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Volumn 32, Issue , 2014, Pages 39-49

New therapeutic avenues for treatment of fibrosis: Can we learn from other diseases?

Author keywords

Environmental factors; IBD; Induction of flares; Pathogenesis

Indexed keywords

ANTIINFLAMMATORY AGENT; GROWTH FACTOR RECEPTOR; PIRFENIDONE; PROTEIN TYROSINE KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84919794562     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000367825     Document Type: Article
Times cited : (10)

References (110)
  • 1
    • 0035188740 scopus 로고    scopus 로고
    • Behaviour of crohn's disease according to the vienna classification: Changing pattern over the course of the disease
    • Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J: Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 2001; 49: 777-782.
    • (2001) Gut , vol.49 , pp. 777-782
    • Louis, E.1    Collard, A.2    Oger, A.F.3    Degroote, E.4    Aboul Nasr El Yafi, F.A.5    Belaiche, J.6
  • 3
    • 0021864017 scopus 로고
    • Long-term follow-up of patients with crohn's disease. Relationship between the clinical pattern and prognosis
    • Farmer RG, Whelan G, Fazio VW: Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis. Gastroenterology 1985; 88: 1818-1825.
    • (1985) Gastroenterology , vol.88 , pp. 1818-1825
    • Farmer, R.G.1    Whelan, G.2    Fazio, V.W.3
  • 4
    • 0033053631 scopus 로고    scopus 로고
    • Epidemiology and the natural course of inflammatory bowel disease
    • vii
    • Andres PG, Friedman LS: Epidemiology and the natural course of inflammatory bowel disease. Gastroenterol Clin North Am 1999; 28: 255-281, vii.
    • (1999) Gastroenterol Clin North Am , vol.28 , pp. 255-281
    • Andres, P.G.1    Friedman, L.S.2
  • 6
    • 79955844087 scopus 로고    scopus 로고
    • Development of the crohn's disease digestive damage score, the lemann score
    • Pariente B, Cosnes J, Danese S, et al: Development of the Crohn's disease digestive damage score, the Lemann score. Inflamm Bowel Dis 2011; 17: 1415-1422.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1415-1422
    • Pariente, B.1    Cosnes, J.2    Danese, S.3
  • 8
    • 84908227294 scopus 로고    scopus 로고
    • Results of the 4th scientific workshop of the ecco (group ii): Markers of intestinal fibrosis in inflammatory bowel disease
    • Epub ahead of print
    • Rieder F, de Bruyn JR, Pham BT, Katsanos K, Annese V, Higgins PD, Magro F, Dotan I: Results of the 4th Scientific Workshop of the ECCO (Group II): markers of intestinal fibrosis in inflammatory bowel disease. J Crohns Colitis 2014, Epub ahead of print.
    • (2014) J Crohns Colitis
    • Rieder, F.1    De Bruyn, J.R.2    Pham, B.T.3    Katsanos, K.4    Annese, V.5    Higgins, P.D.6    Magro, F.7    Dotan, I.8
  • 9
  • 11
    • 84902675168 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update
    • Elpek GO: Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: an update. World J Gastroenterol 2014; 20: 7260-7276.
    • (2014) World J Gastroenterol , vol.20 , pp. 7260-7276
    • Elpek, G.O.1
  • 12
    • 84877141184 scopus 로고    scopus 로고
    • Evolving therapies for liver fibrosis
    • Schuppan D, Kim YO: Evolving therapies for liver fibrosis. J Clin Invest 2013; 123: 1887-1901.
    • (2013) J Clin Invest , vol.123 , pp. 1887-1901
    • Schuppan, D.1    Kim, Y.O.2
  • 14
    • 84906264574 scopus 로고    scopus 로고
    • Hedgehog signaling pathway as key player in liver fibrosis: New insights and perspectives
    • Yang JJ, Tao H, Li J: Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives. Expert Opin Ther Targets 2014; 18: 1011-1021.
    • (2014) Expert Opin Ther Targets , vol.18 , pp. 1011-1021
    • Yang, J.J.1    Tao, H.2    Li, J.3
  • 18
    • 42249113861 scopus 로고    scopus 로고
    • SM16, an orally active tgf-beta type i receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
    • Fu K, Corbley MJ, Sun L, et al: SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscl Thromb Vasc Biol 2008; 28: 665-671.
