-
2
-
-
0034809804
-
Hepatic stellate cells as a target for the treatment of liver fibrosis
-
Bataller R, Brenner DA. (2001) Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin. Liver Dis. 21:437-51.
-
(2001)
Semin. Liver Dis
, vol.21
, pp. 437-451
-
-
Bataller, R.1
Brenner, D.A.2
-
4
-
-
42949163491
-
Mechanisms of hepatic fibrogenesis
-
Friedman SL. (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology. 134:1655-69.
-
(2008)
Gastroenterology
, vol.134
, pp. 1655-1669
-
-
Friedman, S.L.1
-
7
-
-
63449105700
-
Role of cannabinoids in chronic liver diseases
-
Parfieniuk A, Flisiak R. (2008) Role of cannabinoids in chronic liver diseases. World J. Gastroenterol. 14:6109-14.
-
(2008)
World J. Gastroenterol
, vol.14
, pp. 6109-6114
-
-
Parfieniuk, A.1
Flisiak, R.2
-
8
-
-
39149111268
-
Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis
-
Siegmund SV, Schwabe RF. (2008) Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 294:G357-62.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.294
-
-
Siegmund, S.V.1
Schwabe, R.F.2
-
9
-
-
33745003240
-
CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
-
Teixeira-Clerc F, et al. (2006) CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat. Med. 12:671-6.
-
(2006)
Nat. Med
, vol.12
, pp. 671-676
-
-
Teixeira-Clerc, F.1
-
10
-
-
15744388722
-
Antifibrogenic role of the cannabinoid receptor CB2 in the liver
-
Julien B, et al. (2005) Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. 128:742-55.
-
(2005)
Gastroenterology
, vol.128
, pp. 742-755
-
-
Julien, B.1
-
11
-
-
37349087434
-
Influence of cannabis use on severity of hepatitis C disease
-
Ishida JH, et al. (2008) Influence of cannabis use on severity of hepatitis C disease. Clin. Gastroenterol. Hepatol. 6:69-75.
-
(2008)
Clin. Gastroenterol. Hepatol
, vol.6
, pp. 69-75
-
-
Ishida, J.H.1
-
12
-
-
21344472982
-
Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C
-
Hezode C, et al. (2005) Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. Hepatology. 42:63-71.
-
(2005)
Hepatology
, vol.42
, pp. 63-71
-
-
Hezode, C.1
-
13
-
-
38649131428
-
Daily cannabis use: A novel risk factor of steatosis severity in patients with chronic hepatitis C
-
Hezode C, et al. (2008) Daily cannabis use: a novel risk factor of steatosis severity in patients with chronic hepatitis C. Gastroenterology. 134:432-9.
-
(2008)
Gastroenterology
, vol.134
, pp. 432-439
-
-
Hezode, C.1
-
14
-
-
77954375662
-
Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis
-
Caraceni P, et al. (2009) Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. Liver Int. 30:816-25.
-
(2009)
Liver Int
, vol.30
, pp. 816-825
-
-
Caraceni, P.1
-
15
-
-
0142244903
-
Membrane cholesterol but not putative receptors mediates anandamideinduced hepatocyte apoptosis
-
Biswas KK, et al. (2003) Membrane cholesterol but not putative receptors mediates anandamideinduced hepatocyte apoptosis. Hepatology. 38:1167-77.
-
(2003)
Hepatology
, vol.38
, pp. 1167-1177
-
-
Biswas, K.K.1
-
16
-
-
20944436157
-
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
-
Osei-Hyiaman D, et al. (2005) Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J. Clin. Invest. 115:1298-305.
-
(2005)
J. Clin. Invest
, vol.115
, pp. 1298-1305
-
-
Osei-Hyiaman, D.1
-
17
-
-
33744542391
-
Fatty acid amide hydrolase determines anandamide-induced cell death in the liver
-
Siegmund SV, et al. (2006) Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J. Biol. Chem. 281:10431-8.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10431-10438
-
-
Siegmund, S.V.1
-
18
-
-
0041411118
-
The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
-
Maccarrone M, Finazzi-Agro A. (2003) The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ. 10:946-55.
-
(2003)
Cell Death Differ
, vol.10
, pp. 946-955
-
-
Maccarrone, M.1
Finazzi-Agro, A.2
-
19
-
-
17844404783
-
Anandamide induces necrosis in primary hepatic stellate cells
-
Siegmund SV, Uchinami H, Osawa Y, Brenner DA, Schwabe RF. (2005) Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 41:1085-95.
-
(2005)
Hepatology
, vol.41
, pp. 1085-1095
-
-
Siegmund, S.V.1
Uchinami, H.2
Osawa, Y.3
Brenner, D.A.4
Schwabe, R.F.5
-
20
-
-
34548499520
-
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
-
Siegmund SV, et al. (2007) The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. FASEB J. 21:2798-806.
