메뉴 건너뛰기




Volumn 6, Issue 6, 2014, Pages 651-664

Epigenetic mechanisms of breast cancer: An update of the current knowledge

Author keywords

BRCA1; breast cancer; DNA methylation; epigenetic therapy; epigenetics; estrogen; EZH2; histone modification

Indexed keywords

3 DEAZANEPLANOCIN A; 4,4' ISOPROPYLIDENEDIPHENOL; 5 METHYLCYTOSINE; BEVACIZUMAB; BUTYRIC ACID; DIETHYLSTILBESTROL; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ENTINOSTAT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; KI 67 ANTIGEN; METHYL CPG BINDING PROTEIN; MICRORNA; PACLITAXEL; PANOBINOSTAT; POLYCOMB GROUP PROTEIN; PROGESTERONE; REPETITIVE DNA; ROMIDEPSIN; TAMOXIFEN; TRANSCRIPTION FACTOR EZH2; TRICHOSTATIN A; VORINOSTAT; ANTINEOPLASTIC AGENTS; HISTONE DEACETYLASE INHIBITORS; HISTONES;

EID: 84919787782     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.14.59     Document Type: Review
Times cited : (89)

References (101)
  • 1
    • 63449113187 scopus 로고    scopus 로고
    • Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment
    • Dworkin AM, Huang TH, Toland AE. Epigenetic alterations in the breast: implications for breast cancer detection, prognosis and treatment. Semin. Cancer Biol. 19(3), 165-171 (2009
    • (2009) Semin. Cancer Biol , vol.19 , Issue.3 , pp. 165-171
    • Dworkin, A.M.1    Huang, T.H.2    Toland, A.E.3
  • 2
    • 55949095127 scopus 로고    scopus 로고
    • Chromatin, cancer and drug therapies
    • Cortez CC, Jones PA. Chromatin, cancer and drug therapies. Mutat. Res. 647(1-2), 44-51 (2008
    • (2008) Mutat. Res , vol.647 , Issue.1-2 , pp. 44-51
    • Cortez, C.C.1    Jones, P.A.2
  • 3
    • 84855862393 scopus 로고    scopus 로고
    • Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome
    • Khan SI, Aumsuwan P, Khan IA, Walker LA, Dasmahapatra AK. Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome. Chem. Res. Toxicol. 25(1), 61-73 (2012
    • (2012) Chem. Res. Toxicol , vol.25 , Issue.1 , pp. 61-73
    • Khan, S.I.1    Aumsuwan, P.2    Khan, I.A.3    Walker, L.A.4    Dasmahapatra, A.K.5
  • 5
    • 84874033876 scopus 로고    scopus 로고
    • Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-hdac in breast cancer cell lines
    • Dagdemir A, Durif J, Ngollo M, Bignon YJ, Bernard-Gallon D. Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics 5(1), 51-63 (2013
    • (2013) Epigenomics , vol.5 , Issue.1 , pp. 51-63
    • Dagdemir, A.1    Durif, J.2    Ngollo, M.3    Bignon, Y.J.4    Bernard-Gallon, D.5
  • 6
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res. 61(8), 3225-3229 (2001
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 7
    • 65649096557 scopus 로고    scopus 로고
    • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression
    • Suzuki J, Chen YY, Scott GK, et al. Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. Clin. Cancer Res. 15(9), 3163-3171 (2009
    • (2009) Clin. Cancer Res , vol.15 , Issue.9 , pp. 3163-3171
    • Suzuki, J.1    Chen, Y.Y.2    Scott, G.K.3
  • 8
    • 61549112191 scopus 로고    scopus 로고
    • Epigenomics and breast cancer
    • Lo PK, Sukumar S. Epigenomics and breast cancer. Pharmacogenomics 9(12), 1879-1902 (2008
    • (2008) Pharmacogenomics , vol.9 , Issue.12 , pp. 1879-1902
    • Lo, P.K.1    Sukumar, S.2
  • 9
    • 77149135270 scopus 로고    scopus 로고
    • Breast cancer epigenetics: From dna methylation to micrornas
    • Veeck J, Esteller M. Breast cancer epigenetics: From DNA methylation to microRNAs. J. Mammary Gland Biol. Neoplasia 15(1), 5-17 (2010
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , Issue.1 , pp. 5-17
    • Veeck, J.1    Esteller, M.2
  • 10
    • 79960123768 scopus 로고    scopus 로고
    • Epigenetic mechanisms and cancer: An interface between the environment and the genome
    • Herceg Z, Vaissiere T. Epigenetic mechanisms and cancer: an interface between the environment and the genome. Epigenetics 6(7), 804-819 (2011
    • (2011) Epigenetics , vol.6 , Issue.7 , pp. 804-819
    • Herceg, Z.1    Vaissiere, T.2
  • 11
    • 0032102949 scopus 로고    scopus 로고
    • Dnmt2 is not required for de novo and maintenance methylation of viral dna in embryonic stem cells
    • Okano M, Xie S, Li E. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res. 26(11), 2536-2540 (1998
    • (1998) Nucleic Acids Res , vol.26 , Issue.11 , pp. 2536-2540
    • Okano, M.1    Xie, S.2    Li, E.3
  • 12
    • 0033615717 scopus 로고    scopus 로고
    • Dna methyltransferases dnmt3a and dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3), 247-257 (1999
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 13
    • 0036144048 scopus 로고    scopus 로고
    • Dna methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 16(1), 6-21 (2002
    • (2002) Genes Dev , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 14
    • 0034929515 scopus 로고    scopus 로고
    • Dna methylation: An alternative pathway to cancer
    • Wajed SA, Laird PW, Demeester TR. DNA methylation: an alternative pathway to cancer. Ann. Surg. 234(1), 10-20 (2001
