The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A

Carcinogenesis

Volumn 17, Issue 9, 1996, Pages 1861-1869

  Peterson, T Greg ^b   Coward, Lori ^a   Kirk, Marion ^a   Falany, Charles N ^a   Barnes, Stephen ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHANIN A; CARBON 14; GENISTEIN; GROWTH INHIBITOR; ISOFLAVONE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CELL GROWTH; CELL METABOLISM; CELL STRAIN MCF 7; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROXYLATION; MASS SPECTROMETRY; METABOLITE; METHYLATION; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

EID: 0029831118     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.9.1861     Document Type: Article

References (33)

1. Messina, M.J., Persky, V., Setchell, K.D.R. and Barnes, S. (1994) Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer, 21, 113-131.
2. Lee, H.P., Gourley, L., Duffy, S.W., Esteve, J. and Day, N.E. (1991) Dietary effect of breast cancer risk in Singapore. Lancet, 337, 1197-1200.
3. Severson, R.K., Nomura, A.M.Y., Grove, J.S. and Stemmermann, G.N. (1989) A prospective study of demographics, diet and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res., 49, 1857-1860.
4. Messina, M. and Barnes, S. (1991) Workshop report from the Division of Cancer Etiology, National Cancer Institute, National Institute of Health. The role of soy in reducing the risk of certain cancers. J. Natl Cancer Inst., 83, 541-546.
5. Peterson, G. (1995) Evaluation of the biochemical targets of genistein in tumor cells. J. Nutr., 125, 784s-789s.
6. Markovitz, J., Linassier, C., Fosse, P., Couprie, J., Pierre, J., Jacqemin-Sablon, A., Saucier, J.-M., Le Pecq, J.-B. and Larson, A.K. (1989) Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res., 49, 5111-5117.
7. Constantinou, A. and Huberman, E. (1995) Genistein as an inducer of tumor cell differentiation: possible mechanisms of action. Proc. Soc. Exp. Biol. Med, 125, 109-115.
8. Fotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R. and Schweigerer, L. (1995) Genistein, a dietary ingested isoflavone, inhibits cell proliferation and in vitro angiogenesis. J. Nutr., 125, 790-797.
9. Akiyama, T., Ishida J., Nakagawa, S., Ogawara, H, Watanabe, S.-I., Itoh, N., Shibuya, M. and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592-5595.
10. Cantley, L.C., Auger. K.R., Carpenter. C., Duckworth, B., Kapeller, R. and Soltoff, S. (1991) Oncogenes and signal transduction. Cell, 64, 281-302.
11. Boutin J.A. (1994) Tyrosine protein kinase inhibition and cancer. Int. J. Biochem., 26, 1203-1226.
12. Burke, T.R. (1992) Protein-tyrosine kinase inhibitors. Drugs Future. 17, 119-131.
13. Powis, G. and Kozikowski, A. (1991) Growth factor and oncogene signalling pathways as targets for rational anticancer drug development. Clin. Biochem., 24, 385-397.
14. Barnes, S., Grubbs, C., Setchell, K.D.R. and Carlson, J. (1990) Soybeans inhibit breast tumor in models of breast cancer. In Pariza, M.W., Aeschbacher, H.-U., Felton, J.S. and Sato, S. (eds), Mutagens and carcinogens in the Diet. Wiley-Liss, New York, pp. 239-253.
15. Adlercreutz, H. (1990) Western diet and western disease: some hormonal and biochemical mechanisms of action. Scand. J. Clin. Lab. Invest., 50, 3-23.
16. Setchell, K.D.R., Borriello, S.P., Hulme, P., Kirk, D.N. and Axelson, M. (1984) Non-estradiol estrogens of dietary origin: possible roles in hormone dependent diseases. Am. J. Clin. Nutr,. 40, 569-578.
17. Peterson, G. and Barnes, S. (1991) Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and multi-drug resistance gene product. Biochem. Biophys. Res. Commun., 179, 661-667.
18. Peterson, G. and Barnes, S. (1993) Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate, 22, 335-345.
19. Yanagihara, K., Ito, A., Toge, T. and Numoto, M. (1993) Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res., 53, 5815-5821.
20. Lee, Y.S., Kim, T.H., Cho, K.J. and Jang J.J. (1992) Inhibitory effects of biochanin A on benzo[a]pyrene induced carcinogenesis in mice. In Vivo, 6, 283-286.
21. Peterson, T.G. and Barnes, S. (1994) Genistein potently inhibits the growth of human primary breast epithelial cells correlation with a lack of genistein metabolism. Mol. Biol Cell, 5 (Suppl.) 323.
22. Peterson, T.G. (1995) Genistein and breast cancer: biochemical rationale tor its chemoprevemive, not chemotherapeutic, use. Ph.D Thesis, University of Alabama at Birmingham, AL.
23. Peterson, T.G. and Barnes, S. (1995) Genistien inhibits both estrogen and growth factor stimulated proliferation of transformed mammary epithelial cells. Cell Growth. Different., in press.
24. Falany, C.N., Wheeler, J., Oh, T.S. and Falany, J.L. (1995) Steroid sulfation by expressed human cytosolic sulfotransferases. J. Steroid Biochem. Molec. Biol., 48, 369-375.
25. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measeurements with folin phenol reagent. J. Biol. Chem., 193, 265-275.
26. Falany, J.L., Lawing, L. and Falany, C.N. (1993) Identification and characterization of cytosolic sulfotransferase activities in MCF-7 human breast carcinoma cells. J. Steroid Biochem. Molec. Biol. 46, 481-487.
27. Wilborn, T.W., Comer, K.A., Dooley, T.P., Reardon, I.M., Heinrikson, R.L. and Falany, C.N. (1993) Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase. Mol. Pharmacol. 263, 70-77.
28. Osherov, N., Gazit, A., Gilon, C. and Levitzki, A. (1993) Selective inhibition of the epidermal growth factor and HER2/neureceptors by tyrphostins. J. Biol. Chem., 268, 11134-11142.
29. Ramdas, L., McMurray, J.S. and Budde, R.J.A. (1994) The degree of inhibition of protein kinase activity by tyrphostin 23 and 25 is related to their instability. Cancer Res., 54, 867-869.
30. Dickinson, J.M., Smith, G.R., Randell, R.D. and Pemberton, I.J. (1988) In vitro metabolism of formomentin and biochanin A in bovine rumen fluid. J. Animal Sci., 66, 1969-1973.
31. Setchell, K.D.R., Welsh, M.B. and Lim, C.K. (1987) High performance liquid chromatography of phytoestrogens in soy protein preparations with ultraviolet, electrochemical, and thermospray mass spectrometric detection. J. Chrom., 386, 315-323.
32. Barnes, S. and Peterson, T.G. (1995) Biochemical targets of the isoflavone genistein in tumor cell lines. Proc. Soc. Exp. Med. Biol. 208, 103-108.
33. Mulder, G.J. and Jakoby, W.B. (1990) Sulfation. In Mulder, G.J. (ed.), Conjugation mictions in drug metabolism. Taylor and Francis, London, pp. 107-161.