    • (2008) Arterioscl Thromb Vasc Biol , vol.28 , pp. 665-671
    • Fu, K.1    Corbley, M.J.2    Sun, L.3
  • 19
    • 84860390569 scopus 로고    scopus 로고
    • Inhibition of pdgf, tgf-beta, and abl signaling and reduction of liver fibrosis by the small molecule bcr-abl tyrosine kinase antagonist nilotinib
    • Liu Y, Wang Z, Kwong SQ, Lui EL, Friedman SL, Li FR, Lam RW, Zhang GC, Zhang H, Ye T: Inhibition of PDGF, TGF-beta, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib. J Hepatol 2011; 55: 612-625.
    • (2011) J Hepatol , vol.55 , pp. 612-625
    • Liu, Y.1    Wang, Z.2    Kwong, S.Q.3    Lui, E.L.4    Friedman, S.L.5    Li, F.R.6    Lam, R.W.7    Zhang, G.C.8    Zhang, H.9    Ye, T.10
  • 21
    • 77950608186 scopus 로고    scopus 로고
    • Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats
    • Moreno M, Gonzalo T, Kok RJ, et al: Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology 2010; 51: 942-952.
    • (2010) Hepatology , vol.51 , pp. 942-952
    • Moreno, M.1    Gonzalo, T.2    Kok, R.J.3
  • 23
    • 15844390050 scopus 로고    scopus 로고
    • Combined effect of an ace inhibitor, perindopril, and interferon on liver fibrosis markers in patients with chronic hepatitis c
    • Yoshiji H, Noguchi R, Fukui H: Combined effect of an ACE inhibitor, perindopril, and interferon on liver fibrosis markers in patients with chronic hepatitis C. J Gastroenterol 2005; 40: 215-216.
    • (2005) J Gastroenterol , vol.40 , pp. 215-216
    • Yoshiji, H.1    Noguchi, R.2    Fukui, H.3
  • 24
    • 33746265975 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor by sirna prevents liver fibrosis in rats
    • Li G, Xie Q, Shi Y, Li D, Zhang M, Jiang S, Zhou H, Lu H, Jin Y: Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006; 8: 889-900.
    • (2006) J Gene Med , vol.8 , pp. 889-900
    • Li, G.1    Xie, Q.2    Shi, Y.3    Li, D.4    Zhang, M.5    Jiang, S.6    Zhou, H.7    Lu, H.8    Jin, Y.9
  • 26
    • 84893953769 scopus 로고    scopus 로고
    • The peripheral cannabinoid receptor 1 antagonist vd60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression
    • Wei Y, Kang XL, Wang X: The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression. Exp Biol Med (Maywood) 2014; 239: 183-192.
    • (2014) Exp Biol Med (Maywood) , vol.239 , pp. 183-192
    • Wei, Y.1    Kang, X.L.2    Wang, X.3
  • 28
    • 33847733156 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
    • Wasmuth HE, Trautwein C: CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Hepatology 2007; 45: 543-544.
    • (2007) Hepatology , vol.45 , pp. 543-544
    • Wasmuth, H.E.1    Trautwein, C.2
  • 30
    • 38049091636 scopus 로고    scopus 로고
    • The lysophosphatidic acid receptor lpa1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
    • Tager AM, LaCamera P, Shea BS, et al: The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 2008; 14: 45-54.
    • (2008) Nat Med , vol.14 , pp. 45-54
    • Tager, A.M.1    Lacamera, P.2    Shea, B.S.3
  • 31
    • 84877066766 scopus 로고    scopus 로고
    • Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation
    • Iredale JP, Thompson A, Henderson NC: Extracellular matrix degradation in liver fibrosis: biochemistry and regulation. Biochim Biophys Acta 2013; 1832: 876-883.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 876-883
    • Iredale, J.P.1    Thompson, A.2    Henderson, N.C.3
  • 32
    • 0030453783 scopus 로고    scopus 로고
    • Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo
    • Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME, Amento EP: Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 1996; 98: 2739-2745.
