Epigenetic silencing of DSC3 is a common event in human breast cancer

Breast Cancer Research

Volumn 7, Issue 5, 2005, Pages

  Oshiro, Marc M ^a   Kim, Christina J ^b   Wozniak, Ryan J ^a   Junk, Damian J ^a   Muñoz Rodríguez, José L ^a   Burr, Jeanne A ^a   Fitzgerald, Matthew ^c   Pawar, Sangita C ^a   Cress, Anne E ^a   Domann, Frederick E ^c   Futscher, Bernard W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; DESMOCOLLIN; DSC3 PROTEIN, HUMAN; MEMBRANE PROTEIN; PRIMER DNA; RNA;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; DOWN REGULATION; DSC3 GENE; EPIGENETICS; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; PRIMARY TUMOR; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GENE; VERY ELDERLY; BREAST TUMOR; DNA METHYLATION; ENZYMOLOGY; EPITHELIUM CELL; FEMALE; GENETICS; MASTECTOMY; PATHOLOGY; PROSTATE; SEGMENTAL MASTECTOMY;

BREAST NEOPLASMS; DESMOCOLLINS; DNA METHYLATION; DNA PRIMERS; EPITHELIAL CELLS; FEMALE; GENE SILENCING; HUMANS; MALE; MASTECTOMY; MASTECTOMY, SEGMENTAL; MEMBRANE GLYCOPROTEINS; PROMOTER REGIONS (GENETICS); PROSTATE; RNA, NEOPLASM;

EID: 33644877242     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr1273     Document Type: Article

References (43)