    • (2001) Ann. Surg , vol.234 , Issue.1 , pp. 10-20
    • Wajed, S.A.1    Laird, P.W.2    Demeester, T.R.3
  • 15
    • 1442357202 scopus 로고    scopus 로고
    • Epigenetic silencing of the adhesion molecule adam23 is highly frequent in breast tumors
    • Costa FF, Verbisck NV, Salim AC, et al. Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors. Oncogene 23(7), 1481-1488 (2004
    • (2004) Oncogene , vol.23 , Issue.7 , pp. 1481-1488
    • Costa, F.F.1    Verbisck, N.V.2    Salim, A.C.3
  • 16
    • 33644877242 scopus 로고    scopus 로고
    • Epigenetic silencing of dsc3 is a common event in human breast cancer
    • Oshiro MM, Kim CJ, Wozniak RJ, et al. Epigenetic silencing of DSC3 is a common event in human breast cancer. Breast Cancer Res. 7(5), R669-680 (2005
    • (2005) Breast Cancer Res , vol.7 , Issue.5 , pp. R669-R680
    • Oshiro, M.M.1    Kim, C.J.2    Wozniak, R.J.3
  • 17
    • 77958540564 scopus 로고    scopus 로고
    • Molecular subtypes of breast cancer are associated with characteristic dna methylation patterns
    • Holm K, Hegardt C, Staaf J, et al. Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns. Breast Cancer Res. 12(3), R36 (2010
    • (2010) Breast Cancer Res , vol.12 , Issue.3 , pp. R36
    • Holm, K.1    Hegardt, C.2    Staaf, J.3
  • 18
    • 40849116461 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of wnt antagonist genes in breast cancer
    • Suzuki H, Toyota M, Carraway H, et al. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br. J. Cancer 98(6), 1147-1156 (2008
    • (2008) Br. J. Cancer , vol.98 , Issue.6 , pp. 1147-1156
    • Suzuki, H.1    Toyota, M.2    Carraway, H.3
  • 19
    • 33745026527 scopus 로고    scopus 로고
    • Aberrant methylation of the wnt antagonist sfrp1 in breast cancer is associated with unfavourable prognosis
    • Veeck J, Niederacher D, An H, et al. Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 25(24), 3479-3488 (2006
    • (2006) Oncogene , vol.25 , Issue.24 , pp. 3479-3488
    • Veeck, J.1    Niederacher, D.2    An, H.3
  • 20
    • 58149345192 scopus 로고    scopus 로고
    • Promoter hypermethylation of the sfrp2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer
    • Veeck J, Noetzel E, Bektas N, et al. Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Mol. Cancer 7, 83 (2008
    • (2008) Mol. Cancer , vol.7 , pp. 83
    • Veeck, J.1    Noetzel, E.2    Bektas, N.3
  • 21
    • 84876453305 scopus 로고    scopus 로고
    • Silencing of tumor suppressor genes rassf1a slit2, and wif1 by promoter hypermethylation in hereditary breast cancer
    • Alvarez C, Tapia T, Cornejo V, et al. Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer. Mol. Carcinog. 52(6), 475-487 (2013
    • (2013) Mol. Carcinog , vol.52 , Issue.6 , pp. 475-487
    • Alvarez, C.1    Tapia, T.2    Cornejo, V.3
  • 22
    • 84878741904 scopus 로고    scopus 로고
    • Rassf1a promoter methylation levels positively correlate with estrogen receptor expression in breast cancer patients
    • Kajabova V, Smolkova B, Zmetakova I, et al. RASSF1A promoter methylation levels positively correlate with estrogen receptor expression in breast cancer patients. Transl. Oncol. 6(3), 297-304 (2013
    • (2013) Transl. Oncol , vol.6 , Issue.3 , pp. 297-304
    • Kajabova, V.1    Smolkova, B.2    Zmetakova, I.3
  • 23
    • 47549107706 scopus 로고    scopus 로고
    • Expression and promoter methylation of the rassf1a gene in sporadic breast cancers in chinese women
    • Li Y, Wei Q, Cao F, Cao X. Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. Oncol. Rep. 19(5), 1149-1153 (2008
    • (2008) Oncol. Rep , vol.19 , Issue.5 , pp. 1149-1153
    • Li, Y.1    Wei, Q.2    Cao, F.3    Cao, X.4
  • 24
    • 84862191974 scopus 로고    scopus 로고
    • Methylation of hin-1, rassf1a, ril and cdh13 in breast cancer is associated with clinical characteristics, but only rassf1a methylation is associated with outcome
    • Xu J, Shetty PB, Feng W, et al. Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome. BMC Cancer 12, 243 (2012
    • (2012) BMC Cancer , vol.12 , pp. 243
    • Xu, J.1    Shetty, P.B.2    Feng, W.3
  • 25
    • 77957859971 scopus 로고    scopus 로고
    • Estrogen and progesterone receptor status affect genome-wide dna methylation profile in breast cancer
    • Li L, Lee KM, Han W, et al. Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer. Hum. Mol. Genet. 19(21), 4273-4277 (2010
    • (2010) Hum. Mol. Genet , vol.19 , Issue.21 , pp. 4273-4277
    • Li, L.1    Lee, K.M.2    Han, W.3
  • 26
    • 80053356357 scopus 로고    scopus 로고
    • Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence
    • Fackler MJ, Umbricht CB, Williams D, et al. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence. Cancer Res. 71(19), 6195-6207 (2011
    • (2011) Cancer Res , vol.71 , Issue.19 , pp. 6195-6207
    • Fackler, M.J.1    Umbricht, C.B.2    Williams, D.3
  • 27