    • (1996) J Clin Invest , vol.98 , pp. 2739-2745
    • Unemori, E.N.1    Pickford, L.B.2    Salles, A.L.3    Piercy, C.E.4    Grove, B.H.5    Erikson, M.E.6    Amento, E.P.7
  • 33
    • 34047121535 scopus 로고    scopus 로고
    • Expression of mmps and timps in liver fibrosis - A systematic review with special emphasis on anti-fibrotic strategies
    • Hemmann S, Graf J, Roderfeld M, Roeb E: Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 2007; 46: 955-975.
    • (2007) J Hepatol , vol.46 , pp. 955-975
    • Hemmann, S.1    Graf, J.2    Roderfeld, M.3    Roeb, E.4
  • 34
    • 0025121968 scopus 로고
    • Synthesis of lysyl oxidase in experimental hepatic fibrosis
    • Wakasaki H, Ooshima A: Synthesis of lysyl oxidase in experimental hepatic fibrosis. Biochem Biophys Res Commun 1990; 166: 1201-1204.
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 1201-1204
    • Wakasaki, H.1    Ooshima, A.2
  • 36
    • 84870487825 scopus 로고    scopus 로고
    • Emerging role of the interleukin (il)-33/st2 axis in gut mucosal wound healing and fibrosis
    • Lopetuso LR, Scaldaferri F, Pizarro TT: Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and fibrosis. Fibrogenesis Tissue Repair 2012; 5: 18.
    • (2012) Fibrogenesis Tissue Repair , vol.5 , pp. 18
    • Lopetuso, L.R.1    Scaldaferri, F.2    Pizarro, T.T.3
  • 38
    • 84871410101 scopus 로고    scopus 로고
    • Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium
    • Yamaguchi H, Suzuki K, Nagata M, et al: Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol 2012; 45: 140-151.
    • (2012) Med Mol Morphol , vol.45 , pp. 140-151
    • Yamaguchi, H.1    Suzuki, K.2    Nagata, M.3
  • 39
    • 84864557487 scopus 로고    scopus 로고
    • Mucosal healing and fibrosis after acute or chronic inflammation in wild type fvb-n mice and c57bl6 procollagen α1(i)-promoter-gfp reporter mice
    • Ding S, Walton KL, Blue RE, McNaughton K, Magness ST, Lund PK: Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57Bl6 procollagen α1(I)-promoter-GFP reporter mice. PloS One 2012; 7:e42568.
    • (2012) PloS One , vol.7
    • Ding, S.1    Walton, K.L.2    Blue, R.E.3    McNaughton, K.4    Magness, S.T.5    Lund, P.K.6
  • 41
    • 84863860108 scopus 로고    scopus 로고
    • Dynamic progress of 2,4,6-trinitrobenzene sulfonic acid induced chronic colitis and fibrosis in rat model
    • Zhu MY, Lu YM, Ou YX, Zhang HZ, Chen WX: Dynamic progress of 2,4,6-trinitrobenzene sulfonic acid induced chronic colitis and fibrosis in rat model. J Dig Dis 2012; 13: 421-429.
    • (2012) J Dig Dis , vol.13 , pp. 421-429
    • Zhu, M.Y.1    Lu, Y.M.2    Ou, Y.X.3    Zhang, H.Z.4    Chen, W.X.5
  • 43
    • 80052130352 scopus 로고    scopus 로고
    • Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with crohn's disease
    • Stidham RW, Xu J, Johnson LA, Kim K, Moons DS, McKenna BJ, Rubin JM, Higgins PD: Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease. Gastroenterology 2011; 141: 819-826.e1.
    • (2011) Gastroenterology , vol.141 , pp. 819-819e1
    • Stidham, R.W.1    Xu, J.2    Johnson, L.A.3    Kim, K.4    Moons, D.S.5    McKenna, B.J.6    Rubin, J.M.7    Higgins, P.D.8
  • 44
    • 79957583692 scopus 로고    scopus 로고
    • The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the tnbs model of colitis
    • Peterson TC, Peterson MR, Raoul JM: The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis. Eur J Pharmacol 2011; 662: 47-54.
    • (2011) Eur J Pharmacol , vol.662 , pp. 47-54
    • Peterson, T.C.1    Peterson, M.R.2    Raoul, J.M.3
  • 47
    • 77953769774 scopus 로고    scopus 로고
    • Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    • Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R: Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010; 285: 20202-20212.
