Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

World Journal of Gastroenterology

Volumn 20, Issue 47, 2014, Pages 17851-17862

  Irvine, Katharine M ^a   Skoien, Richard ^a   Bokil, Nilesh J ^a   Melino, Michelle ^a   Thomas, Gethin P ^a   Loo, Dorothy ^a   Gabrielli, Brian ^a   Hill, Michelle M ^a   Sweet, Matthew J ^a   Clouston, Andrew D ^a   Powell, Elizabeth E ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Cell aging; Chemokines; Hepatocytes; Inflammation; Liver diseases; Macrophages

Indexed keywords

BETA GALACTOSIDASE; FIBRINOGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HETEROCHROMATIN PROTEIN 1; HYDROGEN PEROXIDE; INTERLEUKIN 32; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN P21; AUTACOID; BIOLOGICAL MARKER; CULTURE MEDIUM; CYTOKINE; TRANSCRIPTOME;

ARTICLE; CELL AGING; CELL COMPOSITION; CELL FUNCTION; CELL MIGRATION; CELL STRESS; CYTOCHEMISTRY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE ONTOLOGY; HUMAN; HUMAN CELL; LIVER CELL; MACROPHAGE MIGRATION; MICROENVIRONMENT; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN SECRETION; PROTEOMICS; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; CELL CYCLE CHECKPOINT; CHEMOTAXIS; COCULTURE; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; MACROPHAGE; METABOLISM; OXIDATIVE STRESS; PARACRINE SIGNALING; SECRETION (PROCESS);

BIOMARKERS; CELL AGING; CELL CYCLE CHECKPOINTS; CHEMOTAXIS; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION MEDIATORS; MACROPHAGES; OXIDATIVE STRESS; PARACRINE COMMUNICATION; PHENOTYPE; TRANSCRIPTOME;

EID: 84919754110     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i47.17851     Document Type: Article

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