Hepatocyte growth factor attenuates renal fibrosis through TGF-b1 suppression by apoptosis of myofibroblasts

Journal of Hypertension

Volumn 28, Issue 12, 2010, Pages 2454-2461

  Iekushi, Kazuma ^a   Taniyama, Yoshiaki ^a   Azuma, Junya ^a   Sanada, Fumihiro ^a   Kusunoki, Hiroshi ^a   Yokoi, Toyohiko ^b   Koibuchi, Nobutaka ^c   Okayama, Keita ^a   Rakugi, Hiromi ^a   Morishita, Ryuichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Chronic kidney disease; Fibrosis; Hepatocyte growth factor; Myofibroblast

Indexed keywords

ANGIOTENSIN II; COLLAGEN TYPE 1; COLLAGEN TYPE 4; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT SCATTER FACTOR; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE REPRESSION; HUMAN; HUMAN TISSUE; KIDNEY FIBROSIS; MESANGIUM CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; KIDNEY DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; HEPATOCYTE GROWTH FACTOR; HUMANS; KIDNEY DISEASES; MICE; MICE, TRANSGENIC; MYOFIBROBLASTS; POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79956294234     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32833e4149     Document Type: Article

References (28)

1. Liu Y. Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney Int 2006; 69:213-217. (Pubitemid 43323069)
2. Liu Y. Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol 2004; 287:F7-16. (Pubitemid 38780577)
3. Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol 2008; 173:30-41. (Pubitemid 351947953)
4. Taniyama Y, Morishita R, Nakagami H, Moriguchi A, Sakonjo H, Shokei K, et al. Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters. Circulation 2000; 102:246-252. (Pubitemid 30451784)
5. Taniyama Y, Morishita R, Aoki M, Hiraoka K, Yamasaki K, Hashiya N, et al. Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy. Hypertension 2002; 40:47-53. (Pubitemid 34755978)
6. Kim WH, Matsumoto K, Bessho K, Nakamura T. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 2005; 166:1017-1028. (Pubitemid 40524427)
7. Mizuno S, Matsumoto K, Li MY, Nakamura T. HGF reduces advancing lung fibrosis in mice: A potential role for MMP-dependent myofibroblast apoptosis. FASEB J 2005; 19:580-582. (Pubitemid 40471250)
8. Yang J, Dai C, Liu Y. Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Am J Pathol 2003; 163:621-632. (Pubitemid 36909423)
9. Lo RS, Wotton D, Massague J. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001; 20 (1-2):128-136. (Pubitemid 32099109)
10. Tan R, Zhang X, Yang J, Li Y, Liu Y. Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor. J Am Soc Nephrol 2007; 18:2340-2349. (Pubitemid 47203850)
11. Mizuno S, Nakamura T. Suppressions of chronic glomerular injuries and TGF-beta 1 production by HGF in attenuation of murine diabetic nephropathy. Am J Physiol Renal Physiol 2004; 286: F134-143. (Pubitemid 38045051)
12. Sanada F, Taniyama Y, Azuma J, Iekushi K, Dosaka N, Yokoi T, et al. Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced endothelial progenitor cell senescence. Hypertension 2009; 53:77-82.
13. Mizuno S, Matsumoto K, Nakamura T. Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int 2001; 59:1304-1314. (Pubitemid 32281218)
14. Iekushi K, Taniyama Y, Azuma J, Katsuragi N, Dosaka N, Sanada F, et al. Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin. Hypertension 2007; 49:1409-1414. (Pubitemid 46809387)
15. Sanada F, Taniyama Y, Iekushi K, Azuma J, Okayama K, Kusunoki H, et al. Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. Circ Res 2009; 105:667-675; 613 p following 675.
16. Border WA, Noble NA. Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension 1998; 31 (1 Pt 2):181-188.
17. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: In command and control of cell motility. Nat Rev Mol Cell Biol 2005; 6:56-68. (Pubitemid 40064899)
18. Hauck CR, Sieg DJ, Hsia DA, Loftus JC, Gaarde WA, Monia BP, et al. Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res 2001; 61:7079-7090. (Pubitemid 32946499)
19. Grossmann J. Molecular mechanisms of 'detachment-induced apoptosis: Anoikis'. Apoptosis 2002; 7:247-260. (Pubitemid 34633465)
20. Schlaepfer DD, Hauck CR, Sieg DJ. Signaling through focal adhesion kinase. Prog Biophys Mol Biol 1999; 71 (3-4):435-478. (Pubitemid 29156312)
21. Schaller MD. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochem Biophys Acta 2001; 1540:1-21. (Pubitemid 32710044)
22. Mon NN, Hasegawa H, Thant AA, Huang P, Tanimura Y, Senga T, et al. A role for focal adhesion kinase signaling in tumor necrosis factor-alphadependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1. Cancer Res 2006; 66:6778-6784. (Pubitemid 44085637)
23. Mon NN, Ito S, Senga T, Hamaguchi M. FAK signaling in neoplastic disorders: A linkage between inflammation and cancer. Ann N Y Acad Sci 2006; 1086:199-212. (Pubitemid 47084387)
24. Chen SY, Chen HC. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Mol Cell Biol 2006; 26:5155-5167.
25. Liu Y, Sun AM, Dworkin LD. Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death. Biochem Biophys Res Commun 1998; 246:821-826. (Pubitemid 28420942)
26. Yo Y, Morishita R, Nakamura S, Tomita N, Yamamoto K, Moriguchi A, et al. Potential role of hepatocyte growth factor in the maintenance of renal structure: Antiapoptotic action of HGF on epithelial cells. Kidney Int 1998; 54:1128-1138. (Pubitemid 28449899)
27. Conner EA, Wirth PJ, Kiss A, Santoni-Rugiu E, Thorgeirsson SS. Growth inhibition and induction of apoptosis by HGF in transformed rat liver epithelial cells. Biochem Biophys Res Commun 1997; 236: 396-401. (Pubitemid 27373307)
28. Yang J, Dai C, Liu Y. Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice. J Am Soc Nephrol 2002; 13:2464-2477.