    • (2010) J Biol Chem , vol.285 , pp. 20202-20212
    • Flier, S.N.1    Tanjore, H.2    Kokkotou, E.G.3    Sugimoto, H.4    Zeisberg, M.5    Kalluri, R.6
  • 48
    • 77952678563 scopus 로고    scopus 로고
    • Targeting tgf-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis
    • Ma Y, Guan Q, Bai A, Weiss CR, Hillman CL, Ma A, Zhou G, Qing G, Peng Z: Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflamm Bowel Dis 2010; 16: 1040-1050.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1040-1050
    • Ma, Y.1    Guan, Q.2    Bai, A.3    Weiss, C.R.4    Hillman, C.L.5    Ma, A.6    Zhou, G.7    Qing, G.8    Peng, Z.9
  • 58
    • 48549087887 scopus 로고    scopus 로고
    • Serum ykl-40 as a marker of disease activity and stricture formation in patients with crohn's disease
    • Erzin Y, Uzun H, Karatas A, Celik AF: Serum YKL-40 as a marker of disease activity and stricture formation in patients with Crohn's disease. J Gastroenterol Hepatol 2008; 23:e357-e362.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. e357-e362
    • Erzin, Y.1    Uzun, H.2    Karatas, A.3    Celik, A.F.4
  • 59
    • 84879071255 scopus 로고    scopus 로고
    • Magnetization transfer for the assessment of bowel fibrosis in patients with crohn's disease: Initial experience
    • Pazahr S, Blume I, Frei P, Chuck N, Nanz D, Rogler G, Patak M, Boss A: Magnetization transfer for the assessment of bowel fibrosis in patients with Crohn's disease: initial experience. MAGMA 2013; 26: 291-301.
    • (2013) MAGMA , vol.26 , pp. 291-301
    • Pazahr, S.1    Blume, I.2    Frei, P.3    Chuck, N.4    Nanz, D.5    Rogler, G.6    Patak, M.7    Boss, A.8
  • 60
    • 84886928792 scopus 로고    scopus 로고
    • Update of liver fibrosis and steatosis with transient elastography (fibroscan)
    • Wong GL: Update of liver fibrosis and steatosis with transient elastography (Fibroscan). Gastroenterol Rep (Oxf) 2013; 1: 19-26.
    • (2013) Gastroenterol Rep (Oxf) , vol.1 , pp. 19-26
    • Wong, G.L.1
  • 61
    • 84880649809 scopus 로고    scopus 로고
    • Advanced fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment with mr elastography
    • Kim D, Kim WR, Talwalkar JA, Kim HJ, Ehman RL: Advanced fibrosis in nonalcoholic fatty liver disease: noninvasive assessment with MR elastography. Radiology 2013; 268: 411-419.
    • (2013) Radiology , vol.268 , pp. 411-419
    • Kim, D.1    Kim, W.R.2    Talwalkar, J.A.3    Kim, H.J.4    Ehman, R.L.5
  • 62
    • 37349090047 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis and portal hypertension with transient elastography
    • Rockey DC: Noninvasive assessment of liver fibrosis and portal hypertension with transient elastography. Gastroenterology 2008; 134: 8-14.
    • (2008) Gastroenterology , vol.134 , pp. 8-14
    • Rockey, D.C.1
  • 63
    • 39049101883 scopus 로고    scopus 로고
    • Technology insight: Noninvasive assessment of liver fibrosis by biochemical scores and elastography
    • Pinzani M, Vizzutti F, Arena U, Marra F: Technology insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography. Nat Clin Pract Gastroenterol Hepatol 2008; 5: 95-106.
    • (2008) Nat Clin Pract Gastroenterol Hepatol , vol.5 , pp. 95-106
    • Pinzani, M.1    Vizzutti, F.2    Arena, U.3    Marra, F.4
  • 65
    • 33745388106 scopus 로고    scopus 로고
    • Non-invasive measurement of liver fibrosis: Application of the fibroscan in hepatology
    • Verveer C, de Knegt RJ: Non-invasive measurement of liver fibrosis: application of the FibroScan in hepatology. Scand J Gastroenterol Suppl 2006; 243: 85-88.