    • 79953123510 scopus 로고    scopus 로고
    • Breast cancer methylomes establish an epigenomic foundation for metastasis
    • 75ra25
    • Fang F, Turcan S, Rimner A, et al. Breast cancer methylomes establish an epigenomic foundation for metastasis. Sci. Transl. Med. 3(75), 75ra25 (2011
    • (2011) Sci. Transl. Med , vol.3 , Issue.75
    • Fang, F.1    Turcan, S.2    Rimner, A.3
  • 28
    • 79954623906 scopus 로고    scopus 로고
    • Genome-wide dna methylation profiling of cpg islands in breast cancer identifies novel genes associated with tumorigenicity
    • Hill VK, Ricketts C, Bieche I, et al. Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity. Cancer Res. 71(8), 2988-2999 (2011
    • (2011) Cancer Res , vol.71 , Issue.8 , pp. 2988-2999
    • Hill, V.K.1    Ricketts, C.2    Bieche, I.3
  • 29
    • 84903196176 scopus 로고    scopus 로고
    • Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and dna repair capacity
    • Guerrero-Preston R, Hadar T, Ostrow KL, et al. Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncol. Rep. 32(2), 505-512 (2014
    • (2014) Oncol. Rep , vol.32 , Issue.2 , pp. 505-512
    • Guerrero-Preston, R.1    Hadar, T.2    Ostrow, K.L.3
  • 30
    • 84880892927 scopus 로고    scopus 로고
    • Aberrant ndrg1 methylation associated with its decreased expression and clinicopathological significance in breast cancer
    • Han LL, Hou L, Zhou MJ, et al. Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer. J. Biomed. Sci. 20, 52 (2013
    • (2013) J. Biomed. Sci , vol.20 , Issue.52
    • Han, L.L.1    Hou, L.2    Zhou, M.J.3
  • 31
    • 84855272662 scopus 로고    scopus 로고
    • Epigenetic changes of cxcr4 and its ligand cxcl12 as prognostic factors for sporadic breast cancer
    • Ramos EA, Grochoski M, Braun-Prado K, et al. Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. PLoS ONE 6(12), e29461 (2011
    • (2011) PLoS ONE , vol.6 , Issue.12 , pp. e29461
    • Ramos, E.A.1    Grochoski, M.2    Braun-Prado, K.3
  • 32
    • 79956330964 scopus 로고    scopus 로고
    • Cpg islands and the regulation of transcription
    • Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev. 25(10), 1010-1022 (2011
    • (2011) Genes Dev , vol.25 , Issue.10 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 33
    • 84919793649 scopus 로고    scopus 로고
    • Comparative epigenetic analyses reveal distinct patterns of oncogenic pathways activation in breast cancer subtypes
    • Li Y, Li S, Chen J, et al. Comparative epigenetic analyses reveal distinct patterns of oncogenic pathways activation in breast cancer subtypes. Hum. Mol. Genet. 23(20), 5378-5393 (2014
    • (2014) Hum. Mol. Genet , vol.23 , Issue.20 , pp. 5378-5393
    • Li, Y.1    Li, S.2    Chen, J.3
  • 34
    • 84858205498 scopus 로고    scopus 로고
    • Dna methylation pattern of the slc25a43 gene in breast cancer
    • Lindqvist BM, Farkas SA, Wingren S, Nilsson TK. DNA methylation pattern of the SLC25A43 gene in breast cancer. Epigenetics 7(3), 300-306 (2012
    • (2012) Epigenetics , vol.7 , Issue.3 , pp. 300-306
    • Lindqvist, B.M.1    Farkas, S.A.2    Wingren, S.3    Nilsson, T.K.4
  • 35
    • 84884588875 scopus 로고    scopus 로고
    • Cpg island shore methylation regulates caveolin-1 expression in breast cancer
    • Rao X, Evans J, Chae H, et al. CpG island shore methylation regulates caveolin-1 expression in breast cancer. Oncogene 32(38), 4519-4528 (2013
    • (2013) Oncogene , vol.32 , Issue.38 , pp. 4519-4528
    • Rao, X.1    Evans, J.2    Chae, H.3
  • 36
    • 84872714175 scopus 로고    scopus 로고
    • Breast cancer: Mechanisms involved in action of phytoestrogens and epigenetic changes
    • Dagdemir A, Durif J, Ngollo M, Bignon YJ, Bernard-Gallon D. Breast cancer: mechanisms involved in action of phytoestrogens and epigenetic changes. In Vivo 27(1), 1-9 (2013
    • (2013) Vivo , vol.27 , Issue.1 , pp. 1-9
    • Dagdemir, A.1    Durif, J.2    Ngollo, M.3    Bignon, Y.J.4    Bernard-Gallon, D.5
  • 37
    • 77649238322 scopus 로고    scopus 로고
    • Dna methylome of familial breast cancer identifies distinct profiles defined by mutation status
    • Flanagan JM, Cocciardi S, Waddell N, et al. DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. Am. J. Hum. Genet. 86(3), 420-433 (2010
    • (2010) Am. J. Hum. Genet , vol.86 , Issue.3 , pp. 420-433
    • Flanagan, J.M.1    Cocciardi, S.2    Waddell, N.3
  • 38
    • 77950409567 scopus 로고    scopus 로고
    • Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-dna immunoprecipitation combined with high-Throughput sequencing
    • Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G. Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-Throughput sequencing. BMC Genomics 11, 137 (2010
    • (2010) BMC Genomics , vol.11 , Issue.137
    • Ruike, Y.1    Imanaka, Y.2    Sato, F.3    Shimizu, K.4    Tsujimoto, G.5
  • 39
    • 23844489449 scopus 로고    scopus 로고
    • P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with cdh3 promoter hypomethylation