-
(2007)
FASEB J
, vol.21
, pp. 2798-27806
-
-
Siegmund, S.V.1
-
21
-
-
38649114788
-
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
-
Jeong WI, et al. (2008) Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab. 7:227-35.
-
(2008)
Cell Metab
, vol.7
, pp. 227-235
-
-
Jeong, W.I.1
-
22
-
-
79955635993
-
Role of cannabinoid receptors in alcoholic hepatic injury: Steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts
-
Trebicka J, et al. (2011) Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. Liver Int. 31:860-70.
-
(2011)
Liver Int
, vol.31
, pp. 860-870
-
-
Trebicka, J.1
-
23
-
-
80053314254
-
Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice
-
doi: 10.1002/hep.24524. [Epub ahead of print]
-
Louvet A, et al. (2011) Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice. Hepatology. doi: 10.1002/hep.24524. [Epub ahead of print].
-
(2011)
Hepatology
-
-
Louvet, A.1
-
24
-
-
33644657061
-
Animal models and their results in gastrointestinal alcohol research
-
Siegmund SV, Haas S, Singer MV (2005) Animal models and their results in gastrointestinal alcohol research. Dig. Dis. 23:181-94.
-
(2005)
Dig. Dis
, vol.23
, pp. 181-194
-
-
Siegmund, S.V.1
Haas, S.2
Singer, M.V.3
-
25
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313-21.
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
-
26
-
-
33746544232
-
Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1
-
Kornek M, et al. (2006) Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1. J. Hepatol. 45:370-6.
-
(2006)
J. Hepatol
, vol.45
, pp. 370-376
-
-
Kornek, M.1
-
27
-
-
48549103201
-
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
-
Patsenker E, et al. (2008) Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Gastroenterology. 135:660-70.
-
(2008)
Gastroenterology
, vol.135
, pp. 660-670
-
-
Patsenker, E.1
-
28
-
-
72949093354
-
Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis
-
Patsenker E, et al. (2009) Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology. 50:1501-11.
-
(2009)
Hepatology
, vol.50
, pp. 1501-1511
-
-
Patsenker, E.1
-
29
-
-
34047117772
-
Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BBinduced hepatic stellate cell migration and activation in vitro
-
Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. (2007) Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BBinduced hepatic stellate cell migration and activation in vitro. J. Hepatol. 46:878-87.
-
(2007)
J. Hepatol
, vol.46
, pp. 878-887
-
-
Patsenker, E.1
Popov, Y.2
Wiesner, M.3
Goodman, S.L.4
Schuppan, D.5
-
30
-
-
0028855914
-
The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx
-
Failli P, et al. (1995) The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx. Am. J. Physiol. 269: C1133-9.
-
(1995)
Am. J. Physiol
, vol.269
-
-
Failli, P.1
-
31
-
-
0028978771
-
Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver
-
Inagaki Y, et al. (1995) Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology. 22:573-9.
-
(1995)
Hepatology
, vol.22
, pp. 573-579
-
-
Inagaki, Y.1
-
32
-
-
0029002528
-
Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system
-
Rojkind M, et al. (1995) Characterization and functional studies on rat liver fat-storing cell line and freshly isolated hepatocyte coculture system. Am. J. Pathol. 146:1508-20.
-
(1995)
Am. J. Pathol
, vol.146
, pp. 1508-1520
-
-
Rojkind, M.1
-
33
-
-
42049111404
-
Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: Implications for inflammatory liver diseases
-
Pacher P, Gao B. (2008) Endocannabinoids and liver disease. III. Endocannabinoid effects on immune cells: implications for inflammatory liver diseases. Am. J. Physiol. Gastrointest. Liver Physiol. 294:G850-4.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.294
-
-
Pacher, P.1
Gao, B.2
-
34
-
-
0034814405
-
Extracellular matrix degradation and the role of hepatic stellate cells
-
Benyon RC, Arthur MJ. (2001) Extracellular matrix degradation and the role of hepatic stellate cells. Semin. Liver Dis. 21:373-84.
-
(2001)
Semin. Liver Dis
, vol.21
, pp. 373-384
-
-
Benyon, R.C.1
Arthur, M.J.2
-
35
-
-
34247149014
-
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
-
Fallowfield JA, et al. (2007) Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J. Immunol. 178:5288-95.
-
(2007)
J. Immunol
, vol.178
, pp. 5288-5295
-
-
Fallowfield, J.A.1
-
36
-
-
0029133207
-
Kupffer cell-derived 95- kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells
-
Winwood PJ, et al. (1995) Kupffer cell-derived 95- kd type IV collagenase/gelatinase B: characterization and expression in cultured cells. Hepatology. 22:304-15.
