Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice

Food and Chemical Toxicology

Volumn 76, Issue , 2015, Pages 19-26

  Church, Rachel J ^a   Gatti, Daniel M ^b   Urban, Thomas J ^c   Long, Nanye ^c   Yang, Xi ^d   Shi, Qiang ^d   Eaddy, J Scott ^a   Mosedale, Merrie ^a   Ballard, Shawn ^e   Churchill, Gary A ^b   Navarro, Victor ^f   Watkins, Paul B ^a   Threadgill, David W ^e,g   Harrill, Alison H ^a,h  

^a Hamner UNC Institute for Drug Safety Sciences   (United States)

^b JACKSON LABORATORY   (United States)

^c DUKE UNIVERSITY   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^e NORTH CAROLINA STATE UNIVERSITY   (United States)

^f Einstein Healthcare Network   (United States)

^g TEXAS A AND M UNIVERSITY   (United States)

^h UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Diversity outbred; Epigallocatechin gallate; Green tea; Hepatotoxicity; Herbal; Population variability

Indexed keywords

ALANINE AMINOTRANSFERASE; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; ANTIOXIDANT; CATECHIN; POLYPHENOL; TEA;

ADVERSE OUTCOME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHROMOSOME 4; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG EXPOSURE; DRUG TOLERABILITY; GENE; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HISTOPATHOLOGY; LIVER NECROSIS; LIVER TOXICITY; MALE; MFN2 GENE; MOUSE; MOUSE MODEL; NICK END LABELING; NONHUMAN; OUTBRED MOUSE STRAIN; PER3 GENE; QUANTITATIVE TRAIT LOCUS MAPPING; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TOXIC HEPATITIS; VPS13D GENE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CHROMOSOME MAP; DRUG EFFECTS; GENETICS; GENOTYPING TECHNIQUE; LIVER; METABOLISM; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; TEA; TUNEL ASSAY;

ANIMALIA; MUS;

ANIMALS; ANTIOXIDANTS; CATECHIN; CHROMOSOME MAPPING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GENOTYPING TECHNIQUES; IN SITU NICK-END LABELING; LIVER; MALE; MICE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYPHENOLS; QUANTITATIVE TRAIT LOCI; TEA;

EID: 84919754046     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.11.008     Document Type: Article

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