    • Paredes J, Albergaria A, Oliveira JT, Jeronimo C, Milanezi F, Schmitt FC. P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clin. Cancer Res. 11(16), 5869-5877 (2005
    • (2005) Clin. Cancer Res , vol.11 , Issue.16 , pp. 5869-5877
    • Paredes, J.1    Albergaria, A.2    Oliveira, J.T.3    Jeronimo, C.4    Milanezi, F.5    Schmitt, F.C.6
  • 40
    • 56449116122 scopus 로고    scopus 로고
    • Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers
    • Singh P, Yang M, Dai H, et al. Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers. Mol. Cancer. Res. 6(11), 1710-1717 (2008
    • (2008) Mol. Cancer. Res , vol.6 , Issue.11 , pp. 1710-1717
    • Singh, P.1    Yang, M.2    Dai, H.3
  • 41
    • 40249118885 scopus 로고    scopus 로고
    • Promoter hypomethylation of the n-Acetyltransferase 1 gene in breast cancer
    • Kim SJ, Kang HS, Chang HL, et al. Promoter hypomethylation of the N-Acetyltransferase 1 gene in breast cancer. Oncol. Rep. 19(3), 663-668 (2008
    • (2008) Oncol. Rep , vol.19 , Issue.3 , pp. 663-668
    • Kim, S.J.1    Kang, H.S.2    Chang, H.L.3
  • 43
    • 77049099785 scopus 로고    scopus 로고
    • Histone methyltransferases in cancer
    • Albert M, Helin K. Histone methyltransferases in cancer. Semin. Cell Dev. Biol. 21(2), 209-220 (2010
    • (2010) Semin. Cell Dev. Biol , vol.21 , Issue.2 , pp. 209-220
    • Albert, M.1    Helin, K.2
  • 44
    • 70349335528 scopus 로고    scopus 로고
    • Mechanisms of transcriptional repression by histone lysine methylation
    • Hublitz P, Albert M, Peters AH. Mechanisms of transcriptional repression by histone lysine methylation. Int. J. Dev. Biol. 53(2-3), 335-354 (2009
    • (2009) Int. J. Dev. Biol , vol.53 , Issue.2-3 , pp. 335-354
    • Hublitz, P.1    Albert, M.2    Peters, A.H.3
  • 45
    • 27644589675 scopus 로고    scopus 로고
    • The diverse functions of histone lysine methylation
    • Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell Biol. 6(11), 838-849 (2005
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , Issue.11 , pp. 838-849
    • Martin, C.1    Zhang, Y.2
  • 46
    • 65949086183 scopus 로고    scopus 로고
    • Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome
    • Elsheikh SE, Green AR, Rakha EA, et al. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res. 69(9), 3802-3809 (2009
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 3802-3809
    • Elsheikh, S.E.1    Green, A.R.2    Rakha, E.A.3
  • 47
    • 77956194960 scopus 로고    scopus 로고
    • Methylation of the tumor suppressor protein, brca1, influences its transcriptional cofactor function
    • Guendel I, Carpio L, Pedati C, et al. Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. PLoS ONE 5(6), e11379 (2010
    • (2010) PLoS ONE , vol.5 , Issue.6 , pp. e11379
    • Guendel, I.1    Carpio, L.2    Pedati, C.3
  • 48
    • 84862828921 scopus 로고    scopus 로고
    • Functional elements demarcated by histone modifications in breast cancer cells
    • Choe MK, Hong CP, Park J, Seo SH, Roh TY. Functional elements demarcated by histone modifications in breast cancer cells. Biochem. Biophys. Res. Commun. 418(3), 475-482 (2012
    • (2012) Biochem. Biophys. Res. Commun , vol.418 , Issue.3 , pp. 475-482
    • Choe, M.K.1    Hong, C.P.2    Park, J.3    Seo, S.H.4    Roh, T.Y.5
  • 49
    • 84885470947 scopus 로고    scopus 로고
    • Characterization of chromatin structure-Associated histone modifications in breast cancer cells
    • Hong CP, Choe MK, Roh TY. Characterization of chromatin structure-Associated histone modifications in breast cancer cells. Genomics Inform. 10(3), 145-152 (2012
    • (2012) Genomics Inform , vol.10 , Issue.3 , pp. 145-152
    • Hong, C.P.1    Choe, M.K.2    Roh, T.Y.3
  • 51
    • 0028318783 scopus 로고
    • Methylation of the estrogen receptor gene cpg island marks loss of estrogen receptor expression in human breast cancer cells
    • Ottaviano YL, Issa JP, Parl FF, Smith HS, Baylin SB, Davidson NE. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res. 54(10), 2552-2555 (1994
    • (1994) Cancer Res , vol.54 , Issue.10 , pp. 2552-2555
    • Ottaviano, Y.L.1    Issa, J.P.2    Parl, F.F.3    Smith, H.S.4    Baylin, S.B.5    Davidson, N.E.6
  • 52
    • 22444433425 scopus 로고    scopus 로고
    • Release of methyl cpg binding proteins and histone deacetylase 1 from the estrogen receptor alpha (er) promoter upon reactivation in er-negative human breast cancer cells
    • Sharma D, Blum J, Yang X, Beaulieu N, Macleod AR, Davidson NE. Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells. Mol. Endocrinol. 19(7), 1740-1751 (2005
    • (2005) Mol. Endocrinol , vol.19 , Issue.7 , pp. 1740-1751
    • Sharma, D.1    Blum, J.2    Yang, X.3    Beaulieu, N.4    MacLeod, A.R.5    Davidson, N.E.6
  • 53
    • 77649314541 scopus 로고    scopus 로고
    • Simultaneous cxcl12 and esr1 cpg island hypermethylation correlates with poor prognosis in sporadic breast cancer