    • (2006) Scand J Gastroenterol Suppl , vol.243 , pp. 85-88
    • Verveer, C.1    De Knegt, R.J.2
  • 66
    • 84875208959 scopus 로고    scopus 로고
    • Forced vital capacity as a primary end point in idiopathic pulmonary fibrosis treatment trials: Making a silk purse from a sow's ear
    • Wells AU: Forced vital capacity as a primary end point in idiopathic pulmonary fibrosis treatment trials: Making a silk purse from a sow's ear. Thorax 2013; 68: 309-310.
    • (2013) Thorax , vol.68 , pp. 309-310
    • Wells, A.U.1
  • 68
    • 84904276966 scopus 로고    scopus 로고
    • Pathogenesis of idiopathic pulmonary fibrosis and its clinical implications
    • Spagnolo P, Rossi G, Cavazza A: Pathogenesis of idiopathic pulmonary fibrosis and its clinical implications. Exp Rev Clin Immunol 2014; 10: 1005-1017.
    • (2014) Exp Rev Clin Immunol , vol.10 , pp. 1005-1017
    • Spagnolo, P.1    Rossi, G.2    Cavazza, A.3
  • 69
    • 84893797280 scopus 로고    scopus 로고
    • The epithelium in idiopathic pulmonary fibrosis: Breaking the barrier
    • Camelo A, Dunmore R, Sleeman MA, Clarke DL: The epithelium in idiopathic pulmonary fibrosis: breaking the barrier. Front Pharmacol 2014; 4: 173.
    • (2014) Front Pharmacol , vol.4 , pp. 173
    • Camelo, A.1    Dunmore, R.2    Sleeman, M.A.3    Clarke, D.L.4
  • 70
    • 84873038964 scopus 로고    scopus 로고
    • Molecular mechanisms in progressive idiopathic pulmonary fibrosis
    • Steele MP, Schwartz DA: Molecular mechanisms in progressive idiopathic pulmonary fibrosis. Annu Rev Med 2013; 64: 265-276.
    • (2013) Annu Rev Med , vol.64 , pp. 265-276
    • Steele, M.P.1    Schwartz, D.A.2
  • 72
    • 0028924146 scopus 로고
    • Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin e 2 and to express cyclooxygenase-2
    • Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M: Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E 2 and to express cyclooxygenase-2. J Clin Invest 1995; 95: 1861-1868.
    • (1995) J Clin Invest , vol.95 , pp. 1861-1868
    • Wilborn, J.1    Crofford, L.J.2    Burdick, M.D.3    Kunkel, S.L.4    Strieter, R.M.5    Peters-Golden, M.6
  • 75
    • 84886779431 scopus 로고    scopus 로고
    • Expression of fibroblast growth factor 9 in normal human lung and idiopathic pulmonary fibrosis
    • Coffey E, Newman DR, Sannes PL: Expression of fibroblast growth factor 9 in normal human lung and idiopathic pulmonary fibrosis. J Histochem Cytochem 2013; 61: 671-679.
    • (2013) J Histochem Cytochem , vol.61 , pp. 671-679
    • Coffey, E.1    Newman, D.R.2    Sannes, P.L.3
  • 77
    • 84901759236 scopus 로고    scopus 로고
    • A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
    • King TE Jr, Bradford WZ, Castro-Bernardini S, et al: A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med 2014; 370: 2083-2092.
    • (2014) N Engl J Med , vol.370 , pp. 2083-2092
    • King, T.E.1    Bradford, W.Z.2    Castro-Bernardini, S.3
  • 79
    • 84875167034 scopus 로고    scopus 로고
    • Pirfenidone: A novel agent for the treatment of idiopathic pulmonary fibrosis
    • Potts J, Yogaratnam D: Pirfenidone: a novel agent for the treatment of idiopathic pulmonary fibrosis. Ann Pharmacother 2013; 47: 361-367.
    • (2013) Ann Pharmacother , vol.47 , pp. 361-367
    • Potts, J.1    Yogaratnam, D.2
  • 80
    • 84901796978 scopus 로고    scopus 로고
    • Management of idiopathic pulmonary fibrosis: Selected case reports
    • Kreuter M, Kardos P, Hoffstein V: Management of idiopathic pulmonary fibrosis: selected case reports. Eur Respir Rev 2014; 23: 239-248.
