D 12231416 (Pubitemid 35299623)
40. ML Wellman S Krakowka RM Jacobs GJ Kociba 1988 A macrophage-monocyte cell line from a dog with malignant histiocytosis In Vitro Cell Dev Biol 24 223 229 10.1007/BF02623551 1:STN:280:DyaL1c7mvFCgtw%3D%3D 3350786
41. B Willis A Ablin V Weinberg S Zoger WM Wara KK Matthay 1996 Disease course and late sequelae of Langerhans' cell histiocytosis: 25-year experience at the University of California, San Francisco J Clin Oncol 14 2073 2082 1:STN:280:DyaK283otlWhtQ%3D%3D 8683239
42. R Zavodovskaya AT Liao CL Jones B Yip MB Chien PF Moore CA London 2006 Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs Am J Vet Res 67 633 641 10.2460/ajvr.67.4.633 1:CAS:528:DC%2BD28Xjslahtbs%3D 16579756
43. SM Zeisberger B Odermatt C Marty AH Zehnder-Fjallman K Ballmer-Hofer RA Schwendener 2006 Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach Br J Cancer 95 272 281 10.1038/sj.bjc.6603240 1:CAS:528:DC%2BD28Xnsl2iu7o%3D 16832418 (Pubitemid 44187587)