    • Ramos EA, Camargo AA, Braun K, et al. Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer. BMC Cancer 10, 23 (2010
    • (2010) BMC Cancer , vol.10 , Issue.23
    • Ramos, E.A.1    Camargo, A.A.2    Braun, K.3
  • 54
    • 28244460828 scopus 로고    scopus 로고
    • Brca1 promoter methylation in sporadic breast cancer is associated with reduced brca1 copy number and chromosome 17 aneusomy
    • Wei M, Grushko TA, Dignam J, et al. BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Res. 65(23), 10692-10699 (2005
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10692-10699
    • Wei, M.1    Grushko, T.A.2    Dignam, J.3
  • 55
    • 84860306715 scopus 로고    scopus 로고
    • The epigenetic silencing of the estrogen receptor (er) by hypermethylation of the esr1 promoter is seen predominantly in triplenegative breast cancers in indian women
    • Prabhu JS, Wahi K, Korlimarla A, et al. The epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triplenegative breast cancers in Indian women. Tumour Biol. 33(2), 315-323 (2012
    • (2012) Tumour Biol , vol.33 , Issue.2 , pp. 315-323
    • Prabhu, J.S.1    Wahi, K.2    Korlimarla, A.3
  • 56
    • 84872764016 scopus 로고    scopus 로고
    • Clinical implications of erbeta methylation on sporadic breast cancers in chinese women
    • Zhao L, Yu Z, Li Y, et al. Clinical implications of ERbeta methylation on sporadic breast cancers in Chinese women. Med. Oncol. 29(3), 1569-1575 (2012
    • (2012) Med. Oncol , vol.29 , Issue.3 , pp. 1569-1575
    • Zhao, L.1    Yu, Z.2    Li, Y.3
  • 57
    • 55949124844 scopus 로고    scopus 로고
    • Ezh1 mediates methylation on histone h3 lysine 27 and complements ezh2 in maintaining stem cell identity and executing pluripotency
    • Shen X, Liu Y, Hsu YJ, et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32(4), 491-502 (2008
    • (2008) Mol. Cell , vol.32 , Issue.4 , pp. 491-502
    • Shen, X.1    Liu, Y.2    Hsu, Y.J.3
  • 58
    • 0141816752 scopus 로고    scopus 로고
    • Ezh2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl Acad. Sci. USA 100(20), 11606-11611 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.20 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3
  • 59
    • 33646267689 scopus 로고    scopus 로고
    • Identification of ezh2 as a molecular marker for a precancerous state in morphologically normal breast tissues
    • Ding L, Erdmann C, Chinnaiyan AM, Merajver SD, Kleer CG. Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues. Cancer Res. 66(8), 4095-4099 (2006
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4095-4099
    • Ding, L.1    Erdmann, C.2    Chinnaiyan, A.M.3    Merajver, S.D.4    Kleer, C.G.5
  • 60
    • 77955552108 scopus 로고    scopus 로고
    • In utero exposure to diethylstilbestrol (des) or bisphenol-A (bpa) increases ezh2 expression in the mammary gland: An epigenetic mechanism linking endocrine disruptors to breast cancer
    • Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS. In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer. Horm. Cancer 1(3), 146-155 (2010
    • (2010) Horm. Cancer , vol.1 , Issue.3 , pp. 146-155
    • Doherty, L.F.1    Bromer, J.G.2    Zhou, Y.3    Aldad, T.S.4    Taylor, H.S.5
  • 61
    • 84874231902 scopus 로고    scopus 로고
    • Global changes in the mammary epigenome are induced by hormonal cues and coordinated by ezh2
    • Pal B, Bouras T, Shi W, et al Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep. 3(2), 411-426 (2013
    • (2013) Cell Rep , vol.3 , Issue.2 , pp. 411-426
    • Pal, B.1    Bouras, T.2    Shi, W.3
  • 62
    • 84866050864 scopus 로고    scopus 로고
    • Global h3k27 trimethylation and ezh2 abundance in breast tumor subtypes
    • Holm K, Grabau D, Lovgren K, et al. Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes. Mol. Oncol. 6(5), 494-506 (2012
    • (2012) Mol. Oncol , vol.6 , Issue.5 , pp. 494-506
    • Holm, K.1    Grabau, D.2    Lovgren, K.3
  • 63
    • 50649086570 scopus 로고    scopus 로고
    • Runx3 attenuates betacatenin/t cell factors in intestinal tumorigenesis
    • Ito K, Lim AC, Salto-Tellez M, et al. RUNX3 attenuates betacatenin/T cell factors in intestinal tumorigenesis. Cancer Cell 14(3), 226-237 (2008
    • (2008) Cancer Cell , vol.14 , Issue.3 , pp. 226-237
    • Ito, K.1    Lim, A.C.2    Salto-Tellez, M.3
  • 64
    • 47749134140 scopus 로고    scopus 로고
    • Enhancer of zeste homologue 2 (ezh2) down-regulates runx3 by increasing histone h3 methylation
    • Fujii S, Ito K, Ito Y, Ochiai A. Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. J. Biol. Chem. 283(25), 17324-17332 (2008
    • (2008) J. Biol. Chem , vol.283 , Issue.25 , pp. 17324-17332
    • Fujii, S.1    Ito, K.2    Ito, Y.3    Ochiai, A.4
  • 65
    • 24344500170 scopus 로고    scopus 로고
    • Runx3 suppresses gastric epithelial cell growth by inducing p21(waf1/cip1) expression in cooperation with transforming growth factor {beta}-Activated smad