    • (2014) Eur Respir Rev , vol.23 , pp. 239-248
    • Kreuter, M.1    Kardos, P.2    Hoffstein, V.3
  • 81
    • 84883054431 scopus 로고    scopus 로고
    • Safety and efficacy of pirfenidone in idiopathic pulmonary fibrosis in clinical practice
    • Okuda R, Hagiwara E, Baba T, Kitamura H, Kato T, Ogura T: Safety and efficacy of pirfenidone in idiopathic pulmonary fibrosis in clinical practice. Respir Med 2013; 107: 1431-1437.
    • (2013) Respir Med , vol.107 , pp. 1431-1437
    • Okuda, R.1    Hagiwara, E.2    Baba, T.3    Kitamura, H.4    Kato, T.5    Ogura, T.6
  • 82
    • 84901810710 scopus 로고    scopus 로고
    • Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
    • Richeldi L, du Bois RM, Raghu G, Azuma A, et al: Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 2014; 370: 2071-2082.
    • (2014) N Engl J Med , vol.370 , pp. 2071-2082
    • Richeldi, L.1    Du Bois, R.M.2    Raghu, G.3    Azuma, A.4
  • 83
    • 84876579887 scopus 로고    scopus 로고
    • Nintedanib (bibf 1120) for ipf: A tomorrow therapy?
    • Antoniu SA: Nintedanib (BIBF 1120) for IPF: a tomorrow therapy? Multidiscip Respir Med 2012; 7: 41.
    • (2012) Multidiscip Respir Med , vol.7 , pp. 41
    • Antoniu, S.A.1
  • 84
    • 84879286188 scopus 로고    scopus 로고
    • Reducing lung function decline in patients with idiopathic pulmonary fibrosis: Potential of nintedanib
    • Woodcock HV, Molyneaux PL, Maher TM: Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib. Drug Des Devel Ther 2013; 7: 503-510.
    • (2013) Drug des Devel Ther , vol.7 , pp. 503-510
    • Woodcock, H.V.1    Molyneaux, P.L.2    Maher, T.M.3
  • 85
    • 84898792564 scopus 로고    scopus 로고
    • Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis
    • Wollin L, Maillet I, Quesniaux V, Holweg A, Ryffel B: Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis. J Pharmacol Exp Ther 2014; 349: 209-220.
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 209-220
    • Wollin, L.1    Maillet, I.2    Quesniaux, V.3    Holweg, A.4    Ryffel, B.5
  • 86
    • 78650053726 scopus 로고    scopus 로고
    • A ccl2-based fusokine as a novel biopharmaceutical for the treatment of ccr2-driven autoimmune diseases
    • Rafei M, Galipeau J: A CCL2-based fusokine as a novel biopharmaceutical for the treatment of CCR2-driven autoimmune diseases. Crit Rev Immunol 2010; 30: 449-461.
    • (2010) Crit Rev Immunol , vol.30 , pp. 449-461
    • Rafei, M.1    Galipeau, J.2
  • 87
    • 77955090022 scopus 로고    scopus 로고
    • The role of monocyte chemoattractant protein mcp1/ccl2 in neuroinflammatory diseases
    • Conductier G, Blondeau N, Guyon A, Nahon JL, Rovere C: The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 2010; 224: 93-100.
    • (2010) J Neuroimmunol , vol.224 , pp. 93-100
    • Conductier, G.1    Blondeau, N.2    Guyon, A.3    Nahon, J.L.4    Rovere, C.5
  • 88
    • 0242273334 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 (ccl2) in inflammatory disease and adaptive immunity: Therapeutic opportunities and controversies
    • Daly C, Rollins BJ: Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies. Microcirculation 2003; 10: 247-257.
    • (2003) Microcirculation , vol.10 , pp. 247-257
    • Daly, C.1    Rollins, B.J.2
  • 93
    • 57249094020 scopus 로고    scopus 로고
    • IL-13 signaling via il-13r alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic tnbs colitis
    • 2013 e1-7
    • Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, Strober W: IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 2008; 135: 2003-2013, 2013 e1-7.
