Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria

Biochemical and Biophysical Research Communications

Volumn 443, Issue 3, 2014, Pages 1097-1104

  Weng, Zuquan ^a   Zhou, Peng ^a   Salminen, William F ^a,d   Yang, Xi ^a   Harrill, Alison H ^b   Cao, Zhijun ^a   Mattes, William B ^c   Mendrick, Donna L ^a   Shi, Qiang ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c PharmPoint Consulting   (United States)

^d PAREXEL INTERNATIONAL   (United States)

Author keywords

Epigallocatechin gallate; Green tea; Liver; Mitochondria; Rat; Respiratory chain complexes

Indexed keywords

CYCLOPHILIN D; CYCLOSPORIN A; CYTOCHROME P450; EPIGALLOCATECHIN GALLATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER CELL; LIVER MICROSOME; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; TEA; WESTERN BLOTTING;

ANIMALIA; RATTUS;

ADENOSINE TRIPHOSPHATE; ATP; CSA; CYCLOSPORINE A; DIETARY SUPPLEMENTS; DS; EGCG; EPIGALLOCATECHIN GALLATE; FDA; GREEN TEA; GREEN TEA EXTRACT; GTE; HALF MAXIMAL INHIBITORY CONCENTRATION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; IC(50); IM; INNER MEMBRANES; LIVER; MGST1; MICROSOMAL GLUTATHIONE S-TRANSFERASE 1; MITOCHONDRIA; MITOCHONDRIAL PERMEABILITY TRANSITION; MITOCHONDRIALLY ENCODED CYTOCHROME C OXIDASE I; MPT; MT-CO1; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8; NDUFS3; NDUFS8; RAT; RCCS; RESPIRATORY CHAIN COMPLEXES; SDHA; SDHB; SDHC; SDHD; SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A; SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT B; SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT C; SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT D; U.S. FOOD AND DRUG ADMINISTRATION; UBIQUINOL-CYTOCHROME C REDUCTASE CORE PROTEIN I; UBIQUINOL-CYTOCHROME C REDUCTASE CORE PROTEIN II; UQCRC1; UQCRC2;

ANIMALS; BLOTTING, WESTERN; CATECHIN; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; OXIDATIVE PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; SILVER STAINING; TEA;

EID: 84893694112     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.110     Document Type: Article

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