    • Chi XZ, Yang JO, Lee KY, et al. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-Activated SMAD. Mol. Cell. Biol. 25(18), 8097-8107 (2005
    • (2005) Mol. Cell. Biol , vol.25 , Issue.18 , pp. 8097-8107
    • Chi, X.Z.1    Yang, J.O.2    Lee, K.Y.3
  • 66
    • 84856221154 scopus 로고    scopus 로고
    • Foxc1, a target of polycomb, inhibits metastasis of breast cancer cells
    • Du J, Li L, Ou Z, et al. FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells. Breast Cancer Res. Treat. 131(1), 65-73 (2012
    • (2012) Breast Cancer Res. Treat , vol.131 , Issue.1 , pp. 65-73
    • Du, J.1    Li, L.2    Ou, Z.3
  • 67
    • 82555173684 scopus 로고    scopus 로고
    • Ezh2 methyltransferase and h3k27 methylation in breast cancer
    • Yoo KH, Hennighausen L. EZH2 methyltransferase and H3K27 methylation in breast cancer. Int. J. Biol. Sci. 8(1), 59-65 (2012
    • (2012) Int. J. Biol. Sci , vol.8 , Issue.1 , pp. 59-65
    • Yoo, K.H.1    Hennighausen, L.2
  • 69
    • 0030843274 scopus 로고    scopus 로고
    • Methylation of the brca1 gene in sporadic breast cancer
    • Dobrovic A, Simpfendorfer D. Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res. 57(16), 3347-3350 (1997
    • (1997) Cancer Res , vol.57 , Issue.16 , pp. 3347-3350
    • Dobrovic, A.1    Simpfendorfer, D.2
  • 70
    • 0033857349 scopus 로고    scopus 로고
    • Methylation of the brca1 promoter is associated with decreased brca1 mrna levels in clinical breast cancer specimens
    • Rice JC, Ozcelik H, Maxeiner P, Andrulis I, Futscher BW. Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 21(9), 1761-1765 (2000
    • (2000) Carcinogenesis , vol.21 , Issue.9 , pp. 1761-1765
    • Rice, J.C.1    Ozcelik, H.2    Maxeiner, P.3    Andrulis, I.4    Futscher, B.W.5
  • 71
    • 0034607234 scopus 로고    scopus 로고
    • Promoter hypermethylation and brca1 inactivation in sporadic breast and ovarian tumors
    • Esteller M, Silva JM, Dominguez G, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J. Natl Cancer Inst. 92(7), 564-569 (2000
    • (2000) J. Natl Cancer Inst , vol.92 , Issue.7 , pp. 564-569
    • Esteller, M.1    Silva, J.M.2    Dominguez, G.3
  • 72
    • 33847022042 scopus 로고    scopus 로고
    • Brca1 dysfunction in sporadic basal-like breast cancer
    • Turner NC, Reis-Filho JS, Russell AM, et al. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 26(14), 2126-2132 (2007
    • (2007) Oncogene , vol.26 , Issue.14 , pp. 2126-2132
    • Turner, N.C.1    Reis-Filho, J.S.2    Russell, A.M.3
  • 73
    • 79957562586 scopus 로고    scopus 로고
    • Cpg island hypermethylation of brca1 and loss of prb as co-occurring events in basal/triple-negative breast cancer
    • Stefansson OA, Jonasson JG, Olafsdottir K, et al. CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer. Epigenetics 6(5), 638-649 (2011
    • (2011) Epigenetics , vol.6 , Issue.5 , pp. 638-649
    • Stefansson, O.A.1    Jonasson, J.G.2    Olafsdottir, K.3
  • 74
    • 78650803552 scopus 로고    scopus 로고
    • Constitutional methylation of the brca1 promoter is specifically associated with brca1 mutation-Associated pathology in early-onset breast cancer
    • Wong EM, Southey MC, Fox SB, et al. Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-Associated pathology in early-onset breast cancer. Cancer Prev. Res. 4(1), 23-33 (2011
    • (2011) Cancer Prev. Res , vol.4 , Issue.1 , pp. 23-33
    • Wong, E.M.1    Southey, M.C.2    Fox, S.B.3
  • 75
    • 84888607941 scopus 로고    scopus 로고
    • Comparison of methylation profiling in cancerous and their corresponding normal tissues from korean patients with breast cancer
    • Jung EJ, Kim IS, Lee EY, et al. Comparison of methylation profiling in cancerous and their corresponding normal tissues from korean patients with breast cancer. Ann. Lab. Med. 33(6), 431-440 (2013
    • (2013) Ann. Lab. Med , vol.33 , Issue.6 , pp. 431-440
    • Jung, E.J.1    Kim, I.S.2    Lee, E.Y.3
  • 76
    • 79960843163 scopus 로고    scopus 로고
    • Brca1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with brca1 promoter methylation
    • Iwamoto T, Yamamoto N, Taguchi T, Tamaki Y, Noguchi S. BRCA1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with BRCA1 promoter methylation. Breast Cancer Res. Treat. 129(1), 69-77 (2011
    • (2011) Breast Cancer Res. Treat , vol.129 , Issue.1 , pp. 69-77
    • Iwamoto, T.1    Yamamoto, N.2    Taguchi, T.3    Tamaki, Y.4    Noguchi, S.5
  • 77
    • 79956017227 scopus 로고    scopus 로고
    • Methylationrelated mutations in the brca1 promoter in peripheral blood cells from cancer-free women
    • Al-Moghrabi N, Al-Qasem AJ, Aboussekhra A. Methylationrelated mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women. Int. J. Oncol. 39(1), 129-135 (2011
    • (2011) Int. J. Oncol , vol.39 , Issue.1 , pp. 129-135
    • Al-Moghrabi, N.1    Al-Qasem, A.J.2    Aboussekhra, A.3
  • 78
    • 84868368069 scopus 로고    scopus 로고