    • (2008) Gastroenterology , vol.135 , pp. 2003-2013
    • Fichtner-Feigl, S.1    Young, C.A.2    Kitani, A.3    Geissler, E.K.4    Schlitt, H.J.5    Strober, W.6
  • 96
    • 84883413596 scopus 로고    scopus 로고
    • Pharmacological treatment of idiopathic pulmonary fibrosis: From the past to the future
    • Antoniou KM, Margaritopoulos GA, Siafakas NM: Pharmacological treatment of idiopathic pulmonary fibrosis: from the past to the future. Eur Respir Rev 2013; 22: 281-291.
    • (2013) Eur Respir Rev , vol.22 , pp. 281-291
    • Antoniou, K.M.1    Margaritopoulos, G.A.2    Siafakas, N.M.3
  • 97
    • 0345824715 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis study g: A placebo- controlled trial of interferon gamma- 1b in patients with idiopathic pulmonary fibrosis
    • Raghu G, Brown KK, Bradford WZ, Starko K, Noble PW, Schwartz DA, King TE Jr, Idiopathic Pulmonary Fibrosis Study G: A placebo- controlled trial of interferon gamma- 1b in patients with idiopathic pulmonary fibrosis. N Engl J Med 2004; 350: 125-133.
    • (2004) N Engl J Med , vol.350 , pp. 125-133
    • Raghu, G.1    Brown, K.K.2    Bradford, W.Z.3    Starko, K.4    Noble, P.W.5    Schwartz, D.A.6    King, T.E.7
  • 99
    • 28144459814 scopus 로고    scopus 로고
    • High-dose acetylcysteine in idiopathic pulmonary fibrosis
    • Demedts M, Behr J, Buhl R, et al: High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 2005; 353: 2229-2242.
    • (2005) N Engl J Med , vol.353 , pp. 2229-2242
    • Demedts, M.1    Behr, J.2    Buhl, R.3
  • 101
    • 77951160564 scopus 로고    scopus 로고
    • Pirfenidone in idiopathic pulmonary fibrosis
    • Taniguchi H, Ebina M, Kondoh Y, et al: Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J 2010; 35: 821-829.
    • (2010) Eur Respir J , vol.35 , pp. 821-829
    • Taniguchi, H.1    Ebina, M.2    Kondoh, Y.3
  • 104
    • 80053091084 scopus 로고    scopus 로고
    • Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis
    • Richeldi L, Costabel U, Selman M, et al: Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med 2011; 365: 1079-1087.
    • (2011) N Engl J Med , vol.365 , pp. 1079-1087
    • Richeldi, L.1    Costabel, U.2    Selman, M.3
  • 105
    • 77749324295 scopus 로고    scopus 로고
    • Imatinib treatment for idiopathic pulmonary fibrosis: Randomized placebo- controlled trial results
    • Daniels CE, Lasky JA, Limper AH, Mieras K, Gabor E, Schroeder DR, Imatinib-IPF Study Investigators: Imatinib treatment for idiopathic pulmonary fibrosis: randomized placebo- controlled trial results. Am J Respir Crit Care Med 2010; 181: 604-610.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 604-610
    • Daniels, C.E.1    Lasky, J.A.2    Limper, A.H.3    Mieras, K.4    Gabor, E.5    Schroeder, D.R.6
  • 109
    • 84877297353 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with ambrisentan: A parallel, randomized trial
    • Raghu G, Behr J, Brown KK, et al: Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med 2013; 158: 641-649.
    • (2013) Ann Intern Med , vol.158 , pp. 641-649
    • Raghu, G.1    Behr, J.2    Brown, K.K.3
  • 110
    • 84865136582 scopus 로고    scopus 로고
    • Efficacy and safety of macitentan in idiopathic pulmonary fibrosis: Results of a prospective, randomized, double-blind, placebo- controlled trial
    • Raghu G, Million-Rousseau R, Morganti A, et al: Efficacy and safety of macitentan in idiopathic pulmonary fibrosis: results of a prospective, randomized, double-blind, placebo- controlled trial. Clin Trials Idiopath Pulmonary Fibrosis Sarcoidosis 2012, p A3631.
    • (2012) Clin Trials Idiopath Pulmonary Fibrosis Sarcoidosis , pp. A3631
    • Raghu, G.1    Million-Rousseau, R.2    Morganti, A.3


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