1. Domann FE, Rice JC, Hendrix MJ, Futscher BW: Epigenetic silencing of maspin gene expression in human breast cancers. Int J Cancer. 2000, 85: 805-810 10.1002/(SICI)1097-0215(20000315)85:6<805::AID-IJC12>3.0.CO;2-5.
2. Esteller M, Fraga MF, Paz MF, Campo E, Colomer D, Novo FJ, Calasanz MJ, Galm O, Guo M, Benitez J, Herman JG: Cancer epigenetics and methylation. Science. 2002, 297: 1807-1808 10.1126/science.297.5588.1807d.
3. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP: Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res. 1998, 72: 141-196.
4. Jones PA: DNA methylation and cancer. Oncogene. 2002, 21: 5358-5360 10.1038/sj.onc.1205597.
5. Rice JC, Futscher BW: Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter. Nucleic Acids Res. 2000, 28: 3233-3239 10.1093/nar/28.17.3233.
6. Oshiro MM, Watts GS, Wozniak RJ, Junk DJ, Munoz-Rodriguez JL, Domann FE, Futscher BW: Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression. Oncogene. 2003, 22: 3624-3634 10.1038/sj.onc.1206545.
7. Rice JC, Allis CD: Code of silence. Nature. 2001, 414: 258-261 10.1038/35104721.
8. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70 10.1016/S0092-8674(00)81683-9.
9. Widschwendter M, Jones PA: DNA methylation and breast carcinogenesis. Oncogene. 2002, 21: 5462-5482 10.1038/sj.onc.1205606.
10. Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM: Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem. 1997, 272: 22322-22329 10.1074/jbc.272.35.22322.
11. Bianco T, Chenevix-Trench G, Walsh DC, Cooper JE, Dobrovic A: Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer. Carcinogenesis. 2000, 21: 147-151 10.1093/carcin/21.2.147.
12. Dobrovic A, Simpfendorfer D: Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res. 1997, 57: 3347-3350.
13. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB: E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res. 1995, 55: 5195-5199.
14. Rice JC, Ozcelik H, Maxeiner P, Andrulis I, Futscher BW: Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis. 2000, 21: 1761-1765 10.1093/carcin/21.9.1761.
15. Dammann R, Yang G, Pfeifer GP: Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers. Cancer Res. 2001, 61: 3105-3109.
16. Bachman KE, Herman JG, Corn PG, Merlo A, Costello JF, Cavenee WK, Baylin SB, Graff JR: Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res. 1999, 59: 798-802.
17. Costa FF, Verbisck NV, Salim AC, Ierardi DF, Pires LC, Sasahara RM, Sogayar MC, Zanata SM, Mackay A, O'Hare M, et al: Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors. Oncogene. 2004, 23: 1481-1488 10.1038/sj.onc.1207263.
18. Wheelock MJ, Soler AP, Knudsen KA: Cadherin junctions in mammary tumors. J Mammary Gland Biol Neoplasia. 2001, 6: 275-285 10.1023/A:1011319507155.
19. Getsios S, Huen AC, Green KJ: Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol. 2004, 5: 271-281 10.1038/nrm1356.
20. Garrod DR, Merritt AJ, Nie Z: Desmosomal cadherins. Curr Opin Cell Biol. 2002, 14: 537-545 10.1016/S0955-0674(02)00366-6.
21. Kowalski PJ, Rubin MA, Kleer CG: E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 2003, 5: R217-222 10.1186/bcr651.
22. Chidgey MA, Yue KK, Gould S, Byrne C, Garrod DR: Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development. Dev Dyn. 1997, 210: 315-327 10.1002/(SICI)1097-0177(199711)210:3<315::AID-AJA11>3.0.CO;2-9.
23. Koch PJ, Franke WW: Desmosomal cadherins: another growing multigene family of adhesion molecules. Curr Opin Cell Biol. 1994, 6: 682-687 10.1016/0955-0674(94)90094-9.
24. Arnemann J, Sullivan KH, Magee AI, King IA, Buxton RS: Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis. J Cell Sci. 1993, 104: 741-750.
25. Collins JE, Legan PK, Kenny TP, MacGarvie J, Holton JL, Garrod DR: Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains. J Cell Biol. 1991, 113: 381-391 10.1083/jcb.113.2.381.
26. Troyanovsky SM, Troyanovsky RB, Eshkind LG, Leube RE, Franke WW: Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation. Proc Natl Acad Sci USA. 1994, 91: 10790-10794.
27. Tselepis C, Chidgey M, North A, Garrod D: Desmosomal adhesion inhibits invasive behavior. Proc Natl Acad Sci USA. 1998, 95: 8064-8069 10.1073/pnas.95.14.8064.
28. Hanakawa Y, Amagai M, Shirakata Y, Sayama K, Hashimoto K: Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes. J Cell Sci. 2000, 113: 1803-1811.
29. Klus GT, Rokaeus N, Bittner ML, Chen Y, Korz DM, Sukumar S, Schick A, Szallasi Z: Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. Int J Oncol. 2001, 19: 169-174.
30. Huang Y, Domann FE: Transcription factor AP-2 mRNA and DNA binding activity are constitutively expressed in SV40-immortalized but not normal human lung fibroblasts. Arch Biochem Biophys. 1999, 364: 241-246 10.1006/abbi.1999.1142.
31. Johnson GK, Organ CC: Prostaglandin E2 and interleukin-1 concentrations in nicotine-exposed oral keratinocyte cultures. J Periodontal Res. 1997, 32: 447-454.
32. Futscher BW, Oshiro MM, Wozniak RJ, Holtan N, Hanigan CL, Duan H, Domann FE: Role for DNA methylation in the control of cell type specific maspin expression. Nat Genet. 2002, 31: 175-179 10.1038/ng886.
33. Kondo M, Finkbeiner WE, Widdicombe JH: Simple technique for culture of highly differentiated cells from dog tracheal epithelium. Am J Physiol. 1991, 261: L106-L117.
34. Zabner J, Zeiher BG, Friedman E, Welsh MJ: Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. J Virol. 1996, 70: 6994-7003.
35. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol. 1988, 106: 761-771 10.1083/jcb.106.3.761.
36. Gadhavi PL, Greenwood MD, Strom M, King IA, Buxton RS: The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction. Biochem Biophys Res Commun. 2001, 281: 520-528 10.1006/bbrc.2001.4375.
37. Millar DS, Krawczak M, Cooper DN: Variation of site-specific methylation patterns in the factor VIII (F8C) gene in human sperm DNA. Hum Genet. 1998, 103: 228-233 10.1007/s004390050810.
38. Millar DS, Ow KK, Paul CL, Russell PJ, Molloy PL, Clark SJ: Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer. Oncogene. 1999, 18: 1313-1324 10.1038/sj.onc.1202415.
39. Tost J, Schatz P, Schuster M, Berlin K, Gut IG: Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry. Nucleic Acids Res. 2003, 31: e50. 10.1093/nar/gng050.
40. Nuber UA, Schafer S, Stehr S, Rackwitz HR, Franke WW: Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. Eur J Cell Biol. 1996, 71: 1-13.
41. Beroud C, Soussi T: The UMD-p53 database: new mutations and analysis tools. Hum Mutat. 2003, 21: 176-181 10.1002/humu.10187.
42. Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z: The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 1999, 98: 137-146 10.1016/S0092-8674(00)81009-0.
43. Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR: Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol. 2001, 3: 823-830 10.1038/ncb0901-823.