    • Detection of promoter methylation of tumor suppressor genes in serum dna of breast cancer cases and benign breast disease controls
    • Sturgeon SR, Balasubramanian R, Schairer C, Muss HB, Ziegler RG, Arcaro KF. Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls. Epigenetics 7(11), 1258-1267 (2012
    • (2012) Epigenetics , vol.7 , Issue.11 , pp. 1258-1267
    • Sturgeon, S.R.1    Balasubramanian, R.2    Schairer, C.3    Muss, H.B.4    Ziegler, R.G.5    Arcaro, K.F.6
  • 79
    • 84860699837 scopus 로고    scopus 로고
    • Brca1 promoter methylation in peripheral blood dna was identified in sporadic breast cancer and controls
    • Bosviel R, Garcia S, Lavediaux G, et al. BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls. Cancer Epidemiol. 36(3), e177-e182 (2012
    • (2012) Cancer Epidemiol , vol.36 , Issue.3 , pp. e177-e182
    • Bosviel, R.1    Garcia, S.2    Lavediaux, G.3
  • 80
    • 84870904712 scopus 로고    scopus 로고
    • Brca2 promoter hypermethylation in sporadic breast cancer
    • Bosviel R, Durif J, Guo J, et al. BRCA2 promoter hypermethylation in sporadic breast cancer. Omics 16(12), 707-710 (2012
    • (2012) Omics , vol.16 , Issue.12 , pp. 707-710
    • Bosviel, R.1    Durif, J.2    Guo, J.3
  • 81
    • 79952766783 scopus 로고    scopus 로고
    • Histone methyltransferase ezh2 induces akt-dependent genomic instability and brca1 inhibition in breast cancer
    • Gonzalez ME, Duprie ML, Krueger H, et al. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. Cancer Res. 71(6), 2360-2370 (2011
    • (2011) Cancer Res , vol.71 , Issue.6 , pp. 2360-2370
    • Gonzalez, M.E.1    Duprie, M.L.2    Krueger, H.3
  • 82
    • 84890262848 scopus 로고    scopus 로고
    • Ezh2 takes the stage when brca1 loses
    • Wang L, Huang H. EZH2 takes the stage when BRCA1 loses. Cell Cycle 12(23), 3575-3576 (2013
    • (2013) Cell Cycle , vol.12 , Issue.23 , pp. 3575-3576
    • Wang, L.1    Huang, H.2
  • 83
    • 84874410182 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors (hdacis): Multitargeted anticancer agents
    • Ververis K, Hiong A, Karagiannis TC, Licciardi PV. Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics 7, 47-60 (2013
    • (2013) Biologics , vol.7 , pp. 47-60
    • Ververis, K.1    Hiong, A.2    Karagiannis, T.C.3    Licciardi, P.V.4
  • 84
    • 36148950997 scopus 로고    scopus 로고
    • Fda approval summary: Vorinostat for treatment of advanced primary cutaneous t-cell lymphoma
    • Mann BS, Johnson JR, Cohen MH, Justice R, Pazdur R. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 12(10), 1247-1252 (2007
    • (2007) Oncologist , vol.12 , Issue.10 , pp. 1247-1252
    • Mann, B.S.1    Johnson, J.R.2    Cohen, M.H.3    Justice, R.4    Pazdur, R.5
  • 85
    • 77749309291 scopus 로고    scopus 로고
    • Romidepsin for the treatment of cutaneous t-cell lymphoma
    • Campas-Moya C. Romidepsin for the treatment of cutaneous T-cell lymphoma. Drugs Today 45(11), 787-795 (2009
    • (2009) Drugs Today , vol.45 , Issue.11 , pp. 787-795
    • Campas-Moya, C.1
  • 86
    • 0034297220 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment
    • Huang L, Pardee AB. Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment. Mol. Med. 6(10), 849-866 (2000
    • (2000) Mol. Med , vol.6 , Issue.10 , pp. 849-866
    • Huang, L.1    Pardee, A.B.2
  • 87
    • 68949105725 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase suppresses egf signaling pathways by destabilizing egfr mrna in er-negative human breast cancer cells
    • Zhou Q, Shaw PG, Davidson NE. Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cells. Breast Cancer Res. Treat. 117(2), 443-451 (2009
    • (2009) Breast Cancer Res. Treat , vol.117 , Issue.2 , pp. 443-451
    • Zhou, Q.1    Shaw, P.G.2    Davidson, N.E.3
  • 88
    • 84855862321 scopus 로고    scopus 로고
    • Saha/trail combination induces detachment and anoikis of mda-mb231 and mcf-7 breast cancer cells
    • Lauricella M, Ciraolo A, Carlisi D, Vento R, Tesoriere G. SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells. Biochimie 94(2), 287-299 (2012
    • (2012) Biochimie , vol.94 , Issue.2 , pp. 287-299
    • Lauricella, M.1    Ciraolo, A.2    Carlisi, D.3    Vento, R.4    Tesoriere, G.5
  • 89
    • 79958084461 scopus 로고    scopus 로고
    • A phase ii study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
    • Munster PN, Thurn KT, Thomas S, et al. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br. J. Cancer 104(12), 1828-1835 (2011
    • (2011) Br. J. Cancer , vol.104 , Issue.12 , pp. 1828-1835
    • Munster, P.N.1    Thurn, K.T.2    Thomas, S.3
  • 90
    • 84865168464 scopus 로고    scopus 로고
    • Phase i-ii study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: Evidence for vorinostat-induced tubulin acetylation and hsp90 inhibition in vivo
    • Ramaswamy B, Fiskus W, Cohen B, et al. Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo. Breast Cancer Res. Treat. 132(3), 1063-1072 (2012
