A group of novel HIF-1α inhibitors, glyceollins, blocks HIF-1α synthesis and decreases its stability via inhibition of the PI3K/AKT/mTOR pathway and Hsp90 binding

Journal of Cellular Physiology

Volumn 230, Issue 4, 2015, Pages 853-862

  Lee, Sun Hee ^a   Jee, Jun Goo ^a   Bae, Jong Sup ^a   Liu, Kwang Hyoen ^a   Lee, You Mie ^a  

^a Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE 4; CYCLOHEXIMIDE; GELDANAMYCIN; GLYCEOLLIN; HEAT SHOCK PROTEIN 90; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHYTOALEXIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MTOR PROTEIN, HUMAN; PTEROCARPAN DERIVATIVE; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOLID TUMOR; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

GLYCINE MAX;

ANGIOGENESIS INHIBITORS; CELL HYPOXIA; CELL LINE, TUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEROCARPANS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84919753042     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24813     Document Type: Article

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