Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1143-1148

  Morioka, Masahiko ^a,c   Kamizono, Akihito ^a   Takikawa, Hirosato ^b   Mori, Akihisa ^a   Ueno, Hiroaki ^a   Kadowaki, Shu ichiro ^a   Nakao, Yoshihide ^a   Kato, Kuniki ^c   Umezawa, Kazuo ^c  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Bisphosphonate; Estrogen; Osteoporosis

Indexed keywords

3 [3 (BIS PHOSPHONOMETHYL)UREIDO]PROPIONIC ACID 3 HYDROXY 1,3,5 ESTRATRIEN 17 YL ESTER 2 SODIUM SALT; [[3 (17 HYDROXY 1,3,5 ESTRATRIEN 3 YLOXYCARBONYLAMINO)PROPIONYL AMINO]METHYL]BISPHOSPHONIC ACID 2 SODIUM SALT; ANTIESTROGEN; BISPHOSPHONIC ACID DERIVATIVE; ESTRADIOL; MCC 565; N (BIS PHOSPHONOMETHYL) 2,2 DIMETHYLMALONAMIC ACID 3 HYDROXY 1,3,5 ESTRATRIEN 17 YL ESTER 2 SODIUM SALT; N (BIS PHOSPHONOMETHYL)MALONAMIC ACID 17 HYDROXY 1,3,5 ESTRATRIEN 3 YL ESTER 2 SODIUM SALT; N (BIS PHOSPHONOMETHYL)PHTHALAMIC ACID 3 HYDROXY 1,3,5 ESTRATRIEN 17 YL ESTER 2 SODIUM SALT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BONE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DESIGN; DRUG POTENTIATION; DRUG SCREENING; DRUG SPECIFICITY; ESTROGEN ACTIVITY; FEMALE; IN VIVO STUDY; NONHUMAN; RAT; UTERUS;

ANIMALS; BONE AND BONES; DIPHOSPHONATES; ESTRADIOL; FEMALE; OSTEOPOROSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; UTERUS;

EID: 75149155164     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.041     Document Type: Article

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