    • (2012) Breast Cancer Res. Treat , vol.132 , Issue.3 , pp. 1063-1072
    • Ramaswamy, B.1    Fiskus, W.2    Cohen, B.3
  • 91
    • 84861968080 scopus 로고    scopus 로고
    • Targeting triplenegative breast cancer cells with the histone deacetylase inhibitor panobinostat
    • Tate CR, Rhodes LV, Segar HC, et al. Targeting triplenegative breast cancer cells with the histone deacetylase inhibitor panobinostat. Breast Cancer Res. 14(3), R79 (2012
    • (2012) Breast Cancer Res , vol.14 , Issue.3 , pp. R79
    • Tate, C.R.1    Rhodes, L.V.2    Segar, H.C.3
  • 92
    • 39649093202 scopus 로고    scopus 로고
    • The important role of caspase-10 in sodium butyrate-induced apoptosis
    • Nohara K, Yokoyama Y, Kano K. The important role of caspase-10 in sodium butyrate-induced apoptosis. Kobe J. Med. Sci. 53(5), 265-273 (2007
    • (2007) Kobe J. Med. Sci , vol.53 , Issue.5 , pp. 265-273
    • Nohara, K.1    Yokoyama, Y.2    Kano, K.3
  • 93
    • 67649659846 scopus 로고    scopus 로고
    • The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in rko colorectal cancer and mcf-7 breast cancer cell lines
    • Cho HJ, Kim SY, Kim KH, et al. The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines. World J. Surg. Oncol. 7, 49 (2009
    • (2009) World J. Surg. Oncol , vol.7 , pp. 49
    • Cho, H.J.1    Kim, S.Y.2    Kim, K.H.3
  • 94
    • 33745685866 scopus 로고    scopus 로고
    • Restoration of tamoxifen sensitivity in estrogen receptornegative breast cancer cells: Tamoxifen-bound reactivated er recruits distinctive corepressor complexes
    • Sharma D, Saxena NK, Davidson NE, Vertino PM. Restoration of tamoxifen sensitivity in estrogen receptornegative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res. 66(12), 6370-6378 (2006
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6370-6378
    • Sharma, D.1    Saxena, N.K.2    Davidson, N.E.3    Vertino, P.M.4
  • 95
    • 44749085668 scopus 로고    scopus 로고
    • Er alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both hdac inhibitor and dnmt inhibitor
    • Fan J, Yin WJ, Lu JS, et al. ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor. J. Cancer Res. Clin. Oncol. 134(8), 883-890 (2008
    • (2008) J. Cancer Res. Clin. Oncol , vol.134 , Issue.8 , pp. 883-890
    • Fan, J.1    Yin, W.J.2    Lu, J.S.3
  • 96
    • 0035477320 scopus 로고    scopus 로고
    • Synergistic activation of functional estrogen receptor (er)-Alpha by dna methyltransferase and histone deacetylase inhibition in human er-Alpha-negative breast cancer cells
    • Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE. Synergistic activation of functional estrogen receptor (ER)-Alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-Alpha-negative breast cancer cells. Cancer Res. 61(19), 7025-7029 (2001
    • (2001) Cancer Res , vol.61 , Issue.19 , pp. 7025-7029
    • Yang, X.1    Phillips, D.L.2    Ferguson, A.T.3    Nelson, W.G.4    Herman, J.G.5    Davidson, N.E.6
  • 97
    • 79952237710 scopus 로고    scopus 로고
    • Functional activation of the estrogen receptoralpha and aromatase by the hdac inhibitor entinostat sensitizes er-negative tumors to letrozole
    • Sabnis GJ, Goloubeva O, Chumsri S, Nguyen N, Sukumar S, Brodie AM. Functional activation of the estrogen receptoralpha and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letrozole. Cancer Res. 71(5), 1893-1903 (2011
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1893-1903
    • Sabnis, G.J.1    Goloubeva, O.2    Chumsri, S.3    Nguyen, N.4    Sukumar, S.5    Brodie, A.M.6
  • 98
    • 0018756907 scopus 로고
    • Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo
    • Chiang PK, Cantoni GL. Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo. Biochem. Pharmacol. 28(12), 1897-1902 (1979
    • (1979) Biochem. Pharmacol , vol.28 , Issue.12 , pp. 1897-1902
    • Chiang, P.K.1    Cantoni, G.L.2
  • 99
    • 0026739034 scopus 로고
    • Rational approaches to the design of antiviral agents based on s-Adenosyl-lhomocysteine hydrolase as a molecular target
    • Liu S, Wolfe MS, Borchardt RT. Rational approaches to the design of antiviral agents based on S-Adenosyl-Lhomocysteine hydrolase as a molecular target. Antiviral Res. 19(3), 247-265 (1992
    • (1992) Antiviral Res , vol.19 , Issue.3 , pp. 247-265
    • Liu, S.1    Wolfe, M.S.2    Borchardt, R.T.3
  • 100
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21(9), 1050-1063 (2007
    • (2007) Genes Dev , vol.21 , Issue.9 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 101
    • 84919830922 scopus 로고    scopus 로고
    • Aberrant epigenetic regulation in breast cancer (p91-122
    • Minarovits J, Niller HH (Eds). Springer NY USA
    • Toland AE. Aberrant epigenetic regulation in breast cancer (p91-122). In: Patho-Epigenetics of Disease. Minarovits J, Niller HH (Eds). Springer, NY, USA (2012
    • (2012) Patho-Epigenetics of Disease
    • Toland, A.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.