-
(1995)
Hepatology
, vol.22
, pp. 304-315
-
-
Winwood, P.J.1
-
37
-
-
77249139206
-
Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
-
Popov Y, et al. Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 298:G323-34.
-
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.298
-
-
Popov, Y.1
-
38
-
-
0035179839
-
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
-
Olaso E, et al. (2001) DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J. Clin. Invest. 108:1369-78.
-
(2001)
J. Clin. Invest
, vol.108
, pp. 1369-1378
-
-
Olaso, E.1
-
39
-
-
27744512904
-
Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
-
Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. (2005) Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes. J. Hepatol. 43:1045-54.
-
(2005)
J. Hepatol
, vol.43
, pp. 1045-1054
-
-
Popov, Y.1
Patsenker, E.2
Fickert, P.3
Trauner, M.4
Schuppan, D.5
-
40
-
-
0346350327
-
The cannabinoid system and immune modulation
-
Klein TW, et al. (2003) The cannabinoid system and immune modulation. J. Leukoc. Biol. 74:486-96.
-
(2003)
J. Leukoc. Biol
, vol.74
, pp. 486-496
-
-
Klein, T.W.1
-
41
-
-
34547423962
-
Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
-
Gary-Bobo M, et al. (2007) Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology. 46:122-9.
-
(2007)
Hepatology
, vol.46
, pp. 122-129
-
-
Gary-Bobo, M.1
-
42
-
-
69449085341
-
Beneficial effects of nicotinamide on alcoholinduced liver injury in senescence-accelerated mice
-
Chen YH, Wang MF, Liao JW, Chang SP, Hu ML. (2008) Beneficial effects of nicotinamide on alcoholinduced liver injury in senescence-accelerated mice. Biofactors. 34:97-107.
-
(2008)
Biofactors
, vol.34
, pp. 97-107
-
-
Chen, Y.H.1
Wang, M.F.2
Liao, J.W.3
Chang, S.P.4
Hu, M.L.5
-
43
-
-
0023637142
-
Acetaldehyde increases collagen gene transcription in cultured human fibroblasts
-
Brenner DA, Chojkier M. (1987) Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J. Biol. Chem. 262:17690-5.
-
(1987)
J. Biol. Chem
, vol.262
, pp. 17690-17695
-
-
Brenner, D.A.1
Chojkier, M.2
-
44
-
-
0017328826
-
The distribution and metabolism of acetaldehyde in rats during ethanol oxidation-I. The distribution of acetaldehyde in liver, brain, blood and breath
-
Eriksson CJ, Sippel HW. (1977) The distribution and metabolism of acetaldehyde in rats during ethanol oxidation-I. The distribution of acetaldehyde in liver, brain, blood and breath. Biochem. Pharmacol. 26:241-7.
-
(1977)
Biochem. Pharmacol
, vol.26
, pp. 241-247
-
-
Eriksson, C.J.1
Sippel, H.W.2
-
45
-
-
0037115736
-
Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells
-
Chen A. (2002) Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem. J. 368:683-93.
-
(2002)
Biochem. J
, vol.368
, pp. 683-693
-
-
Chen, A.1
-
46
-
-
33644636619
-
Molecular mechanisms of alcohol-induced hepatic fibrosis
-
Siegmund SV, Dooley S, Brenner DA. (2005) Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig. Dis. 23:264-74.
-
(2005)
Dig. Dis
, vol.23
, pp. 264-274
-
-
Siegmund, S.V.1
Dooley, S.2
Brenner, D.A.3
-
47
-
-
51449097793
-
Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: Results from a placebocontrolled, double-blind trial
-
Soyka M, et al. (2008) Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebocontrolled, double-blind trial. J. Clin. Psychopharmacol. 28:317-24.
-
(2008)
J. Clin. Psychopharmacol
, vol.28
, pp. 317-324
-
-
Soyka, M.1
-
48
-
-
56649087379
-
-
European Medicines Agency, cited 2011 Oct 28]. Available from
-
European Medicines Agency. (2008) The European Medicines Agency recommends suspension of the marketing authorisation of Acomplia [press release]. [cited 2011 Oct 28]. Available from: http://www.ema.europa.eu/ema/ index.jsp?curl= pages/news_and_events/news/ 2009/11/news_detail_000244.jsp&murl=menus/news_and_events/ news_and_events.jsp&mid=WC0b01ac058004d5c1&jsenabled=true
-
(2008)
The European Medicines Agency Recommends Suspension of the Marketing Authorisation of Acomplia [press Release]
-
-
|