Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Qin, Zhaoping ^a   Robichaud, Patrick ^a   He, Tianyuan ^a   Fisher, Gary J ^a   Voorhees, John J ^a   Quan, Taihao ^a   Zhou, Zhongjun ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; COLLAGEN TYPE 1; CYSTEINE RICH PROTEIN 61; MESSENGER RNA; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; ANTIOXIDANT; OXIDIZING AGENT; PROTEIN BINDING;

ADULT; AGING; ARTICLE; BINDING SITE; CCN1 GENE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; NORMAL HUMAN; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SKIN FIBROBLAST; ULTRAVIOLET IRRADIATION; CELL CULTURE; CYTOLOGY; DERMIS; DRUG EFFECTS; FIBROBLAST; GENETICS; INTRACELLULAR SPACE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RADIATION RESPONSE; ULTRAVIOLET RADIATION; YOUNG ADULT;

ADULT; ANTIOXIDANTS; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; COLLAGEN TYPE I; CYSTEINE-RICH PROTEIN 61; DERMIS; FIBROBLASTS; HUMANS; INTRACELLULAR SPACE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OXIDANTS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1; ULTRAVIOLET RAYS; YOUNG ADULT;

EID: 84919783300     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115402     Document Type: Article

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