Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model

Journal of Pharmacology and Experimental Therapeutics

Volumn 352, Issue 1, 2015, Pages 139-147

  Zhang, Pengcheng ^a,b   Qiang, Xiaoyan ^a,b   Zhang, Miao ^a,b   Ma, Dongshen ^a,b   Zhao, Zheng ^a,b   Zhou, Cuisong ^a,b   Liu, Xie ^a,b   Li, Ruiyan ^a,b   Chen, Huan ^a,b   Zhang, Yubin ^a,b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BERBERINE DERIVATIVE; CYTOCHROME P450 2E1; DEMETHYLENEBERBERINE; GLUTATHIONE PEROXIDASE; HERBACEOUS AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLACEBO; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; ALCOHOL; ANTIOXIDANT; BERBERINE; FATTY ACID; HIF1A PROTEIN, MOUSE; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; CELL LINE; CHINESE MEDICINE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG EFFICACY; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER CELL; MALE; MEDICINAL PLANT; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PHELLODENDRI CHINENSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; HEPG2 CELL LINE; LIVER DISEASES, ALCOHOLIC; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; BERBERINE; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; ETHANOL; FATTY ACIDS; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MITOCHONDRIA; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 84919768429     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.219832     Document Type: Article

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